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Czynniki prognostyczne w grupie chorych na niezaawansowanego raka trzonu macicy leczonych chirurgicznie z uzupelniajacym napromienianiem./ [Prognostic factors in patients with cervical--confined endometrial carcinoma treated with surgery and postoperative radiotherapy].

Autor(es): Karolewski, Kazimierz; Kojs, Zbigniew; Jakubowicz, Jerzy; Urbanski, Krzysztof; Reinfuss, Marian; Dymek, Pawel; Józwik, Piotr
Fonte: Przegl Lek;62(12): 1444-6, 2005.
Artigo [ PMID: 16786769 ] Idioma(s):
Publicação: Resumo em Inglês; Artigo de Revista
OBJECTIVE: The aim of the study was to determine prognostic factors in the group of the patients with uterine--confined endometrial carcinoma treated with surgery and postoperative radiotherapy. MATERIAL AND METHODS: The authors analyzed 102 patients (mean age 58 years) with stage 1 (74 patients) and stage 11 (28 patients) endometrial carcinoma. All patients were treated with surgery (abdominal hysterectomy and bilateral adnexectomy) and postoperative radiotherapy: external beam pelvic irradiation (20 patients), vaginal cuff irradiation (33 patients) and combination (49 patients). Analysed were prognostic factors as follows: age, stage, tumor grade, depth of myometrial invasion, hormone receptors, expression of the tumor suppressor gene p53, Her 2/neu and MIB-1 (ki-67 paraffin). RESULTS: In our group of patients, multivariate analysis has identified tumor grade, progesterone receptors status and MIB-1 as independent significant prognostic factors.