Seminoma in a gray brocket deer (Mazama gouazoubira) with unilateral cryptorchidism

Cryptorchidism is the incomplete descent of the testes and associated structures, and cryptorchid testes are more likely to develop testicular neoplasms, such as seminoma. This is the first report of a seminoma in a cryptorchid wild-caught gray brocket deer (Mazama gouazoubira). The animal developed a unilateral seminoma with classical histopathological findings and benign behavior. Six months after the orchiectomy the cervid presented a metatarsal opened fracture, dying during the orthopedic surgery. No macro or micrometric metastasis was observed at the necropsy.(AU)

Bilateral dysgerminoma in a senile bitch associated with nodular lymphoid hyperplasia in spleen and pyometra: a case report / Disgerminoma bilateral em cadela senil associado a hiperplasia nodular linfoide em baço e piometra: relato de caso

Ovarian neoplasms affect a low percentage of female dogs, and these tumors are classified according to their cellular origin and are considered rare. Dysgerminoma is a tumor derived from undifferentiated primordial ovarian germinal epithelium cells. In the male, this neoplasm is diagnosed as seminoma. Thus, dysgerminoma is not linked to the production of ovarian hormones such as estrogen and progesterone, which play a fundamental role in the establishment of pyometra. At Araujo Veterinary Hospital (HVA), a 15-year-old female Pinscher was admitted with mucopurulent vaginal discharge, abdominal enlargement, anorexia, polydipsia, and prostration clinical signs indicative of pyometra, radiographic and ultrasound examinations were requested, as well as a blood collection for hemogram and serum biochemistry. Ultrasound examination revealed uterine enlargement and hypoechoic content, in addition to bilateral ovarian cysts, measuring 7 cm in the right ovary and 3 cm in the left. The blood count revealed normal values in the erythrogram and the leukogram showed monocytosis and lymphopenia, in addition to macroplatelets. Biochemical examination revealed increased GGT values of 10 U/L. Ovariohysterectomy was performed and, in the trans-surgical period, nodules in the spleen were observed. So, the ovaries and a fragment of the lymphoid organ, were fixed and sent to the histopathology laboratory after surgical resection. Histopathology revealed ovarian dysgerminoma and lymphoid nodular hyperplasia. Ten days after the surgical procedure, the dog returned to the HVA for clinical evaluation and suture removal. However, three days after the return, the patient presented a convulsive condition evolving to death.

Neoplasias ovarianas acometem baixa porcentagem de cadelas, e estes tumores são classificados de acordo com a origem celular, sendo considerados raros. O disgerminoma é um tumor derivado de células do epitélio germinativo primordial ovariano, indiferenciado. No macho, essa neoplasia é diagnosticada como seminoma. Assim, o disgerminoma não está ligado a produção de hormônios ovarianos, como o estrógeno e a progesterona, que desempenham papel fundamental para o estabelecimento da piometra. No Hospital Veterinário Araújo (HVA), uma cachorra da raça Pinscher, com 15 anos, foi antendida apresentando, secreção vaginal mucopurulenta, aumento abdominal, anorexia, polidipsia e prostração sinais clínicos indicativos de piometra, solicitou-se exame de radiográfico e ultrassonografia, bem como a coleta de sangue para hemograma e bioquímico sérico. O exame ultrassonográfico revelou aumento uterino e conteúdo hipoecóico, além de cistos ovarianos bilaterais, com mensurações de 7 cm no ovário direito e 3 cm no esquerdo. O hemograma revelou valores normais no eritrograma e o leucograma apresentou monocitose e linfopenia, além de macroplaquetas. O exame bioquímico revelou valores de GGT aumentados, em 10 U/L. A ovariohisterectomia foi realizada e no trans cirúrgico observou-se nódulos no baço. Assim, os ovários e um fragmento do órgão linfoide, após a ressecção cirúrgica, foram fixados e encaminhadas para laboratório de histopatologia. A histopatologia revelou disgerminoma ovariano e hiperplasia nodular linfoide. Dez dias após o procedimento cirúrgico, a paciente retornou ao HVA para avaliação clínica e retirada da sutura. No entanto, três dias após o retorno, o animal apresentou um quadro convulsivo evoluindo ao óbito.

Seminoma and sertolioma in non-cryptorchid dog – case report / Seminoma e sertolioma em cão não criptorquida – relato de caso

The most common testicular neoplasms in dogs are seminoma, leydigocytoma and sertolioma, affecting middle--aged and elderly dogs, where cryptorchidism is a predisposing factor, as well as some breeds. It can occur alone or, less fren-quently, concurrently, generally affecting the same testicle. This study aimed to report the case of a non-cryptorchid 14-year--old mixed breed dog diagnosed with seminoma and sertolioma, each in a testicle. The animal showed an increase in scrotal volume, with no changes in other clinical parameters on physical examination. On ultrasound examination, it was possible to observe alterations suggestive of neoplasia in both testicles and prostatic alteration suggestive of benign prostatic hyperplasia. Complementary blood count and biochemical tests were performed and, as treatment, orchiectomy was performed. Fragments were collected from both testicles and sent for histopathological examination. Microscopy of the left testicle showed the presence of round cells, multiple and evident nucleoli, cells in different phases of mitosis and binucleation, these changes being compa-tible with seminoma. In contrast, in the right testicle, spindle and elongated cells (pseudo-lobular) were observed, presence of long cytoplasmic projections with rounded ovoid nucleus, spindle cells and degeneration of seminiferous tubules, compatible with sertolioma. It was observed that physical examination associated with ultrasound was efficient to detect the presence of neoplasms, being validated by histopathological examination. Orchiectomy was an assertive treatment indicated for this case.

As neoplasias testiculares mais comuns em cães são o seminoma, leydigocitoma e o sertolioma, acometendo cães de meia idade e idosos, com predisposição racial e animais criptorquidas, podendo ocorrer isoladamente, ou concomitantemente, porém com menor frequência. Esse trabalho objetivou relatar o caso de um cão, SRD, 14 anos, não criptorquida diagnosticado com seminoma e sertolioma em testículos distintos. O animal apresentou aumento do volume testicular bilateral, sem alterações nos demais parâmetros clínicos ao exame físico. Ao exame ultrassonográfico foi possível observar alterações sugestivas de neoplasia para ambos os testículos e alteração prostática sugestiva de hiperplasia prostática benigna. Foram realizados exames complemen-tares de hemograma e bioquímico e como tratamento a realização de orquiectomia. Fragmentos foram coletados de ambos os tes-tículos e enviados para análise histopatológica. A microscopia do testículo esquerdo, evidenciou a presença de células arredonda-das, nucléolos múltiplos e evidentes, células em diferentes fases de mitose e binucleação, alteração compatíveis de seminoma. Em contrapartida, no testículo direito foi observado a presença de células fusiformes e alongadas (pseudo-lobular), presença de longas projeções citoplasmáticas com núcleo ovóide arredondado, células fusiformes e degeneração dos túbulos seminíferos compatíveis de sertolioma. Observou-se que o exame físico associado ao ultrassonográfico foi eficiente para detectar a presença das neopla-sias e isto foi validado pelo exame histopatológico. A realização de orquiectomia foi tratamento assertivo indicado para este caso.

Seminoma and sertolioma in non-cryptorchid dog case report / Seminoma e sertolioma em cão não criptorquida relato de caso

The most common testicular neoplasms in dogs are seminoma, leydigocytoma and sertolioma, affecting middle--aged and elderly dogs, where cryptorchidism is a predisposing factor, as well as some breeds. It can occur alone or, less fren-quently, concurrently, generally affecting the same testicle. This study aimed to report the case of a non-cryptorchid 14-year--old mixed breed dog diagnosed with seminoma and sertolioma, each in a testicle. The animal showed an increase in scrotal volume, with no changes in other clinical parameters on physical examination. On ultrasound examination, it was possible to observe alterations suggestive of neoplasia in both testicles and prostatic alteration suggestive of benign prostatic hyperplasia. Complementary blood count and biochemical tests were performed and, as treatment, orchiectomy was performed. Fragments were collected from both testicles and sent for histopathological examination. Microscopy of the left testicle showed the presence of round cells, multiple and evident nucleoli, cells in different phases of mitosis and binucleation, these changes being compa-tible with seminoma. In contrast, in the right testicle, spindle and elongated cells (pseudo-lobular) were observed, presence of long cytoplasmic projections with rounded ovoid nucleus, spindle cells and degeneration of seminiferous tubules, compatible with sertolioma. It was observed that physical examination associated with ultrasound was efficient to detect the presence of neoplasms, being validated by histopathological examination. Orchiectomy was an assertive treatment indicated for this case.(AU)

As neoplasias testiculares mais comuns em cães são o seminoma, leydigocitoma e o sertolioma, acometendo cães de meia idade e idosos, com predisposição racial e animais criptorquidas, podendo ocorrer isoladamente, ou concomitantemente, porém com menor frequência. Esse trabalho objetivou relatar o caso de um cão, SRD, 14 anos, não criptorquida diagnosticado com seminoma e sertolioma em testículos distintos. O animal apresentou aumento do volume testicular bilateral, sem alterações nos demais parâmetros clínicos ao exame físico. Ao exame ultrassonográfico foi possível observar alterações sugestivas de neoplasia para ambos os testículos e alteração prostática sugestiva de hiperplasia prostática benigna. Foram realizados exames complemen-tares de hemograma e bioquímico e como tratamento a realização de orquiectomia. Fragmentos foram coletados de ambos os tes-tículos e enviados para análise histopatológica. A microscopia do testículo esquerdo, evidenciou a presença de células arredonda-das, nucléolos múltiplos e evidentes, células em diferentes fases de mitose e binucleação, alteração compatíveis de seminoma. Em contrapartida, no testículo direito foi observado a presença de células fusiformes e alongadas (pseudo-lobular), presença de longas projeções citoplasmáticas com núcleo ovóide arredondado, células fusiformes e degeneração dos túbulos seminíferos compatíveis de sertolioma. Observou-se que o exame físico associado ao ultrassonográfico foi eficiente para detectar a presença das neopla-sias e isto foi validado pelo exame histopatológico. A realização de orquiectomia foi tratamento assertivo indicado para este caso.(AU)

Bilateral canine seminoma with ocular metastasis: histochemical and immunohistochemical characterization

A 10-year old male dog was examined due to a buphthalmia in the left eye and a nodule in the two testicles. Due to the limited resources of the owner and loss of visual acuity of the patient, the enucleation and castration were chosen as treatment. Microscopic analysis of the testicular tissue revealed neoplastic germ cells. Morphologically, neoplastic cells were characterized by distinct cell borders, scarce and eosinophilic cytoplasm, large round nucleus, with thick chromatin and a prominent nucleolus. Binucleated and multinucleated neoplastic cells were also frequently observed. In 10 high powerfields (400x), 62 typical and atypical mitosis were counted. Similar neoplastic cells were identified within the vessels of theretina, sclera and in the sub-epithelial conjunctive tissue of the eyelid. The neoplastic cells observed in the testicle and in the eye were positive for PAS. By immunochemistry technique was identified an intense immunostaining of the neoplastic cells for Vimentin and Ki-67 in both testicular and ocular tissue. While, discrete immunoreactivity was identified to c-KIT from the neoplastic cells in both organs. Based on morphological, histochemical and immunohistochemical analysis, it was possible to characterize the ocular lesion as seminoma metastasis.

Bilateral canine seminoma with ocular metastasis: histochemical and immunohistochemical characterization

A 10-year old male dog was examined due to a buphthalmia in the left eye and a nodule in the two testicles. Due to the limited resources of the owner and loss of visual acuity of the patient, the enucleation and castration were chosen as treatment. Microscopic analysis of the testicular tissue revealed neoplastic germ cells. Morphologically, neoplastic cells were characterized by distinct cell borders, scarce and eosinophilic cytoplasm, large round nucleus, with thick chromatin and a prominent nucleolus. Binucleated and multinucleated neoplastic cells were also frequently observed. In 10 high powerfields (400x), 62 typical and atypical mitosis were counted. Similar neoplastic cells were identified within the vessels of theretina, sclera and in the sub-epithelial conjunctive tissue of the eyelid. The neoplastic cells observed in the testicle and in the eye were positive for PAS. By immunochemistry technique was identified an intense immunostaining of the neoplastic cells for Vimentin and Ki-67 in both testicular and ocular tissue. While, discrete immunoreactivity was identified to c-KIT from the neoplastic cells in both organs. Based on morphological, histochemical and immunohistochemical analysis, it was possible to characterize the ocular lesion as seminoma metastasis.(AU)

Metástase de seminoma em região orbital em cão - relato de caso / Metastatic seminoma in the orbital region in a dog - case report

O seminoma é uma neoformação testicular originária de células germinativas de ocorrência comum em cães, com maior prevalência em animais senis. Em geral, o comportamento biológico do seminoma canino é benigno. Relata-se neste trabalho um caso de seminoma com metástase em região orbital em um cão com 14 anos de idade. O animal foi atendido com queixa de aumento de volume em órbita esquerda, com posterior detecção de nódulo testicular. A punção aspirativa por agulha fina da massa orbital sugeriu tratar-se de linfoma de alto grau, contudo o diagnóstico definitivo de seminoma difuso foi estabelecido pela avaliação histopatológica, a qual revelou tratar-se de neoplasia maligna pouco diferenciada, sendo o diagnóstico de seminoma difuso confirmado pelo exame imunoistoquímico. Relatos de seminomas metastáticos em cães são incomuns. Objetivou-se com este trabalho relatar um caso de seminoma anaplásico difuso em cão cujo foco principal de metástase ocorreu em região orbital, além de descrever e discutir as dificuldades diagnósticas encontradas.(AU)

Seminoma is a testicular neoformation originating from germ cells, commonly occurring in dogs. With higher prevalence in senile animals, the biological behavior of canine seminomas generally benign. This case reports seminoma with mestastasis in the orbital region in a 14-year-old dog. The animal was treated with a complaint of increased volume in the left orbit, and later a nodule in the testicle was discovered. Fine-needle aspiration of the orbit mass initially indicated a high-grade lymphoma. The definitive diagnosis of diffused seminoma was established by histopathological examination, resulting in poorly differentiated malignant neoplasia. Finally, the diagnosis was confirmed through immunohistochemistry, being the result compatible with diffused seminoma. Metastatic seminomas reported in dogs are quite uncommon. In this work we report a case of diffused anaplastic seminoma in dogs, where the main focus of metastasis was observed in the orbital region, and we also describe and discuss the difficulties encountered in the diagnostic.(AU)

Metástase de seminoma em região orbital em cão - relato de caso / Metastatic seminoma in the orbital region in a dog - case report

O seminoma é uma neoformação testicular originária de células germinativas de ocorrência comum em cães, com maior prevalência em animais senis. Em geral, o comportamento biológico do seminoma canino é benigno. Relata-se neste trabalho um caso de seminoma com metástase em região orbital em um cão com 14 anos de idade. O animal foi atendido com queixa de aumento de volume em órbita esquerda, com posterior detecção de nódulo testicular. A punção aspirativa por agulha fina da massa orbital sugeriu tratar-se de linfoma de alto grau, contudo o diagnóstico definitivo de seminoma difuso foi estabelecido pela avaliação histopatológica, a qual revelou tratar-se de neoplasia maligna pouco diferenciada, sendo o diagnóstico de seminoma difuso confirmado pelo exame imunoistoquímico. Relatos de seminomas metastáticos em cães são incomuns. Objetivou-se com este trabalho relatar um caso de seminoma anaplásico difuso em cão cujo foco principal de metástase ocorreu em região orbital, além de descrever e discutir as dificuldades diagnósticas encontradas.(AU)

Seminoma is a testicular neoformation originating from germ cells, commonly occurring in dogs. With higher prevalence in senile animals, the biological behavior of canine seminomas generally benign. This case reports seminoma with mestastasis in the orbital region in a 14-year-old dog. The animal was treated with a complaint of increased volume in the left orbit, and later a nodule in the testicle was discovered. Fine-needle aspiration of the orbit mass initially indicated a high-grade lymphoma. The definitive diagnosis of diffused seminoma was established by histopathological examination, resulting in poorly differentiated malignant neoplasia. Finally, the diagnosis was confirmed through immunohistochemistry, being the result compatible with diffused seminoma. Metastatic seminomas reported in dogs are quite uncommon. In this work we report a case of diffused anaplastic seminoma in dogs, where the main focus of metastasis was observed in the orbital region, and we also describe and discuss the difficulties encountered in the diagnostic.(AU)

Testicular tumors in 190 dogs: clinical, macroscopic and histopathological aspects / Neoplasmas testiculares em 190 cães: aspectos clínicos, macroscópicos e histopatológicos

This study aimed to characterize the prevalence and clinical, macroscopic and histopathological aspects of dogs affected by testicular tumors based on biopsy specimens from the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria (LPV-UFSM) over 19 years. Parameters regarding the age, size, and breed of the affected dogs were also established. Of all dogs with some type of neoplasm submitted to histopathological analysis at the LPV over these 19 years (n=1,900), 213 (11.2%) had at least one testicular neoplasm. The tissues of 190 dogs (with 220 neoplasms) were available for histological reassessment. The dogs in this study had different types of testicular tumors with relatively similar frequencies. In descending order, the most frequent testicular neoplasms were seminomas (88/220), Leydig (interstitial) cell tumor (LCT; 64/220), Sertoli cell tumor (SCT; 61/220), and mixed germ cell-sex cord stromal tumor (MGSCT) (07/220). Among the dogs of defined breed (119 cases), large breeds had the largest number of cases (50/119), followed by small (47/119) and medium-sized (22/119) breeds. The ages of dogs affected by testicular tumors ranged from 10 months to 18 years. Increased testicular volume was the most common clinical manifestation. Eleven dogs presented information about clinical signs suggestive of hyperestrogenism syndrome (feminization). In seminomas, the diffuse pattern predominated over the intratubular pattern. Two sites (luminal and basal compartments) suggestive of the onset of neoplastic transformations in germ cells were observed in intratubular seminomas. They corroborate the hypothesis that canine seminomas possibly have pathogenesis similar to that observed in human spermatocytic seminomas. The SCTs and LCTs presented high cell morphology variation. SCTs had neoplastic cells organized in five different histological arrangements. As for LCT, solid-diffuse and cystic-vascular histological patterns were the most commonly observed. Through this study, it was possible to establish some of the leading clinical, macroscopic, and histopathological aspects of testicular neoplasms diagnosed over 19 years in the area covered by the LPV-UFSM.(AU)

Este estudo teve por objetivo caracterizar a prevalência, aspectos clínicos, macroscópicos e histopatológicos dos cães acometidos por neoplasmas testiculares, a partir dos espécimes de biópsias do Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (LPV-UFSM) em 19 anos. Parâmetros quanto à idade, porte, raça dos cães acometidos também foram estabelecidos. De todos os cães com algum tipo de neoplasma submetido à análise histopatológica no LPV nesses 19 anos (n=1.900), 213 (11,2%) tinham ao menos um neoplasma testicular. Os tecidos de 190 cães (com 220 neoplasmas) estavam disponíveis para reavaliação histológica. Os cães deste estudo apresentaram diferentes tipos de neoplasmas testiculares com frequências relativamente semelhantes. Em ordem decrescente, os neoplasmas testiculares mais frequentes foram: seminomas (88/220), leydigomas (64/220), sertoliomas (61/220) e o tumor misto de células germinativas e do estroma do cordão sexual (MGSCT; 07/220). Dentre os cães com raça definida (119 casos), as raças de grande porte tiveram o maior número de casos (50/119), seguido das raças de pequeno (47/119) e médio porte (22/119). As idades dos cães acometidos por neoplasmas testiculares variaram de 10 meses a 18 anos. Aumento de volume testicular foi a manifestação clínica mais comum. Onze cães tinham informações sobre sinais clínicos sugestivos da síndrome da feminilização. Nos seminomas, houve o predomínio do padrão difuso sobre o intratubular. Dois locais (compartimentos luminal e basal) sugestivos de início das transformações neoplásicas nas células germinativas foram observados nos seminomas intratubulares, corroborando com a hipótese de que os seminomas caninos possivelmente tem patogênese semelhante à observada nos seminomas espermatocíticos humanos. Sertoliomas e leydigomas foram neoplasmas com alta variação na morfologia celular. Os sertoliomas tinham células neoplásicas dispostas em cinco arranjos histológicos distintos. Quanto aos leydigomas, os padrões histológicos sólido-difuso e cístico-vascular foram os mais comumente observados. Através deste estudo foi possível estabelecer alguns dos principais aspectos clínicos, macroscópicos e histopatológicos dos neoplasmas testiculares diagnosticados em 19 anos na área de abrangência do LPV-UFSM.(AU)

Metastatic seminoma in a male Alpine goat: clinical and histopathological approach

Background: Seminomas are germ cell tumors mainly originating from spermatogonia in the seminiferous tubules andhas been described in several domestic animal species, even though has rarely been described in goats. Moreover, seminomas tumors are not usually metastatic and rarely trigger paraneoplastic syndrome. In this sense, this is a case report ofa 12-year-old male Alpine goat, suspected of testicular neoplasm based on clinical examination and ultrasound imaging,diagnosed as a seminoma with metastasis in liver by histopathology upon necropsy.Case: A 12-year-old male Alpine goat presented a 10 month history of progressive weight loss, prostration, and scrotalsac enlargement. The major clinical findings were pale conjunctival mucus, bilateral nasal catarrhal secretion, obstructivedyspnea, an increased abdominal component, crackling at trachea auscultation, silence upon lung auscultation of the ventralarea and wheezing upon auscultation of the dorsal area, and enlargement of the left testicle with contralateral atrophy. Atthe Ultrasonography scan, the enlarged left testicle presented architecture loss, as well as circumscribed masses differingin echogenicity and echotexture with scattered small hyperechoic nodules. The shrunken right testicle showed acousticshading across the surface suggestive of calcification. Due to the poor prognosis and regard for animal welfare, the goatwas euthanized. The main necropsy findings on testicles were: enlarged left testicle with white parenchyma on the dorsalside as well as diffuse yellow elliptical lesions of 0.5-2.5 cm on the surface in association with two circumscribed areasat the cranial and caudal poles, firm upon cutting. The right testicle was half the typical size, slightly pale, firm at cuttingof the tunica albuginea, and presented dark parenchyma with abundant calcification dots suggestive of microlithiasis.The histological findings included diffuse tumoral stroma of the left testicle...

Metastatic seminoma in a male Alpine goat: clinical and histopathological approach

Background: Seminomas are germ cell tumors mainly originating from spermatogonia in the seminiferous tubules andhas been described in several domestic animal species, even though has rarely been described in goats. Moreover, seminomas tumors are not usually metastatic and rarely trigger paraneoplastic syndrome. In this sense, this is a case report ofa 12-year-old male Alpine goat, suspected of testicular neoplasm based on clinical examination and ultrasound imaging,diagnosed as a seminoma with metastasis in liver by histopathology upon necropsy.Case: A 12-year-old male Alpine goat presented a 10 month history of progressive weight loss, prostration, and scrotalsac enlargement. The major clinical findings were pale conjunctival mucus, bilateral nasal catarrhal secretion, obstructivedyspnea, an increased abdominal component, crackling at trachea auscultation, silence upon lung auscultation of the ventralarea and wheezing upon auscultation of the dorsal area, and enlargement of the left testicle with contralateral atrophy. Atthe Ultrasonography scan, the enlarged left testicle presented architecture loss, as well as circumscribed masses differingin echogenicity and echotexture with scattered small hyperechoic nodules. The shrunken right testicle showed acousticshading across the surface suggestive of calcification. Due to the poor prognosis and regard for animal welfare, the goatwas euthanized. The main necropsy findings on testicles were: enlarged left testicle with white parenchyma on the dorsalside as well as diffuse yellow elliptical lesions of 0.5-2.5 cm on the surface in association with two circumscribed areasat the cranial and caudal poles, firm upon cutting. The right testicle was half the typical size, slightly pale, firm at cuttingof the tunica albuginea, and presented dark parenchyma with abundant calcification dots suggestive of microlithiasis.The histological findings included diffuse tumoral stroma of the left testicle...(AU)

Seminoma e sertolioma em cão criptorquida: relato de caso / Seminoma and sertolyoma diseases in criptorquida dog: case report

Tumores testiculares são neoplasias de genitália muito comuns em cães, aparentando estar fortemente relacionados ao criptorquidismo. O presente trabalho tem como objetivo relatar um caso de tumores testiculares em um cão de quatro anos com criptorquidia, que apresentou aumento de volume na região inguinal direita, sinais de feminização associado à anemia normocítica enormocrômica. O exame histopatológico concluiu tratar-se de seminoma e sertolioma. Após dois meses da orquiectomia bilateral, o cão teve regressão das manifestações clínicas.(AU)

Testicular tumors are some very common sort of genitalia neoplasie in dogs, appearing tobe strongly related to cryptorchidism. This article aims to report a case of testicular tumor in a four years old dog with cryptorchidism, that presented an increased volume in the right inguinal region,signs of feminization associated to normocytic and normochromic anemia. The histopathological test concluded that the case was referred to a seminoma and sertolyoma diseases. After two months of bilateral orchiectomy, the clinical symptoms were eliminated from the dog.(AU)

Seminoma e sertolioma em cão criptorquida: relato de caso / Seminoma and sertolyoma diseases in criptorquida dog: case report

Tumores testiculares são neoplasias de genitália muito comuns em cães, aparentando estar fortemente relacionados ao criptorquidismo. O presente trabalho tem como objetivo relatar um caso de tumores testiculares em um cão de quatro anos com criptorquidia, que apresentou aumento de volume na região inguinal direita, sinais de feminização associado à anemia normocítica enormocrômica. O exame histopatológico concluiu tratar-se de seminoma e sertolioma. Após dois meses da orquiectomia bilateral, o cão teve regressão das manifestações clínicas.

Testicular tumors are some very common sort of genitalia neoplasie in dogs, appearing tobe strongly related to cryptorchidism. This article aims to report a case of testicular tumor in a four years old dog with cryptorchidism, that presented an increased volume in the right inguinal region,signs of feminization associated to normocytic and normochromic anemia. The histopathological test concluded that the case was referred to a seminoma and sertolyoma diseases. After two months of bilateral orchiectomy, the clinical symptoms were eliminated from the dog.

Sertolioma in a Canadian Husky: relationship between tumor, hormones, neurons and skin

Background: Sertolioma is a slow-growing, non-invasive, firm and nodular tumor, malignant in 10% to 22% of cases andwith low metastatic potential. Old age and cryptorchidism increase up to 26 times its chances of development and associates it with malignancy. Paraneoplastic syndrome, shown in 20% to 30% of the animals, is due to the aromatization oftestosterone or the direct production of estrogen by tumor cells, leading to signs of feminization and bone marrow aplasia.The objective of this article is to report a case of sertolioma in a dog with dermatological characteristic symptoms, butpresenting an unusual aggressive behavior, both completely reverted after castration.Case: A 9-year-old, uncastrated, aggressive and uncontrollable Canadian Husky dog was treated at the InstitutionalVeterinary Hospital with parapenial volume increase and generalized alopecia. A scrotal testis of reduced size and flaccid consistency and a mass in a parapenial region of 11 x 7.5 x 8 cm in diameter, with a cystic contour, adhered to theabdominal musculature and painless to palpation were detected. Cytology of the parapenial mass presented an imagecompatible with seminoma or sertolioma, and the preputial smear revealed a predominance of superficial cells. Ultrasoundexamination showed a heterogeneous inguinal mass, with expansive cystic area, compatible with mass in retained inguinaltestis. Therapeutic course consisted of bilateral orchiectomy. Ectopic testis was firm to the cut, had whitish to yellowishcoloration and was surrounded by a tunica containing 200 mL of serosanguinolent liquid. The histology of the mass revealed sertolioma-compatible cell characteristics, with cell proliferation circumvented by fibrous connective tissue formingpoorly delimited lobes, moderate polymorphism with elongated cells, arranged in a palisade at the periphery of the lobes,vacuolated eosinophilic cytoplasm and vesiculous...(AU)

Sertolioma in a Canadian Husky: relationship between tumor, hormones, neurons and skin

Background: Sertolioma is a slow-growing, non-invasive, firm and nodular tumor, malignant in 10% to 22% of cases andwith low metastatic potential. Old age and cryptorchidism increase up to 26 times its chances of development and associates it with malignancy. Paraneoplastic syndrome, shown in 20% to 30% of the animals, is due to the aromatization oftestosterone or the direct production of estrogen by tumor cells, leading to signs of feminization and bone marrow aplasia.The objective of this article is to report a case of sertolioma in a dog with dermatological characteristic symptoms, butpresenting an unusual aggressive behavior, both completely reverted after castration.Case: A 9-year-old, uncastrated, aggressive and uncontrollable Canadian Husky dog was treated at the InstitutionalVeterinary Hospital with parapenial volume increase and generalized alopecia. A scrotal testis of reduced size and flaccid consistency and a mass in a parapenial region of 11 x 7.5 x 8 cm in diameter, with a cystic contour, adhered to theabdominal musculature and painless to palpation were detected. Cytology of the parapenial mass presented an imagecompatible with seminoma or sertolioma, and the preputial smear revealed a predominance of superficial cells. Ultrasoundexamination showed a heterogeneous inguinal mass, with expansive cystic area, compatible with mass in retained inguinaltestis. Therapeutic course consisted of bilateral orchiectomy. Ectopic testis was firm to the cut, had whitish to yellowishcoloration and was surrounded by a tunica containing 200 mL of serosanguinolent liquid. The histology of the mass revealed sertolioma-compatible cell characteristics, with cell proliferation circumvented by fibrous connective tissue formingpoorly delimited lobes, moderate polymorphism with elongated cells, arranged in a palisade at the periphery of the lobes,vacuolated eosinophilic cytoplasm and vesiculous...

Gastrointestinal stromal tumor associated with hypertrophic osteopathy in a dog

Background: Gastrointestinal stromal tumor (GIST) is a malignant mesenchymal neoplasm rarely described in the veterinary routine. The aim of this study was to report a case of GIST accompanied by a periosteal reaction, suggestive ofhypertrophic osteopathy, in a dog.Case: An 11-year-old male dog had a history of progressive weight loss, difficulty in locomotion, and dyspnea. During clinical care, increased bone volume was observed. Blood samples were collected for a complete blood count and biochemicalanalysis. The dog also underwent thoracic radiography and abdominal ultrasonography. The test results revealed anemia,leukocytosis, hypocalcemia, hypoalbuminemia, and hypocholesterolemia. The radiographic images of the limbs showeda generalized periosteal reaction, and thoracic radiography indicated changes compatible with mild chronic lung disease.Ultrasonographic findings indicated a neoformation in the intestinal loop of the right mesogastric region and increasedvolume in the left testicle, both of which were indicative of neoplasia. Therefore, the dog was referred for surgery, whereinthe intestinal mass and both testes were removed; the intestinal mass and left testicle were subjected to histopathologicaldiagnosis. The results of the biopsies confirmed that the testicular neoplasm was a seminoma, whereas the intestinal nodulewas compatible with GIST, and immunohistochemical analysis was necessary to confirm the diagnosis. On the basis ofpositive labeling for the antibodies vimentin, desmin, S100, and c-kit, the diagnosis of GIST was confirmed. Therefore,the animal underwent metronomic chemotherapy with 12 mg/m2 cyclophosphamide every 24 h for 3 months, and thereafter every 48 h for 6 months. Moreover, the dog was periodically monitored via imaging (radiography of the anteriorand posterior limbs, abdominal ultrasonography, and computed tomography)...

Gastrointestinal stromal tumor associated with hypertrophic osteopathy in a dog

Background: Gastrointestinal stromal tumor (GIST) is a malignant mesenchymal neoplasm rarely described in the veterinary routine. The aim of this study was to report a case of GIST accompanied by a periosteal reaction, suggestive ofhypertrophic osteopathy, in a dog.Case: An 11-year-old male dog had a history of progressive weight loss, difficulty in locomotion, and dyspnea. During clinical care, increased bone volume was observed. Blood samples were collected for a complete blood count and biochemicalanalysis. The dog also underwent thoracic radiography and abdominal ultrasonography. The test results revealed anemia,leukocytosis, hypocalcemia, hypoalbuminemia, and hypocholesterolemia. The radiographic images of the limbs showeda generalized periosteal reaction, and thoracic radiography indicated changes compatible with mild chronic lung disease.Ultrasonographic findings indicated a neoformation in the intestinal loop of the right mesogastric region and increasedvolume in the left testicle, both of which were indicative of neoplasia. Therefore, the dog was referred for surgery, whereinthe intestinal mass and both testes were removed; the intestinal mass and left testicle were subjected to histopathologicaldiagnosis. The results of the biopsies confirmed that the testicular neoplasm was a seminoma, whereas the intestinal nodulewas compatible with GIST, and immunohistochemical analysis was necessary to confirm the diagnosis. On the basis ofpositive labeling for the antibodies vimentin, desmin, S100, and c-kit, the diagnosis of GIST was confirmed. Therefore,the animal underwent metronomic chemotherapy with 12 mg/m2 cyclophosphamide every 24 h for 3 months, and thereafter every 48 h for 6 months. Moreover, the dog was periodically monitored via imaging (radiography of the anteriorand posterior limbs, abdominal ultrasonography, and computed tomography)...(AU)

Diffuse unilateral seminoma in a fighting rooster (Gallus gallus)

The aim of this study was to report a diffuse unilateral seminoma in a 4-year-old fighting rooster (Gallus gallus) by considering the anatomic, pathological and ultrastructural features. A significant decline in the viability of the bird's embryos was reported during the last year. The bird died with a marked abdominal distention. During necropsy, a firm ovoid neoplasm of approximately 9 cm long, 8 cm wide and 5 cm thick was found in the region adjacent to the pronephros, replacing the left testicle. The neoplasia was soft and encapsulated, and the cut surface showed extensive areas of haemorrhage interspersed with necrotic areas. Histologically, the neoplastic cells formed large mantles or cords with moderate and eosinophilic cytoplasm. The nuclei were pleomorphic, and some of them were central, while others were eccentric. Mitoses were scarce. Some important findings in the ultrastructural study were nuclei exhibited an elongated, electrodense, rope-like nucleoli and the presence of scarce intracytoplasmic glycogen. The anatomo-pathological and ultrastructural findings of the tumour were consistent with a seminoma. The ultrastructural study provided important support for the diagnosis, as other tumours were ruled out. The early diagnosis of malignant or benign testicular tumours in birds is the key for a timely treatment, as these tumours can metastasize or grow to such an extent that they compromise the lives of birds, as in the present case.

Diffuse unilateral seminoma in a fighting rooster (Gallus gallus)

The aim of this study was to report a diffuse unilateral seminoma in a 4-year-old fighting rooster (Gallus gallus) by considering the anatomic, pathological and ultrastructural features. A significant decline in the viability of the bird's embryos was reported during the last year. The bird died with a marked abdominal distention. During necropsy, a firm ovoid neoplasm of approximately 9 cm long, 8 cm wide and 5 cm thick was found in the region adjacent to the pronephros, replacing the left testicle. The neoplasia was soft and encapsulated, and the cut surface showed extensive areas of haemorrhage interspersed with necrotic areas. Histologically, the neoplastic cells formed large mantles or cords with moderate and eosinophilic cytoplasm. The nuclei were pleomorphic, and some of them were central, while others were eccentric. Mitoses were scarce. Some important findings in the ultrastructural study were nuclei exhibited an elongated, electrodense, rope-like nucleoli and the presence of scarce intracytoplasmic glycogen. The anatomo-pathological and ultrastructural findings of the tumour were consistent with a seminoma. The ultrastructural study provided important support for the diagnosis, as other tumours were ruled out. The early diagnosis of malignant or benign testicular tumours in birds is the key for a timely treatment, as these tumours can metastasize or grow to such an extent that they compromise the lives of birds, as in the present case.(AU)

Seminoma and sertolioma in a male pseudohermaphrodite dog with unilateral cryptorchidism: short communication / Seminoma e sertolioma em um cão pseudo-hermafrodita masculino e criptorquida unilateral: comunicação científica

A male miniature Schnauzer with cryptorchidism and a mass growth in the right inguinal canal was admitted to the clinical center of a veterinary hospital. During surgical resection of the mass, tubular formations were found, connecting the mass to the left testicle. Histopathology revealed that the tubular formations were uterine tubes and the mass was a seminoma associated with a sertolioma of the right testicle. Further analysis also showed atrophy of the left testicle. Cytogenetic evaluation revealed normal chromosomes of male gender, 78, XY, which led to the conclusion that this was a male pseudohermaphrodite.(AU)

Foi atendido na rotina clínica de um hospital veterinário, um cão, macho, da raça Schnauzer, criptorquida com massa em canal inguinal direito. Durante o procedimento cirúrgico para a retirada da massa, foi encontrada uma formação tubular a qual fazia a ligação entre essa massa e o testículo esquerdo. A análise histopatológica concluiu que a formação tubular tratava-se de tubas uterinas, a massa era o testículo direito com seminoma e sertolioma e o testículo esquerdo apresentava atrofia. A avaliação citogenética revelou cromossomos normais, do sexo masculino, 78, XY concluindo que se tratava de um pseudo-hermafrodita masculino.(AU)