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Instituto Evandro Chagas

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Puerperal brain cryptococcoma in an HIV-negative woman successfully treated with fluconazole: a case report

Hagan, José Edward; Dias, Jesângeli Sousa; Villasboas-Bisneto, José Caetano; Falcão, Melissa Barreto; Ko, Albert Icksang; Ribeiro, Guilherme Sousa.
Rev. Soc. Bras. Med. Trop ; 47(2): 254-256, Mar-Apr/2014. graf
Artigo em Inglês | LILACS | ID: lil-710359
Cryptococcus spp. cerebral abscesses are uncommon in immunocompetent subjects. The recommended induction treatment is the administration of amphotericin B plus flucytosine combined with resection for lesions ≥3cm. In this paper, we describe an HIV-negative woman diagnosed with a large cryptococcoma in the immediate postpartum period. The lesion was not resected, and due to amphotericin B intolerance, she received an extended course of fluconazole monotherapy. There was no disease recurrence during the 4 years of follow-up. The abrupt onset of her symptoms following delivery suggests that she developed a postpartum immune reconstitution syndrome. This case also demonstrates that in specific situations fluconazole monotherapy can be attempted in immunocompetent patients with cryptococcoma.
Biblioteca responsável: BR1.1