Primary pulmonary chondrosarcoma in a bitch

Background: Primary lung neoplasms are uncommon in veterinary medicine, and when they develop, they are more frequently observed to be of epithelial origin. Although chondrosarcomas are the second most diagnosed type of neoplasm in dogs at skeletal sites, their development in extraskeletal tissues, including the spleen, aorta, heart, tongue, peritoneum, and lungs, corresponds to approximately only 1% of cases. Therefore, the occurrence of primary pulmonary chondrosarcoma is considered very rare in domestic animals. Considering the rare occurrence and scarcity of data regarding its development, the present report describes the clinical and pathological aspects of a case of primary pulmonary chondrosarcoma in a bitch. Case: A 8-year-old mixed-breed bitch, weighing 14.2 kg, was examined at one private veterinary clinic with the principal complaint of prolonged respiratory distress and resistance to exercise. Clinical evaluation revealed tachypnea with expiratory dyspnea due to intense pleural effusion, tachycardia, and diffusely pale mucous membranes. Thoracocentesis was performed with drainage of 1000 mL of modified transudate, and fluid cytology, blood count, and chest radiography were performed. Cytological analysis of the thoracic fluid did not identify neoplastic cells, the blood count showed intense regenerative anemia, and the radiograph showed an extensive area of consolidation in the left caudal lung lobe, compatible with neoplasia. The results of the tests performed, in addition to the evolution of the clinical picture and the impossibility of performing the indicated surgical intervention, culminated in the patient's unfavorable prognosis, followed by euthanasia, necropsy, and histopathological evaluation of the collected material. Necropsy revealed a white neoplastic formation with reddish areas and firm consistency that diffused into the parenchyma of the left caudal lung lobe with invasion of the rib cage, fracture of the fifth and sixth left ribs, diaphragmatic metastasis, intense hydrothorax, and moderate hydroperitoneum. Microscopically, in the histological sections of the lung and diaphragm, poorly differentiated mesenchymal cells with moderate anisocytosis and anisokaryosis and interspersed with them, moderately differentiated chondrocytes surrounded by chondroid matrix, moderate anisocytosis and anisokaryosis, and a low mitotic index culminated in the diagnosis of primary pulmonary mesenchymal chondrosarcoma. Discussion: Malignant epithelial neoplasms were suspected; however, the histopathological features observed were compatible with primary pulmonary chondrosarcoma. The characteristics of the fluid collected through thoracentesis led to its classification as a modified transudate, which is often associated with neoplastic and hemorrhagic processes; both alterations were present in this case. The diagnosis of primary pulmonary chondrosarcoma was established based on the histopathological findings since the cell type and distribution observed in the present case were compatible with the typical pattern observed in extraskeletal chondrosarcomas. An unfavorable prognosis is common in cases of primary or metastatic lung neoplasm since, in most cases, the condition is identified in the advanced stages of the disease, making therapeutic management challenging. Given the increase in the number of dog deaths due to neoplasms in recent years, this case report may contribute to a better understanding of the biological behavior of pulmonary chondrosarcoma and assist in the choice of treatment to be adopted when required.

A comparative analysis of anatomopathological features and COX-2 expression of mammary neoplasms with malignant mesenchymal components in female dogs / Análise comparativa das características anatomopatológicas e expressão de COX2 em neoplasias mamárias com componentes mesenquimais malignos em cadelas

ABSTRACT: Canine mammary neoplasms with malignant mesenchymal components, such as carcinosarcomas and sarcomas, belong to an uncommon and histologically heterogeneous group. Little is known about the biological behavior of these histogenic variants. This study aimed to compare the clinicopathological characteristics and the COX-2 immunohistochemical expression of different histologic subtypes of carcinosarcomas and sarcomas. Samples of 23 carcinosarcomas and 15 sarcomas from the mammary glands of female dogs were studied. Medical records were reviewed to obtain clinical data. Subsequently, histology microscope slides were analyzed to assess for mesenchymal subtypes, necrosis, vascular invasion, histologic grades, and lymph node metastasis. Immunohistochemistry was used to assess the COX-2 expression. The malignant mesenchymal proliferation was categorized into osteosarcomas (23/40), fibrosarcomas (5/40), liposarcomas (6/40) and chondrosarcomas (4/40). The osteosarcomatous differentiation was the most predominant type among the sarcomas and carcinosarcomas and was associated with vascular invasion (P=0.010) and lymph node metastases (P=0.014). High COX-2 expression was detected in 14.3% of the carcinosarcomas (carcinoma and/or sarcoma cells) and 27.3% of the sarcomas. The carcinosarcomas and sarcomas had similar clinical and pathological characteristics and developed as large tumors, with intratumoral necrosis and a predominance of high histologic grades, although the frequency of vascular invasion and lymph node metastasis was low. Osteosarcoma subtypes presented more aggressive characteristics than non-osteosarcoma subtypes.

RESUMO: Neoplasias mamárias caninas com componentes mesenquimais malignos, como carcinossarcomas e sarcomas, são um grupo de neoplasias pouco frequentes e histologicamente heterogêneas e pouco se sabe sobre o comportamento biológico das variantes histogênicas. O objetivo desse estudo é comparar as características anatomopatológicas e a expressão imunoistoquímica de COX-2 de diferentes subtipos histológicos de carcinossarcomas e sarcomas. Foram estudados 23 carcinosarcomas e 17 sarcomas da glândula mamária de cadelas. Os prontuários médicos foram revisados para obtenção de dados clínicos. Posteriormente, as lâminas histológicas foram avaliadas para acessar os subtipos mesenquimais, necrose, invasão vascular, grau histológico, metástase linfonodal. A imunoistoquímica foi realizada para avaliar a expressão de COX-2. Os tipos encontrados de proliferação mesenquimal maligna foram osteossarcoma (23/40), fibrossarcoma (7/40), lipossarcoma (6/40) e condrossarcoma (4/40). A diferenciação osteossarcomatosa foi predominante entre os sarcomas e carcinossarcomas e foi associado com invasão vascular (P=0,006) e metástase linfonodal (P=0,014). Uma expressão alta de COX-2 foi detectada em 14,3% dos carcinossarcomas (células carcinomatosas e/ou sarcomatosas) e 27,3% dos sarcomas. Os carcinossarcomas e sarcomas apresentaram características clínicas e patológicas semelhantes e se desenvolveram como tumores grandes, com necrose intratumoral e predomínio de alto grau histológico, mas com baixa frequência de invasão vascular e metástase distante. Os subtipos osteossarcomatosos apresentaram características mais agressivas quando comparados com subtipos não osteossarcomatosos.

Partial hemipelvectomy: an alternative for improving dogs' life quality / Hemipelvectomia parcial: alternativa para melhoria na qualidade de vida em cães

Partial hemipelvectomy refers to the surgical removal of a pelvic segment, which is performed for pelvic bone neoplasms, severe fractures, or poor bone union. This study presents the cases of seven dogs, six of which have neoplasms involving the hip joint and one with severe pelvic canal narrowing due to a poorly consolidated trauma. Partial caudal hemipelvectomy was performed for all the dogs to improve the quality of life and delay euthanasia. Of the seven cases, six required the use of a polypropylene mesh for the pelvic wall closure, with 85.71% of them acquiring manageable complications in the postoperative period. Despite these complications, an overall improvement in the quality of life was reported to be significant in the operated animals due to the removal of the cause of pain or discomfort. Thus, it was concluded that partial hemipelvectomyis beneficial for dogs with pelvic conditions. Furthermore, the main complication due to the lack of a pelvic wall for primary occlusion was circumvented by using a polypropylene mesh, showing that possible complications in this procedure can be appropriately managed.

A hemipelvectomia parcial consiste na remoção de segmento pélvico, indicada para neoplasmas com envolvimento de ossos da pelve, fraturas graves ou má união óssea. Esse trabalho apresenta sete pacientes caninos, dos quais seis portadores de neoplasmas envolvendo a articulação coxofemoral e um com grave estreitamento do canal pélvico, resultado de traumatismo mal consolidado. Com o intuito de fornecer qualidade de vida aos cães e postergar a eutanásia, todos foram operados pela técnica de hemipelvectomia parcial média a caudal. Dos sete pacientes, seis necessitaram do uso de tela de polipropileno para fechamento da parede pélvica e apresentaram 85,71% de complicações manejáveis no pós-operatório. No entanto, a melhora na qualidade de vida dos animais operados foi significativa, tendo sido removida a causa da dor ou desconforto desencadeado pela alteração anatômica local. Conclui-se que a técnica é benéfica aos pacientes, tendo como principal complicação, a falta de parede pélvica para oclusão primária, contornada com uso de tela de polipropileno pelos autores.

Sinonasal neoplasms in 49 dogs: clinical, macroscopic, and histopathological aspects / Neoplasmas nasossinusais em 49 cães: aspectos clínicos, macroscópicos e histopatológicos

This study aimed to quantify nasosinusal neoplasms diagnosed in dogs in 20 years (2000-2019) and characterize the main clinical, macroscopic, and histological aspects of these neoplasms. The sex, breed, age, skull conformation, the main clinical signs, and the anatomopathological characteristics (distribution, macroscopy, and histology) were computed. During this period, 49 dogs were affected by neoplasms in these regions, totaling 50 neoplasms (one dog had two neoplasms of different locations and histogenetic origins). Similar amounts of mixed-breed dogs (25/49) and purebred dogs (24/49) were affected, these distributed in 16 breeds. Among purebreds, it was noted that dogs with mesocephalic cranial conformation (12/24) were the most affected, followed by dolichocephalic (10/24) and brachycephalic (2/24). There were 22 cases in males and 27 in females, making a proportion of 1:1.23. There was an age variation from 11 months to 16 years old. The epithelial neoplasms have occurred in older dogs compared to those of other histogenic origins (mesenchymal and other origins/round cells). The main clinical signs were similar between the histogenetic categories, related to the involvement of the upper respiratory tract, sometimes accompanied by nervous signs (when there was brain invasion of nasal neoplasms or vice versa). The possible origin site was mostly in the nasal cavity concerning the paranasal sinuses (and other locations). Invasions occurred in different tissues adjacent to the nasal cavity and paranasal sinuses, resulting in cranial and facial deformities (21/49). The frequency was 48% of epithelial neoplasms, 32% of mesenchymal neoplasms, and 10% of neoplasms with other origins and round cells. The neoplasms most frequently observed, in decreasing order of frequency, were: adenocarcinoma (9/50), squamous cell carcinoma (9/50), transmissible venereal tumor (5/50), osteosarcoma (5/50), chondrosarcoma (4/50), and undifferentiated sarcoma (4/50). Through this study, it was possible to establish the frequency of these neoplasms in 20 years and their clinical, macroscopic, and histological characteristics.(AU)

Este estudo teve como objetivo quantificar os neoplasmas nasossinusais diagnosticados em cães em 20 anos (2000-2019) e caracterizar os principais aspectos clínicos, macroscópicos e histológicos desses neoplasmas. Foram computados sexo, raça, idade, conformação do crânio, principais sinais clínicos e características anatomopatológicas (distribuição, macroscopia e histologia). Nesse período, 49 cães foram acometidos por neoplasmas nessas regiões, totalizando 50 neoplasmas (um cão tinha dois neoplasmas de localização e origens histogenéticas distintas). Foram acometidas quantidades semelhantes de cães sem raça definida (25/49) e de cães com raça definida (24/49), estes distribuídos em 16 raças. Entre os cães com raça definida, notou-se que os cães com conformação craniana mesocefálica (12/24) foram os mais acometidos, seguidos pelos dolicocefálicos (10/24) e braquicefálicos (2/24). Foram observados 22 casos em machos e 27 em fêmeas, perfazendo a relação de 1:1,23. Ocorreu uma variação de idade de 11 meses a 16 anos; tendo os neoplasmas epiteliais ocorrido em cães mais velhos quando comparado aos de outras origens histogênicas (mesenquimais e outras origens/células redondas). Os principais sinais clínicos foram semelhantes entre as categorias histogenéticas, sendo relacionados ao comprometimento do trato respiratório superior, por vezes acompanhados de sinais nervosos (quando houve invasão encefálica de neoplasmas nasais ou vice-versa). O possível local de origem em sua maioria foi na cavidade nasal em relação aos seios nasais (e de outras localizações). Ocorreram invasões para diferentes tecidos adjacentes à cavidade nasal e seios paranasais, tendo como consequência deformidades cranianas e faciais (21/49). A frequência foi de 48% de neoplasmas epiteliais, 32% de neoplasmas mesenquimais e 10% de neoplasmas com outras origens e de células redondas. Os neoplasmas mais frequentemente observados, em ordem decrescente de frequência, foram: adenocarcinoma (9/50), carcinoma de células escamosas (9/50), tumor venéreo transmissível (5/50), osteossarcoma (5/50), condrossarcoma (4/50) e sarcoma indiferenciado (4/50). Com isso, pode-se estabelecer a frequência desses neoplasmas em 20 anos, bem como suas características clínicas, macroscópicas e histológicas.(AU)

Sinonasal neoplasms in 49 dogs: clinical, macroscopic, and histopathological aspects / Neoplasmas nasossinusais em 49 cães: aspectos clínicos, macroscópicos e histopatológicos

This study aimed to quantify nasosinusal neoplasms diagnosed in dogs in 20 years (2000-2019) and characterize the main clinical, macroscopic, and histological aspects of these neoplasms. The sex, breed, age, skull conformation, the main clinical signs, and the anatomopathological characteristics (distribution, macroscopy, and histology) were computed. During this period, 49 dogs were affected by neoplasms in these regions, totaling 50 neoplasms (one dog had two neoplasms of different locations and histogenetic origins). Similar amounts of mixed-breed dogs (25/49) and purebred dogs (24/49) were affected, these distributed in 16 breeds. Among purebreds, it was noted that dogs with mesocephalic cranial conformation (12/24) were the most affected, followed by dolichocephalic (10/24) and brachycephalic (2/24). There were 22 cases in males and 27 in females, making a proportion of 1:1.23. There was an age variation from 11 months to 16 years old. The epithelial neoplasms have occurred in older dogs compared to those of other histogenic origins (mesenchymal and other origins/round cells). The main clinical signs were similar between the histogenetic categories, related to the involvement of the upper respiratory tract, sometimes accompanied by nervous signs (when there was brain invasion of nasal neoplasms or vice versa). The possible origin site was mostly in the nasal cavity concerning the paranasal sinuses (and other locations). Invasions occurred in different tissues adjacent to the nasal cavity and paranasal sinuses, resulting in cranial and facial deformities (21/49). The frequency was 48% of epithelial neoplasms, 32% of mesenchymal neoplasms, and 10% of neoplasms with other origins and round cells. The neoplasms most frequently observed, in decreasing order of frequency, were: adenocarcinoma (9/50), squamous cell carcinoma (9/50), transmissible venereal tumor (5/50), osteosarcoma (5/50), chondrosarcoma (4/50), and undifferentiated sarcoma (4/50). Through this study, it was possible to establish the frequency of these neoplasms in 20 years and their clinical, macroscopic, and histological characteristics.(AU)

Este estudo teve como objetivo quantificar os neoplasmas nasossinusais diagnosticados em cães em 20 anos (2000-2019) e caracterizar os principais aspectos clínicos, macroscópicos e histológicos desses neoplasmas. Foram computados sexo, raça, idade, conformação do crânio, principais sinais clínicos e características anatomopatológicas (distribuição, macroscopia e histologia). Nesse período, 49 cães foram acometidos por neoplasmas nessas regiões, totalizando 50 neoplasmas (um cão tinha dois neoplasmas de localização e origens histogenéticas distintas). Foram acometidas quantidades semelhantes de cães sem raça definida (25/49) e de cães com raça definida (24/49), estes distribuídos em 16 raças. Entre os cães com raça definida, notou-se que os cães com conformação craniana mesocefálica (12/24) foram os mais acometidos, seguidos pelos dolicocefálicos (10/24) e braquicefálicos (2/24). Foram observados 22 casos em machos e 27 em fêmeas, perfazendo a relação de 1:1,23. Ocorreu uma variação de idade de 11 meses a 16 anos; tendo os neoplasmas epiteliais ocorrido em cães mais velhos quando comparado aos de outras origens histogênicas (mesenquimais e outras origens/células redondas). Os principais sinais clínicos foram semelhantes entre as categorias histogenéticas, sendo relacionados ao comprometimento do trato respiratório superior, por vezes acompanhados de sinais nervosos (quando houve invasão encefálica de neoplasmas nasais ou vice-versa). O possível local de origem em sua maioria foi na cavidade nasal em relação aos seios nasais (e de outras localizações). Ocorreram invasões para diferentes tecidos adjacentes à cavidade nasal e seios paranasais, tendo como consequência deformidades cranianas e faciais (21/49). A frequência foi de 48% de neoplasmas epiteliais, 32% de neoplasmas mesenquimais e 10% de neoplasmas com outras origens e de células redondas. Os neoplasmas mais frequentemente observados, em ordem decrescente de frequência, foram: adenocarcinoma (9/50), carcinoma de células escamosas (9/50), tumor venéreo transmissível (5/50), osteossarcoma (5/50), condrossarcoma (4/50) e sarcoma indiferenciado (4/50). Com isso, pode-se estabelecer a frequência desses neoplasmas em 20 anos, bem como suas características clínicas, macroscópicas e histológicas.(AU)

Vertebral chondrosarcoma in a blue-fronted parrot (Amazona aestiva)

Chondrosarcoma is a malignant mesenchymal tumor in which the neoplastic cells produce cartilaginous matrix and is uncommonly described in birds. This report describes the clinical and pathological findings of one case of chondrosarcoma in a blue-fronted parrot (Amazona aestiva). Macroscopically a 3.6x3.5x1.8cm, nodular, ulcerated, and firm mass was identified in the dorsal synsacrum. Microscopically, the mass was composed of a monomorphic proliferation of pleomorphic spindle chondrocytes with abundant cartilaginous matrix, consistent with chondrosarcoma

Condrossarcomas são tumores mesenquimais malignos incomuns em aves, em que as células neoplásicas produzem matriz cartilaginosa. Este trabalho objetiva descrever os achados clínico-patológicos de um caso de condrossarcoma em um papagaio verdadeiro (Amazona aestiva). O animal apresentou aumento de volume progressivo na região dorsal do sinsacro. Macroscopicamente, notou-se uma massa firme, irregular, ulcerada, medindo 3,6x3,5x1,8cm. A histopatologia revelou proliferação monomórfica de condrócitos fusiformes e pleomórficos, com abundante matriz cartilagionasa, compatível com condrossarcoma

Vertebral chondrosarcoma in a blue-fronted parrot (Amazona aestiva)

Chondrosarcoma is a malignant mesenchymal tumor in which the neoplastic cells produce cartilaginous matrix and is uncommonly described in birds. This report describes the clinical and pathological findings of one case of chondrosarcoma in a blue-fronted parrot (Amazona aestiva). Macroscopically a 3.6x3.5x1.8cm, nodular, ulcerated, and firm mass was identified in the dorsal synsacrum. Microscopically, the mass was composed of a monomorphic proliferation of pleomorphic spindle chondrocytes with abundant cartilaginous matrix, consistent with chondrosarcoma

Condrossarcomas são tumores mesenquimais malignos incomuns em aves, em que as células neoplásicas produzem matriz cartilaginosa. Este trabalho objetiva descrever os achados clínico-patológicos de um caso de condrossarcoma em um papagaio verdadeiro (Amazona aestiva). O animal apresentou aumento de volume progressivo na região dorsal do sinsacro. Macroscopicamente, notou-se uma massa firme, irregular, ulcerada, medindo 3,6x3,5x1,8cm. A histopatologia revelou proliferação monomórfica de condrócitos fusiformes e pleomórficos, com abundante matriz cartilagionasa, compatível com condrossarcoma

NEOPLASMAS NASOSSINUSAIS EM CÃES: ASPECTOS CLÍNICO-EPIDEMIOLÓGICOS, MACROSCÓPICOS E HISTOPATOLÓGICOS

A ocorrência de neoplasmas nasossinusais em cães é considerada muito baixa, por isso estudos relacionados a esses neoplasmas são escassos. Eles podem ser neoplasmas benignos ou malignos, entretanto a maior parte deles é classificada como maligna. Devido às características anatômicas e histológicas da cavidade nasal e dos seios nasais, podem surgir neoplasmas de diversas origens histológicas, devido a sua diversidade de epitélios que revestem essas cavidades e pela presença de estruturas ósseas e cartilaginosas adjacentes. Este estudo teve como objetivo realizar um levantamento retrospectivo de 2000 a 2019, contabilizando todos os casos de neoplasmas nasossinusais em cães nesse período, dentre todos os casos de biópsias e necropsias nessa espécie. Foram também computados o sexo, raça, idade, conformação do crânio, os principais sinais clínicos e as características anatomopatológicas (distribuição, macroscopia e histologia). Nesse período, 49 cães foram acometidos por neoplasmas nessas regiões, totalizando 50 neoplasmas (um cão tinha dois neoplasmas de localização e origens histogenéticas distintas). Foram acometidas quantidades semelhantes de cães sem raça definida (25/49) e cães com raça definida (24/49), estes distribuídos em 16 raças. Entre os cães com raça definida, notou-se que os cães com conformação craniana mesocefálica (12/24) foram os mais acometidos, seguidos pelos dolicocefálicos (10/24) e braquicefálicos (2/24). Foram observados 22 casos em machos e 27 em fêmeas, perfazendo a relação de 1:1,23. Ocorreu uma variação de idade de 11 meses a 16 anos; tendo os neoplasmas epiteliais ocorrido em cães mais velhos quando comparado aos de outras origens histogênicas (mesenquimais e outras origens/células redondas). Os principais sinais clínicos foram semelhantes entre as categorias histogenéticas, sendo relacionados ao comprometimento do trato respiratório superior, por vezes acompanhados de sinais nervosos (quando houve invasão encefálica de neoplasmas nasais ou vice-versa). O possível local de origem em sua maioria foi na cavidade nasal em relação aos seios nasais (e de outras localizações). Ocorreram invasões para diferentes tecidos adjacentes à cavidade nasal e seios paranasais, tendo como consequência deformidades cranianas e faciais (21/49). A frequência foi de 48% de neoplasmas epiteliais, 32% de neoplasmas mesenquimais e 10% de neoplasmas com outras origens e de células redondas. Os neoplasmas mais frequentemente observados, em ordem decrescente de frequência, foram: adenocarcinoma (9/50), carcinoma de células escamosas (9/50), tumor venéreo transmissível (5/50), osteossarcoma (5/50), condrossarcoma (4/50) e sarcoma indiferenciado (4/50). Com isso, pode-se estabelecer a frequência desses neoplasmas em 20 anos, bem como suas características clínicas, macroscópicas e histológicas.

The occurrence of nasosinusal neoplasms in dogs is considered to be very low, therefore studies related to these neoplasms are scarce. They can be either benign or malignant neoplasms, however most of them are classified as malignant. Due to the anatomical and histological characteristics of the nasal cavity and sinuses, neoplasms of different histological origins may arise, due to their diversity of epithelia that line these cavities and the presence of adjacent bone and cartilaginous structures. This study aimed to carry out a retrospective survey from 2000 to 2019, counting for all cases of nasosinusal neoplasms in dogs in that period, among all cases of biopsies and necropsies in this species. The sex, breed, age, skull conformation, the main clinical signs and the anatomopathological characteristics (distribution, macroscopy and histology) were also computed. During this period, 49 dogs were affected by neoplasms in these regions, totaling 50 neoplasms (one dog had two neoplasms of different location and histogenetic origins). Similar amounts of mixed breed dogs (25/49) and defined breed dogs (24/49) were affected, these distributed in 16 breeds. Among dogs with defined breed, it was noted that dogs with mesocephalic cranial conformation (12/24) were the most affected, followed by dolichocephalic (10/24) and brachycephalic (2/24). There were 22 cases in males and 27 in females, making a proportion of 1:1.23. There was an age variation from 11 months to 16 years; the epithelial neoplasms having occurred in older dogs when compared to those of other histogenic origins (mesenchymal and other origins/round cells). The main clinical signs were similar between the histogenetic categories, being related to the involvement of the upper respiratory tract, sometimes accompanied by nervous signs (when there was brain invasion of nasal neoplasms or vice versa). The possible origin site was mostly in the nasal cavity in relation to the paranasal sinuses (and other locations). Invasions occurred in different tissues adjacent to the nasal cavity and paranasal sinuses, resulting in cranial and facial deformities (21/49). The frequency was 48% of epithelial neoplasms, 32% of mesenchymal neoplasms and 10% of neoplasms with other origins and round cells. The neoplasms most frequently observed, in decreasing order of frequency, were: adenocarcinoma (9/50), squamous cell carcinoma (9/50), transmissible venereal tumor (5/50), osteosarcoma (5/50), chondrosarcoma (4/50) and undifferentiated sarcoma (4/50). Through this study it was possible to establish the frequency of these neoplasms in 20 years, as well as their clinical, macroscopic and histological characteristics.

Condrossarcoma mesenquimal extraesquelético em um gato: relato de caso / Extraskeletal mesenchymal chondrosarcoma in a cat: case report

Condrossarcoma mesenquimal extraesquelético (CME) é um neoplasma maligno e raro em animais domésticos. Descreve-se um caso de CME em uma gata que apresentava uma massa firme, branco-amarelada, medindo 18cm de diâmetro, aderida à musculatura do membro pélvico esquerdo. O exame citológico revelou presença de células fusiformes individualizadas pleomórficas e agregados de pequenas células ovais, sem bordas definidas em meio à matriz intercelular amorfa. Devido à impossibilidade de tratamento e ao prognóstico desfavorável, foi realizada eutanásia. Microscopicamente foram observadas células fusiformes indiferenciadas e agregados de células condroides pleomórficas. O diagnóstico de CME foi confirmado pelas técnicas de azul alciano, tricrômico de Masson e pela prova imunoistoquímica, utilizando-se anticorpos antivimentina.(AU)

Extraskeletal mesenchymal chondrosarcoma (EMC) is a rare malignant tumor in domestic animals. We described a case of EMC in a cat with a mass measuring 18cm in diameter, yellowish-white and firm attached to the muscles in left hind limb. Cytological examination revealed the presence of individual pleomorphic spindle cells and clusters of small oval cells with no hard edges in the midst of an amorphous intercellular matrix. Due to the impossibility of treatment and poor prognosis, the cat was euthanized. Microscopically undifferentiated spindle cells and clusters of pleomorphic chondroid cells were observed. The CME diagnosis was confirmed with thealcian blue, Masson's trichrome and immunohistochemistry techniques, using antivimentin antibodies.(AU)

Primary intraocular chondrosarcoma in a dog / Condrossarcoma intraocular primário em cão

A five-year-old male Cocker Spaniel was presented for evaluation of the right eye due to discomfort, abundant purulent discharge and progressive enlargement of the eyeball. The owner revealed that the right eye has appeared to be inflamed and smaller then the left eye for years. Ophthalmic examination revealed corneal perforation, buphthalmia and conjuctival hyperemia. Enucleating was performed due to signs of endophthalmitis and ocular discomfort. Histopathology revealed a multilobulated proliferation of chondrocytes producing hyaline cartilage with occasional pleomorphism and binucleate cells. A diagnosis of primary intraocular chondrosarcoma was done.(AU)

Foi atendido um cão, da raça Cocker Spaniel, de cinco anos de idade, com desconforto ocular, secreção purulenta abundante e aumento progressivo do bulbo ocular. Ao exame oftálmico, evidenciaram-se perfuração corneana, buftalmia e hiperemia conjuntival. Foi realizada enucleação em decorrência do desconforto ocular intenso e dos sinais de endoftalmite. Exame histopatológico revelou proliferação multilobulada de condrócitos produzindo cartilagem hialina com pleomorfismo ocasional e células binucleadas. Foi diagnosticado condrossarcoma intraocular primário.(AU)

Evolution of tibial Chondrosarcoma in a dog / Evolução do condrossarcoma em tíbia de cão

Background: Chondrosarcoma is a malignant neoplasm of mesenchymal origin that generally develops slowly and has a low incidence of metastasis. It was related in dogs, but rarely in small or giant breeds. The most common site of skeletal chondrossarcoma in dogs is the nasal cavity. The lungs are the most common site of metastatic disease, but other organs may be affected. Chondrosarcoma may be classifi ed into primary or secondary according to location in bone, and histologically into mesenchymal and myxoid subtypes. Thus, this study reports the evolution of an uncommon case of chondrossarcoma in a dogs tibia. Case: A 1.4-year-old dog, 58 kg intact-male Brazilian Mastiff was admitted to the veterinary hospital due to lameness and swelling of the stifl e region present for 20 days. Radiographic examination showed lytic bone lesions in the proximal third of the right tibia with periosteal reaction, suggestive of bone tumor. Cytological examination revealed infl ammatory process indicative of acute periostitis. The clinical signs improved after treatment with nonsteroidal anti-infl ammatory (meloxicam, 0.1 mg/kg orally every 24 h) and analgesic (tramadol hydrochloride, 2 mg/kg orally every 8 h) drugs. However, eight months after the initial presentation, the dog had a recurrence of the lameness, and increase in volume and crepitus on palpation of the right knee. Radiographic exami

Background: Chondrosarcoma is a malignant neoplasm of mesenchymal origin that generally develops slowly and has a low incidence of metastasis. It was related in dogs, but rarely in small or giant breeds. The most common site of skeletal chondrossarcoma in dogs is the nasal cavity. The lungs are the most common site of metastatic disease, but other organs may be affected. Chondrosarcoma may be classifi ed into primary or secondary according to location in bone, and histologically into mesenchymal and myxoid subtypes. Thus, this study reports the evolution of an uncommon case of chondrossarcoma in a dogs tibia. Case: A 1.4-year-old dog, 58 kg intact-male Brazilian Mastiff was admitted to the veterinary hospital due to lameness and swelling of the stifl e region present for 20 days. Radiographic examination showed lytic bone lesions in the proximal third of the right tibia with periosteal reaction, suggestive of bone tumor. Cytological examination revealed infl ammatory process indicative of acute periostitis. The clinical signs improved after treatment with nonsteroidal anti-infl ammatory (meloxicam, 0.1 mg/kg orally every 24 h) and analgesic (tramadol hydrochloride, 2 mg/kg orally every 8 h) drugs. However, eight months after the initial presentation, the dog had a recurrence of the lameness, and increase in volume and crepitus on palpation of the right knee. Radiographic exami

Evolução do condrossarcoma em tíbia de cão / Evolution of Tibial Chondrosarcoma in a Dog

Background: Chondrosarcoma is a malignant neoplasm of mesenchymal origin that generally develops slowly and has a low incidence of metastasis. It was related in dogs, but rarely in small or giant breeds. The most common site of skeletal chondrossarcoma in dogs is the nasal cavity. The lungs are the most common site of metastatic disease, but other organs may be affected. Chondrosarcoma may be classified into primary or secondary according to location in bone, and histologically into mesenchymal and myxoid subtypes. Thus, this study reports the evolution of an uncommon case of chondrossarcoma in a dog's tibia. Case: A 1.4-year-old dog, 58 kg intact-male Brazilian Mastiff was admitted to the veterinary hospital due to lameness and swelling of the stifle region present for 20 days. Radiographic examination showed lytic bone lesions in the proximal third of the right tibia with periosteal reaction, suggestive of bone tumor. Cytological examination revealed inflammatory process indicative of acute periostitis. The clinical signs improved after treatment with nonsteroidal anti-inflammatory (meloxicam, 0.1 mg/kg orally every 24 h) and analgesic (tramadol hydrochloride, 2 mg/kg orally every 8 h) drugs. However, eight months after the initial presentation, the dog had a recurrence of the lameness, and increase in volume and crepitus on palpation of the right knee. Radiographic examination showed cystic lesion located in proximal tibial epiphysis. After curettage of the lesion, the defect was fi lled with calcium phosphate biomaterial. Cephalexin (30 mg/kg every 12 h orally for 10 days), carprofen (4.4 mg/kg orally every 24 h for 15 days) and chondroitin sulphate (1000 mg orally each 12 h per 30 days) were prescribed postoperatively. The animal showed improvement. At one year after surgery, the dog was presented due progressive weight loss and intermittent lameness of the right hind limb observed for approximately two months. On palpation of the right knee was painful sensitivity and it had a cutaneous nodule three inches. Radiographic examination showed extensive radiolucent cystic area with bone remodeling and periosteal proliferation of the medial aspect of the proximal third of the right tibia. Computed Tomography (CT) demonstrated bone destruction in the proximal portion of the tibia with areas of bone lysis and proliferative irregular reaction, irregular hyperdensity in the medullary region of the right tibia extending to the distal portion of the tibial tuberosity associated with the presence of proliferative periosteal reaction adjacent the bony surfaces, and atrophy of muscles of right hindlimb. Both exams suggested a bone tumor, and bone biopsy was done. The diagnosis was chondrosarcoma. The owner did not authorize the hind limb amputation. Discussion: The diagnosis of chondrosarcoma is based on clinical signs, orthopedic examination findings, radiographic and CT appearance, and cytology. However, definite diagnosis may be obtained only by histopathological examination. Fine needle aspiration samples may contain few cells, and presence of inflammatory process may interfere in diagnosis, as observed in the present case. The tumor is resistant to radiotherapy and chemotherapy. However, surgical removal can be curative, depending upon the location of the chondrosarcoma. Unfortunately, the owner was reluctant to proceed with limb amputation, and the dog was euthanatized after three months of the last evaluation.

Condrossarcoma em gradil costal de cão: relato de caso / Chondrosarcoma in grating costal in a dog a case report / Condrosarcoma en costal rejilla en un perro - un informe del caso

O condrossarcoma é uma neoplasia maligna, de origem mesenquimal, cujas células neoplásicas produzem uma matriz cartilaginosa, não osteoide ou diretamente óssea. O diagnóstico pode ser auxiliado por meio de métodos imaginológicos, porém apenas a histopatologia é definitivo. O presente relato descreve o caso de um cão sem padrão racial definido, com sete anos de idade, o qual apresentou um aumento de volume com cerca de 6,0 x 5,0 x 4,0 cm na região do hemitórax esquerdo, o qual segundo o proprietário estava presente há dois meses. Após a histopatologia, foi realizado o diagnóstico de condrossarcoma, porém o proprietário não procedeu com o tratamento instituído e o animal retornou a clínica 11 meses após o primeiro incidente em sofrimento irreversível. Objetiva-se descrever os aspectos macro e microscópico da respectiva neoplasia.(AU)

Chondrosarcoma is a malignant tumor of mesenchymal origin, which the neoplastic cells produce a cartilage matrix, no osteoid or bone directly. Diagnosis can be aided by imaginological methods, but only histopathology is definitive. This report describes the case of a mongrel dog, seven years old, with a volume increase of about 6,0 x 5,0 x 4,0 cm in the left hemithorax, which according to the owner there was two months ago. Histopathology after the diagnosis of chondrosarcoma was made and treatment instituted, but as the owner lost the thread it was not performed and the animal returned to clinical 11 months after the first incident irreversible suffering. Objective is to describe the macro and microscopic aspects of the neoplasm.(AU)

El condrosarcoma es un tumor maligno de origen mesenquimal, cuyas células neoplásicas producir una matriz de cartílago, no osteoide o hueso directamente. El diagnóstico puede ser assistido por métodos de imagen, pero sólo la histología esdefinitiva. Este informe describe el caso de un perro sin raza definida, de siete anos, con un aumento de volumen de alrededor de 6,0 x 5,0 x 4,0 cm en el hemitórax izquierdo, que según el propietario estaba allí hace dos meses. Después se realizó el diagnóstico histopatológico de condrosarcoma y el tratamiento instituido, pero como el propietario pierde el hilo no se hizo y el animal volvió a clínicas 11 meses después del primer incidente en el sufrimiento irreversible. Su objetivo es describir los aspectos macroscópicos y microscópicos de su neoplasia.(AU)

Condrossarcoma em gradil costal de cão: relato de caso / Chondrosarcoma in grating costal in a dog – a case report / Condrosarcoma en costal rejilla en un perro - un informe del caso

O condrossarcoma é uma neoplasia maligna, de origem mesenquimal, cujas células neoplásicas produzem uma matriz cartilaginosa, não osteoide ou diretamente óssea. O diagnóstico pode ser auxiliado por meio de métodos imaginológicos, porém apenas a histopatologia é definitivo. O presente relato descreve o caso de um cão sem padrão racial definido, com sete anos de idade, o qual apresentou um aumento de volume com cerca de 6,0 x 5,0 x 4,0 cm na região do hemitórax esquerdo, o qual segundo o proprietário estava presente há dois meses. Após a histopatologia, foi realizado o diagnóstico de condrossarcoma, porém o proprietário não procedeu com o tratamento instituído e o animal retornou a clínica 11 meses após o primeiro incidente em sofrimento irreversível. Objetiva-se descrever os aspectos macro e microscópico da respectiva neoplasia.

Chondrosarcoma is a malignant tumor of mesenchymal origin, which the neoplastic cells produce a cartilage matrix, no osteoid or bone directly. Diagnosis can be aided by imaginological methods, but only histopathology is definitive. This report describes the case of a mongrel dog, seven years old, with a volume increase of about 6,0 x 5,0 x 4,0 cm in the left hemithorax, which according to the owner there was two months ago. Histopathology after the diagnosis of chondrosarcoma was made and treatment instituted, but as the owner lost the thread it was not performed and the animal returned to clinical 11 months after the first incident irreversible suffering. Objective is to describe the macro and microscopic aspects of the neoplasm.

El condrosarcoma es un tumor maligno de origen mesenquimal, cuyas células neoplásicas producir una matriz de cartílago, no osteoide o hueso directamente. El diagnóstico puede ser assistido por métodos de imagen, pero sólo la histología esdefinitiva. Este informe describe el caso de un perro sin raza definida, de siete anos, con un aumento de volumen de alrededor de 6,0 x 5,0 x 4,0 cm en el hemitórax izquierdo, que según el propietario estaba allí hace dos meses. Después se realizó el diagnóstico histopatológico de condrosarcoma y el tratamiento instituido, pero como el propietario pierde el hilo no se hizo y el animal volvió a clínicas 11 meses después del primer incidente en el sufrimiento irreversible. Su objetivo es describir los aspectos macroscópicos y microscópicos de su neoplasia.

Condrossarcoma primário de cavidade nasal em um cão / Primary nasal cavity chondrosarcoma in a dog

Background: Chondrosarcoma is a malignant neoplasm originated from chondroid cells with production of cartilage matrix with lot of degrees of differentiation. It may be found in skeletal or extraskeletal tissue, more commonly in flat bones. It most often has an aggressive behavior with involvement of bone and adjacent soft tissues, which necessitates their rapid identification, surgical intervention and therapy. Chondrosarcoma is reported as uncommon neoplasm in the nasal cavity of dogs and should be distinguished by both other malignancies and for non-neoplastic diseases. Case: A 7-years-old dog, mixed breed, male, had a swelling in the nasal cavity for more than 30 days. The change was seen in the right frontal-nasal region with invasion of the oral cavity, with serous nasal discharge and also, inspiratory and expiratory noises. Even after cytology and biopsy of the tumor to chemotherapy instituted, there was not successful and the dog was euthanized. At necropsy, there was a large multilobulated mass, with firm consistency, interspersed with soft areas in the right nasal region. In the cut surface, the mass showed staining grayish-white interspersed with dark areas, which block most of the nasal cavity causing partial lysis of frontal, temporal and tubinates bones, as well as purulent secretion of the frontal sinuses (sinusitis). Microscopically, the mass consisted of mesenchymal neoplastic cells arranged in bundles or nodules without orientation, separated by fine bands of fibrous connective tissue poorly vascularized. The neoplastic cells showed round to oval nucleus, sparse chromatin and conspicuous nucleoli. Some areas were more solid and composed of cells with few cytoplasm, similar to chondroblastic cells. It was observed multifocal areas of chondroid matrix formation. Discussion: Based on pathological findings, the diagnosis of chondrosarcoma was confirmed. The histopathological findings confirmed the diagnosis of chondrosarcoma suggested by cytology. Despite being an uncommon neoplasm in dogs, chondrosarcoma should be considered as differential diagnosis of other nasal diseases that can lead macroscopic changes and similar clinical signs. The osteosarcoma is the most common bone tumor of the nasal cavity in dogs. The similarity of the macroscopic findings of chondrosarcoma and oesteosarcoma, as well as histological and immunohistochemical stain, may be a challenge to diagnosis for the clinician and pathologist. Other neoplasms such as squamous cell carcinoma, fibrosarcoma and hemangiosarcoma, as well as proliferative rhinitis caused by fungal agents, should also be considered in the differential diagnosis. These conditions can be differentiated by microscopic features and immunohistochemical stain. The fine needle aspiration biopsy is an important method, however to establish the definitive diagnosis is always required histopathologic evaluation. In primary chondrosarcoma of the nasal cavity in dogs, the survival with treatment is made from three to six months, however, often results in local severe invasion and serious clinical changes. In this case, the treatment was not effective because the degree of tumor differentiation and infiltration of the surrounding structures, as well as worsens of the clinical signs. The knowledge of the clinicopathological findings and biology of this tumor is essential for rapid diagnosis and more effective clinical interventions.

Primary nasal cavity chondrosarcoma in a dog / Condrossarcoma primário de cavidade nasal em um cão

Background: Chondrosarcoma is a malignant neoplasm originated from chondroid cells with production of cartilage matrix with lot of degrees of differentiation. It may be found in skeletal or extraskeletal tissue, more commonly in flat bones. It most often has an aggressive behavior with involvement of bone and adjacent soft tissues, which necessitates their rapid identification, surgical intervention and therapy. Chondrosarcoma is reported as uncommon neoplasm in the nasal cavity of dogs and should be distinguished by both other malignancies and for non-neoplastic diseases.Case: A 7-years-old dog, mixed breed, male, had a swelling in the nasal cavity for more than 30 days. The change was seen in the right frontal-nasal region with invasion of the oral cavity, with serous nasal discharge and also, inspiratory and expiratory noises. Even after cytology and biopsy of the tumor to chemotherapy instituted, there was not successful and the dog was euthanized. At necropsy, there was a large multilobulated mass, with firm consistency, interspersed with soft areas in the right nasal region. In the cut surface, the mass showed staining grayish-white interspersed with dark areas, which block most of the nasal cavity causing partial lysis of frontal, temporal and tubinates bones, as well as purulent secretion of the frontal sinuses (sinusitis). Microscopically, the mass consisted of mesench

Background: Chondrosarcoma is a malignant neoplasm originated from chondroid cells with production of cartilage matrix with lot of degrees of differentiation. It may be found in skeletal or extraskeletal tissue, more commonly in flat bones. It most often has an aggressive behavior with involvement of bone and adjacent soft tissues, which necessitates their rapid identification, surgical intervention and therapy. Chondrosarcoma is reported as uncommon neoplasm in the nasal cavity of dogs and should be distinguished by both other malignancies and for non-neoplastic diseases.Case: A 7-years-old dog, mixed breed, male, had a swelling in the nasal cavity for more than 30 days. The change was seen in the right frontal-nasal region with invasion of the oral cavity, with serous nasal discharge and also, inspiratory and expiratory noises. Even after cytology and biopsy of the tumor to chemotherapy instituted, there was not successful and the dog was euthanized. At necropsy, there was a large multilobulated mass, with firm consistency, interspersed with soft areas in the right nasal region. In the cut surface, the mass showed staining grayish-white interspersed with dark areas, which block most of the nasal cavity causing partial lysis of frontal, temporal and tubinates bones, as well as purulent secretion of the frontal sinuses (sinusitis). Microscopically, the mass consisted of mesench

Contribuição da imuno-histoquímica na caracterização histogênica e prognóstico de condrossarcoma nasal e carcinoma gástrico de células em anel de sinete em cães

O número crescente de processos oncológicos em cães tem determinado uma progressiva demanda por métodos diagnósticos mais acurados, objetivando a rápida e adequada caracterização da doença, permitindo a seleção do protocolo terapêutico mais adequado. Nesse sentido, a imuno-histoquímica apresenta-se como uma ferramenta potencialmente relevante. Neste estudo são relatados aspectos clínico-patológicos e imuno-histoquímicos de dois casos de lesões neoplásicas pouco frequentes em cães, nos quais o emprego de painel imuno-histoquímico foi relevante em termos de diagnósticos e prognósticos.

The increasing number of oncological processes in dogs has determined a progressive demand for an accurate diagnostic method, aiming at the rapid and adequate characterization of the disease, allowing the selection of the most adequate therapeutic protocol. In this sense, immunohistochemistry presents itself as a potentially relevant tool. In this study it was reported clinical-pathological and immunohistochemical aspects of two cases of neoplastic lesions infrequent in dogs, in which the use of immunohistochemical panel was relevant in terms of diagnosis and prognosis.

Aspectos clínico-patológicos e imuno-histoquímicos de condrossarcoma nasal em cão: relato de caso / Clinicopathologic and immunohistochemical features of nasal chondrosarcoma in a dog: a case report / Aspectos clínico-patológicos e inmunohistoquímicos de condrosarcoma nasal en un perro: reporte de un caso

Neoplasias sinunasales son poco frecuentes en los perros, destacando los sarcomas. En el presente informe se refiere a la aparición, en la perra de 10 anos de edad, la formación nasal, estudiando con epistaxis. El procedimiento fue el diagnóstico de sitio de la biopsia, lo que evidencia un hipercelular lesión sólida que consiste en células redondas dispuestas sobre alfombras con tiendas organización ocasionales, asociados con la matriz de deposición basófilo discreta, lo que sugiere la naturaliza condroide. Para la confirmación histogenic se utiliza panel de inmunohistoquímica, la investigación de las queratinas de expresión, vimentina y proteína S-1 00, la identificación positiva los dos últimos. La combinación de los datos morfológicos e inmunohistoquímicos permitió el diagnóstico de condrosarcoma, una neoplasia poco frecuente en el territorio nasal de los perros.(AU)

Sino nasal tumors are rare in dogs, especially sarcomas. The present report deals with the occurrence of a nasal mass in a ten-year-old female mongrel dog, associated with epistaxis. The diagnosis was performed from a local biopsy in which it was observed a hypercellular lesion consisting of round cells arranged in a solid manner with occasional organization of small nests, associated with discrete deposition of a pale blue matrix, suggesting chondroid nature. In order to obtain a histogenic confirmation, a panel of keratins, vimentin and S-100 protein was prepared, in which positivity was identified for the last two. The combination of morphological and immunohistochemically data allowed the diagnosis of chondrosarcoma, arare malignant neoplasia in nasal territory of dogs.(AU)

Os neoplasmas sino-nasais são raros em cães, particularmente os sarcomas. No presente relato aborda-se a ocorrência, em cadela de 10 anos de idade, de formação nasal, cursando com epistaxe. Procedeu-se o diagnóstico a partir de biópsia local, evidenciando-se lesão sólida hipercelular, composta por células redondas dispostas em tapetes, com ocasional organização em lojas, associada à discreta deposição de matriz basofílica, sugerindo natureza condróide. Para confirmação histogênica empregou-se painel imuno-histoquímico, pesquisando-se a expressão de ceratinas, vimentina e proteína S-100, identificando-se positividade das duas últimas. A associação dos dados morfológicos e imuno-histoquímicos permitiu o diagnóstico de condrossarcoma, uma neoplasia maligna incomum em território nasal de cães.(AU)

Aspectos clínico-patológicos e imuno-histoquímicos de condrossarcoma nasal em cão: relato de caso / Clinicopathologic and immunohistochemical features of nasal chondrosarcoma in a dog: a case report / Aspectos clínico-patológicos e inmunohistoquímicos de condrosarcoma nasal en un perro: reporte de un caso

Neoplasias sinunasales son poco frecuentes en los perros, destacando los sarcomas. En el presente informe se refiere a la aparición, en la perra de 10 anos de edad, la formación nasal, estudiando con epistaxis. El procedimiento fue el diagnóstico de sitio de la biopsia, lo que evidencia un hipercelular lesión sólida que consiste en células redondas dispuestas sobre alfombras con tiendas organización ocasionales, asociados con la matriz de deposición basófilo discreta, lo que sugiere la naturaliza condroide. Para la confirmación histogenic se utiliza panel de inmunohistoquímica, la investigación de las queratinas de expresión, vimentina y proteína S-1 00, la identificación positiva los dos últimos. La combinación de los datos morfológicos e inmunohistoquímicos permitió el diagnóstico de condrosarcoma, una neoplasia poco frecuente en el territorio nasal de los perros.

Sino nasal tumors are rare in dogs, especially sarcomas. The present report deals with the occurrence of a nasal mass in a ten-year-old female mongrel dog, associated with epistaxis. The diagnosis was performed from a local biopsy in which it was observed a hypercellular lesion consisting of round cells arranged in a solid manner with occasional organization of small nests, associated with discrete deposition of a pale blue matrix, suggesting chondroid nature. In order to obtain a histogenic confirmation, a panel of keratins, vimentin and S-100 protein was prepared, in which positivity was identified for the last two. The combination of morphological and immunohistochemically data allowed the diagnosis of chondrosarcoma, arare malignant neoplasia in nasal territory of dogs.

Os neoplasmas sino-nasais são raros em cães, particularmente os sarcomas. No presente relato aborda-se a ocorrência, em cadela de 10 anos de idade, de formação nasal, cursando com epistaxe. Procedeu-se o diagnóstico a partir de biópsia local, evidenciando-se lesão sólida hipercelular, composta por células redondas dispostas em tapetes, com ocasional organização em lojas, associada à discreta deposição de matriz basofílica, sugerindo natureza condróide. Para confirmação histogênica empregou-se painel imuno-histoquímico, pesquisando-se a expressão de ceratinas, vimentina e proteína S-100, identificando-se positividade das duas últimas. A associação dos dados morfológicos e imuno-histoquímicos permitiu o diagnóstico de condrossarcoma, uma neoplasia maligna incomum em território nasal de cães.

Hemipelvectomia no tratamento de condrossarcoma no acetábulo de cão

Hemipelvectomy is the removal of part of the pelvis and is indicated for the surgical treatment of malignant tumors. This study presents the case of a canine patient with recurrent chondrosarcoma, submitted to hemipelvectomy with limb amputation. The report aims to highlight the importance of surgery in the treatment of radial bone chondrosarcoma, addressing a viable and unconventional alternative for patients suffering from tumors in the pelvis, which against the extension of the lesion may be misdiagnosed as intractable cancer. After the partial hemipelvectomy with amputation of the limb the animal satisfactory returned to ambulation without difficulty in supporting or alteration in balance.

Hemipelvectomia é a remoção de parte da pelve e tem sido indicada no tratamento cirúrgico de tumores malignos. Este estudo apresenta o caso de um paciente canino, portador de condrossarcoma recidivante, submetido à hemipelvectomia parcial com amputação do membro. O objetivo deste trabalho é ressaltar a importância da cirurgia radical no tratamento de condrossarcoma ósseo, abordando uma alternativa viável e pouco convencional para pacientes acometidos por tumores na pelve, que frente à extensão da lesão podem ser erroneamente diagnosticados como portadores de neoplasias não tratáveis. Após a realização da hemipelvectomia parcial com amputação do membro, o animal obteve retorno satisfatório à deambulação, sem dificuldade de apoio ou alteração de equilíbrio.