Artículo
en Inglés
| IBECS (España) | ID: ibc-133310
Introduction. Recent reports of an association between androgen deprivation treatment (ADT) and increased risk of cardiovascular (CV) events have generated debate on the use of ADT in patients with prostate cancer (PCa) and CV comorbidities. This study aims to describe the recommendations of radiation oncologists in the most controversial aspects of treating such patients. Materials and methods. The project involved 61 oncologists and comprised 4 phases (1) selection of the most controversial aspects in the administration of ADT in patients with a history of CV disease and PCa, (2) selection of the most relevant published evidence, (3) preparation of case reports, (4) critical reading and discussion. Therapeuticprocedures were classified as highly recommendable, recommendable in some cases, or not recommendable/not applicable. For each item assessed, the mode of the scores given, and the percentage of experts who selected each score were calculated. Results. The panel recommended that patients with high/very high-riskPCa and a history of CV disease should receive gonadotropin-releasing hormoneagonists (GnRHa). ADT with GnRHa for 2436 months + radiotherapy (RT) was also considered highly recommendable. In intermediate-riskPCa and a history of CV, ADT with GnRHa for 68 months + RT, and not administering ADT were considered highly recommendable. Conclusions. Studies are necessary to investigate the impact of ADT on CV mortality in patientswho benefit most from adjuvant ADT in terms of survival. In the meantime, the experts believe that clinical evidence on the proven therapeutic benefits of ADT should override concerns about potential cardiac toxicity (AU)
