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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 28

Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.

Autor(es): Kossyvakis, A; Mentis, A-F A; Tryfinopoulou, K; Pogka, V; Kalliaropoulos, A; Antalis, E; Lytras, T; Meijer, A; Tsiodras, S; Karakitsos, P; Mentis, A F
Fonte: Eur J Clin Microbiol Infect Dis;36(2): 361-371, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27848039
Resumo: There was an increase in severe and fatal influenza cases in Greece during the 2011-2015 post-pandemic period. To investigate causality, we determined neuraminidase (NA) inhibitor susceptibility and resistance-conferring NA and hemagglutinin (HA) mutations in circulating influenza type A viruses during the pandemic (2009-2010) and post-pandemic periods in Greece. One hundred thirty-four influenza A(H1N1)pdm09 and 95 influenza A(H3N2) viruses submitted to the National Influenza Reference Lab (mais)

Fate of new three anti-influenza drugs and one prodrug in the water environment.

Autor(es): Azuma, Takashi; Ishida, Mao; Hisamatsu, Kanae; Yunoki, Ayami; Otomo, Kana; Kunitou, Mari; Shimizu, Mai; Hosomaru, Kaori; Mikata, Shiori; Mino, Yoshiki
Fonte: Chemosphere;169: 550-557, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27898328
Resumo: We evaluated the environmental fate of new three anti-influenza drugs, favipiravir (FAV), peramivir (PER), and laninamivir (LAN), and an active prodrug of LAN, laninamivir octanoate (LANO), in comparison with four conventional drugs, oseltamivir (OS), oseltamivir carboxylate (OC), amantadine (AMN), and zanamivir (ZAN) by photodegradation, biodegradation, and sorption to river sediments. In addition, we conducted 9-month survey of urban rivers in the Yodo River basin from 2015 to 2016 (inclu (mais)

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors.

Autor(es): Das, Anindya; Adak, Avijit K; Ponnapalli, Kalyankumar; Lin, Chien-Hung; Hsu, Kai-Cheng; Yang, Jinn-Moon; Hsu, Tsu-An; Lin, Chun-Cheng
Fonte: Eur J Med Chem;123: 397-406, 2016 Nov 10.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27487569
Resumo: The design of potent metabolically stable neuraminidase (NA) inhibitors represents an attractive approach for treating influenza virus infection. In this study, we describe the exploitation of the 150-cavity in the active site of group 1 NA for the design, synthesis, and in vitro evaluation of new triazole-containing N-acyl derivatives related to Zanamivir. Inhibition studies with influenza virus NAs of group 1 (H1N1) and group 2 (H3N2) revealed that several of them are good inhibitors, wi (mais)

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents.

Autor(es): Lin, Cai; Sun, Chenghai; Liu, Xiao; Zhou, Yiqian; Hussain, Muzammal; Wan, Junting; Li, Minke; Li, Xue; Jin, Ruiliang; Tu, Zhengchao; Zhang, Jiancun
Fonte: Antiviral Res;129: 13-20, 2016 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26802557
Resumo: Among many subtypes of influenza A viruses, influenza A(H1N1) and A(H3N2) subtypes are currently circulating among humans (WHO report 2014-15). Therapeutically, the emergence of viral resistance to currently available drugs (adamantanes and neuraminidase inhibitors) has heightened alarms for developing novel drugs that could address diverse targets in the viral replication cycle in order to improve treatment outcomes. To this regard, the design and synthesis of nucleoside analog inhibitors (mais)

Within-Host Models of High and Low Pathogenic Influenza Virus Infections: The Role of Macrophages.

Autor(es): Pawelek, Kasia A; Dor, Daniel; Salmeron, Cristian; Handel, Andreas
Fonte: PLoS One;11(2): e0150568, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26918620
Resumo: The World Health Organization identifies influenza as a major public health problem. While the strains commonly circulating in humans usually do not cause severe pathogenicity in healthy adults, some strains that have infected humans, such as H5N1, can cause high morbidity and mortality. Based on the severity of the disease, influenza viruses are sometimes categorized as either being highly pathogenic (HP) or having low pathogenicity (LP). The reasons why some strains are LP and others HP a (mais)

Impact of a large deletion in the neuraminidase protein identified in a laninamivir-selected influenza A/Brisbane/10/2007 (H3N2) variant on viral fitness in vitro and in ferrets.

Autor(es): Ann, Julie; Abed, Yacine; Beaulieu, Edith; Bouhy, Xavier; Joly, Marie-Hélène; Dubé, Karen; Carbonneau, Julie; Hamelin, Marie-Eve; Mallett, Corey; Boivin, Guy
Fonte: Influenza Other Respir Viruses;10(2): 122-6, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26526406
Resumo: Viral fitness of a laninamivir-selected influenza A/Brisbane/10/2007-like (H3N2) isolate (LRVp9) containing a 237-amino acid neuraminidase deletion and a P194L hemagglutinin mutation was evaluated in vitro and in ferrets. LRVp9 and the wild-type (WT) virus showed comparable replication kinetics in MDCK-ST6GalI cells. Cultured virus was recovered between days 2 and 5 post-infection in nasal washes (NW) from the 4 WT-infected ferrets whereas no virus was recovered from the LRVp9-infected ani (mais)

Relenza-Induced Acute Myopia Change.

Autor(es): Weng, Tzu-Heng; Lin, Shih-Min; Pao, Sui-I; Chiang, Shang-Yi
Fonte: Optom Vis Sci;93(3): 307-9, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26641023
Resumo: PURPOSE: To report a case of a patient with a notable side effect to Relenza, an anti-influenza virus medication, who also developed acute transient myopia. CASE REPORT: A 31-year-old woman was diagnosed as having seasonal influenza and treated with Relenza. However, an allergic reaction and blurred vision caused by a transient myopic change were noted after she received Relenza treatment. Relenza-induced acute transient myopia had never been reported. The possible mechanisms include (1) ci (mais)

Pharmacophore-Based Virtual Screening for Identification of Novel Neuraminidase Inhibitors and Verification of Inhibitory Activity by Molecular Docking.

Autor(es): Batool, Sidra; Mushtaq, Gohar; Kamal, Warda; Kamal, Mohammad A
Fonte: Med Chem;12(1): 63-73, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26152143
Resumo: Oseltamivir and Zanamivir are two of the recently licensed neuraminidase inhibitors used for the treatment of influenza. However, alternative antiviral agents are needed due to the development of resistant mutations in Oseltamivir subtype H1N1 and H5N1 avian influenza A viruses, the latter being a highly pathogenic avian virus that can be transferred to humans upon immediate contact with H5N1 infected poultry or surface. Novel drug inhibiting group 1 neuraminidases may potentially be develo (mais)

NAIplot: An opensource web tool to visualize neuraminidase inhibitor (NAI) phenotypic susceptibility results using kernel density plots.

Autor(es): Lytras, Theodore; Kossyvakis, Athanasios; Mentis, Andreas
Fonte: Antiviral Res;126: 18-20, 2016 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26692213
Resumo: The results of neuraminidase inhibitor (NAI) enzyme inhibition assays are commonly expressed as 50% inhibitory concentration (IC50) fold-change values and presented graphically in box plots (box-and-whisker plots). An alternative and more informative type of graph is the kernel density plot, which we propose should be the preferred one for this purpose. In this paper we discuss the limitations of box plots and the advantages of the kernel density plot, and we present NAIplot, an opensource (mais)
Resultados  1-12 de 28