Carcinoma de células escamosas em gato - tratamento com quimioterapia metronômica / Squamous cell carcinoma in a cat - treatment with metronomic chemotherapy

Background: Squamous cell carcinoma (SCC) is a malignant neoplasm associated with prolonged exposure to ultraviolet light and lack of skin pigment in white-coated animals. The disease diagnosis is based on the animal's history, clinical signs and histopathology of the samples collected. The therapeutic alternatives are diverse. Among them, one of the most used is the metronomic chemotherapy which is based on the use of cytostatics drugs, applied in low and frequent doses for a longer period of time. One of the mechanisms of action of this type of therapy is the decrease in angiogenesis. Non-steroidal anti-inflammatory drugs (NSAIDs) are simultaneously used to maximize the angiogenic effect. The objective of this study is to report the results of a treatment accomplised with metronomic chemotherapy (cyclophosphamide with meloxicam) in a domestic feline which presented a squamous cell tumor. Case: A 7-year-old female cat, mixed breed, not neutered, weighing 3.5 kg, was assisted at the Veterinary Specialties Teaching Clinic (CEEV) of the Technical University of Machala (UTMACH), presenting bilateral ulcerative lesion in the nasal plane for 5 months. Chronic exposure to sunlight is referred to in the patient's anamnesis. Aspiration cytology performed in the patient revealed an inflammatory process with a predominance of neutrophils and macrophages, and showed absence of neoplastic cells. A treatment based on antibiotics and corticosteroids was adopted. As there were no favorable results, an excisional biopsy procedure was chosen to collect the affected tissues. The result of the histopathological analysis was a level 2 squamous cell carcinoma (SCC). The initial treatment consisted of surgical removal of the tumor and later the use of metronomic chemotherapy based on Cyclophosphamide, Meloxicam, DHA (docosahexaenoic acid) and Sucralfate for 5 months was adopted. At the beginning of the second phase of treatment, the patient developed a macula that progressively diminished. Currently, the patient does not have any recurrence of the diagnosed neoplasm. Discussion: The diagnosis of squamous cell carcinoma was based on clinical and histopathological findings. The macroscopic lesions were crusted ulcers that do not heal in the nasal plane and auricular pavilion, as reported in the literature. SCC is characterized by the infiltration of squamous cells in the dermal layer of the skin, forming epithelial islands with keratin pearls. The histopathological findings of this case present the same characteristics. The climatic conditions of Ecuador, high temperatures with greater incidence of sunlight, hypopigmented areas of the animal's body and chronic exposure to solar radiation are risk factors present in this case that foster the development of this malignant neoplasm. There are multiple treatments to be introduced in this sort of pathology. In this case, surgical removal of the tumor was adopted, followed by metronomic chemotherapy based on cyclophosphamide at 10 mg/m2 and meloxicam at a 0.05 mg/kg per day for a period of time of five months, obtaining favorable results and absence of recurrence. Despite metronomic chemotherapy being easy to administer, with fewer side effects, which includes a better acceptance of care takers who are reluctant to administer conventional chemotherapy, further studies are still necessary in what concerns certain variables such as age, carcinoma level, appropriate dosages and drugs according to each neoplasm.

Sarcoide em equinos - tratamento com associação de Aciclovir e excisão cirúrgica / Equine sarcoids - treatment with a combination of Acyclovir and surgical excision

Background: Sarcoids are the most frequent skin tumors among horses, causing serious lesions due to their different shapes, sizes, degree of invasiveness and distribution on the body. The pathogenesis of sarcoids is multifactorial, with genetic, viral and environmental involvement, making their treatment complex. The aggressiveness and high rate of recurrence of sarcoids makes it difficult to use an effective treatment, which is why there are several therapeutic routes described in the literature. Aiming to describe and expand sarcoid treatments, this paper reports on the use of acyclovir in the treatment of this type of tumor. Cases: Four horses sent to the Large Animal Veterinary Hospital of the Federal University of Lavras - UFLA were diagnosed and treated for sarcoids. Case 1. Lesions on the right ear, region of the masseter muscle of the right side of the face, neck, vulva and medial aspect of the left pelvic limb. Case 2. Lesion in the left groin region. Case 3. Lesions on the face, masseter muscle region on the left side, mandibular region and right ear pinna. Case 4. Lesion in the lateral region of the left pelvic limb, close to the tarsometatarsal joint. All horses had a diagnosis of sarcoid, which was confirmed by histopathological examination of material collected after surgical excision. Macroscopically, the neoplastic lesions were classified as fibroblastic, verrucous and nodular. The tumors exhibited irregular surfaces, keratinization, and a firm consistency. Their surfaces were alopecic, slightly rough, some of them were ulcerated, and their color ranged from greyish to rosy and reddish. All the tumor masses were surgically excised from the 4 horses, and one sarcoid was treated by thermal cauterization with liquid nitrogen due to the lesion's depth and size. In most cases, the sarcoid removal sites were closed with sutures. Only 2 lesions were not sutured due to the impossibility of bringing the edges of tissue close together, or due to proximity to the tarsometatarsal joint. The surgical wounds were cleaned twice a day with sterile saline solution followed by the topical application of Acyclovir. One of the animals received complementary therapy with Cimetidine. Discussion: The equines recovered completely from their sarcoid treatment, and no recurrences were reported a year later. Thus, the combination of treatments employed for the extirpation of sarcoids proved to have greater chances of success. First, all the tumors were surgically removed with the largest possible margins of safety in order to ensure the elimination of neoplastic cells. In the postoperative period, all the animals received topical treatment of the lesions with acyclovir after surgical resection of the tumors. The drug aided the complete healing of post-surgical wounds, and healing time varied according to the size and depth of the lesion. One tumor was treated with liquid nitrogen after surgical excision of the sarcoid. Another horse was treated with cimetidine over a 3-month period after surgical excision of the neoplasm in order to reduce the sarcoid and prevent its evolution. Surgical excision of the sarcoid associated with topical application of acyclovir ointment showed satisfactory results. Moreover, the combination of surgical excision and administration of liquid nitrogen on the lesion and topical application of acyclovir ointment in the postoperative period also provided good results. Given the complexity of sarcoid treatment and the high recurrence rate of these tumors, the use of combined treatments should be taken into account.

Evaluación de la calidad del pescado comercializado en la región de botucatu-sp / Evaluation of the quality of fish marketed in the region of botucatu, são paulo / Avaliação da qualidade do pescado comercializado na região de botucatu, são paulo

El Reglamento de Inspección Industrial y Sanitaria de Productos de Origen Animal (RIISPOA) establece normas de calidad para el pescado destinado al consumo humano, garantizando un producto servido al consumidor con seguridad e inocuidad. El objetivo del presente trabajo fue evaluar la calidad de los peces comercializados en los distritos de Ipaussu y Botucatu, São Paulo, más precisamente la Tilapia do Nilo (Oreochromis niloticus) y la Merluza (Merluccius hubbsi), a través de los resultados de la necropsia y del análisis físico-químico. Ocho muestras de Tilapia y tres muestras de Merluza fueron adquiridas en una piscifactoría, eutanasiadas en hielo en la propiedad y enviadas al Laboratorio de análisis del Instituto de Biotecnología (IBTEC) de la Universidade Estadual Paulista (UNESP), Botucatu-SP. Las Tilapias fueron sometidas a inspección macroscópica mediante observación externa e interna y los filetes de Merluza fueron sometidos a análisis físico-químicos para evaluar la frescura. En el examen externo, la lesión más frecuente fue la hemorragia de la piel (50%), las aletas (50%), las branquias (25%) y la cavidad oral (12,5%), mientras que en el examen interno predominaron la esplenomegalia (75%) y la hemorragia renal (50%). El análisis físico-químico mostró alteraciones significativas en las bases volátiles totales (BTV), lo que hace que el alimento no sea apto para el consumo

The Regulamento de Inspeção Industrial e Sanitária de Produtos de Origem Animal (RIISPOA) establishes quality standards for fish intended for human consumption, ensuring a product served to the consumer with safety and innocuity. The objective of the present work was to evaluate the quality of fish commercialized in the districts of Ipaussu and Botucatu, São Paulo, more precisely the Tilapia do Nilo (Oreochromis niloticus) and the Merluza (Merluccius hubbsi), through necropsy findings and physical-chemical analysis. Eight Tilapia and three hake samples were acquired from a fish farm, euthanized on ice at the farm, and sent to the Laboratory of analysis of the Biotechnology Institute (IBTEC) of the Universidade Estadual Paulista (UNESP), in Botucatu-SP. The Tilapias were submitted to macroscopic inspection by means of external and internal observation and the Merluza fillets were submitted to physical-chemical analysis to evaluate the freshness. In the external examination the most frequent lesion was hemorrhage of skin (50%), fins (50%), gills (25%) and oral cavity (12.5%), while in the internal examination splenomegaly (75%) and kidney hemorrhage (50%) prevailed. The physical-chemical analysis showed significant alterations in the total volatile bases (TVB), making the food unfit for consumption according to current legislation. The observed alterations configure loss of quali

O Regulamento de Inspeção Industrial e Sanitária de Produtos de Origem Animal (RIISPOA) estabelece padrões de qualidade para peixes destinados a consumo humano, garantindo um produto servido ao consumidor com inocuidade e segurança. O objetivo do presente trabalho foi avaliar a qualidade do pescado comercializado nos distritos de Ipaussu e Botucatu, São Paulo, mais precisamente da Tilápia do Nilo (Oreochromis niloticus) e da Merluza (Merluccius hubbsi), por meio de achados de necrópsia e análises físico-quimicas. Foram adquiridas 8 amostras de Tilápia e 3 amostras de Merluza provindas de uma piscicultura, eutanasiadas com gelo na propriedade, e encaminhadas ao Laboratório de análises do Instituto de Biotecnologia (IBTEC) da Universidade Estadual Paulista (UNESP), em Botucatu. As Tilápias foram submetidas à inspeção macroscópica por meio de observação externa e interna e os filés de Merluza foram submetidos à análises físico-quimicas para avalição do frescor. No exame externo a lesão mais frequente foi hemorragia de pele (50%), nadadeiras (50%), brânquias (25%) e cavidade oral (12.5%), enquanto que no exame interno, esplenomegalia (75%) e hemorragia renal (50%) prevaleceram. As análises físico-quimicas apresentaram alterações significativas nas bases voláteis totais (BVT), tornando o alimento impróprio para o consumo de acordo com a legislação vigente. As alterações observadas c

Automutilação em abutre real (Sarcoramphus papa) mantido em cativeiro / Automutilation in real vulture (Sarcoramphus papa) maintained in captivity / Automutilación en un buitre dorado (Sarcoramphus papa) mantenido en cautividad

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)

The real vulture is a compact bird of extraordinary color (in adult plumage). Its bare head, as the scientific name suggests, has caricatures and fleshy red papillae applied around the beak, and an iris of the eye is white with a red orbital ring. In captivity, stress is a widely observed condition, which can lead to self-mutilation, which can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in the case of automation in Sarcoramphus papa, kept in captivity and with an importance of the appropriate manual for this species in captivity. He was seen at a University Veterinary Hospital, a king vulture showed a contaminated wound, with bone exposure on the right. After treatment or animal was sent to a conservation reserve to be conditioned and return to its natural habitat.(AU)

buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza desnuda, tiene carúnculas y papilas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede llevar a la automutilación, posiblemente evolucionando en lesiones graves de la piel y los músculos. El objetivo del presente informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenido en cautividad, y la importancia del manejo adecuado para esta especie en cautividad. Un buitre real que presentaba una lesión contaminada con exposición ósea en el ala derecha fue tratado en un Hospital Universitario Veterinario. Tras el tratamiento, el animal fue enviado a una reserva de conservación para que pudiera ser acondicionado para volver a su hábitat natural.(AU)

Avaliação da qualidade do pescado comercializado na região de Botucatu, São Paulo / Evaluation of the quality of fish marketed in the region of Botucatu, São Paulo / Evaluación de la calidad del pescado comercializado en la región de Botucatu-SP

O Regulamento de Inspeção Industrial e Sanitária de Produtos de Origem Animal (RIISPOA) estabelece padrões de qualidade para peixes destinados a consumo humano, garantindo um produto servido ao consumidor com inocuidade e segurança. O objetivo do presente trabalho foi avaliar a qualidade do pescado comercializado nos distritos de Ipaussu e Botucatu, São Paulo, mais precisamente da Tilápia do Nilo (Oreochromis niloticus) e da Merluza (Merluccius hubbsi), por meio de achados de necrópsia e análises físico-quimicas. Foram adquiridas 8 amostras de Tilápia e 3 amostras de Merluza provindas de uma piscicultura, eutanasiadas com gelo na propriedade, e encaminhadas ao Laboratório de análises do Instituto de Biotecnologia (IBTEC) da Universidade Estadual Paulista (UNESP), em Botucatu. As Tilápias foram submetidas à inspeção macroscópica por meio de observação externa e interna e os filés de Merluza foram submetidos à análises físico-quimicas para avalição do frescor. No exame externo a lesão mais frequente foi hemorragia de pele (50%), nadadeiras (50%), brânquias (25%) e cavidade oral (12.5%), enquanto que no exame interno, esplenomegalia (75%) e hemorragia renal (50%) prevaleceram. As análises físico-quimicas apresentaram alterações significativas nas bases voláteis totais (BVT), tornando o alimento impróprio para o consumo de acordo com a legislação vigente. As alterações observadas configuram perda da qualidade do pescado, deterioração e lesões sugestivas de doença zoonótica. O pescado comercializado nos distritos de Ipaussu e Botucatu não encontrava-se de acordo com os padrões de frescor exigidos para o consumo estabelecidos pela legislação brasileira.(AU)

The Regulamento de Inspeção Industrial e Sanitária de Produtos de Origem Animal (RIISPOA) establishes quality standards for fish intended for human consumption, ensuring a product served to the consumer with safety and innocuity. The objective of the present work was to evaluate the quality of fish commercialized in the districts of Ipaussu and Botucatu, São Paulo, more precisely the Tilapia do Nilo (Oreochromis niloticus) and the Merluza (Merluccius hubbsi), through necropsy findings and physical-chemical analysis. Eight Tilapia and three hake samples were acquired from a fish farm, euthanized on ice at the farm, and sent to the Laboratory of analysis of the Biotechnology Institute (IBTEC) of the Universidade Estadual Paulista (UNESP), in Botucatu-SP. The Tilapias were submitted to macroscopic inspection by means of external and internal observation and the Merluza fillets were submitted to physical-chemical analysis to evaluate the freshness. In the external examination the most frequent lesion was hemorrhage of skin (50%), fins (50%), gills (25%) and oral cavity (12.5%), while in the internal examination splenomegaly (75%) and kidney hemorrhage (50%) prevailed. The physical-chemical analysis showed significant alterations in the total volatile bases (TVB), making the food unfit for consumption according to current legislation. The observed alterations configure loss of quality of the fish, deterioration and lesions suggestive of zoonotic disease. The fish commercialized in the districts of Ipaussu and Botucatu did not meet the freshness standards required for consumption established by the Brazilian legislation.(AU)

El Reglamento de Inspección Industrial y Sanitaria de Productos de Origen Animal (RIISPOA) establece normas de calidad para el pescado destinado al consumo humano, garantizando un producto servido al consumidor con seguridad e inocuidad. El objetivo del presente trabajo fue evaluar la calidad de los peces comercializados en los distritos de Ipaussu y Botucatu, São Paulo, más precisamente la Tilapia do Nilo (Oreochromis niloticus) y la Merluza (Merluccius hubbsi), a través de los resultados de la necropsia y del análisis físico-químico. Ocho muestras de Tilapia y tres muestras de Merluza fueron adquiridas en una piscifactoría, eutanasiadas en hielo en la propiedad y enviadas al Laboratorio de análisis del Instituto de Biotecnología (IBTEC) de la Universidade Estadual Paulista (UNESP), Botucatu-SP. Las Tilapias fueron sometidas a inspección macroscópica mediante observación externa e interna y los filetes de Merluza fueron sometidos a análisis físico-químicos para evaluar la frescura. En el examen externo, la lesión más frecuente fue la hemorragia de la piel (50%), las aletas (50%), las branquias (25%) y la cavidad oral (12,5%), mientras que en el examen interno predominaron la esplenomegalia (75%) y la hemorragia renal (50%). El análisis físico-químico mostró alteraciones significativas en las bases volátiles totales (BTV), lo que hace que el alimento no sea apto para el consumo según la legislación vigente. Las alteraciones observadas configuran la pérdida de calidad del pescado, el deterioro y las lesiones sugestivas de enfermedad zoonótica. El pescado comercializado en los distritos de Ipaussu y Botucatu no cumplía con los estándares de frescura requeridos para el consumo establecidos por la legislación brasileña.(AU)

Parasitic lesions in fish in the Federal District, Brazil

Brazil has a vast territory and favorable climatic conditions that allow the cultivation of freshwater fish. The intensification of the productive system can cause an imbalance in the aquatic environment as a result of poor water quality, nutritional deficiencies and infectious or parasitic diseases. The laboratory diagnosis and the determination of the prevalence of the main lesions, which occur in a certain region, help to guide towards the etiological diagnosis. This study aimed to describe the main parasitic lesions in fish in the routine at the Veterinary Pathology Laboratory of the Universidade de Brasília (UnB). All records of fish with parasitic lesions were recovered. Those cases in which there was an intralesional parasite and which presented lesions compatible with the parasite were included. The screening of ectoparasites was done by scraping the superficial mucus from the gills and skin. Organ sections were routinely processed for histopathologyand stained with hematoxylin-eosin (HE). In some records, parasitological identification was carried. The information was divided into the species of the affected fish, epidemiology of the outbreak (water quality, temperature, type of breeding), lesion distribution, etiology and macroscopic and microscopic changes. The resulting data was organized in absolute frequency and percentage. In this study, 22 cases were counted, between individual deaths and outbreaks, totaling 83 necropsied teleost fish. Inflammatory changes of parasitic origin were seen in 13/22 (59%) of the cases had lesions of parasitic origin. Skin lesions and gills were the most relevant. Macroscopically, red areas or spots of hyperemia or hemorrhage on the body surface were the most prevalent findings. Under microscopy, proliferative gill inflammation was the most relevant diagnosis. Pscinoodinium pilullare (Dinoflagellida), Ichthyophthirius multifiliis (Ciliophora), and monogenetic worms (Monogenea) were the main parasites found. Trichodina sp. (Ciliophora), Ichtyobodo sp. (Kinetoplastida), Amoebas, and Chilodonella sp. (Ciliophora), were seen in fewer numbers. An unusual case suggestive of parasitism by Eustrongylides sp. (Nematoda), in a pirá-brasília (Simpsonichthys boitonei), specimen has been recorded. The diagnoses were based on epidemiology, anatomopathological and parasitological findings. The most frequent and significantly lethal lesion in the study was proliferative and / or hyperplastic branchitis. Proliferative branchitis with lamellar epithelial hyperplasia (LEH) is a response to some type of chemical or mechanical injury to the gill epithelium in order to protect the capillaries from further damage or microbial penetration. However, it also increases the diffusion distance between capillaries and the environment and, therefore, hinders breathing, excretory and osmoregulatory functions. Protozoan infections and monogenetic worms in general generated LEH and skin lesions of mechanical origin. Secondary bacterial infection, were observed in this parasitosis determining the cause of death of the fish. Its pathogenicity comes from the lesions caused by the colonization and histophagy of the epithelial surfaces, mainly gills and skin, causing epithelial proliferation, lamellar cell fusion, epithelial cell degeneration and necrosis forming several ulcers in the epithelium after the release of mature trophies. The pathogenesis of parasitism by Eustrongylides spp. is considerable when there is a large quantity of these larvae that can cause intestinal obstruction, rupture and compression of viscera, of greater importance in small fish. The main parasites of necropsied fish were protozoa and monogenetic worms, which mainly cause branquitis and dermatitis in varying grades.(AU)

Lesões de pele diagnosticadas em búfalos (Bubalus bubalis) na região do baixo Amazonas / Skin injuries diagnosed in buffaloes (Bubalus bubalis) in the lower Amazon region

A pele é o maior órgão do corpo e pode ser acometida por uma série de processos patológicos. As doenças dermatológicas em geral são um aspecto frustrante na clínica de animais de grande porte. Desse modo, o objetivo deste estudo foi relatar lesões de pele diagnosticadas em búfalos na região do Baixo Amazonas, estado do Pará. Foram avaliados 156 búfalos das raças Murrah, Mediterrâneo e seus mestiços; adultos e jovens, com idade variando de oito meses a nove anos. No exame físico constatou-se que 36,5% (57/156) dos animais apresentavam abscessos no local de vacinação. Destes, 12,2% (19/156) eram abscessos com presença de alopecia e 1,3% (2/156) com fistulação Além disso, 1,3% (2/156) dos animais apresentaram ainda no local de vacinação, feridas ulceradas com presença de secreção purulenta. Identificou-se que 3,8% (6/156) dos búfalos possuíam lesões provenientes da marcação a fogo, com queimaduras, de aspecto crostoso, eritematoso e exsudativo, na região da garupa.; A maioria 64,1% (100/156) dos animais apresentaram corte das orelhas, 1,9% (3/156) apresentaram lesões por penetração de corno e em 1,2% (2/156) observou-se lesão de pele no membro posterior direito. Conclui-se que foi possível diagnosticar diversas lesões cutâneas nos búfalos na região do Baixo Amazonas, sendo o erro no manejo dos animais as principais causas das lesões diagnosticadas. Além disso, houve correlação entre dois grupos de animais avaliados (com e sem lesão).

The skin is the largest organ in the body and can be affected by a series of pathological processes. Dermatological diseases in general are a frustrating aspect in the clinic of large animals. Thus, the objective of this study was to report skin lesions diagnosed in buffaloes in the region of Baixo Amazonas, state of Pará. 156 buffaloes of the Murrah, Mediterranean and crossbred breeds were taken; Adults and young people, with ages varying from eight months to nine years. On physical examination, it was found that 36.5% (57/156) of the animals had abscesses at the vaccination site. Of these, 12.2% (19/156) were abscesses with the presence of alopecia and 1.3% (2/156) with fistulation. In addition, 1.3% (2/156) of the animals separated at the vaccination site, ulcerated wounds with the presence of purulent secretion. It was identified that 3.8% (6/156) of the buffaloes had the location of the fire mark, with burns, with a crusted, erythematous and exudative aspect, in the croup region. The majority 64.1% (100/156) of the animals separation of the ears, 1.9% (3/156) dissipation by penetration of the horn and in 1.2% (2/156) a skin lesion was observed in any limb posterior right. It was concluded that it was possible to diagnose several cutaneous lesions in buffaloes in the region of Baixo Amazonas, with the error in handling animals being the main causes of the diagnosed injuries. In addition, there was a correlation between two groups of acquired animals (with and without injury).

Lesões de pele diagnosticadas em búfalos (Bubalus bubalis) na região do baixo Amazonas / Skin injuries diagnosed in buffaloes (Bubalus bubalis) in the lower Amazon region

A pele é o maior órgão do corpo e pode ser acometida por uma série de processos patológicos. As doenças dermatológicas em geral são um aspecto frustrante na clínica de animais de grande porte. Desse modo, o objetivo deste estudo foi relatar lesões de pele diagnosticadas em búfalos na região do Baixo Amazonas, estado do Pará. Foram avaliados 156 búfalos das raças Murrah, Mediterrâneo e seus mestiços; adultos e jovens, com idade variando de oito meses a nove anos. No exame físico constatou-se que 36,5% (57/156) dos animais apresentavam abscessos no local de vacinação. Destes, 12,2% (19/156) eram abscessos com presença de alopecia e 1,3% (2/156) com fistulação Além disso, 1,3% (2/156) dos animais apresentaram ainda no local de vacinação, feridas ulceradas com presença de secreção purulenta. Identificou-se que 3,8% (6/156) dos búfalos possuíam lesões provenientes da marcação a fogo, com queimaduras, de aspecto crostoso, eritematoso e exsudativo, na região da garupa.; A maioria 64,1% (100/156) dos animais apresentaram corte das orelhas, 1,9% (3/156) apresentaram lesões por penetração de corno e em 1,2% (2/156) observou-se lesão de pele no membro posterior direito. Conclui-se que foi possível diagnosticar diversas lesões cutâneas nos búfalos na região do Baixo Amazonas, sendo o erro no manejo dos animais as principais causas das lesões diagnosticadas. Além disso, houve correlação entre dois grupos de animais avaliados (com e sem lesão).(AU)

The skin is the largest organ in the body and can be affected by a series of pathological processes. Dermatological diseases in general are a frustrating aspect in the clinic of large animals. Thus, the objective of this study was to report skin lesions diagnosed in buffaloes in the region of Baixo Amazonas, state of Pará. 156 buffaloes of the Murrah, Mediterranean and crossbred breeds were taken; Adults and young people, with ages varying from eight months to nine years. On physical examination, it was found that 36.5% (57/156) of the animals had abscesses at the vaccination site. Of these, 12.2% (19/156) were abscesses with the presence of alopecia and 1.3% (2/156) with fistulation. In addition, 1.3% (2/156) of the animals separated at the vaccination site, ulcerated wounds with the presence of purulent secretion. It was identified that 3.8% (6/156) of the buffaloes had the location of the fire mark, with burns, with a crusted, erythematous and exudative aspect, in the croup region. The majority 64.1% (100/156) of the animals separation of the ears, 1.9% (3/156) dissipation by penetration of the horn and in 1.2% (2/156) a skin lesion was observed in any limb posterior right. It was concluded that it was possible to diagnose several cutaneous lesions in buffaloes in the region of Baixo Amazonas, with the error in handling animals being the main causes of the diagnosed injuries. In addition, there was a correlation between two groups of acquired animals (with and without injury).(AU)

Lesões de pele diagnosticadas em búfalos (Bubalus bubalis) na região do baixo Amazonas / Skin injuries diagnosed in buffaloes (Bubalus bubalis) in the lower Amazon region

A pele é o maior órgão do corpo e pode ser acometida por uma série de processos patológicos. As doenças dermatológicas em geral são um aspecto frustrante na clínica de animais de grande porte. Desse modo, o objetivo deste estudo foi relatar lesões de pele diagnosticadas em búfalos na região do Baixo Amazonas, estado do Pará. Foram avaliados 156 búfalos das raças Murrah, Mediterrâneo e seus mestiços; adultos e jovens, com idade variando de oito meses a nove anos. No exame físico constatou-se que 36,5% (57/156) dos animais apresentavam abscessos no local de vacinação. Destes, 12,2% (19/156) eram abscessos com presença de alopecia e 1,3% (2/156) com fistulação Além disso, 1,3% (2/156) dos animais apresentaram ainda no local de vacinação, feridas ulceradas com presença de secreção purulenta. Identificou-se que 3,8% (6/156) dos búfalos possuíam lesões provenientes da marcação a fogo, com queimaduras, de aspecto crostoso, eritematoso e exsudativo, na região da garupa.; A maioria 64,1% (100/156) dos animais apresentaram corte das orelhas, 1,9% (3/156) apresentaram lesões por penetração de corno e em 1,2% (2/156) observou-se lesão de pele no membro posterior direito. Conclui-se que foi possível diagnosticar diversas lesões cutâneas nos búfalos na região do Baixo Amazonas, sendo o erro no manejo dos animais as principais causas das lesões diagnosticadas. Além disso, houve correlação entre dois grupos de animais avaliados (com e sem lesão).

The skin is the largest organ in the body and can be affected by a series of pathological processes. Dermatological diseases in general are a frustrating aspect in the clinic of large animals. Thus, the objective of this study was to report skin lesions diagnosed in buffaloes in the region of Baixo Amazonas, state of Pará. 156 buffaloes of the Murrah, Mediterranean and crossbred breeds were taken; Adults and young people, with ages varying from eight months to nine years. On physical examination, it was found that 36.5% (57/156) of the animals had abscesses at the vaccination site. Of these, 12.2% (19/156) were abscesses with the presence of alopecia and 1.3% (2/156) with fistulation. In addition, 1.3% (2/156) of the animals separated at the vaccination site, ulcerated wounds with the presence of purulent secretion. It was identified that 3.8% (6/156) of the buffaloes had the location of the fire mark, with burns, with a crusted, erythematous and exudative aspect, in the croup region. The majority 64.1% (100/156) of the animals separation of the ears, 1.9% (3/156) dissipation by penetration of the horn and in 1.2% (2/156) a skin lesion was observed in any limb posterior right. It was concluded that it was possible to diagnose several cutaneous lesions in buffaloes in the region of Baixo Amazonas, with the error in handling animals being the main causes of the diagnosed injuries. In addition, there was a correlation between two groups of acquired animals (with and without injury).

Ocorrência de neoplasias cutâneas em cães com dermatite actínica em um Hospital Veterinário Escola (HCV - UFRGS) / Occurrence of cutaneous neoplasia in dogs with actinic dermatitis in a Veterinary Medical Teaching Hospital - UFRGS, Brazil

Background: Actinic dermatitis is an environmental skin disease resulting from excessive exposure to ultraviolet light irradiated by thesun. This phototoxic reaction affects dogs and cats, particularly with short hair and lightly pigmented skin, exposed to sun light. Primarylesions are typical from a sunburn and chronic exposure, and may induce to a premalignant lesion known as actinic keratosis, whichmay develop to neoplasms. The aim of the present study was to describe a retrospective study of actinic dermatitis and the occurrenceof cutaneous neoplasia in dogs presented to a Veterinary Medical Teaching Hospital (HCV/UFRGS) in Porto Alegre, Rio Grande doSul, Brazil in a period of 10 years.Materials, Methods & Results: A retrospective review of medical records from January 2009 to December 2019 was performed toidentify dogs with actinic dermatitis. Twenty-eight dogs were diagnosed based on a history of sun exposure and skin lesions includingerythema, scaling, comedones, thickened skin, hyperpigmentation, ulceration and/or secondary infections on poorly pigmented skin. Inaddition, in twelve dogs (42.8%) the disease was also confirmed by histopathology. Cutaneous lesions locations were previously definedas head, limbs, neck and trunk. The head was subdivided in chin, ears, face, lips and nasal plane; the limbs in pelvic and thoracic; andthe trunk, in abdomen, dorsal pelvis, perianal and thorax. All 28 dogs diagnosed with actinic dermatitis in the study had been chronically exposed to solar radiation and had light skin and coat. Dogs were between 3 and 20 years old, mean 7.6 years and median 7 years,mostly female dogs (64.3%) and neutered or spayed (64.3%). The most affected breeds were American Pitbull Terrier (35.7%) andBoxers (28.5%). Other breeds were Bull Terrier, Dalmatian, Dogo Argentino and Scottish Terrier...

Ocorrência de neoplasias cutâneas em cães com dermatite actínica em um Hospital Veterinário Escola (HCV - UFRGS) / Occurrence of cutaneous neoplasia in dogs with actinic dermatitis in a Veterinary Medical Teaching Hospital - UFRGS, Brazil

Background: Actinic dermatitis is an environmental skin disease resulting from excessive exposure to ultraviolet light irradiated by thesun. This phototoxic reaction affects dogs and cats, particularly with short hair and lightly pigmented skin, exposed to sun light. Primarylesions are typical from a sunburn and chronic exposure, and may induce to a premalignant lesion known as actinic keratosis, whichmay develop to neoplasms. The aim of the present study was to describe a retrospective study of actinic dermatitis and the occurrenceof cutaneous neoplasia in dogs presented to a Veterinary Medical Teaching Hospital (HCV/UFRGS) in Porto Alegre, Rio Grande doSul, Brazil in a period of 10 years.Materials, Methods & Results: A retrospective review of medical records from January 2009 to December 2019 was performed toidentify dogs with actinic dermatitis. Twenty-eight dogs were diagnosed based on a history of sun exposure and skin lesions includingerythema, scaling, comedones, thickened skin, hyperpigmentation, ulceration and/or secondary infections on poorly pigmented skin. Inaddition, in twelve dogs (42.8%) the disease was also confirmed by histopathology. Cutaneous lesions locations were previously definedas head, limbs, neck and trunk. The head was subdivided in chin, ears, face, lips and nasal plane; the limbs in pelvic and thoracic; andthe trunk, in abdomen, dorsal pelvis, perianal and thorax. All 28 dogs diagnosed with actinic dermatitis in the study had been chronically exposed to solar radiation and had light skin and coat. Dogs were between 3 and 20 years old, mean 7.6 years and median 7 years,mostly female dogs (64.3%) and neutered or spayed (64.3%). The most affected breeds were American Pitbull Terrier (35.7%) andBoxers (28.5%). Other breeds were Bull Terrier, Dalmatian, Dogo Argentino and Scottish Terrier...(AU)

Calcinosis cutis with large extension and uncommon location in a dog

Background: Calcinosis cutis is an uncommon dermatopathy characterized by the deposition of minerals in the skin,usually involving collagen and elastic fibers in the dermis. Usually, it results from dystrophic calcification and can begeneralized or focal. The dermatopathy may be primary or secondary to certain disorders, especially chronic proliferativeotitis, foreign body reactions, hyperadrenocorticism (HAC) and less frequently percutaneous penetration of calcium-richproducts. The aim of this report is to describe a presentation of calcinosis cutis affecting the skin of the back, internal faceof hind limbs and anal region of a 9-years-old bitch.Case: A 9-year-old, non-defined breed, bitch, ovariohysterectomized, weighing 9.45 kg, was attended at the DermatologicalService of companion animals at the Veterinary Hospital of the Federal University of Jataí (UFJ). The animal came in withthe complaint of extensive dorsal alopecia, covered by firm lesions, with a 3-month evolution, additionally to polyuria andpolydipsia. After physical examination, alopecic areas of great extension were confirmed on the dorsum, on the internalsurface of the hind limbs and in the anal region. Also, an exudative and painful lesion located on the back was detected,plus loss of elasticity of the ventral abdomen skin and visible abdominal vessels. The screening tests showed a markedincrease in the alanine aminotransferase enzyme (ALT), alkaline phosphatase (ALP) and total cholesterol. The specificurinary density was decreased. On the ultrasound examination, hepatomegaly and an increase in the caudal pole of the leftadrenal were detected. Based on these findings, calcinosis cutis secondary to spontaneous hyperadrenocorticism (HAC)was suspected. For confirmation, skin biopsy and low dose dexamethasone suppression test (LDDS) were performed.LDDS test showed no reduction of serum cortisol after 8 h of dexamethasone dose administration and histopathological...

Calcinosis cutis with large extension and uncommon location in a dog

Background: Calcinosis cutis is an uncommon dermatopathy characterized by the deposition of minerals in the skin,usually involving collagen and elastic fibers in the dermis. Usually, it results from dystrophic calcification and can begeneralized or focal. The dermatopathy may be primary or secondary to certain disorders, especially chronic proliferativeotitis, foreign body reactions, hyperadrenocorticism (HAC) and less frequently percutaneous penetration of calcium-richproducts. The aim of this report is to describe a presentation of calcinosis cutis affecting the skin of the back, internal faceof hind limbs and anal region of a 9-years-old bitch.Case: A 9-year-old, non-defined breed, bitch, ovariohysterectomized, weighing 9.45 kg, was attended at the DermatologicalService of companion animals at the Veterinary Hospital of the Federal University of Jataí (UFJ). The animal came in withthe complaint of extensive dorsal alopecia, covered by firm lesions, with a 3-month evolution, additionally to polyuria andpolydipsia. After physical examination, alopecic areas of great extension were confirmed on the dorsum, on the internalsurface of the hind limbs and in the anal region. Also, an exudative and painful lesion located on the back was detected,plus loss of elasticity of the ventral abdomen skin and visible abdominal vessels. The screening tests showed a markedincrease in the alanine aminotransferase enzyme (ALT), alkaline phosphatase (ALP) and total cholesterol. The specificurinary density was decreased. On the ultrasound examination, hepatomegaly and an increase in the caudal pole of the leftadrenal were detected. Based on these findings, calcinosis cutis secondary to spontaneous hyperadrenocorticism (HAC)was suspected. For confirmation, skin biopsy and low dose dexamethasone suppression test (LDDS) were performed.LDDS test showed no reduction of serum cortisol after 8 h of dexamethasone dose administration and histopathological...(AU)

Automutilação em abutre real (Sarcoramphus papa) mantido em cativeiro / Self-mutilation in king vulture (Sarcoramphus papa) kept in captivity / Automutilación en buitre real (Sarcoramphus papa) mantenido en cautiverio

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)

The king vulture (Sarcoramphus papa) is a large bird with extraordinary color, bold head, presenting red and orange fleshy papules and papillae around its beak, with white iris and a red orbital ring. In captivity, stress is a condition that is widely observed, which can lead to self-mutilation. Such mutilation, in turn, can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in a case of self-mutilation in Sarcoramphus papa, kept in captivity, and the importance of proper management for this species in captivity. The king vulture presenting a contaminated wound with bone exposure on the right wing was treated at a University Veterinary Hospital. After treatment, the bird was sent to a conservation reserve to be conditioned to return to its natural habitat.(AU)

El buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza descubierta, tiene carúnculas y papilas carnosas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede conducir a la automutilación, pudiendo progresar lesiones graves en la piel y músculos. El propósito de este informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenida en cautiverio, y la importancia del manejo adecuado de esta especie en cautiverio. Se atendió en un Hospital Veterinario Universitario, un buitre real presentando una herida contaminada, con exposición ósea en el ala derecha. Luego después del tratamiento, se envió el animal a una reserva de conservación para que fuera condicionado a volver a su hábitat natural.(AU)

Automutilação em abutre real (Sarcoramphus papa) mantido em cativeiro / Self-mutilation in king vulture (Sarcoramphus papa) kept in captivity / Automutilación en buitre real (Sarcoramphus papa) mantenido en cautiverio

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)

The king vulture (Sarcoramphus papa) is a large bird with extraordinary color, bold head, presenting red and orange fleshy papules and papillae around its beak, with white iris and a red orbital ring. In captivity, stress is a condition that is widely observed, which can lead to self-mutilation. Such mutilation, in turn, can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in a case of self-mutilation in Sarcoramphus papa, kept in captivity, and the importance of proper management for this species in captivity. The king vulture presenting a contaminated wound with bone exposure on the right wing was treated at a University Veterinary Hospital. After treatment, the bird was sent to a conservation reserve to be conditioned to return to its natural habitat.(AU)

El buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza descubierta, tiene carúnculas y papilas carnosas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede conducir a la automutilación, pudiendo progresar lesiones graves en la piel y músculos. El propósito de este informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenida en cautiverio, y la importancia del manejo adecuado de esta especie en cautiverio. Se atendió en un Hospital Veterinario Universitario, un buitre real presentando una herida contaminada, con exposición ósea en el ala derecha. Luego después del tratamiento, se envió el animal a una reserva de conservación para que fuera condicionado a volver a su hábitat natural.(AU)

Automutilação em abutre real (Sarcoramphus papa) mantido em cativeiro / Self-mutilation in king vulture (Sarcoramphus papa) kept in captivity / Automutilación en buitre real (Sarcoramphus papa) mantenido en cautiverio

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)

The king vulture (Sarcoramphus papa) is a large bird with extraordinary color, bold head, presenting red and orange fleshy papules and papillae around its beak, with white iris and a red orbital ring. In captivity, stress is a condition that is widely observed, which can lead to self-mutilation. Such mutilation, in turn, can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in a case of self-mutilation in Sarcoramphus papa, kept in captivity, and the importance of proper management for this species in captivity. The king vulture presenting a contaminated wound with bone exposure on the right wing was treated at a University Veterinary Hospital. After treatment, the bird was sent to a conservation reserve to be conditioned to return to its natural habitat.(AU)

El buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza descubierta, tiene carúnculas y papilas carnosas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede conducir a la automutilación, pudiendo progresar lesiones graves en la piel y músculos. El propósito de este informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenida en cautiverio, y la importancia del manejo adecuado de esta especie en cautiverio. Se atendió en un Hospital Veterinario Universitario, un buitre real presentando una herida contaminada, con exposición ósea en el ala derecha. Luego después del tratamiento, se envió el animal a una reserva de conservación para que fuera condicionado a volver a su hábitat natural.(AU)

Hyperbaric oxygen therapy in wound healing in mice / [Oxigenoterapia hiperbárica na cicatrização de feridas em camundongos]

We investigated the local and systemic effects of hyperbaric oxygen therapy in BALB/C mice, exposed to two different exposure times, under 2.4 atmosphere (ATM). Fifteen animals were divided into three groups (GI, GII and Control) and underwent a surgical excision of a skin fragment of approximately one square centimeter of the dorsal region. The wounds were treated and monitored for 21 days. In the control group, the wound was cleaned once a day with sterile 0.9% NaCl solution. GI and GII mice were submitted to daily hyperbaric oxygen therapy of 30 or 60minutes sessions, respectively. The wounds were photographed every three days and their surfaces were analyzed by an image analyzer. At 21 days, all animals were euthanatized for histopathological analysis of the skin, lungs and liver in order to identify eventual alterations in wound healing or in the analyzed organs. Animals belonging to GI showed a faster skin wound healing in comparison to the other groups. Animals from GII, however, showed a delayed wound healing process and exhibited lung and microcirculatory alterations. These findings allow us to conclude that the exposure time to the oxygen in hyperbaric environment is crucial and can help or disturb skin wound healing or even be deleterious to other organs.(AU)

Investigaram-se os efeitos locais e sistêmicos da oxigenoterapia hiperbárica em camundongos BALB / C, submetidos a dois tempos de exposição diferentes, sob atmosfera 2,4 (ATM). Quinze animais foram divididos em três grupos (GI, GII e controle) e submetidos à excisão cirúrgica de fragmento de pele de aproximadamente um centímetro quadrado da região dorsal. As feridas foram tratadas e acompanhadas por 21 dias. No grupo controle, a ferida foi limpa uma vez ao dia, com solução estéril de NaCl 0,9%. Camundongos GI e GII foram submetidos à oxigenoterapia hiperbárica diária de 30 ou 60 minutos de sessões, respectivamente. As feridas foram fotografadas a cada três dias, e suas superfícies analisadas por um analisador de imagens. Aos 21 dias, todos os animais foram submetidos à eutanásia para análise histopatológica da pele, do pulmão e do fígado, em busca de eventuais alterações na cicatrização da ferida ou nos órgãos analisados. Animais pertencentes ao GI apresentaram cicatrização mais rápida de feridas cutâneas em comparação aos outros grupos. Já os animais do GII apresentaram retardo na cicatrização da ferida e alterações pulmonares e microcirculatórias. Esses achados permitem concluir que o tempo de exposição ao oxigênio em ambiente hiperbárico é fundamental e pode auxiliar ou atrapalhar a cicatrização de feridas cutâneas ou mesmo ser deletério para outros órgãos.(AU)

Uso da túnica vaginal canina conservada em glicerina a 98% como curativo biológico no tratamento de feridas cutâneas produzidas em ratos Wistar / Use of canine vaginal tunic preserved in 98% glycerin as biological curative in the treatment of skin produced in wound Wistar rats

Na procura por material alternativo no tratamento de feridas cutâneas, buscou-se com este estudo avaliar o comportamento da túnica vaginal canina conservada em glicerina a 98% como curativo biológico no tratamento de feridas cutâneas provocadas experimentalmente em ratos. Foram utilizados 16 ratos Wistar, nos quais foram induzidas experimentalmente duas lesões cutâneas na região dorsal, sendo uma cranial e a outra caudal. Uma ferida serviu de controle, a qual não recebeu tratamento, a outra recebeu a túnica vaginal recobrindo toda extensão da lesão. A seleção de qual das feridas, cranial ou caudal, iria receber a membrana foi feita de forma aleatória. Os animais foram distribuídos em quatro grupos de igual número para análises clínicas, macroscópicas e histológicas decorridos três, sete, 14 e 21 dias de pós-operatório. Na avaliação clínica e macroscópica pode-se observar que o processo de reparação teve evolução semelhante tanto no grupo controle quanto no grupo membrana. Na análise histopatológica foi constatada grande quantidade de infiltrado inflamatório nos períodos iniciais, no entanto, decorridos 21 dias, a epiderme já se encontrava reparada, e em todos os momentos foi observada maior presença de tecido conjuntivo no grupo membrana, sugerindo maior precocidade na cicatrização. Deste modo, concluiu-se que a túnica vaginal canina pode ser utilizada como nova alternativa no tratamento de feridas cutâneas.

In the search for alternative material in the treatment of cutaneous wounds, this study aimed to evaluate the behavior of canine vaginal tunic conserved in glycerin 98% as a biological dressing in the treatment of cutaneous wounds provoked experimentally in rats. Sixteen animals were used in which two cutaneous lesions were caused in the dorsal region, one cranial and the other caudal. One wound served as a control which did not receive treatment, the other received the vaginal tunic covering all extension of the lesion. The selection of which of the wounds, cranial or caudal, would receive the membrane was made at random. The animals were divided into four groups of equal numbers for clinical, macroscopic, and histological analyzes after three, seven, 14 and 21 postoperative days. In the clinical and macroscopic evaluation, it can be observed that the healing process had similar evolution in both the control group and the membrane group. In the histopathological analysis, a large amount of inflammatory infiltrate was observed in the initial periods; however, after 21 days the epidermis was already healed, and at all times a greater presence of connective tissue was observed in the membrane group, suggesting a greater precocity in healing. Thus, it was concluded that the canine vaginal tunic can be used as a new alternative in the treatment of cutaneous wounds.

Enxerto cutâneo em semeadura associado à malha não aderente em membro pélvico de um cão / Island skin graft associated with non-adherent mesh in a dog's pelvic limb

Background: Large skin defects are caused by tumor excision, making appropriate reconstruction and complete healingof the lesion a challenge for surgeons. There are some difficulties in reaching these goals, especially in cases of surgicalwound in the limbs, due to the scarce amount of skin and its reduced elasticity, which limit the possibility of flaps whencompared to the head, neck, and trunk. This study reports a case of wound closure on the lateral skin in the femoral regionof a dog’s pelvic limb via island skin graft associated with the implantation of a non-adherent cellulose acetate mesh andintensive postoperative care.Case: An 8-year-old Rottweiler female dog was attended at Pontifical Catholic University of Paraná’s Veterinary Clinic(CVE) in Curitiba, Paraná, presenting a tumor located laterocaudally to the right stifle joint. After preoperative examinations the patient underwent tumor surgery; however, two more surgical procedures were required due to suture dehiscence in the region, which resulted in increased wound size. At first, the wound was treated for granulation tissue to beformed. Subsequently, the island skin grafting technique was chosen to close the wound, associated with the implantationof a non-adherent cellulose acetate mesh imbibed with petrolatum emulsion to keep the grafted fragments in place. Themesh was fixed in a simple interrupted suture pattern using 2-0 nylon thread. The lateral regions of the chest and abdomen were chosen as donor skin beds due to their large dimensions, skin elasticity, and ease in defect reconstruction. Thefragments were obtained using a 10-mm biopsy punch and scalpel, and the defects were sutured in a simple interruptedpattern using 2-0 nylon thread. The patient remained hospitalized for movement restriction and postoperative monitoringfor 72 h, and the bandage remained untouched during this time interval. Thereafter, the patient...

Enxerto cutâneo em semeadura associado à malha não aderente em membro pélvico de um cão / Island skin graft associated with non-adherent mesh in a dog's pelvic limb

Background: Large skin defects are caused by tumor excision, making appropriate reconstruction and complete healingof the lesion a challenge for surgeons. There are some difficulties in reaching these goals, especially in cases of surgicalwound in the limbs, due to the scarce amount of skin and its reduced elasticity, which limit the possibility of flaps whencompared to the head, neck, and trunk. This study reports a case of wound closure on the lateral skin in the femoral regionof a dogs pelvic limb via island skin graft associated with the implantation of a non-adherent cellulose acetate mesh andintensive postoperative care.Case: An 8-year-old Rottweiler female dog was attended at Pontifical Catholic University of Paranás Veterinary Clinic(CVE) in Curitiba, Paraná, presenting a tumor located laterocaudally to the right stifle joint. After preoperative examinations the patient underwent tumor surgery; however, two more surgical procedures were required due to suture dehiscence in the region, which resulted in increased wound size. At first, the wound was treated for granulation tissue to beformed. Subsequently, the island skin grafting technique was chosen to close the wound, associated with the implantationof a non-adherent cellulose acetate mesh imbibed with petrolatum emulsion to keep the grafted fragments in place. Themesh was fixed in a simple interrupted suture pattern using 2-0 nylon thread. The lateral regions of the chest and abdomen were chosen as donor skin beds due to their large dimensions, skin elasticity, and ease in defect reconstruction. Thefragments were obtained using a 10-mm biopsy punch and scalpel, and the defects were sutured in a simple interruptedpattern using 2-0 nylon thread. The patient remained hospitalized for movement restriction and postoperative monitoringfor 72 h, and the bandage remained untouched during this time interval. Thereafter, the patient...(AU)