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1.

Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

Kim, Yu Ree; Hwang, In Cheol; Lee, Yong Joo; Ham, Eun Bee; Park, Dong Kyun; Kim, Sewan
Evidence in LILACS | Language(s): English
Increased stroke risk among chronic obstructive pulmonary disease patients has not yet been established. In this study, we conducted a systematic review and meta-analysis to assess stroke risk among chronic obstructive pulmonary disease patients. PubMed, EMBASE, and the Cochrane Library were systematically searched from database inception until December 31, 2016 to identify longitudinal observational studies that investigated the association between chronic obstructive pulmonary disease and stroke. Stroke risk was quantified by overall and subgroup analyses, and a pooled hazard ratio was calculated. Study quality was evaluated using the Newcastle-Ottawa Scale. Publication bias was assessed using Begg's rank correlation test. Eight studies met the inclusion criteria. In (more)
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2.

A comparison of the efficiency of 22G versus 25G needles in EUS-FNA for solid pancreatic mass assessment: A systematic review and meta-analysis

Guedes, Hugo Gonçalo; Moura, Diogo Turiani Hourneaux de; Duarte, Ralph Braga; Cordero, Martin Andres Coronel; Santos, Marcos Eduardo Lera dos; Cheng, Spencer; Matuguma, Sergio Eiji; Chaves, Dalton Marques; Bernardo, Wanderley Marques; Moura, Eduardo Guimarães Hourneaux de
Evidence in LILACS | Language(s): English
Our aim in this study was to compare the efficiency of 25G versus 22G needles in diagnosing solid pancreatic lesions by EUS-FNA. We performed a systematic review and meta-analysis. Studies were identified in five databases using an extensive search strategy. Only randomized trials comparing 22G and 25G needles were included. The results were analyzed by fixed and random effects. A total of 504 studies were found in the search, among which 4 randomized studies were selected for inclusion in the analysis. A total of 462 patients were evaluated (233: 25G needle/229: 22G needle). The diagnostic sensitivity was 93% for the 25G needle and 91% for the 22G needle. The specificity of the 25G needle was 87%, and that of the 22G needle was 83%. The positive likelihood ratio was 4. (more)
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3.

Intervenção guiada por videofeedback a famílias de crianças com deficiência auditiva/ Video feedback for families of hearing impaired children

Santos, Ingrid Rafaella Dantas dos; Brazorotto, Joseli Soares
Evidence in LILACS | Language(s): Portuguese
RESUMO Para melhoria do desenvolvimento das habilidades auditivas e da linguagem na criança com deficiência auditiva, além da terapia fonoaudiológica, a família deve ser o agente modificador para uma resposta terapêutica satisfatória. Estudos que analisem a efetividade de programas de intervenção fonoaudiológica por meio de videofeedback são importantes, dados os efeitos positivos desta ferramenta para a modificação de comportamentos com famílias de crianças com deficiência. Acredita-se, assim, que a intervenção por meio do videofeedback contribuirá para a melhoria das interações comunicativas entre as famílias e crianças atendidas pelos serviços de reabilitação auditiva. Os objetivos deste estudo foram investigar a interação entre as famíli (more)
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4.

Zidovudine/Lamivudine vs. Abacavir/Lamivudine vs. Tenofovir/Emtricitabine in fixed-dose combinations as initial treatment for HIV patients: a systematic review and network meta-analysis/ Zidovudina/Lamivudina vs Abacavir/Lamivudina vs Tenofovir/Emtricitabina en combinaciones de dosis fija como tratamiento inicial en pacientes con VIH: revisión sistemática y metanálisis en red

Alzate Angel, Juan Carlos; Duque Molina, Marcela María; García García, Héctor Iván
Evidence in LILACS | Language(s): English
Abstract Introduction: Initial treatment of the HIV is based on the use of three drugs, two of which are nucleoside analog reverse-transcriptase inhibitors. There are three combinations of these drugs which have been approved by different guidelines, each with divergent results in terms of efficacy and safety. Objective: To compare the efficacy and safety of these three combinations. Methods: Systematic review and network meta-analysis of randomized clinical trials comparing fixed doses of Tenofovir Disoproxil Fumarate / Emtricitabine (TDF/FTC), Abacavir / Lamivudine (ABC/3TC) and Zidovudine / Lamivudine (ZDV/3TC). Results: Seven clinical trials met the eligibility criteria. The results suggested higher efficacy with TDF/FTC vs. ABC/3TC at 96 weeks and vs. ZDV/3 (more)
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5.

Immunotherapy and gene therapy as novel treatments for cancer/ Inmunoterapia y terapia génica como nuevos tratamientos contra el cáncer

Rangel-Sosa, Martha Montserrat; Aguilar-Córdova, Estuardo; Rojas-Martínez, Augusto
Evidence in LILACS | Language(s): English
Abstract The immune system interacts closely with tumors during the disease development and progression to metastasis. The complex communication between the immune system and the tumor cells can prevent or promote tumor growth. New therapeutic approaches harnessing protective immunological mechanisms have recently shown very promising results. This is performed by blocking inhibitory signals or by activating immunological effector cells directly. Immune checkpoint blockade with monoclonal antibodies directed against the inhibitory immune receptors CTLA-4 and PD-1 has emerged as a successful treatment approach for patients with advanced melanoma. Ipilimumab is an anti-CTLA-4 antibody which demonstrated good results when administered to patients with melanoma. Gene therap (more)
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6.

Effect of pulsed electromagnetic field on the consolidation of posterolateral arthrodeses in the lumbosacral spine: a prospective, double-blind, randomized study/ Efeito do campo eletromagnético pulsado na consolidação das artrodeses posterolaterais lombossacras: estudo prospectivo, duplo-cego e randomizado/ Efecto del campo electromagnético pulsado en la consolidación de artrodesis posterolaterales en la columna lumbosacral: estudio prospectivo, doble ciego, randomizado

RISSO NETO, MARCELO ITALO; ZUIANI, GUILHERME REBECHI; CAVALI, PAULO TADEU MAIA; VEIGA, IVAN GUIDOLIN; PASQUALINI, WAGNER; AMATO FILHO, AUGUSTO CELSO SCARPARO; CLIQUET JÚNIOR, ALBERTO; LANDIM, ELCIO; MIRANDA, JOÃO BATISTA DE
Evidence in LILACS | Language(s): English
ABSTRACT Objective: To assess the effect of pulsed electromagnetic field (PEMF) on the consolidation of instrumented lumbar posterolateral arthrodeses in patients who have been surgically treated for degenerative spine disease. Methods: Forty cases were recruited from 163 consecutive patients undergoing lumbar arthrodesis at the same center. The patients were randomized into two groups of 20 patients: Active Group, who were exposed to PEMF for 4 hours a day for 90 days after surgery, and Inactive Group, who received an identical device, with the same instructions for use but without the ability to generate PEMF. The patients underwent computed tomography scans at 45, 90, 180 and 360 days after surgery to check for the occurrence of arthrodesis at each operated spinal (more)
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7.

Effectiveness of chiropractic adjustment in lumbar pain in crossfit practitioners/ Eficácia do ajuste quiroprático nas dores lombares em praticantes de crossfit/ Eficacia del ajuste quiropráctico en los dolores lumbares en practicantes de crossfit

MOEHLECKE, DESIREE; FORGIARINI JUNIOR, LUIZ ALBERTO
Evidence in LILACS | Language(s): English
ABSTRACT Objective: To evaluate the efficacy of acute chiropractic adjustment in individuals who practice CrossFit with regard to complaints of low back pain and the joint range of motion in this region. Methods: A randomized clinical trial comprised of CrossFit practitioners from a box in Novo Hamburgo-RS, of both sexes and aged 18 to 40 years who had low back pain at the time of the study. The following tools were used: Semi-structured Anamnesis Questionnaire, Visual Analog Scale, McGill Pain Questionnaire, and SF-36 Quality of Life Questionnaire. Individuals in the control group answered the questionnaires before and after CrossFit training. The chiropractic group performed the same procedure, plus pre-training chiropractic adjustment and joint range of motion (ROM (more)
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8.

Effect of educational status on performance of older adults in digital cognitive tasks: A systematic review/ O efeito da escolaridade no desempenho de idosos em testes cognitivos digitais: uma revisão sistemática

Carvalho, Lucas Pelegrini Nogueira de; Monteiro, Diana Quirino; Orlandi, Fabiana de Souza; Zazzetta, Marisa Silvana; Pavarini, Sofia Cristina Iost
Evidence in LILACS | Language(s): English
ABSTRACT As people age, cognitive abilities may decline resulting in serious disabilities. Neuropsychological instruments can provide information on the cognitive state of older adults. Researchers worldwide have been using digital cognitive tests to assess cognitive domains. Objective: To determine whether educational status affects the performance of older adults on digital cognitive tasks. Methods: A systematic review of articles in English, Portuguese, or Spanish published in the last 5 years was conducted. The databases searched were SCOPUS, PubMed, Lilacs, Scielo and PsychInfo. The PRISMA method was used. Results: A total of 7,089 articles were initially retrieved. After search and exclusion with justification, seven articles were selected for further review. (more)
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9.

Language and communication non-pharmacological interventions in patients with Alzheimer's disease: a systematic review. Communication intervention in Alzheimer/ Linguagem e intervenções da comunicação na doença de alzheimer: uma revisão sistemática. intervenção de comunicação em alzheimer

Morello, Aline Nunes da Cruz; Lima, Tatiane Machado; Brandão, Lenisa
Evidence in LILACS | Language(s): English
ABSTRACT Alzheimer's disease considerably compromises communication skills. Language changes become more prominent as the disease progresses. Deterioration of language and cognition reduces the ability of holding conversations, which has a negative impact on social interaction. OBJECTIVE: To conduct a systematic review of the literature for articles reporting interventions focused on the language and communication of people with Alzheimer's disease (AD) without use of medication. METHODS: We performed a search using the keywords Alzheimer's disease, language, communication, cognition, cognitive intervention, rehabilitation and therapy, and their corresponding Portuguese and Spanish terms, on the SciELO, LILACS, PubMed and PsychINFO databases. We analyzed intervention (more)
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10.

Delirium in the elderly: A systematic review of pharmacological and non-pharmacological treatments/ Delirium em idosos: revisão sistemática de tratamentos farmacológicos e não-farmacológicos

Cerveira, Cecília Carboni Tardelli; Pupo, Cláudia Cristina; Santos, Sigrid De Sousa dos; Santos, José Eduardo Mourão
Evidence in LILACS | Language(s): English
ABSTRACT Delirium is a common disorder associated with poor prognosis, especially in the elderly. The impact of different treatment approaches for delirium on morbimortality and long-term welfare is not completely understood. OBJECTIVE: To determine the efficacy of pharmacological and non-pharmacological treatments in elderly patients with delirium. METHODS: This systematic review compared pharmacological and non-pharmacological treatments in patients over 60 years old with delirium. Databases used were: MEDLINE (PubMed), EMBASE, Cochrane CENTRAL and LILACS from inception to January 6th, 2016. RESULTS: A total of ten articles were selected. The six non-pharmacological intervention studies showed no impact on duration of delirium, mortality or institutionalization, bu (more)
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11.

Motor learning characterization in people with autism spectrum disorder: A systematic review/ Caracterização da aprendizagem motora em pessoas com transtorno do espectro autista: uma revisão sistemática

Moraes, Íbis Ariana Peña de; Massetti, Thais; Crocetta, Tânia Brusque; Silva, Talita Dias da; Menezes, Lilian Del Ciello de; Monteiro, Carlos Bandeira de Mello; Magalhães, Fernando Henrique
Evidence in LILACS | Language(s): English
ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder primarily characterized by deficits in social interaction, communication and implicit skill learning. OBJECTIVE: To analyse the results of research on "motor learning" and the means used for measuring "autistic disorder". METHODS: A systematic literature search was done using Medline/PubMed, Web of Science, BVS (virtual health library), and PsycINFO. We included articles that contained the keywords "autism" and "motor learning". The variables considered were the methodological aspects; results presented, and the methodological quality of the studies. RESULTS: A total of 42 studies were identified; 33 articles were excluded because they did not meet the inclusion criteria. Data were extracted fro (more)
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12.

A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis/ Um contínuo de déficits em função executiva no comprometimento cognitivo subcortical inicial: revisão sistemática e metanálise

Sudo, Felipe Kenji; Amado, Patricia; Alves, Gilberto Sousa; Laks, Jerson; Engelhardt, Eliasz
Evidence in LILACS | Language(s): English
ABSTRACT. Background. Subcortical Vascular Cognitive Impairment (SVCI) is a clinical continuum of vascular-related cognitive impairment, including Vascular Mild Cognitive Impairment (VaMCI) and Vascular Dementia. Deficits in Executive Function (EF) are hallmarks of the disorder, but the best methods to assess this function have yet to be determined. The insidious and almost predictable course of SVCI and the multidimensional concept of EF suggest that a temporal dissociation of impairments in EF domains exists early in the disorder. Objective: This study aims to review and analyze data from the literature about performance of VaMCI patients on the most used EF tests through a meta-analytic approach. Methods: Medline, Web of Knowledge and PsycINFO were searched, using (more)
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13.

Mixed dementia: A review of the evidence/ Demência mista: revisão das evidências

Custodio, Nilton; Montesinos, Rosa; Lira, David; Herrera-Pérez, Eder; Bardales, Yadira; Valeriano-Lorenzo, Lucía
Evidence in LILACS | Language(s): English
ABSTRACT. Mixed dementia is the coexistence of Alzheimer's disease and cerebrovascular disease (CVD) in the same demented patient. Currently, its diagnosis and treatment remains a challenge for practitioners. To provide an overview of the epidemiology, pathogenesis, natural history, diagnosis, and therapy of Mixed Vascular-Alzheimer Dementia (MVAD). The literature was reviewed for articles published between 1990-2016 by using the keywords linked to MVAD. Neuropathological studies indicate that MVAD is a very common pathological finding in the elderly with a prevalence about of 22%. The distinction between Alzheimer's dementia and vascular dementia (VD) is complex because their clinical presentation can overlap. There are international criteria for the MVAD diagnosis. Th (more)
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14.

Mandibular dental arch short and long-term spontaneous dentoalveolar changes after slow or rapid maxillary expansion: a systematic review

Alves, Arthur César de Medeiros; Maranhão, Olga Benário Vieira; Janson, Guilherme; Garib, Daniela Gamba
Evidence in LILACS | Language(s): English
ABSTRACT Objective: The aim of this systematic review was to analyze the short and long-term spontaneous dentoalveolar changes of the mandibular dental arch after slow (SME) or rapid (RME) maxillary expansion in the mixed and early permanent dentitions. Methods: An electronic search was performed in the following databases: PubMed/Medline, Cochrane Library, Scopus, Embase and Web of Science. Eligibility criteria for article selection included randomized controlled trials and prospective studies written in English, with no restriction of year of publication, involving patients who underwent SME or RME during the mixed or early permanent dentitions. A double-blind search of articles was performed by two reviewers. Initially, the title and the abstract of the studies we (more)
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15.

Influence of the cranial base flexion on Class I, II and III malocclusions: a systematic review

Almeida, Kélei Cristina Mathias de; Raveli, Taísa Boamorte; Vieira, Camila Ivini Viana; Santos-Pinto, Ary dos; Raveli, Dirceu Barnabé
Evidence in LILACS | Language(s): English
ABSTRACT Objective: The aim of this study was to perform a systematic review on the morphological characteristics of the skull base (flexion, anterior length and posterior length) and the concomitant development of malocclusions, by comparing differences in dimorphism, ethnicity and age. Methods: The articles were selected by means of electronic search on BBO, MEDLINE and LILACS databases from 1966 to 2016. A qualitative evaluation of the methodologies used on the articles was also performed. Results: Although the literature on this topic is abundant, only 16 articles were selected for the present systematic review. The cranial base angle itself does not seem to play a significant role in the development of malocclusions. In fact, the cranial base angle is relativel (more)
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