Dormancy models for Mycobacterium tuberculosis: A minireview

Alnimr, Amani M

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Dormancy models for Mycobacterium tuberculosis: A minireview

Alnimr, Amani M.

Braz. J. Microbiol.; 46(3): 641-647, July-Sept. 2015. tab, ilus

Artigo em Inglês | VETINDEX | ID: vti-14834

Resumo

Dormancy models for Mycobacterium tuberculosis play important roles in understanding various aspects of tuberculosis pathogenesis and in the testing of novel therapeutic regimens. By simulating the latent tuberculosis infection, in which the bacteria exist in a non-replicative state, the models demonstrate reduced susceptibility to antimycobacterial agents. This minireview outlines the models available for simulating latent tuberculosis both in vitro and in several animal species. Additionally, this minireview discusses the advantages and disadvantages of these models for investigating the bacterial subpopulations and susceptibilities to sterilization by various antituberculosis drugs..(AU)

Assuntos

Animais Cobaias Camundongos Coelhos Antituberculosos/farmacologia Modelos Animais de Doenças Tuberculose Latente/patologia Tuberculose Pulmonar/patologia Farmacorresistência Bacteriana Indicadores e Reagentes/farmacologia Tuberculose Latente/tratamento farmacológico Tuberculose Latente/microbiologia Macaca fascicularis Mycobacterium tuberculosis Mycobacterium tuberculosis/metabolismo Oxazinas/farmacologia /tratamento farmacológico Tuberculose Pulmonar/microbiologia Xantenos/farmacologia Peixe-Zebra

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Dormancy models for Mycobacterium tuberculosis: A minireview

Resumo

Assuntos