58 patients (ages 5.4-18.3 years; 60.3% girls) were included (T0); 55 patients were reevaluated after 12 (±3) months (T1). Low bone mass for chronological age was found in 6/58 (10.4%) and 6/55(10.9%) patients at T0 and at T1, respectively. There was no statistical relationship between z-scores for BMD (BMD z-score) and the variables sex, fracture history, familyhistory of osteoporosis, physical activity and pubertal stage. There was a relation between BMD z-score alterations for TB and HIVviral load at T1 (p = 0.016). There was no association between duration or classes of antiretroviral therapy and bone density. The mean value of vitamin D in T0 was 23.43 ng/mL ± 2.015 and in T1 22.1 ng/mL ± 0.707 and considered insufficient levels for this population.
Conclusion:
Patients infected with HIV are at risk for BMD alterations and lower vitamin Dserum concentrations; both of these variables should be evaluated at routine examinations in order to improve both prevention and therapeuticplanning.