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2.

Avaliação das condições socioeconômicas, dos parâmetros clínicos e da autopercepção em saúde bucal dos pacientes atendidos na clínica de Graduação em Odontologia/ Evaluation of socio-economic conditions, clinical parameters, and oral health self perception of patients treated at the clinic of the Dentistry

Almeida, Dayanne Nunes; Finck, Nathalia Silveira; Aquino, Verônica Mendes de; Werneck, Rafael Dário; Marba, Luciana Fernandes; Vieira Netto, Moyses Francisco
| Idioma: Português
Entendendo que a condição de saúde bucal pode afetar a qualidade de vida (QdV) das pessoas, este estudo busca avaliar a autopercepção dos pacientes atendidos na Clínica Odontológica das Faculdades Integradas São Pedro (FAESA, Vitória-ES), no que se refere à saúde bucal, e como esta interfere no seu dia a dia e na sua QdV, a partir do preenchimento do questionário deOral Heath Impact Profile, versão simplificada (OHIP-14), correlacionando com as condições socioeconômicas e os parâmetros clínicos (CPO-D - Dentes Cariados Perdidos e Obturados e oCommunity Periodontal Index and Treatment Needs - CPITN ou IP - Índice Periodontal). O índice OHIP-14 foi obtido pelo método aditivo, sendo os pacientes distribuídos segundo gênero, idade, grau de instrução e renda, com n (mais)
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3.

Estudo dos mediadores inflamatórios e de coagulação na epidemia 2013 pelo DENV-4/ Evaluation of inflammatory and coagulation mediators in 2013 dengue virus type 4 outbreak

Solorzano, Victor Edgar Fiestas
| Idioma: Português
A dengue se tornou a arbovirose mais difundida no mundo, atingindo mais de 100 países. O sorotipo DENV-4 foi reintroduzido no Brasil em 2010, se espalhou para as diferentes regiões brasileiras sendo responsável por uma das maiores epidemias de dengue relatadas no país em 2013. O objetivo deste estudo foi avaliar o perfilclínico-laboratorial, citocinas/quimiocinas inflamatórias e mediadores da coagulação em pacientes infectados pelo DENV durante esta epidemia. Para isto, foram avaliados 265 casos confirmados de dengue atendidos nos centros de saúde dos estados do RJ e MS no ano de 2013. Os pacientes foram classificados de acordo com a nova classificação da OMS, 2009 nos grupos: 158 (70,2 por cento) dengue sem sinais de alarme (DSSA), 65 (28,9 por cento) dengue com sinais de (mais)
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4.

Avaliação da resposta de células T frente aos peptídeos de GAG e NEF do HIV-1 e de parâmetros imunológicos e genéticos associados ao controle da replicação viral/ Evaluation of t cells responses against hiv-1 gag and nef peptides and immunological and genetic parameters associated to control of viral replication

Côrtes, Fernanda Heloise
| Idioma: Português
A pandemia do HIV-1 é a infecção emergente mais importante das últimas décadas. O desenvolvimento de uma vacina é colocado como a melhor estratégia para o controle da pandemia. No entanto, entre os candidatos vacinais que evoluíram para testes clínicos de eficácia, apenas um mostrou resultados positivos, mas com uma modesta eficácia (31,2 por cento). Além da busca por uma vacina eficiente contra a infecção pelo HIV-1, o desenvolvimento de estratégias para se atingir a cura também é essencial. Considerando esses dois objetivos principais, diversos fatores são colocados como obstáculos, sendo a enorme diversidade genética do HIV-1 e a falta de correlatos de proteção contra a doença ou a infecção, os pontos centrais e nos quais focamos nossa atenção. No primei (mais)
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5.

Spine radiosurgery for the local treatment of spine metastases: Intensity-modulated radiotherapy, image guidance, clinical aspects and future directions

Moraes, Fabio Ynoe de; Taunk, Neil Kanth; Laufer, Ilya; Neves-Junior, Wellington Furtado Pimenta; Carvalho, Heloisa de Andrade; Hanna, Samir Abdallah; Yamada, Yoshiya
| Idioma: Inglês
Many cancer patients will develop spinal metastases. Local control is important for preventing neurologic compromise and to relieve pain. Stereotactic body radiotherapy or spinal radiosurgery is a new radiation therapy technique for spinal metastasis that can deliver a high dose of radiation to a tumor while minimizing the radiation delivered to healthy, neighboring tissues. This treatment is based on intensity-modulated radiotherapy, image guidance and rigid immobilization. Spinal radiosurgery is an increasingly utilized treatment method that improves local control and pain relief after delivering ablative doses of radiation. Here, we present a review highlighting the use of spinal radiosurgery for the treatment of metastatic tumors of the spine. The data used in the review were coll (mais)
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6.

Clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation: a meta-analysis of seven case-control studies

Yuan, Heng-feng; Zhang, Jing; Guo, Chang-an; Yan, Zuo-qin
| Idioma: Inglês
The purpose of this study was to evaluate the clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation. We searched the PubMed, Embase and Web of Science databases and included all case-control trials that reported on the clinical outcomes of osteonecrosis progression, incidence of total hip arthroplasty and improvement in Harris hip scores. Overall, seven case-control trials were included. Compared with the controls, patients treated with the bone marrow stem cells implantation treatment showed improved clinical outcomes with delayed osteonecrosis progression (odds ratio = 0.17, 95% CI: 0.09 - 0.32; p <0.001), a lower total hip arthroplasty incidence (odds ratio = 0.30, 95% CI: 0.12 - 0.72; p <0.01) and increased Harris hip scor (mais)
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7.

The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review

Matsuoka, Priscila Katsumi; Locali, Rafael Fagionato; Pacetta, Aparecida Maria; Baracat, Edmund Chada; Haddad, Jorge Milhem
| Idioma: Inglês
To evaluate the efficacy and safety of different bulking agents for treating urinary incontinence in women, a systematic review including only randomized controlled trials was performed. The subjects were women with urinary incontinence. The primary outcomes were clinical and urodynamic parameters. The results were presented as a weighted mean difference for non-continuous variables and as relative risk for continuous variables, both with 95% confidence intervals. Initially, 942 studies were identified. However, only fourteen eligible trials fulfilled the prerequisites. Altogether, the review included 1814 patients in trials of eight different types of bulking agents, and all studies were described and analyzed. The measured outcomes were evaluated using a large variety of instruments (mais)
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8.

Alternative Physical Therapy Protocol Using a Cycle Ergometer During Hospital Rehabilitation of Coronary Artery Bypass Grafting: a Clinical Trial

Trevisan, Margarete Diprat; Lopes, Diene Gomes Colvara; Mello, Renato Gorga Bandeira de; Macagnan, Fabrício Edler; Kessler, Adriana
| Idioma: Inglês
ABSTRACT OBJECTIVE: To compare the efficacy of a cycle ergometer-based exercise program to a standard protocol on the increment of the maximum distance walked during the six-minute walk test in the postoperative rehabilitation of patients submitted to coronary artery bypass grafting. METHODS: A controlled clinical trial pilot, blinded to the outcome, enrolled subjects who underwent coronary artery bypass grafting in a hospital from Southern Brazil. Subjects were designated for the standard physical rehabilitation protocol or to an alternative cycle ergometer-based protocol through simple random sampling. The primary outcome was the difference in the maximum distance walked in the six-minute walk test before and after the allocated intervention. RESULTS: Twenty-four patients were inclu (mais)
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9.

Effects of Resistance Exercise Applied Early After Coronary Artery Bypass Grafting: a Randomized Controlled Trial

Ximenes, Nayana Nazaré Pessoa Sousa; Silva, Luan Nascimento da; Silva, Mayara Gabrielle Barbosa e; Lima, Reijane Oliveira; Borges, Daniel Lago; Costa, Marina de Albuquerque Gonçalves; Baldez, Thiago Eduardo Pereira; Nina, Vinícius José da Silva
| Idioma: Inglês
ABSTRACT OBJECTIVE: To evaluate the effects of resistance exercise applied early after coronary artery bypass grafting. METHODS: It is a randomized controlled trial with 34 patients undergoing coronary artery bypass grafting between August 2013 and May 2014. Patients were randomized into two groups by simple draw: a control group (n=17), who received conventional physical therapy and an intervention group (n=17), who received, additionally, resistance exercise. Pulmonary function and functional capacity were evaluated in preoperative period and hospital discharge by spirometry and the six-minute walk test. For statistical analysis, we used the following tests: Shapiro-Wilk, Mann-Whitney, Student'st and Fisher's exact. Variables withP<0.05 were considered significant. RESULTS: Group (mais)
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10.

Desempenho de intervenções de saúde em países da América Latina: uma revisão sistemática/ Performance evaluation of health interventions in Latin America: a systematic review

Costa, Juliana Martins Barbosa da Silva; Cesse, Eduarda Ângela Pessoa; Samico, Isabella Chagas; Silva, Vanessa de Lima
| Idioma: Português
Este estudo teve como objetivo investigar na literatura latino-americana os modelos teóricos de avaliação de desempenho de intervenções de saúde nessa Região. Para tanto, realizou-se revisão sistemática da literatura nas bases do Lilacs, Medline e Capes, com termos relacionados à avaliação e desempenho, durante o período 2008-2013. Utilizaram-se critérios da Joint Committee on Standards for Educational Evaluation para apreciação da qualidade bem como de matriz para análise dos atributos bibliométricos e dos modelos. Encontraram-se seis estudos explicitando o modelo de avaliação de desempenho de intervenções em saúde com destaque para modelos unidimensionais com abordagem sistêmica.
This study aimed to investigate, in Latin American literature, theoretical (mais)
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11.

Prolactinomas: evolution after menopause

Mallea-Gil, Maria Susana; Ballarino, Maria Carolina; Alfieri, Analia; Manavela, Marcos; Chervin, Alberto; Danilowicz, Karina; Diez, Sabrina; Day, Patricia Fainstein; Guitelman, Mirtha; Glerean, Mariela; Katz, Débora; Loto, Monica Graciela; Martinez, Marcela; Miragaya, Karina; Moncet, Daniel; García-Basavilbaso, Natalia; Boero, Laura; Servidio, Marisa; Rogozinski, Amelia Susana; Vitale, Marcelo; Stalldecker, Graciela
| Idioma: Inglês
ABSTRACT Objetive The aim was to assess the evolution of tumor size and prolactin (PRL) levels in patients with micro and macroprolactinomas diagnosed and treated with dopamine agonists during fertile age, and the effects of suspension of drugs after menopause. Retrospective study, 29 patients with prolactinomas, 22 microadenomas and 7 macroadenomas, diagnosed during their fertile age were studied in their menopause; treatment was stopped in this period. Age at menopause was 49 ± 3.6 years. The average time of treatment was 135 ± 79 months. The time of follow-up after treatment suspension was 4 to 192 months. Results Pre-treatment PRL levels in micro and macroadenomas were 119 ± 57 ng/mL and 258 ± 225 ng/mL, respectively. During menopause after treatment suspension, and at the lat (mais)
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12.

Incidence of vertebral fractures in calcium and vitamin D-supplemented postmenopausal Brazilian women with osteopenia or osteoporosis: data from Arzoxifene Generations Trial

Arantes, Henrique Pierotti; Gimeno, Suely Godoy Agostinho; Chiang, Alan Y.; Bilezikian, John P.; Lazaretti-Castro, Marise
| Idioma: Inglês
ABSTRACT Objective Vertebral fracture is the most common osteoporotic fracture, affecting quality of life and increasing mortality. Epidemiological data on incidence of vertebral fracture are scarce in Brazil and throughout Latin America. Our aim was to determine vertebral fracture incidence and risk factors in a female Brazilian population. Subjects and methods Postmenopausal women with low bone mass were studied from the Brazilian placebo group of Arzoxifene Generations Trial (n = 974), followed for up to 5 years. The primary endpoint was new vertebral fractures, detected by X-Ray. Experimental design defined two strata: A. Osteoporosis or previous vertebral fracture with osteopenia; B. Osteopenia without previous fracture. Previous fracture, T-score, ionized calcium, alkaline phosp (mais)
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13.

Vitamin A supplementation reduces the Th17-Treg – Related cytokines in obese and non-obese women

Farhangi, Mahdieh Abbasalizad; Keshavarz, Seyyed Ali; Saboor-Yaraghi, Ali Akbar
| Idioma: Inglês
ABSTRACT Objective The objective of the present study was to investigate the effect of vitamin A supplementation on serum Th17 (IL-6, IL-17, IFNγ) and Treg (TGF-β, IL-10) related cytokines in obese and non-obese women. Subjects and methods In a randomized double blind placebo controlled design, 56 obese women were randomly assigned to receive either an oral dose of 25,000 IU retinyl palmitate or placebo per day for 4 months. Twenty eight ages matched non-obese women were also received vitamin A. At the study entry, anthropometric variables were measured and serum Th17 and Treg related cytokine profile were determined at baseline and 4 months after intervention. Results Significantly higher baseline concentrations of IL-6 were observed in obese compared with non-obese women ( (mais)
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14.

Comparative study between two recombinant human NPH insulin formulations for the treatment of type 2 diabetes mellitus

Rassi, Nelson; Bellório, Karini Bruno; Rassi, Salvador; Teixeira, Leonardo de Souza; Moreira, Josianny Mesquita; Cavalheiro, Daniela Cunha; Alves, Adriana Ganam; Moraes, Sandra Maria Campos Teixeira de; Abreu, Fernanda Cruvinel de; Prata, Paulo Roberto Mendonça
| Idioma: Inglês
ABSTRACT Objective To compare the effects of the neutral protamine Hagedorn (NPH) recombinant human insulin formulations Gansulin and Humulin N® on the glycemic control of patients with type 2 diabetes mellitus (T2DM). Subjects and methods Prospective, double-blind, randomized, parallel, single-center study of 37 individuals with T2DM treated with NPH insulin formulations. The Tukey-Kramer test for multiple comparisons, the Wilcoxon paired comparison test and the Chi-Square test were used for the statistical analyses. The significance level was set at 5% (p < 0.05). Results The NPH insulin formulations Humulin and Gansulin similarly reduced the HbA1c levels observed at the end of the study compared with the values obtained at the beginning of the study. In the Humulin group, the i (mais)
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15.

Maternal 75-g OGTT glucose levels as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus

Brankica, Krstevska; Valentina, Velkoska Nakova; Slagjana, Simeonova Krstevska; Sasha, Jovanovska Mishevska
| Idioma: Inglês
ABSTRACT Objective Our goal was to investigate which glucose measurement from the 75-g oral glucose tolerance test (OGTT) has more capability of predicting large for-gestational-age (LGA) newborns of mothers with gestational diabetes mellitus (GDM). Subjects and methods The study group consisted of 118 consecutively pregnant women with singleton pregnancy, patients of Outpatients Department of the Endocrinology, Diabetes, and Metabolic Disorders Clinic. All were prospectively screened for GDM between 24th and 28th week of pregnancy and followed to delivery. Outcome measures included: patients’ ages, pre-pregnancy BMI, BMI before delivery, FPG, 1 and 2 hour OGTT glucose values, haemoglobin A1c at third trimester, gestational week of delivery, mode of delivery and baby birth weigh (mais)
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