Medicamentos termolabiles. Protocolo de actuacion en la rotura de la cadena de frio / Thermolabile drugs. Operating procedure in the event of cold chain failure

RESUMEN

Objetivo: Establecer un procedimiento normalizado de trabajo en caso de rotura de cadena de frio. Metodo Se seleccionaron los medicamentos termolabiles incluidos en la guia farmacoterapeutica del hospital y se reviso la bibliografia disponible, clasificandolos en categorias con un protocolo de actuacion en cada caso. Resultados Se revisaron 254 medicamentos (162 principios activos). La distribucion por categorias fue In addition, 433 (4.3%) of dispensed doses were returned to the Pharmacy Department. After the Unit Dose Quality Control Group conducted their feedback analysis, 64 improvement measures for Pharmacy Department nurses, 37 for pharmacists, and 24 for the hospital ward were introduced. Conclusions: The SSS programme has proven to be useful as a quality control strategy to identify Unit Dose Distribution System errors at initial, intermediate and final stages of the process, improving the involvement of the Pharmacy Department and ward nurses (AU)

ABSTRACT

Objective: To establish a standard operating procedure in the event of cold chain failure. Method: We selected thermolabile drugs included in the hospitals pharmaceutical guide. We performed a review of the available literature, classifying each drug into a given category with an intervention protocol for each one. Results: We reviewed 254 drugs (162 active ingredients). Categories were A (stable ≥ 28 day sat 25◦C) 65 drugs; B (≥7 days at 25◦C) 47 drugs; C (≥48hat25◦C) 30 drugs; D (< 48 h at25◦C) 47 drugs; E (unstable> 8◦C) 12 drugs; F (batch-dependent) 22 drugs. 31 drugs were not classified in any category. The intervention protocol consisted of establishing a system to monitor the products concerned, and discarding or returning them to the laboratory if they were to exceed the time or temperature limit indicated for each category. Discussion: The aim of this study is to make intervention quicker in the event of cold chain failure (AU)