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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 22

Recommendations for Prevention and Control of Influenza in Children, 2016-2017.

Fonte: Pediatrics;138(4)2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27600320
Resumo: The purpose of this statement is to update recommendations for the routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The AAP recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents. Highlights for the upcoming 2016-2017 season include the following: 1. Annual universal influenza immunization is indicated with either a trivalent or quadrivalent (no prefer (mais)

Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background.

Autor(es): Hoffmann, Anja; Schade, Dennis; Kirchmair, Johannes; Clement, Bernd; Sauerbrei, Andreas; Schmidtke, Michaela
Fonte: J Virol Methods;237: 192-199, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27659246
Resumo: Efforts to develop novel neuraminidase inhibitors (NAIs) for the treatment of influenza are ongoing. Novel NAIs should in particular be also effective against seasonal and/or pandemic N1 that carry a H274Y or N294S substitution (N2 numbering), which are most commonly linked to oseltamivir resistance. Here we report a platform for profiling the efficacy of novel NAIs in the N1 genetic background of influenza A virus. Employing reverse genetics, a set of influenza virus variants containing an (mais)

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors.

Autor(es): Das, Anindya; Adak, Avijit K; Ponnapalli, Kalyankumar; Lin, Chien-Hung; Hsu, Kai-Cheng; Yang, Jinn-Moon; Hsu, Tsu-An; Lin, Chun-Cheng
Fonte: Eur J Med Chem;123: 397-406, 2016 Nov 10.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27487569
Resumo: The design of potent metabolically stable neuraminidase (NA) inhibitors represents an attractive approach for treating influenza virus infection. In this study, we describe the exploitation of the 150-cavity in the active site of group 1 NA for the design, synthesis, and in vitro evaluation of new triazole-containing N-acyl derivatives related to Zanamivir. Inhibition studies with influenza virus NAs of group 1 (H1N1) and group 2 (H3N2) revealed that several of them are good inhibitors, wi (mais)

In vitro neuraminidase inhibitory concentration (IC50) of four neuraminidase inhibitors against clinical isolates of the influenza viruses circulating in the 2010-2011 to 2014-2015 Japanese influenza seasons.

Autor(es): Ikematsu, Hideyuki; Kawai, Naoki; Iwaki, Norio; Kashiwagi, Seizaburo
Fonte: J Infect Chemother;22(9): 599-604, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27346379
Resumo: To assess the extent of viral resistance to the four neuraminidase inhibitors (NAIs), we measured their 50% inhibitory concentration (IC50) for influenza virus isolates from the 2014-2015 influenza season for comparison with those circulating in the 2010-2011 to 2013-2014 influenza seasons. Viral isolation was done with specimens obtained prior to treatment, and the type and subtype of influenza was determined by RT-PCR using type- and subtype-specific primers. The IC50 was determined by a (mais)

Within-Host Models of High and Low Pathogenic Influenza Virus Infections: The Role of Macrophages.

Autor(es): Pawelek, Kasia A; Dor, Daniel; Salmeron, Cristian; Handel, Andreas
Fonte: PLoS One;11(2): e0150568, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26918620
Resumo: The World Health Organization identifies influenza as a major public health problem. While the strains commonly circulating in humans usually do not cause severe pathogenicity in healthy adults, some strains that have infected humans, such as H5N1, can cause high morbidity and mortality. Based on the severity of the disease, influenza viruses are sometimes categorized as either being highly pathogenic (HP) or having low pathogenicity (LP). The reasons why some strains are LP and others HP a (mais)

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents.

Autor(es): Lin, Cai; Sun, Chenghai; Liu, Xiao; Zhou, Yiqian; Hussain, Muzammal; Wan, Junting; Li, Minke; Li, Xue; Jin, Ruiliang; Tu, Zhengchao; Zhang, Jiancun
Fonte: Antiviral Res;129: 13-20, 2016 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26802557
Resumo: Among many subtypes of influenza A viruses, influenza A(H1N1) and A(H3N2) subtypes are currently circulating among humans (WHO report 2014-15). Therapeutically, the emergence of viral resistance to currently available drugs (adamantanes and neuraminidase inhibitors) has heightened alarms for developing novel drugs that could address diverse targets in the viral replication cycle in order to improve treatment outcomes. To this regard, the design and synthesis of nucleoside analog inhibitors (mais)

Molecular modeling and lead design of substituted zanamivir derivatives as potent anti-influenza drugs.

Autor(es): Dholakia, Dhwani; Goyal, Sukriti; Jamal, Salma; Singh, Aditi; Das, Asmita; Grover, Abhinav
Fonte: BMC Bioinformatics;17(Suppl 19): 512, 2016 Dec 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 28155702
Resumo: BACKGROUND: Influenza virus spreads infection by two main surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA). NA cleaves the sialic acid receptors eventually releasing newly formed virus particles which then invade new cells. Inhibition of NA could limit the replication of virus to one round which is insufficient to cause the disease. RESULTS: An experimentally reported series of acylguanidine zanamivir derivatives was used to develop GQSAR model targeting NA in differe (mais)

Pharmacophore-Based Virtual Screening for Identification of Novel Neuraminidase Inhibitors and Verification of Inhibitory Activity by Molecular Docking.

Autor(es): Batool, Sidra; Mushtaq, Gohar; Kamal, Warda; Kamal, Mohammad A
Fonte: Med Chem;12(1): 63-73, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26152143
Resumo: Oseltamivir and Zanamivir are two of the recently licensed neuraminidase inhibitors used for the treatment of influenza. However, alternative antiviral agents are needed due to the development of resistant mutations in Oseltamivir subtype H1N1 and H5N1 avian influenza A viruses, the latter being a highly pathogenic avian virus that can be transferred to humans upon immediate contact with H5N1 infected poultry or surface. Novel drug inhibiting group 1 neuraminidases may potentially be develo (mais)

Impact of a large deletion in the neuraminidase protein identified in a laninamivir-selected influenza A/Brisbane/10/2007 (H3N2) variant on viral fitness in vitro and in ferrets.

Autor(es): Ann, Julie; Abed, Yacine; Beaulieu, Edith; Bouhy, Xavier; Joly, Marie-Hélène; Dubé, Karen; Carbonneau, Julie; Hamelin, Marie-Eve; Mallett, Corey; Boivin, Guy
Fonte: Influenza Other Respir Viruses;10(2): 122-6, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26526406
Resumo: Viral fitness of a laninamivir-selected influenza A/Brisbane/10/2007-like (H3N2) isolate (LRVp9) containing a 237-amino acid neuraminidase deletion and a P194L hemagglutinin mutation was evaluated in vitro and in ferrets. LRVp9 and the wild-type (WT) virus showed comparable replication kinetics in MDCK-ST6GalI cells. Cultured virus was recovered between days 2 and 5 post-infection in nasal washes (NW) from the 4 WT-infected ferrets whereas no virus was recovered from the LRVp9-infected ani (mais)

NAIplot: An opensource web tool to visualize neuraminidase inhibitor (NAI) phenotypic susceptibility results using kernel density plots.

Autor(es): Lytras, Theodore; Kossyvakis, Athanasios; Mentis, Andreas
Fonte: Antiviral Res;126: 18-20, 2016 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26692213
Resumo: The results of neuraminidase inhibitor (NAI) enzyme inhibition assays are commonly expressed as 50% inhibitory concentration (IC50) fold-change values and presented graphically in box plots (box-and-whisker plots). An alternative and more informative type of graph is the kernel density plot, which we propose should be the preferred one for this purpose. In this paper we discuss the limitations of box plots and the advantages of the kernel density plot, and we present NAIplot, an opensource (mais)

Gripe ou resfriado? Sinusite ou rinite?/ Influenza or cold? Sinusitis or rhinitis?

Autor(es): Campos, Hisbello S
Fonte: J. bras. med;102(1)jan.-fev. 2014.
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 712212
Resumo: Resfriado comum e gripe são habitualmente confundidos, principalmente se o resfriado for mais intenso. Coriza é rotulada tanto como alergia como sinusite. Os processos inflamatórios das vias aéreas superiores envolvidos nessas entidades clínicas conjugam fatores comuns, embora tenham etiologias diferentes. Graças a isso, diagnósticos equivocados geram tratamento inadequado, geralmente com emprego desnecessário de antibióticos. O resfriado comum e a gripe (influenza) são infecçõe (mais)

Virological surveillance and antiviral resistance of human influenza virus in Argentina, 2005–2008/ Vigilancia virológica y resistencia a los antivíricos del virus de la gripe humana en la Argentina, 2005–2008

Autor(es): Pontoriero, Andrea; Baumeister, Elsa; Campos, Ana M; L. Savy, Vilma
Fonte: Rev Panam Salud Publica;30(6): 634-640, Dec. 2011.
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 612962
Resumo: Objective. To describe the virological characteristics of the influenza strains circulating in Argentina in 2005–2008 and to assess the prevalence of antiviral resistance. Methods. On the basis of their geographical spread and prevalence, influenza A and B isolates grown in Madin–Darby canine kidney cells were selected after antigenic and genomic characterization to be analyzed for antiviral resistance by enzymatic assay and pyrosequencing. Amantadine susceptibility was evaluated by pyros (mais)
Resultados  1-12 de 22