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Resultados  1-12 de 24

A De- -acylated Lipooligosaccharide-Based Adjuvant System Promotes Antibody and Th1-Type Immune Responses to H1N1 Pandemic Influenza Vaccine in Mice.

Autor(es): Ryu, Ji In; Park, Shin Ae; Wui, Seo Ri; Ko, Ara; Han, Ji Eun; Choi, Jung Ah; Song, Man Ki; Kim, Kwang Sung; Cho, Yang Je; Lee, Na Gyong
Fonte: Biomed Res Int;2016: 3713656, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27891512
Resumo: Vaccine adjuvants are agents that are used to promote immune responses to vaccine antigens and thereby to enhance the protective efficacy of the vaccines. In this study, we investigated the adjuvant activity of CIA06, an adjuvant system that is composed of a toll-like receptor 4 agonist de- -acylated lipooligosaccharide (dLOS) and aluminum hydroxide, on the H1N1 pandemic influenza vaccine Greenflu-S® in mice. CIA06 significantly enhanced influenza-specific serum IgG, hemagglutination-inhib (mais)

Encefalopatía no fatal por influenza AH1N1 en paciente pediátrico/ Non-fatal case of H1n1 influenza encephalopathy in a pediatric patient

Autor(es): Valdivia-Tapia, María del Carmen; Carreazo, Nilton Yhuri
Fonte: Rev Peru Med Exp Salud Publica;33(3): 585-587, jul.-sep. 2016. graf
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 798227  LILACS Express
Resumo: RESUMEN Niña de dos años con fiebre y síntomas catarrales que presenta convulsiones focales de hemicuerpo derecho, las cuales persisten adicionándose signos de hipertensión endocraneana. Se identifica Influenza AH1N1 mediante reacción de cadena de polimerasa en hisopado nasofaríngeo. Paciente evoluciona favorablemente con medidas de soporte. No recibió Oseltamivir.
ABSTRACT A 2-year-old girl presented with fever, catarrhal symptoms, and focal right hemispheric seizures that per (mais)

Combination of ribavirin and reduning protects mice against severe pneumonia induced by H1N1 influenza a virus.

Autor(es): Ma, Yuexia; Zhang, Wei; Zhao, Zhongpeng; Li, Min; Liu, Jian; Wang, Yuguang
Fonte: J Tradit Chin Med;36(2): 181-6, 2016 Apr.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27400472
Resumo: OBJECTIVE: To investigate the effects of ribavirin administration combined with Reduning in a mouse model of influenza A (H1N1)-induced severe pneumonia. METHODS: Influenza A/Beijing/501/2009 (H1N1)-infected C57BL/6 mice were randomly divided into four experimental groups treated with either a mock injection of phosphate-buffered saline (PBS), ribavirin (66.6 mg/kg daily) or Reduning (86.6 mg/ kg daily), or a combination of both, for 7 days. Mice were monitored for clinical signs and surviv (mais)

Burden of influenza in Germany: a retrospective claims database analysis for the influenza season 2012/2013.

Autor(es): Haas, Jennifer; Braun, Sebastian; Wutzler, Peter
Fonte: Eur J Health Econ;17(6): 669-79, 2016 Jul.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26143025
Resumo: OBJECTIVE: Seasonal influenza occurs in annual epidemics. The virus can cause severe illness and concomitant diseases with the highest risk for children, the elderly, and individuals with disease dispositions. The study objective is to assess the influenza burden in Germany. METHODS: This retrospective claims data analysis used the Health Risk Institute research database containing anonymized data of 4 million individuals. The study period comprised the influenza season 2012/2013 in which p (mais)

Transitory ventricular tachycardia associated with influenza A infection of cardiac conduction tissue.

Autor(es): Frustaci, Andrea; Petrosillo, Nicola; Ippolito, Giuseppe; Chimenti, Cristina
Fonte: Infection;44(3): 353-6, 2016 Jun.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27084370
Resumo: PURPOSE: To describe the influence of cardiac conduction tissue infection by Influenza A virus. METHODS AND RESULTS: A 54-year-old man with non-sustained ventricular tachycardia underwent noninvasive and invasive cardiac studies including left ventricular endomyocardial biopsy (LVEMB). Non-invasive studies showed normal cardiac parameters with no signal abnormalities. LVEMB revealed an influenza virus focal myocarditis with inflammatory infiltration of conduction tissue. Non-invasive studie (mais)

Influenza Activity - United States, 2015-16 Season and Composition of the 2016-17 Influenza Vaccine.

Autor(es): Davlin, Stacy L; Blanton, Lenee; Kniss, Krista; Mustaquim, Desiree; Smith, Sophie; Kramer, Natalie; Cohen, Jessica; Cummings, Charisse Nitura; Garg, Shikha; Flannery, Brendan; Fry, Alicia M; Grohskopf, Lisa A; Bresee, Joseph; Wallis, Teresa; Sessions, Wendy; Garten, Rebecca; Xu, Xiyan; Elal, Anwar Isa Abd; Gubareva, Larisa; Barnes, John; Wentworth, David E; Burns, Erin; Katz, Jacqueline; Jernigan, Daniel; Brammer, Lynnette
Fonte: MMWR Morb Mortal Wkly Rep;65(22): 567-75, 2016 Jun 10.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27281364
Resumo: During the 2015-16 influenza season (October 4, 2015-May 21, 2016) in the United States, influenza activity* was lower and peaked later compared with the previous three seasons (2012-13, 2013-14, and 2014-15). Activity remained low from October 2015 until late December 2015 and peaked in mid-March 2016. During the most recent 18 influenza seasons (including this season), only two other seasons have peaked in March (2011-12 and 2005-06). Overall influenza activity was moderate this season, w (mais)

Personalized medicine in severe influenza.

Autor(es): Valenzuela-Sánchez, F; Valenzuela-Méndez, B; Rodríguez-Gutiérrez, J F; Rello, J
Fonte: Eur J Clin Microbiol Infect Dis;35(6): 893-7, 2016 Jun.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26936615
Resumo: Existing therapies against infectious diseases may only be effective in limited subpopulations during specific phases of diseases, incorporating theranostics, and there is a clear need to individualize different therapeutic approaches depending on the host. Influenza A virus infection evolves into a severe respiratory failure in some young adult patients, related to an exaggerated inflammatory response. Mortality rates remain high despite antiviral treatment and aggressive respiratory suppo (mais)

Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.

Autor(es): Kim, Hyemin; Jang, Mirim; Kim, Yejin; Choi, Jiyea; Jeon, Jane; Kim, Jihoon; Hwang, Young-Il; Kang, Jae Seung; Lee, Wang Jae
Fonte: J Pharm Pharmacol;68(3): 406-20, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26898166
Resumo: OBJECTIVES: Because red ginseng and vitamin C have immunomodulatory function and anti-viral effect, we investigated whether red ginseng and vitamin C synergistically regulate immune cell function and suppress viral infection. METHODS: Red ginseng and vitamin C were treated to human peripheral blood mononuclear cells (PBMCs) or sarcoma-associated herpesvirus (KSHV)-infected BCBL-1, and administrated to Gulo(-/-) mice, which are incapable of synthesizing vitamin C, with or without influenza A (mais)

Influenza A and methicillin-resistant Staphylococcus aureus co-infection in rhesus macaques - A model of severe pneumonia.

Autor(es): Chertow, Daniel S; Kindrachuk, Jason; Sheng, Zong-Mei; Pujanauski, Lindsey M; Cooper, Kurt; Nogee, Daniel; Claire, Marisa St; Solomon, Jeffrey; Perry, Donna; Sayre, Philip; Janosko, Krisztina B; Lackemeyer, Matthew G; Bohannon, Jordan K; Kash, John C; Jahrling, Peter B; Taubenberger, Jeffery K
Fonte: Antiviral Res;129: 120-9, 2016 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26923881
Resumo: BACKGROUND: Influenza results in up to 500,000 deaths annually. Seasonal influenza vaccines have an estimated 60% effectiveness, but provide little or no protection against novel subtypes, and may be less protective in high-risk groups. Neuraminidase inhibitors are recommended for the treatment of severe influenza infection, but are not proven to reduce mortality in severe disease. Preclinical models of severe influenza infection that closely correlate to human disease are needed to assess (mais)

The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis.

Autor(es): Winthrop, Kevin L; Silverfield, Joel; Racewicz, Arthur; Neal, Jeffrey; Lee, Eun Bong; Hrycaj, Pawel; Gomez-Reino, Juan; Soma, Koshika; Mebus, Charles; Wilkinson, Bethanie; Hodge, Jennifer; Fan, Haiyun; Wang, Tao; Bingham, Clifton O
Fonte: Ann Rheum Dis;75(4): 687-95, 2016 Apr.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 25795907
Resumo: OBJECTIVE: To evaluate tofacitinib's effect upon pneumococcal and influenza vaccine immunogenicity. METHODS: We conducted two studies in patients with rheumatoid arthritis using the 23-valent pneumococcal polysaccharide vaccine (PPSV-23) and the 2011-2012 trivalent influenza vaccine. In study A, tofacitinib-naive patients were randomised to tofacitinib 10 mg twice daily or placebo, stratified by background methotrexate and vaccinated 4 weeks later. In study B, patients already rec (mais)

Outcomes and Prognostic Features of Patients With Influenza Requiring Hospitalization and Receiving Early Antiviral Therapy: A Prospective Multicenter Cohort Study.

Autor(es): Maruyama, Takaya; Fujisawa, Takao; Suga, Shigeru; Nakamura, Haruna; Nagao, Mizuho; Taniguchi, Kiyosu; Tsutsui, Kiyoyuki; Ihara, Toshiaki; Niederman, Michael S
Fonte: Chest;149(2): 526-34, 2016 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26203671
Resumo: BACKGROUND: In Japan, the routine use of early antiviral therapy for patients with influenza is standard. METHODS: This multicenter prospective cohort evaluation of hospitalized patients with laboratory-confirmed influenza identified prognostic factors among the patients receiving antiviral therapy. RESULTS: Of 1,345 patients with influenza (766 pediatric, 579 adult), excluding those aged < 1 year (who are not approved for antiviral therapy), 97.7% (1,224 of 1,253) received antiviral therap (mais)
Resultados  1-12 de 24