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Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.

Autor(es): Otten, S; Rosazza, J P
Fonte: Appl Environ Microbiol;35(3): 554-7, 1978 Mar.
Artigo [ PMID: 637549 ] Idioma(s): Inglês
Publicação: Artigo de Revista; Research Support, U.S. Gov't, P.H.S.
The naphthoquinone lapachol (1) is readily metabolized by several fungi and streptomycetes. Preparative-scale fermentations with Penicillium notatum (UI 1602) provided a major polar metabolite (4), which was isolated and identified as an intermediate of the Hooker oxidation. The metabolite was synthesized by reacting lapachol with hydrogen peroxide under alkaline conditions.