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Resultados  1-12 de 78
1.

Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient

Autor(es): Pontoriero, Andrea; Avaro, Martín; Benedetti, Estefania; Russo, Mara; Czech, Andrea; Periolo, Natalia; Campos, Ana; Zamora, Ana; Baumeister, Elsa
Fonte: Mem Inst Oswaldo Cruz;111(12): 745-749, Dec. 2016. graf
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 829259
Resumo: Although vaccines are the best means of protection against influenza, neuraminidase inhibitors are currently the main antiviral treatment available to control severe influenza cases. One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation. We describe the emergence of a mixed viral population with the E119E/V mutation in the NA protein sequence in a post-treatment influenza sample (mais)
2.

Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016.

Autor(es): Fraaij, Pieter L A; Wildschut, Enno D; Houmes, Robert J; Swaan, Corien M; Hoebe, Christian J; de Jonge, H C C; Tolsma, Paulien; de Kleer, Isme; Pas, Suzan D; Oude Munnink, Bas B; Phan, My V T; Bestebroer, Theo M; Roosenhoff, R Shanty; van Kampen, Jeroen J A; Cotten, Matthew; Beerens, Nancy; Fouchier, Ron A M; van den Kerkhof, Johannes H; Timen, Aura; Koopmans, Marion P
Fonte: Euro Surveill;21(48)2016 Dec 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934581
Resumo: In October 2016, a severe infection with swine influenza A(H1N1) virus of the Eurasian avian lineage occurred in a child with a previous history of eczema in the Netherlands, following contact to pigs. The patient's condition deteriorated rapidly and required life support through extracorporeal membrane oxygenation. After start of oseltamivir treatment and removal of mucus plugs, the patient fully recovered. Monitoring of more than 80 close unprotected contacts revealed no secondary cases.
3.

Genetic Characterization of Circulating 2015 A(H1N1)pdm09 Influenza Viruses from Eastern India.

Autor(es): Mukherjee, Anupam; Nayak, Mukti Kant; Dutta, Shanta; Panda, Samiran; Satpathi, Biswa Ranjan; Chawla-Sarkar, Mamta
Fonte: PLoS One;11(12): e0168464, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27997573
Resumo: In 2015, the swine derived A(H1N1)pdm09 pandemic strain outbreak became widespread throughout the different states of India. The reported cases and deaths in 2015 surpassed the previous years with more than 39000 laboratory confirmed cases and a death toll of more than 2500 people. There are relatively limited complete genetic sequences available for this virus from Asian countries. In this study, we describe the full genome analysis of influenza 2015 A(H1N1)pdm09 viruses isolated from West (mais)
4.

Seasonal Influenza A H1N1pdm09 Virus and Severe Outcomes: A Reason for Broader Vaccination in Non-Elderly, At-Risk People.

Autor(es): Minchole, Elisa; Figueredo, Ana L; Omeñaca, Manuel; Panadero, Carolina; Royo, Laura; Vengoechea, Jose J; Fandos, Sergio; de Pablo, Francisco; Bello, Salvador
Fonte: PLoS One;11(11): e0165711, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27832114
Resumo: BACKGROUND: Recent pandemics of influenza A H1N1pdm09 virus have caused severe illness, especially in young people. Very few studies on influenza A H1N1pdm09 in post-pandemic periods exist, and there is no information on the severity of both seasonal influenza A(H1N1) and A(H3N2) from the same season, adjusting for potential confounders, including vaccine. METHODS AND RESULTS: We performed a retrospective observational study of adults hospitalized during the 2014 season with influenza A(H1N (mais)
5.

Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient.

Autor(es): Pontoriero, Andrea; Avaro, Martín; Benedetti, Estefania; Russo, Mara; Czech, Andrea; Periolo, Natalia; Campos, Ana; Zamora, Ana; Baumeister, Elsa
Fonte: Mem Inst Oswaldo Cruz;111(12): 745-749, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27849220
Resumo: Although vaccines are the best means of protection against influenza, neuraminidase inhibitors are currently the main antiviral treatment available to control severe influenza cases. One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation. We describe the emergence of a mixed viral population with the E119E/V mutation in the NA protein sequence in a post-treatment influenza sample (mais)
7.

Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality.

Autor(es): Talmi-Frank, Dalit; Altboum, Zeev; Solomonov, Inna; Udi, Yael; Jaitin, Diego Adhemar; Klepfish, Mordehay; David, Eyal; Zhuravlev, Alina; Keren-Shaul, Hadas; Winter, Deborah R; Gat-Viks, Irit; Mandelboim, Michal; Ziv, Tamar; Amit, Ido; Sagi, Irit
Fonte: Cell Host Microbe;20(4): 458-470, 2016 Oct 12.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27736644
Resumo: Mounting an effective immune response, while also protecting tissue integrity, is critical for host survival. We used a combined genomic and proteomic approach to investigate the role of extracellular matrix (ECM) proteolysis in achieving this balance in the lung during influenza virus infection. We identified the membrane-tethered matrix metalloprotease MT1-MMP as a prominent host-ECM-remodeling collagenase in influenza infection. Selective inhibition of MT1-MMP protected the tissue from (mais)
8.

Recommendations for Prevention and Control of Influenza in Children, 2016-2017.

Fonte: Pediatrics;138(4)2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27600320
Resumo: The purpose of this statement is to update recommendations for the routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The AAP recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents. Highlights for the upcoming 2016-2017 season include the following: 1. Annual universal influenza immunization is indicated with either a trivalent or quadrivalent (no prefer (mais)
9.

Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background.

Autor(es): Hoffmann, Anja; Schade, Dennis; Kirchmair, Johannes; Clement, Bernd; Sauerbrei, Andreas; Schmidtke, Michaela
Fonte: J Virol Methods;237: 192-199, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27659246
Resumo: Efforts to develop novel neuraminidase inhibitors (NAIs) for the treatment of influenza are ongoing. Novel NAIs should in particular be also effective against seasonal and/or pandemic N1 that carry a H274Y or N294S substitution (N2 numbering), which are most commonly linked to oseltamivir resistance. Here we report a platform for profiling the efficacy of novel NAIs in the N1 genetic background of influenza A virus. Employing reverse genetics, a set of influenza virus variants containing an (mais)
10.

Granulomatous interstitial nephritis associated with influenza A: H1N1 infection--A case report.

Autor(es): Milosevski-Lomic, Gordana; Markovic-Lipkovski, Jasmina; Kostic, Mirjana; Spasojevic-Dimitrijeva, Brankica; Peco-Antic, Amira
Fonte: Srp Arh Celok Lek;144(3-4): 215-8, 2016 Mar-Apr.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27483570
Resumo: INTRODUCTION: The causes of acute tubulointerstitial nephritis can be grouped into four broad categories: medications, infections, immunologic diseases, or idiopathic processes. Here we report a 17-year-old female who developed acute kidney injury (AKI) due to granulomatous interstitial nephritis (GIN) associated with influenza A: H1N1 infection. CASE OUTLINE: The illness presented after two weeks of respiratory tract infection, skin rash and hypermenorrhea. On admission the patient was feb (mais)
11.

Oseltamivir as a cause of acute enterorrhagia.

Autor(es): Beraldi-Magalhães, Francisco; Batista, Vera; Cordeiro-Santos, Marcelo
Fonte: Braz J Infect Dis;20(5): 521, 2016 Sep-Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27542865
12.

Immortal time bias in observational studies of time-to-event outcomes.

Autor(es): Jones, Mark; Fowler, Robert
Fonte: J Crit Care;36: 195-199, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27546771
Resumo: PURPOSE: The purpose of the study is to show, through simulation and example, the magnitude and direction of immortal time bias when an inappropriate analysis is used. MATERIALS AND METHODS: We compare 4 methods of analysis for observational studies of time-to-event outcomes: logistic regression, standard Cox model, landmark analysis, and time-dependent Cox model using an example data set of patients critically ill with influenza and a simulation study. RESULTS: For the example data set, lo (mais)
Resultados  1-12 de 78