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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 45

High antiviral effect of TiO ·PL-DNA nanocomposites targeted to conservative regions of (-)RNA and (+)RNA of influenza A virus in cell culture.

Autor(es): Levina, Asya S; Repkova, Marina N; Bessudnova, Elena V; Filippova, Ekaterina I; Mazurkova, Natalia A; Zarytova, Valentina F
Fonte: Beilstein J Nanotechnol;7: 1166-1173, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27826491
Resumo: The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most vulnerable conservative regions in the viral genome as targets for the action of these agents. Another challenge is the development of an efficient system for their delivery into cells. To solve this problem, we proposed a TiO ·PL-DNA nanocomposite consisting of titanium dioxide nanoparticles and polylysine (PL)-containing oligonucleotides. The TiO ·PL- (mais)

Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus Infection.

Autor(es): Perwitasari, Olivia; Johnson, Scott; Yan, Xiuzhen; Register, Emery; Crabtree, Jackelyn; Gabbard, Jon; Howerth, Elizabeth; Shacham, Sharon; Carlson, Robert; Tamir, Sharon; Tripp, Ralph A
Fonte: PLoS One;11(11): e0167221, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27893810
Resumo: Influenza A virus (IAV) causes seasonal epidemics of respiratory illness that can cause mild to severe illness and potentially death. Antiviral drugs are an important countermeasure against IAV; however, drug resistance has developed, thus new therapeutic approaches are being sought. Previously, we demonstrated the antiviral activity of a novel nuclear export inhibitor drug, verdinexor, to reduce influenza replication in vitro and pulmonary virus burden in mice. In this study, in vivo effic (mais)

Mycoplasma hyopneumoniae does not affect the interferon-related anti-viral response but predisposes the pig to a higher level of inflammation following swine influenza virus infection.

Autor(es): Deblanc, Céline; Delgado-Ortega, Mario; Gorin, Stéphane; Berri, Mustapha; Paboeuf, Frédéric; Berthon, Patricia; Herrler, Georg; Meurens, François; Simon, Gaëlle
Fonte: J Gen Virol;97(10): 2501-2515, 2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27498789
Resumo: In pigs, influenza A viruses and Mycoplasma hyopneumoniae (Mhp) are major contributors to the porcine respiratory disease complex. Pre-infection with Mhp was previously shown experimentally to exacerbate the clinical outcomes of H1N1 infection during the first week after virus inoculation. In order to better understand the interactions between these pathogens, we aimed to assess very early responses (at 5, 24 and 48 h) after H1N1 infection in pigs pre-infected or not with Mhp. Clinical sign (mais)

A Defective Interfering Influenza RNA Inhibits Infectious Influenza Virus Replication in Human Respiratory Tract Cells: A Potential New Human Antiviral.

Autor(es): Smith, Claire M; Scott, Paul D; O'Callaghan, Christopher; Easton, Andrew J; Dimmock, Nigel J
Fonte: Viruses;8(8)2016 Aug 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27556481
Resumo: Defective interfering (DI) viruses arise during the replication of influenza A virus and contain a non-infective version of the genome that is able to interfere with the production of infectious virus. In this study we hypothesise that a cloned DI influenza A virus RNA may prevent infection of human respiratory epithelial cells with infection by influenza A. The DI RNA (244/PR8) was derived by a natural deletion process from segment 1 of influenza A/PR/8/34 (H1N1); it comprises 395 nucleoti (mais)

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design.

Autor(es): Stevaert, Annelies; Naesens, Lieve
Fonte: Med Res Rev;36(6): 1127-1173, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27569399
Resumo: Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with significant morbidity and mortality, and a huge cost. Since resistance to the existing anti-influenza drugs is rising, innovative inhibitors with a different mode of action are urgently needed. The influenza polymerase complex is widely recognized as a key drug target, given its critical role in virus replication and high degree of conservation among influenza A (of human or zoonotic origin) and B viruses. We (mais)

A High Throughput Assay for Screening Host Restriction Factors and Antivirals Targeting Influenza A Virus.

Autor(es): Wang, Lingyan; Li, Wenjun; Li, Shitao
Fonte: Front Microbiol;7: 858, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27375580
Resumo: Influenza A virus (IAV) is a human respiratory pathogen that causes seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality. Currently approved treatments against influenza are losing effectiveness, as new viral strains are often refractory to conventional treatments. Thus, there is an urgent need to find new therapeutic targets with which to develop novel antiviral drugs. The common strategy to discover new drug targets and antivirals is high t (mais)

Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection.

Autor(es): Stevens, Natalie E; Hatjopolous, Antoinette; Fraser, Cara K; Alsharifi, Mohammed; Diener, Kerrilyn R; Hayball, John D
Fonte: Sci Rep;6: 29154, 2016 Jul 06.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27380890
Resumo: Passive immunotherapy may have particular benefits for the treatment of severe influenza infection in at-risk populations, however little is known of the impact of passive immunotherapy on the formation of memory responses to the virus. Ideally, passive immunotherapy should attenuate the severity of infection while still allowing the formation of adaptive responses to confer protection from future exposure. In this study, we sought to determine if administration of influenza-specific ovine (mais)

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans.

Autor(es): To, Kelvin K W; Mok, Ka-Yi; Chan, Andy S F; Cheung, Nam N; Wang, Pui; Lui, Yin-Ming; Chan, Jasper F W; Chen, Honglin; Chan, Kwok-Hung; Kao, Richard Y T; Yuen, Kwok-Yung
Fonte: J Gen Virol;97(8): 1807-17, 2016 Aug.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27259985
Resumo: Immunomodulators have been shown to improve the outcome of severe pneumonia. We have previously shown that mycophenolic acid (MPA), an immunomodulator, has antiviral activity against influenza A/WSN/1933(H1N1) using a high-throughput chemical screening assay. This study further investigated the antiviral activity and mechanism of action of MPA against contemporary clinical isolates of influenza A and B viruses. The 50 % cellular cytotoxicity (CC50) of MPA in Madin Darby canine kidney cell l (mais)

Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection.

Autor(es): Lee, Ji-Hye; Oh, Mi; Seok, Jong Hyeon; Kim, Sella; Lee, Dan Bi; Bae, Garam; Bae, Hae-In; Bae, Seon Young; Hong, Young-Min; Kwon, Sang-Oh; Lee, Dong-Hun; Song, Chang-Seon; Mun, Ji Young; Chung, Mi Sook; Kim, Kyung Hyun
Fonte: Viruses;8(6)2016 Jun 06.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27275830
Resumo: Influenza is a serious public health concern worldwide, as it causes significant morbidity and mortality. The emergence of drug-resistant viral strains requires new approaches for the treatment of influenza. In this study, Rubus coreanus seed (RCS) that is left over from the production of wine or juice was found to show antiviral activities against influenza type A and B viruses. Using the time-of-addition plaque assay, viral replication was almost completely abolished by simultaneous treat (mais)

Antiviral susceptibility of influenza viruses isolated from patients pre- and post-administration of favipiravir.

Autor(es): Takashita, Emi; Ejima, Miho; Ogawa, Rie; Fujisaki, Seiichiro; Neumann, Gabriele; Furuta, Yousuke; Kawaoka, Yoshihiro; Tashiro, Masato; Odagiri, Takato
Fonte: Antiviral Res;132: 170-7, 2016 Aug.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27321665
Resumo: Favipiravir, a viral RNA-dependent RNA polymerase inhibitor, has recently been approved in Japan for influenza pandemic preparedness. Here, we conducted a cell-based screening system to evaluate the susceptibility of influenza viruses to favipiravir. In this assay, the antiviral activity of favipiravir is determined by inhibition of virus-induced cytopathic effect, which can be measured by using a colorimetric cell proliferation assay. To demonstrate the robustness of the assay, we compared (mais)

Antiviral activity of hydroalcoholic extract from Eupatorium perfoliatum L. against the attachment of influenza A virus.

Autor(es): Derksen, Andrea; Kühn, Joachim; Hafezi, Wali; Sendker, Jandirk; Ehrhardt, Christina; Ludwig, Stephan; Hensel, Andreas
Fonte: J Ethnopharmacol;188: 144-52, 2016 Jul 21.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27178637
Resumo: ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Eupatorium perfoliatum have been traditionally used by American natives as a treatment for fever and infections. Also modern phytotherapy in Europe documents the use of hydroalcoholic extracts of this herbal material for the treatment of infections of the upper respiratory tract. AIM OF THE STUDY: The aim of the present study was to characterize the anti-influenza A virus (IAV) potential of extracts derived from the aerial parts of E. perfolia (mais)

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.

Autor(es): Pillai, Padmini S; Molony, Ryan D; Martinod, Kimberly; Dong, Huiping; Pang, Iris K; Tal, Michal C; Solis, Angel G; Bielecki, Piotr; Mohanty, Subhasis; Trentalange, Mark; Homer, Robert J; Flavell, Richard A; Wagner, Denisa D; Montgomery, Ruth R; Shaw, Albert C; Staeheli, Peter; Iwasaki, Akiko
Fonte: Science;352(6284): 463-6, 2016 Apr 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27102485
Resumo: Influenza A virus (IAV) causes up to half a million deaths worldwide annually, 90% of which occur in older adults. We show that IAV-infected monocytes from older humans have impaired antiviral interferon production but retain intact inflammasome responses. To understand the in vivo consequence, we used mice expressing a functional Mx gene encoding a major interferon-induced effector against IAV in humans. In Mx1-intact mice with weakened resistance due to deficiencies in Mavs and Tlr7, we f (mais)
Resultados  1-12 de 45