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Resultados  1-12 de 289

Arginine-rich histones have strong antiviral activity for influenza A viruses.

Autor(es): Hoeksema M; Tripathi S; White M; Qi L; Taubenberger J; van Eijk M; Haagsman H; Hartshorn KL
Fuente: Innate Immun;21(7): 736-45, 2015 Oct.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26138524
Resumen: While histones are best known for DNA binding and transcription-regulating properties, they also have antimicrobial activity against a broad range of potentially pathogenic organisms. Histones are abundant in neutrophil extracellular traps, where they play an important role in NET-mediated antimicrobial killing. Here, we show anti-influenza activity of histones against both seasonal H3N2 and H1N1, but not pandemic H1N1. The arginine rich histones, H3 and H4, had greater neutralizing and vir (mas)

Interplay between influenza A virus and host factors: targets for antiviral intervention.

Autor(es): Tripathi S; Batra J; Lal SK
Fuente: Arch Virol;160(8): 1877-91, 2015 Aug.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26016443
Resumen: Influenza A viruses (IAVs) pose a major public health threat worldwide. Recent experience with the 2013 H7N9 outbreak in China and the 2009 "swine flu" pandemic have shown that antiviral vaccines and drugs fall short of controlling the spread of disease in a timely and effective manner. Major problems include rapid emergence of drug-resistant influenza virus strains and the slow process of vaccine production. With the threat of a highly pathogenic H5N1 bird-flu pandemic looming large, it is (mas)

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

Autor(es): Anastasina M; Schepens B; Söderholm S; Nyman TA; Matikainen S; Saksela K; Saelens X; Kainov DE
Fuente: J Gen Virol;96(8): 2086-91, 2015 Aug.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25934792
Resumen: Non-structural protein NS1 of influenza A viruses interacts with cellular factors through its N-terminal RNA-binding, middle effector and C-terminal non-structured domains. NS1 attenuates antiviral responses in infected cells and thereby secures efficient virus replication. Some influenza strains express C-terminally truncated NS1 proteins due to nonsense mutations in the NS1 gene. To understand the role of the NS1 C-terminal region in regulation of antiviral responses, we engineered influe (mas)

Recommendations pertaining to the use of influenza vaccines and influenza antiviral drugs: Influenza 2015.

Autor(es): Walaza S; Cohen C
Fuente: S Afr Med J;105(2): 90-1, 2015 Feb.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26242521
Resumen: Prevention of influenza is the most effective management strategy. Influenza vaccine is administered each year before the influenza season. Here we provide recommendations for the use of influenza vaccines in anticipation of the 2015 Southern Hemisphere influenza season. For a review of the 2014 influenza season, please refer to the website of the National Institute for Communicable Diseases of the National Health Laboratory Service,

Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses.

Autor(es): Liu R; An L; Liu G; Li X; Tang W; Chen X
Fuente: Antiviral Res;120: 101-11, 2015 Aug.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26022197
Resumen: The influenza A virus is notoriously known for its ability to cause recurrent epidemics and global pandemics. Antiviral therapy is effective when treatment is initiated within 48h of symptom onset, and delaying treatment beyond this time frame is associated with decreased efficacy. Research on anti-inflammatory therapy to ameliorate influenza-induced inflammation is currently underway and seems important to the impact on the clinical outcome. Both antiviral and anti-inflammatory drugs with (mas)

A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein.

Autor(es): Kakisaka M; Sasaki Y; Yamada K; Kondoh Y; Hikono H; Osada H; Tomii K; Saito T; Aida Y
Fuente: PLoS Pathog;11(7): e1005062, 2015 Jul.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26222066
Resumen: Developing antiviral therapies for influenza A virus (IAV) infection is an ongoing process because of the rapid rate of antigenic mutation and the emergence of drug-resistant viruses. The ideal strategy is to develop drugs that target well-conserved, functionally restricted, and unique surface structures without affecting host cell function. We recently identified the antiviral compound, RK424, by screening a library of 50,000 compounds using cell-based infection assays. RK424 showed potent (mas)

Biochemical features and antiviral activity of a monomeric catalytic antibody light-chain 23D4 against influenza A virus.

Autor(es): Hifumi E; Arakawa M; Matsumoto S; Yamamoto T; Katayama Y; Uda T
Fuente: FASEB J;29(6): 2347-58, 2015 Jun.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25713031
Resumen: Catalytic antibodies have exhibited interesting functions against some infectious viruses such as HIV, rabies virus, and influenza virus in vitro as well as in vivo. In some cases, a catalytic antibody light chain takes on several structures from the standpoint of molecular size (monomer, dimer, etc.) and/or isoelectronic point. In this study, we prepared a monomeric 23D4 light chain by mutating the C-terminal Cys to Ala of the wild-type. The mutated 23D4 molecule took a simple monomeric fo (mas)

Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses.

Autor(es): Hayashi T; MacDonald LA; Takimoto T
Fuente: J Virol;89(12): 6442-52, 2015 Jun.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25855745
Resumen: UNLABELLED: Influenza virus infection causes global inhibition of host protein synthesis in infected cells. This host shutoff is thought to allow viruses to escape from the host antiviral response, which restricts virus replication and spread. Although the mechanism of host shutoff is unclear, a novel viral protein expressed by ribosomal frameshifting, PA-X, was found to play a major role in influenza virus-induced host shutoff. However, little is known about the impact of PA-X expression o (mas)

Degree of adherence to recommended antiviral treatment during the pandemic and post-pandemic periods of influenza A(H1N1)pdm09 in 148 intensive care units in Spain.

Autor(es): Canadell L; Martín-Loeches I; Díaz E; Trefler S; Grau S; Yebenes JC; Almirall J; Olona M; Sureda F; Blanquer J; Rodriguez A
Fuente: Med Intensiva;39(4): 222-33, 2015 May.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25107582
Resumen: OBJECTIVE: To determine the degree of antiviral treatment recommendations adherence and its impact to critical ill patients affected by influenza A(H1N1)pdm09 mortality. DESIGN: Secondary analysis of prospective study. SETTING: Intensive care (UCI). PATIENTS: Patients with influenza A(H1N1)pdm09 in the 2009 pandemic and 2010-11 post-Pandemic periods. VARIABLES: Adherence to recommendations was classified as: Total (AT); partial in doses (PD); partial in time (PT), and non-adherence (NA). Vi (mas)

Mitochondrial antiviral signaling adaptor mediated apoptosis in H3N2 swine influenza virus infection is inhibited by viral protein NS1 in vitro.

Autor(es): Zhang J; Miao J; Hou J; Lu C
Fuente: Vet Immunol Immunopathol;165(1-2): 34-44, 2015 May 15.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25800220
Resumen: We investigated the in vitro role of mitochondrial antiviral signaling adaptor (MAVS) in apoptosis induced by H3N2 swine influenza virus infection and the influence of viral NS1 (nonstructural protein 1) protein on this process. H3N2 swine influenza virus (SIV, A/Swine/Shandong/3/2005) was co-cultured with human lung epithelial A549 cells. The relationship of MAVS expression to SIV replication and apoptosis, and the influence of viral proteins on MAVS functions were studied. The data indica (mas)

Assessing the use of antiviral treatment to control influenza.

Autor(es): Kramer SC; Bansal S
Fuente: Epidemiol Infect;143(8): 1621-31, 2015 Jun.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25274250
Resumen: Vaccines are the cornerstone of influenza control policy, but can suffer from several drawbacks. Seasonal influenza vaccines are prone to production problems and low efficacies, while pandemic vaccines are unlikely to be available in time to slow a rapidly spreading global outbreak. Antiviral therapy was found to be beneficial during the influenza A(H1N1)pdm09 pandemic even with limited use; however, antiviral use has decreased further since then. We sought to determine the role antiviral t (mas)
Resultados  1-12 de 289