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Control de diarrea y dengue en escuelas primarias rurales de Colombia: protocolo de estudio para un ensayo aleatorio y controlado por conglomerados / Diarrhea and dengue control in rural primary schools in Colombia: study protocol for a randomized controlled trial

Overgaard, Hans J; Alexander, Neal; Jaramillo, Juan Felipe; Olano, Víctor Alberto; Vargas, Sandra; Sarmiento, Diana; Lenhart, Audrey; Seidu, Razak; Stenstrõm, Thor Axel; Matiz, María Inés.
Rev. salud bosque; 4(1): 75-90, 2014. mapas, tab
Artigo em Espanhol | LILACS | ID: lil-772941
Background: Diarrheal diseases and dengue fever are major global health problems. Where provision of clean water is inadequate, water storage is crucial. Fecal contamination of stored water is a common source of diarrheal illness, but stored water also provides breeding sites for dengue vector mosquitoes. Poor household water management and sanitation are therefore potential determinants of both diseases. Little is known of the role of stored water for the combined risk of diarrhea and dengue, yet a joint role would be important for developing integrated control and management efforts. Even less is known of the effect of integrating control of these diseases in school settings. The objective of this trial was to investigate whether interventions against diarrhea and dengue will significantly reduce diarrheal disease and dengue entomological risk factors in rural primary schools. Methods/design: This is a 2×2 factorial cluster randomized controlled trial. Eligible schools were rural primary schools in La Mesa and Anapoima municipalities, Cundinamarca, Colombia. Eligible pupils were school children in grades 0 to 5. Schools were randomized to one of four study arms: diarrhea interventions (DIA); dengue interventions (DEN); combined diarrea and dengue interventions (DIADEN); and control (C). Schools were allocated publicly in each municipality (strata) at the start of the trial, obviating the need for allocation concealment. The primary outcome for diarrea is incidence rate of diarrhea in school children and for dengue it is density of adult female Aedes aegypti per school. Approximately 800 pupils from 34 schools were enrolled in the trial with eight schools in the DIA arm, nine in the DEN, eight in the DIADEN, and nine in the control arms. The trial was funded by the Research Council of Norway and the Lazos de Calandaima Foundation. Discussion: This is the first trial investigating...