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Prophylaxis and screening options: recommendations for young women with BRCA mutations.

Autor(es): Samuel, Jonathan C; Ollila, David W
Fonte: Breast Dis;23: 31-5, 2005-2006.
Artigo [ PMID: 16823164 ] Idioma(s): Inglês
Publicação: Artigo de Revista; Revisão
Young women who carry a BRCA mutation face difficult decisions regarding radiologic screening modalities and prophylactic surgery. Decisions regarding these choices may have short and/or long-term consequences and significant impacts on breast cancer risk. A comprehensive review of currently available data supports the following recommendations for young women with BRCA mutations: perform monthly self breast exam, obtain clinical breast exam 2-4 times per year, discuss annual imaging options with a breast specialist, complete child-bearing by 35 with subsequent prophylactic oopherectomy, avoid hormone replacement therapy, and consider prophylactic mastectomy.