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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 84

The mechanisms of sudden-onset type adverse reactions to oseltamivir.

Autor(es): Hama, R; Bennett, C L
Fonte: Acta Neurol Scand;135(2): 148-160, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27364959
Resumo: Oseltamivir is contraindicated for people aged 10-19 in principle in Japan, due to concern about abnormal behaviours. Sudden death is another concern. This review examines growing evidence of their association and discusses underlying mechanisms of these sudden-onset type reactions to oseltamivir. First, the importance of animal models and the concept of human equivalent dose (HED) is summarized. Second, the specific condition for oseltamivir use, influenza infection, is reviewed. Third, fi (mais)

Successful use of oseltamivir prophylaxis in managing a nosocomial outbreak of influenza A in a hematology and allogeneic stem cell transplant unit.

Autor(es): Yue, Mimi C; Collins, Joel T; Subramoniapillai, Elango; Kennedy, Glen A
Fonte: Asia Pac J Clin Oncol;13(1): 37-43, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27730741
Resumo: AIM: To describe a nosocomial outbreak of H1N1 influenza A in an inpatient hematology and allogeneic stem cell transplant unit and outcomes of universal oseltamivir prophylaxis. METHODS: Medical records of all patients admitted to the unit were reviewed to define the nosocomial outbreak, commencing 1 week prior to the index case until 4 weeks following institution of oseltamivir prophylaxis. Timelines for clinical symptoms, viral spread, management, patient outcomes and follow up testing we (mais)

The pharmacological management of severe influenza infection - 'existing and emerging therapies'.

Autor(es): Mc Mahon, Aisling; Martin-Loeches, Ignacio
Fonte: Expert Rev Clin Pharmacol;10(1): 81-95, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27797595
Resumo: INTRODUCTION: Over the last century several influenza outbreaks have traversed the globe, most recently the influenza A(H1N1) 2009 pandemic. On each occasion, a highly contagious, virulent pathogen has emerged, leading to significant morbidity and mortality amongst those affected. Areas covered: Early antiviral therapy and supportive care is the mainstay of treatment. Treatment should be started as soon as possible and not delayed for the results of diagnostic testing. Whilst oseltamivir is (mais)

Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO).

Autor(es): Hermann, B; Lehners, N; Brodhun, M; Boden, K; Hochhaus, A; Kochanek, M; Meckel, K; Mayer, K; Rachow, T; Rieger, C; Schalk, E; Weber, T; Schmeier-Jürchott, A; Schlattmann, P; Teschner, D; von Lilienfeld-Toal, M
Fonte: Eur J Clin Microbiol Infect Dis;36(3): 565-573, 2017 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27838792
Resumo: Influenza virus infections (IVI) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. In this study, we collected data on patients with active cancer or with a history of cancer, presenting with documented IVI in eight centres in Germany. Two hundred and three patients were identified, suffering from haematological malignancies or solid tumours; 109 (54 %) patients had ac (mais)

Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.

Autor(es): Kossyvakis, A; Mentis, A-F A; Tryfinopoulou, K; Pogka, V; Kalliaropoulos, A; Antalis, E; Lytras, T; Meijer, A; Tsiodras, S; Karakitsos, P; Mentis, A F
Fonte: Eur J Clin Microbiol Infect Dis;36(2): 361-371, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27848039
Resumo: There was an increase in severe and fatal influenza cases in Greece during the 2011-2015 post-pandemic period. To investigate causality, we determined neuraminidase (NA) inhibitor susceptibility and resistance-conferring NA and hemagglutinin (HA) mutations in circulating influenza type A viruses during the pandemic (2009-2010) and post-pandemic periods in Greece. One hundred thirty-four influenza A(H1N1)pdm09 and 95 influenza A(H3N2) viruses submitted to the National Influenza Reference Lab (mais)

Contribution of a rapid influenza diagnostic test to manage hospitalized patients with suspected influenza.

Autor(es): Busson, Laurent; Mahadeb, Bhavna; De Foor, Marc; Vandenberg, Olivier; Hallin, Marie
Fonte: Diagn Microbiol Infect Dis;87(3): 238-242, 2017 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27939284
Resumo: AIM: To evaluate the performances of the Alere i influenza A&B test and to appraise its contribution to patient management. METHODS: In total, 267 samples were tested. Influenza A and B PCR was performed as the reference. For each positive result, the supervising physician was contacted to collect data regarding patient management. FINDINGS: The overall sensitivity and specificity of the Alere i were 91.4% and 97.6% for influenza A and 54.5% and 98.8% for influenza B, respectively. More spe (mais)

Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards.

Autor(es): Ishiguro, N; Oyamada, R; Nasuhara, Y; Yamada, T; Miyamoto, T; Imai, S; Akizawa, K; Fukumoto, T; Iwasaki, S; Iijima, H; Ono, K
Fonte: J Hosp Infect;94(2): 150-3, 2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27346624
Resumo: Inpatients who had been in close contact with patients with influenza were given oseltamivir [75mg capsules once daily for adults or 2mg/kg (maximum of 75mg) once daily for children] for three days as postexposure prophylaxis (PEP). The index patients with influenza were prescribed a neuraminidase inhibitor and were discharged immediately or transferred to isolation rooms. The protective efficacy of oseltamivir for three days was 93% overall [95% confidence interval (CI) 53-99%; P=0.023] an (mais)

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza.

Autor(es): Albiñana, Carlos Berenguer; Machara, Ales; Rezácová, Pavlína; Pachl, Petr; Konvalinka, Jan; Kozísek, Milan
Fonte: Eur J Med Chem;121: 100-9, 2016 Oct 04.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27236066
Resumo: Influenza virus causes severe respiratory infections that are responsible for up to half a million deaths worldwide each year. Two inhibitors targeting viral neuraminidase have been approved to date (oseltamivir, zanamivir). However, the rapid development of antiviral drug resistance and the efficient transmission of resistant viruses among humans represent serious threats to public health. The approved influenza neuraminidase inhibitors have (oxa)cyclohexene scaffolds designed to mimic the (mais)

Impact of oseltamivir use on the reduction of complications in patients with influenza: a prospective study.

Autor(es): Vardakas, Konstantinos Z; Theocharis, George; Tansarli, Giannoula S; Rafailidis, Petros; Falagas, Matthew E
Fonte: Arch Virol;161(9): 2511-8, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27368992
Resumo: To evaluate the factors associated with oseltamivir prescription and to study the effectiveness of oseltamivir in reducing influenza-related complications. A prospective cohort study using the SOS Doctors (a network of physicians who perform house-call visits in Attica, Greece). Patients with confirmed or clinically suspected influenza were followed up to 14 days during the 2011-2012 influenza period. 410 patients with confirmed or suspected influenza were included. Healthy adults were main (mais)

Chemical constituents from Melicope pteleifolia leaves.

Autor(es): Nguyen, Ngoc Hieu; Ha, Thi Kim Quy; Choi, Sangho; Eum, Sangmi; Lee, Chul Ho; Bach, Tran The; Chinh, Vu Tien; Oh, Won Keun
Fonte: Phytochemistry;130: 291-300, 2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27374481
Resumo: Five acetophenones bearing spiroketal-hexofuranoside rings, one di-C-glycosidic acetophenone and two benzopyrans, along with 16 known compounds were isolated from the leaves of Melicope pteleifolia. Structures of all the isolates were elucidated using extensive spectroscopic methods, including 1D, 2D-NMR and HRESIMS. All the isolates were also evaluated for their neuraminidase inhibitory activities against H1N1, H9N2, wild-type H1N1 and oseltamivir-resistant H1N1 (H274Y mutation) virus stra (mais)

Granulomatous interstitial nephritis associated with influenza A: H1N1 infection--A case report.

Autor(es): Milosevski-Lomic, Gordana; Markovic-Lipkovski, Jasmina; Kostic, Mirjana; Spasojevic-Dimitrijeva, Brankica; Peco-Antic, Amira
Fonte: Srp Arh Celok Lek;144(3-4): 215-8, 2016 Mar-Apr.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27483570
Resumo: INTRODUCTION: The causes of acute tubulointerstitial nephritis can be grouped into four broad categories: medications, infections, immunologic diseases, or idiopathic processes. Here we report a 17-year-old female who developed acute kidney injury (AKI) due to granulomatous interstitial nephritis (GIN) associated with influenza A: H1N1 infection. CASE OUTLINE: The illness presented after two weeks of respiratory tract infection, skin rash and hypermenorrhea. On admission the patient was feb (mais)

Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.

Autor(es): Kawakami, Toru; Hirabayashi, Yukio; Kawakami, Fumihiro; Isobe, Rei; Kaneko, Naoto; Mimura, Yuto; Ito, Toshiro; Furuta, Kiyoshi; Shimazaki, Mami; Nakazawa, Hideyuki; Kitano, Kiyoshi
Fonte: Intern Med;55(13): 1807-10, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27374689
Resumo: We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a (mais)
Resultados  1-12 de 84