Introduction:
The genomic heterogeneity of
hepatitis C virus (HCV) influences
liver disorders. This study aimed to determine the
prevalence of HCV
genotypes and to investigate the influence of these
genotypes on
disease progression.
Methods:
Blood samples and
liver biopsies were collected from HCV-seropositive
patients for serological
analysis,
biochemical marker measurements, HCV genotyping and histopathological evaluation.
Results:
Hepatitis C virus-
ribonucleic acid (HCV-
RNA) was detected in 107
patients (90.6% with
genotype 1 and 9.4% with
genotype 3).
Patients infected with
genotype 1 exhibited higher mean necroinflammatory activity and
fibrosis.
Conclusions:
HCV
genotype 1 was the most prevalent and was associated with greater
liver dysfunction. .