Nanotechnology in veterinary medicine: a review / Nanotecnologia em medicina veterinária: uma revisão

The purpose of this review was to address the applicability of nanotechnology in veterinary medicine, with an emphasis on research in Brazil from 2013 to 2020. Firstly, we introduced to the general aspects of applicability of nanotechnology in veterinary medicine, and lately we pointed the research involving nanoscience performed in Brazil, in the studied period. Nanotechnology is the field of science that has the capacity to organize matter in nanoscale structures (1 to 100 nm), enabling innovations in different areas including biotechnology, agriculture, disease diagnosis, food and clothing industry, electronics, and pharmacological therapies. In veterinary medicine, several studies are being carried out in the world, mainly in the areas that involve search of new treatment options and the development of immunotherapy, as well as in the diagnosis of diseases. In Brazil, it is clear that the use of nanotechnology in veterinary medicine is still incipient, but it can be considered a growing area. In addition, several points have to be reflected and researched, including some adverse effects and implications to validate the safe use of nanotechnology in veterinary medicine. Therefore, this review highlighted the nanotechnology as a promise alternative in the current context of Brazilian technological innovation involving animal health, as well as a possible diagnostic tool and highlighting its potential therapeutic use in disease control in veterinary medicine. Regarding future perspectives, we believed that greater investment in science and technology could contribute to the advancement and strengthening of nanotechnology in Brazil.

O objetivo desta revisão foi abordar a aplicabilidade da nanotecnologia na medicina veterinária, com ênfase nas pesquisas no Brasil de 2013 a 2020. Primeiramente, apresentam-se os aspectos gerais da aplicabilidade da nanotecnologia em medicina veterinária e, posteriormente, apontam-se as pesquisas envolvendo nanociência realizadas no Brasil, no período estudado. A nanotecnologia é o campo da ciência capaz de organizar a matéria em estruturas de nanoescala (1 a 100 nm), permitindo inovações em diferentes áreas, incluindo biotecnologia, agricultura, diagnóstico de doenças, indústria de alimentos e vestuário, eletrônica e terapias farmacológicas. Na medicina veterinária, diversos estudos estão sendo realizados no mundo, principalmente nas áreas que envolvem a busca de novas opções de tratamento e o desenvolvimento de imunoterapia, bem como no diagnóstico de doenças. No Brasil, está claro que o uso da nanotecnologia na medicina veterinária ainda é incipiente, mas pode ser considerada uma área em crescimento. Além disso, vários pontos devem ser refletidos e pesquisados, incluindo alguns efeitos adversos e implicações para validar o uso seguro da nanotecnologia na medicina veterinária. Nesta revisão, destaca-se a nanotecnologia como uma alternativa promissora no atual contexto de inovação tecnológica brasileira, envolvendo saúde animal, o diagnóstico e o potencial uso terapêutico no controle de doenças em medicina veterinária. Em relação às perspectivas futuras, acredita-se que maiores investimentos em ciência e tecnologia são fatores fundamentais a contribuir para o avanço e fortalecimento da nanotecnologia no Brasil.

Detecting estrus in Canindé goats by two infrared thermography methods

The aim of this study was to evaluate the diagnosis of estrous in Canindé goats used infrared thermographic images. The Canindé goats used in experiment, belong to Production Center of Small Ruminants. The goats were subjected to estrus induction and monitored with regard to their behavior and blood levels of hormones. Temperature measurements were continuous during estrous signs and even disappearance of behavioral characteristics. Were evaluated different areas in females: vulva, perivulvar, dorse and venter regions, delimited by a quadrant that allowed the specification of assessed region. In addition to specific behavior of estrus in ruminants were observed in vulvar region perivulvar signals swelling and redness and parallel identified the temperature rise of region by thermographic images. Were observed in vulvar region perivulvar signals swelling and redness and parallel identified the temperature rise of that region by thermographic images in goats in estrus. There was a significant effect for all temperatures of the regions evaluated for the thermographic images and infrared thermometer, except for the temperature of the vulvar region. The temperatures measured using the thermographic camera submitted a difference in the data set, allowing measurements observed higher temperatures compared with the temperatures measured with an infrared thermometer. So, due the precision and speed of the method the thermographic images used for detecting estrus is applicable and important. In animal production, thermography has seen used in detection of metabolic disorders, diseases and infections. In addiction, is usedin understanding thermoregulation due to chenges in temperature and the impact of environmental conditions.

Detecting estrus in Canindé goats by two infrared thermography methods

The aim of this study was to evaluate the diagnosis of estrous in Canindé goats used infrared thermographic images. The Canindé goats used in experiment, belong to Production Center of Small Ruminants. The goats were subjected to estrus induction and monitored with regard to their behavior and blood levels of hormones. Temperature measurements were continuous during estrous signs and even disappearance of behavioral characteristics. Were evaluated different areas in females: vulva, perivulvar, dorse and venter regions, delimited by a quadrant that allowed the specification of assessed region. In addition to specific behavior of estrus in ruminants were observed in vulvar region perivulvar signals swelling and redness and parallel identified the temperature rise of region by thermographic images. Were observed in vulvar region perivulvar signals swelling and redness and parallel identified the temperature rise of that region by thermographic images in goats in estrus. There was a significant effect for all temperatures of the regions evaluated for the thermographic images and infrared thermometer, except for the temperature of the vulvar region. The temperatures measured using the thermographic camera submitted a difference in the data set, allowing measurements observed higher temperatures compared with the temperatures measured with an infrared thermometer. So, due the precision and speed of the method the thermographic images used for detecting estrus is applicable and important. In animal production, thermography has seen used in detection of metabolic disorders, diseases and infections. In addiction, is usedin understanding thermoregulation due to chenges in temperature and the impact of environmental conditions.(AU)

Load cell adoption in an electronic drag force flowmeter

This research introduces the development of an electronic flowmeter based on the drag force that a body experiences when immersed in a fluid stream. Its main goal was the development of an Electronic Drag Force Flowmeter (EDFF) using a load cell, as well as the evaluation of its performance parameters. The developed flowmeter should not require specialized labor, equipments, computers or any sophisticated and complex method, providing an easy and accurate way of flow estimation. This research was carried out in the following stages: (i) EDFF mechanical structure development; (ii) data acquisition system and embedded software design; and (iii) evaluation of EDFF performance parameters. EDFF has routines for instantaneous flow rate measurement, interactive calibration, and also several flow meter parameter adjustments, allowing data transmission via a RS232 protocol. The real-time flow measurement task updates values of instantaneous flow rate each seven seconds, enabling unit selection. The interactive calibration routine guides users during all calibration process showing instructions on EDFF's display. A data digital filtering procedure was implemented in an embedded software using the Grubbs' Test in order to identify and to remove outliers from the acquired data. The Method of Least Squares was also implemented in the embedded software in order to calculate the fitting model coefficients on the calibration procedure. This flowmeter is able to work from 1.94 to 7.78 dm³ s-1 with an uncertainty of ± 5.7%. The coefficient of local head loss (K) was close to 0.55 for Reynolds number values higher than 10(5). The developed EDFF is a low-cost and stand-alone system with potential for agricultural applications.

Este estudo apresenta o desenvolvimento de um medidor de vazão baseado na força de arraste que atua em um corpo imerso em uma corrente líquida. O principal objetivo foi o desenvolvimento de um Medidor de Vazão Eletrônico tipo Força (MVEF) utilizando célula de carga, bem como a avaliação do desempenho do equipamento. Esta pesquisa foi executada nas seguintes etapas: (i) desenvolvimento da estrutura mecânica do MVEF; (ii) desenvolvimento do sistema de aquisição de dados e do software embarcado; e (iii) avaliação dos parâmetros de desempenho do MVEF. O medidor de vazão desenvolvido possibilita a transmissão de dados via serial (RS-232) e possui rotinas para medição de vazão instantânea, calibração interativa e opções para ajuste de alguns parâmetros de funcionamento. O Teste de Grubbs foi utilizado no software embarcado com a finalidade de identificar e remover dados inconsistentes do conjunto amostral, sendo, portanto, um procedimento de filtragem digital de dados. A rotina de calibração do medidor de vazão consta de um algoritmo que utiliza o Método dos Mínimos Quadrados para determinação dos coeficientes de ajuste do modelo adotado. O medidor de vazão desenvolvido opera na faixa de 1,94 a 7,78 dm³ s-1 com incerteza de ± 5,7%. O coeficiente de perda de carga localizada característico do medidor de vazão foi de aproximadamente 0,55 para condições com Número de Reynolds superior a 10(5). O medidor de vazão desenvolvido apresenta baixo custo, sendo viável para utilização em aplicações agrícolas.

Load cell adoption in an electronic drag force flowmeter

This research introduces the development of an electronic flowmeter based on the drag force that a body experiences when immersed in a fluid stream. Its main goal was the development of an Electronic Drag Force Flowmeter (EDFF) using a load cell, as well as the evaluation of its performance parameters. The developed flowmeter should not require specialized labor, equipments, computers or any sophisticated and complex method, providing an easy and accurate way of flow estimation. This research was carried out in the following stages: (i) EDFF mechanical structure development; (ii) data acquisition system and embedded software design; and (iii) evaluation of EDFF performance parameters. EDFF has routines for instantaneous flow rate measurement, interactive calibration, and also several flow meter parameter adjustments, allowing data transmission via a RS232 protocol. The real-time flow measurement task updates values of instantaneous flow rate each seven seconds, enabling unit selection. The interactive calibration routine guides users during all calibration process showing instructions on EDFF's display. A data digital filtering procedure was implemented in an embedded software using the Grubbs' Test in order to identify and to remove outliers from the acquired data. The Method of Least Squares was also implemented in the embedded software in order to calculate the fitting model coefficients on the calibration procedure. This flowmeter is able to work from 1.94 to 7.78 dm³ s-1 with an uncertainty of ± 5.7%. The coefficient of local head loss (K) was close to 0.55 for Reynolds number values higher than 10(5). The developed EDFF is a low-cost and stand-alone system with potential for agricultural applications.

Este estudo apresenta o desenvolvimento de um medidor de vazão baseado na força de arraste que atua em um corpo imerso em uma corrente líquida. O principal objetivo foi o desenvolvimento de um Medidor de Vazão Eletrônico tipo Força (MVEF) utilizando célula de carga, bem como a avaliação do desempenho do equipamento. Esta pesquisa foi executada nas seguintes etapas: (i) desenvolvimento da estrutura mecânica do MVEF; (ii) desenvolvimento do sistema de aquisição de dados e do software embarcado; e (iii) avaliação dos parâmetros de desempenho do MVEF. O medidor de vazão desenvolvido possibilita a transmissão de dados via serial (RS-232) e possui rotinas para medição de vazão instantânea, calibração interativa e opções para ajuste de alguns parâmetros de funcionamento. O Teste de Grubbs foi utilizado no software embarcado com a finalidade de identificar e remover dados inconsistentes do conjunto amostral, sendo, portanto, um procedimento de filtragem digital de dados. A rotina de calibração do medidor de vazão consta de um algoritmo que utiliza o Método dos Mínimos Quadrados para determinação dos coeficientes de ajuste do modelo adotado. O medidor de vazão desenvolvido opera na faixa de 1,94 a 7,78 dm³ s-1 com incerteza de ± 5,7%. O coeficiente de perda de carga localizada característico do medidor de vazão foi de aproximadamente 0,55 para condições com Número de Reynolds superior a 10(5). O medidor de vazão desenvolvido apresenta baixo custo, sendo viável para utilização em aplicações agrícolas.