Dermatomiosite canina-símile em cão sem raça definida: relato de caso / Canine dermatomyositis-like disease in a mixed-breed dog: case report

A dermatomiosite canina é uma vasculopatia inflamatória da pele e músculos, com manifestações cutâneas envolvendo a face, orelhas, extremidades da cauda e distais por sobre proeminências ósseas. O envolvimento muscular manifesta-se sob a forma de mioatrofia cefálica, dificuldade de deglutição, redução do reflexo do vômito e marcha atípica. A dermatomiosite canina é classificada em dermatomiosite canina familiar e em forma variante ou dermatomiosite-símile. Neste relato descreve-se um caso de dermatomiosite-símile em cadela de dois anos de idade, sem raça definida, que apresentava necrose isquêmica dos pavilhões auriculares e atrofia dos músculos temporal e masseter. O exame dermo-histopatológico realizado em fragmentos de pele dos pavilhões auriculares, região cefálica e amostras de tecido muscular (temporal e masseter) confirmou a existência de dermatite perivascular e foliculite de interface pobre em células, focos de atrofia folicular e de fibras musculares e moderada fibrose dérmica. Portanto a histopatologia, associada às manifestações clínicas do animal, permitiu o estabelecimento do diagnóstico de dermatomiosite-símile, enfermidade pouco descrita na dermatologia veterinária brasileira.(AU)

Canine dermatomyositis is a skin and muscles inflammatory vasculopathy with cuta-neous manifestations involving face, ears, tail and distal ends over bony prominences. Mus-cle involvement manifests itself in the form of muscles of the head, difficulty in swallowing, reduction of reflex of vomit and atypical gait. Canine dermatomyositis is classified into variant form or dermatomyositis-like. This report describes a case of dermatomyositis-like in a two-year-old femalemixed-breed dog that presented ischemic necrosis of pinna and temporal and masseter muscle atrophy. In histopathological examinations performed with skin fragments of pinna, cephalic region and muscle samples (temporal and masseter), it was detected a perivascular dermatitis and folliculitis with poor cell interface, foci of follicular atrophy and muscle fibers with moderate dermal fibrosis confirming the diagnosis of derma-tomyositis-like, relatively little described in brazilian veterinary dermatology.(AU)

Dermatomiosite canina-símile em cão sem raça definida: relato de caso / Canine dermatomyositis-like disease in a mixed-breed dog: case report

A dermatomiosite canina é uma vasculopatia inflamatória da pele e músculos, com manifestações cutâneas envolvendo a face, orelhas, extremidades da cauda e distais por sobre proeminências ósseas. O envolvimento muscular manifesta-se sob a forma de mioatrofia cefálica, dificuldade de deglutição, redução do reflexo do vômito e marcha atípica. A dermatomiosite canina é classificada em dermatomiosite canina familiar e em forma variante ou dermatomiosite-símile. Neste relato descreve-se um caso de dermatomiosite-símile em cadela de dois anos de idade, sem raça definida, que apresentava necrose isquêmica dos pavilhões auriculares e atrofia dos músculos temporal e masseter. O exame dermo-histopatológico realizado em fragmentos de pele dos pavilhões auriculares, região cefálica e amostras de tecido muscular (temporal e masseter) confirmou a existência de dermatite perivascular e foliculite de interface pobre em células, focos de atrofia folicular e de fibras musculares e moderada fibrose dérmica. Portanto a histopatologia, associada às manifestações clínicas do animal, permitiu o estabelecimento do diagnóstico de dermatomiosite-símile, enfermidade pouco descrita na dermatologia veterinária brasileira.

Canine dermatomyositis is a skin and muscles inflammatory vasculopathy with cuta-neous manifestations involving face, ears, tail and distal ends over bony prominences. Mus-cle involvement manifests itself in the form of muscles of the head, difficulty in swallowing, reduction of reflex of vomit and atypical gait. Canine dermatomyositis is classified into variant form or dermatomyositis-like. This report describes a case of dermatomyositis-like in a two-year-old femalemixed-breed dog that presented ischemic necrosis of pinna and temporal and masseter muscle atrophy. In histopathological examinations performed with skin fragments of pinna, cephalic region and muscle samples (temporal and masseter), it was detected a perivascular dermatitis and folliculitis with poor cell interface, foci of follicular atrophy and muscle fibers with moderate dermal fibrosis confirming the diagnosis of derma-tomyositis-like, relatively little described in brazilian veterinary dermatology.

Three cases of canine dermatomyositis-like disease

Background: Dermatomyositis is an idiopathic, inflammatory/immunemediated disease of the skin, muscles and blood vessels of hereditary nature and unclear pathogenesis. This familial disease has been described in certain breeds, especially collies and Shetland sheep dogs and is of rare occurrence in mongrel dogs. To describe and discuss three clinical cases of dermatomyositis-like disease and provide a brief review of the literature.Cases: Three young mongrel dogs are included in this report. Case 1: Mandarino, a 4-year-old mongrel dog, having a history of skin lesions for at least a year. Showed an underweight patient, skin ulcers, crusts, alopecia, peri-ocular scarring causing severe lagophthalmia and a corneal ulcer. Muscle atrophy was most notable in the head and legs; the dog had difficulty and pain walking. Treatment was initialised with cephalexin 30 mg/kg BID, pentoxifylline 25 mg/kg BID, and prednisone 2.2 mg/kg SID. The patient was presented after two weeks for follow up; the anaemia and skin condition had improved, the weight had increased by 2 kg, dysphagia and locomotor abnormalities were not present. Case 2: Milagros, a mongrel female dog approximately two years of age, rescued from a shelter. Physical examination showed facial alopecia, erythema and scarring of the periocular skin, crusting and scaling in alopecic areas, pinnae tip necrosis and crusting, ear alopecia, tail tip necrosis and crusting. Also present were distal limb alopecia, crusting and ulcers in areas of trauma in the hock and carpal surfaces; some nails presented onychorhexis and onychoschizia. The patient has been treated for 12 months with a good clinical outcome, with pentoxifylline, azathioprine 2.2 mg/kg EOD alternating with prednisone 1 mg/kg EOD. Case 3: Chuchito, an 11-month-old male mongrel rescued dog had been previously hospitalised due to his skin condition.[...]

Three cases of canine dermatomyositis-like disease

Background: Dermatomyositis is an idiopathic, inflammatory/immunemediated disease of the skin, muscles and blood vessels of hereditary nature and unclear pathogenesis. This familial disease has been described in certain breeds, especially collies and Shetland sheep dogs and is of rare occurrence in mongrel dogs. To describe and discuss three clinical cases of dermatomyositis-like disease and provide a brief review of the literature.Cases: Three young mongrel dogs are included in this report. Case 1: Mandarino, a 4-year-old mongrel dog, having a history of skin lesions for at least a year. Showed an underweight patient, skin ulcers, crusts, alopecia, peri-ocular scarring causing severe lagophthalmia and a corneal ulcer. Muscle atrophy was most notable in the head and legs; the dog had difficulty and pain walking. Treatment was initialised with cephalexin 30 mg/kg BID, pentoxifylline 25 mg/kg BID, and prednisone 2.2 mg/kg SID. The patient was presented after two weeks for follow up; the anaemia and skin condition had improved, the weight had increased by 2 kg, dysphagia and locomotor abnormalities were not present. Case 2: Milagros, a mongrel female dog approximately two years of age, rescued from a shelter. Physical examination showed facial alopecia, erythema and scarring of the periocular skin, crusting and scaling in alopecic areas, pinnae tip necrosis and crusting, ear alopecia, tail tip necrosis and crusting. Also present were distal limb alopecia, crusting and ulcers in areas of trauma in the hock and carpal surfaces; some nails presented onychorhexis and onychoschizia. The patient has been treated for 12 months with a good clinical outcome, with pentoxifylline, azathioprine 2.2 mg/kg EOD alternating with prednisone 1 mg/kg EOD. Case 3: Chuchito, an 11-month-old male mongrel rescued dog had been previously hospitalised due to his skin condition.[...](AU)

Dermatomiosite generalizada de início no cão adulto: relato de caso / Generalized Dermatomyositis in a adult dog: case report

O presente relato descreve o caso clínico de um cão, fêmea, sem raça definida de cinco anos de idadecom apresentação clínicopatológica de dermatomiosite generalizada de início na vida adulta. A apresentação dermatológica consistiu de lesões ulceradas e crostosas, com edema associado, localizadas mormente em membros, axilas e cabeça. A miosite manifestou-se por atrofia muscular e megaesôfago, que regrediram espontaneamente. A despeito da conduta terapêutica utilizada, a doençadermatológica mostrou-se clinicamente refratária aos fármacos n ormalmente preconizados. (AU)

The present report describes a clinical case of a five years old female dog, not defined breed, clinical and pathological presentation of widespread dermatomyositis who had the beginning in the adult life. The dermatological presentation consists in crusting and ulcerative lesions with edema associated, usually located in members, armpit and head. The myositis was demonstrated by muscular atrophy and megaesophagus, who return spontaneous. Despite the treatment protocol used, the dermatologycaldisease not demonstrated clinical responsive to the drugs who often been prescribed. (AU)

Dermatomiosite generalizada de início no cão adulto: relato de caso / Generalized Dermatomyositis in a adult dog: case report

O presente relato descreve o caso clínico de um cão, fêmea, sem raça definida de cinco anos de idadecom apresentação clínicopatológica de dermatomiosite generalizada de início na vida adulta. A apresentação dermatológica consistiu de lesões ulceradas e crostosas, com edema associado, localizadas mormente em membros, axilas e cabeça. A miosite manifestou-se por atrofia muscular e megaesôfago, que regrediram espontaneamente. A despeito da conduta terapêutica utilizada, a doençadermatológica mostrou-se clinicamente refratária aos fármacos n ormalmente preconizados.

The present report describes a clinical case of a five years old female dog, not defined breed, clinical and pathological presentation of widespread dermatomyositis who had the beginning in the adult life. The dermatological presentation consists in crusting and ulcerative lesions with edema associated, usually located in members, armpit and head. The myositis was demonstrated by muscular atrophy and megaesophagus, who return spontaneous. Despite the treatment protocol used, the dermatologycaldisease not demonstrated clinical responsive to the drugs who often been prescribed.

DERMATOMIOSITE CANINA FAMILIAR- SIMILE: RELATO DE CASO. / CANINE FAMILIAL DERMATOMYOSITIS-SIMILE: CASE REPORT. / DERMATOMIOSITIS CANINA FAMILIAR SÍMIL: REPORTE DE CASO.

RESUMO Dermatomiosite canina familiarsímile é afecção caracterizada pelo comprometimento da pele, musculatura estriada e vasos sanguíneos, sem envolvimento genético. O presente relato descreve o diagnóstico clínico e histopatológico, e avalia a eficácia do tratamento com pentoxifilina e prednisona em um cão acometido por tal enfermidade. Palavras-chave: isquemia, pentoxifilina, cães CANINE FAMILIAL DERMATOMYOSITIS-SIMILE: CASE REPORT ABSTRACT Canine familial dermatomyositis-simile is characterized by involvement of the skin, striated muscles and blood vessels, with no involvement genetic. This report describes the clinical and histopathological diagnosis, and evaluates the effectiveness of treatment with pentoxifylline and prednisone in a dog affected by this disease. Keywords: ischemia, pentoxifylline, dogs DERMATOMIOSITIS CANINA FAMILIAR SÍMIL: REPORTE DE CASO RESUMEN La dermatomiositis se caracteriza por el deterioro de la piel, los músculos estriados y los vasos sanguíneos, sin basis genética. Este reporte describe el diagnóstico clínico e histopatológico, y evalúa la eficacia del tratamiento con pentoxifilina y prednisona en un perro afectado por esta enfermedad. Palabras clave: isquemia, pentoxifilina, perros

Dermatomiosite canina familiar- simile: relato de caso. / canine familial dermatomyositis-simile: case report. / dermatomiositis canina familiar símil: reporte de caso

RESUMO Dermatomiosite canina familiarsímile é afecção caracterizada pelo comprometimento da pele, musculatura estriada e vasos sanguíneos, sem envolvimento genético. O presente relato descreve o diagnóstico clínico e histopatológico, e avalia a eficácia do tratamento com pentoxifilina e prednisona em um cão acometido por tal enfermidade. Palavras-chave: isquemia, pentoxifilina, cães CANINE FAMILIAL DERMATOMYOSITIS-SIMILE: CASE REPORT ABSTRACT Canine familial dermatomyositis-simile is characterized by involvement of the skin, striated muscles and blood vessels, with no involvement genetic. This report describes the clinical and histopathological diagnosis, and evaluates the effectiveness of treatment with pentoxifylline and prednisone in a dog affected by this disease. Keywords: ischemia, pentoxifylline, dogs DERMATOMIOSITIS CANINA FAMILIAR SÍMIL: REPORTE DE CASO RESUMEN La dermatomiositis se caracteriza por el deterioro de la piel, los músculos estriados y los vasos sanguíneos, sin basis genética. Este reporte describe el diagnóstico clínico e histopatológico, y evalúa la eficacia del tratamiento con pentoxifilina y prednisona en un perro afectado por esta enfermedad. Palabras clave: isquemia, pentoxifilina, perros