Role of moxifloxacin-dexamethasone in cardiac histomorphometric findings among Wistar rats from infected mothers
Maior, Gustavo Ithamar Souto; Mascena, Guilherme Veras; Marquis, Valéria Wanderley Pinto Brandão; Figueiredo Filho, Carlos Alberto; Paz, Alexandre Rolim da; Moura, Líbia Cristina Rocha Vilela; Brandt, Carlos Teixeira.
Acta cir. bras.;
33(9): 744-752, set. 2018. ilus, tab, graf
Artigo
em Inglês
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| ID: vti-735044
Resumo
Purpose: To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes. Methods: A prospective histomorphometric study was performed on 29 hearts of Wistar four-month old rats. Animals were divided into three groups: Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis. Results: Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG. Conclusion: Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.(AU)
Biblioteca responsável:
BR68.1
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