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Resultados  1-12 de 266
1.

In vitro Antiviral Effects and 3D QSAR Study of Resveratrol Derivatives as Potent Inhibitors of Influenza H1N1 Neuraminidase.

Autor(es): Li C; Fang JS; Lian WW; Pang XC; Liu AL; Du GH
Fuente: Chem Biol Drug Des;85(4): 427-38, 2015 Apr.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25185493
Resumen: The anti-influenza virus activities of 50 resveratrol (RV: 3, 5, 4'-trihydroxy-trans-stilbene) derivatives were evaluated using a neuraminidase (NA) activity assay. The results showed that 35 compounds exerted an inhibitory effect on the NA activity of the influenza virus strain A/PR/8/34 (H1N1) with 50% inhibitory concentration (IC50 ) values ranging from 3.56 to 186.1 µm. Next, the 35 RV derivatives were used to develop 3D quantitative structure-activity relationship (3D QSAR) models fo (mas)
2.

Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza.

Autor(es): Dayem AA; Choi HY; Kim YB; Cho SG
Fuente: PLoS One;10(3): e0121610, 2015.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25806943
Resumen: Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic concern due to the costly countermeasures it necessitates. In this study, we compared the antiviral activities of several flavonols and other flavonoids with similar, but distinct, hydroxyl or methyl substitution patterns at the 3, 3', and 4' positions of the 15-carbon flavonoid skeleton, and found (mas)
3.

Inhalable dry powder formulations of siRNA and pH-responsive peptides with antiviral activity against H1N1 influenza virus.

Autor(es): Liang W; Chow MY; Lau PN; Zhou QT; Kwok PC; Leung GP; Mason AJ; Chan HK; Poon LL; Lam JK
Fuente: Mol Pharm;12(3): 910-21, 2015 Mar 2.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25599953
Resumen: Pulmonary delivery of siRNA has considerable therapeutic potential for treating viral respiratory infectious diseases including influenza. By introducing siRNA that targets the conserved region of viral genes encoding nucleocapsid protein (NP), viral mRNAs can be degraded and viral replication can be inhibited in mammalian cells. To enable siRNA to be used as an antiviral agent, the nucleic acid delivery barrier must be overcome. Effective local delivery of siRNA to lung tissues is required (mas)
4.

A novel video tracking method to evaluate the effect of influenza infection and antiviral treatment on ferret activity.

Autor(es): Oh DY; Barr IG; Hurt AC
Fuente: PLoS One;10(3): e0118780, 2015.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25738900
Resumen: Ferrets are the preferred animal model to assess influenza virus infection, virulence and transmission as they display similar clinical symptoms and pathogenesis to those of humans. Measures of disease severity in the ferret include weight loss, temperature rise, sneezing, viral shedding and reduced activity. To date, the only available method for activity measurement has been the assignment of an arbitrary score by a 'blind' observer based on pre-defined responsiveness scale. This manual s (mas)
5.

Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance.

Autor(es): Lopes e Souza TM; Fintelman-Rodrigues N; Resende PC; Mesquita M; Gregianini TS; Bozza FA; Pecego AC; Fernandes SB; Cury AL; Riediger IN; Siqueira MM
Fuente: Mem Inst Oswaldo Cruz;110(1): 101-5, 2015 Feb.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25742269
Resumen: The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. To spread in community settings, H275Y mutants must contain additional mutations, collectively called permissive mutations. We display t (mas)
6.

Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

Autor(es): Souza, Thiago Moreno Lopes e; Fintelman-Rodrigues, Natalia; Resende, Paola Cristina; Mesquita, Milene; Gregianini, Tatiana Schaffer; Bozza, Fernando A; Pecego, Ana Carla; Fernandes, Sandra Bianchini; Cury, Ana Luisa Furtado; Riediger, Irina Nastassja; Siqueira, Marilda M
Fuente: Mem Inst Oswaldo Cruz;110(1): 101-105, 27/02/2015. tab, graf.
LILACS - Literatura Latinoamericana y del Caribe en Ciencias de la Salud ID: 741611  LILACS Express
Resumen: The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. To spread in community settings, H275Y mutants must contain additional mutations, collectively called permissive mutations. We display t (mas)
7.

Neuraminidase-producing oral mitis group streptococci potentially contribute to influenza viral infection and reduction in antiviral efficacy of zanamivir.

Autor(es): Kamio N; Imai K; Shimizu K; Cueno ME; Tamura M; Saito Y; Ochiai K
Fuente: Cell Mol Life Sci;72(2): 357-66, 2015 Jan.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25001578
Resumen: Influenza is a serious respiratory disease among immunocompromised individuals, such as the elderly, and its prevention is an urgent social issue. Influenza viruses rely on neuraminidase (NA) activity to release progeny viruses from infected cells and spreading the infection. NA is, therefore, an important target of anti-influenza drugs. A causal relationship between bacteria and influenza virus infection has not yet been established, however, a positive correlation between them has been re (mas)
8.

The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA.

Autor(es): Riegger D; Hai R; Dornfeld D; Mänz B; Leyva-Grado V; Sánchez-Aparicio MT; Albrecht RA; Palese P; Haller O; Schwemmle M; García-Sastre A; Kochs G; Schmolke M
Fuente: J Virol;89(4): 2241-52, 2015 Feb.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25505067
Resumen: UNLABELLED: Interferon-induced Mx proteins show strong antiviral activity against influenza A viruses (IAVs). We recently demonstrated that the viral nucleoprotein (NP) determines resistance of seasonal and pandemic human influenza viruses to Mx, while avian isolates retain Mx sensitivity. We identified a surface-exposed cluster of amino acids in NP of pandemic A/BM/1/1918 (H1N1), comprising isoleucine-100, proline-283, and tyrosine-313, that is essential for reduced Mx sensitivity in cell (mas)
9.

Influenza A(H1N1)pdm09 resistance and cross-decreased susceptibility to oseltamivir and zanamivir antiviral drugs.

Autor(es): Correia V; Santos LA; Gíria M; Almeida-Santos MM; Rebelo-de-Andrade H
Fuente: J Med Virol;87(1): 45-56, 2015 Jan.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25042157
Resumen: Neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are currently the only effective antiviral drugs available worldwide for the management of influenza. The potential development of resistance is continually threatening their use, rationalizing and highlighting the need for a close and sustained evaluation of virus susceptibility. This study aimed to analyze and characterize the phenotypic and genotypic NAIs susceptibility profiles of A(H1N1)pdm09 viruses circulating in Portugal from (mas)
10.

Strain-specific antiviral activity of iminosugars against human influenza A viruses.

Autor(es): Hussain S; Miller JL; Harvey DJ; Gu Y; Rosenthal PB; Zitzmann N; McCauley JW
Fuente: J Antimicrob Chemother;70(1): 136-52, 2015 Jan.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25223974
Resumen: OBJECTIVES: Drugs that target host cell processes can be employed to complement drugs that specifically target viruses, and iminosugar compounds that inhibit host α-glucosidases have been reported to show antiviral activity against multiple viruses. Here the effect and mechanism of two iminosugar α-glucosidase inhibitors, N-butyl-deoxynojirimycin (NB-DNJ) and N-nonyl-deoxynojirimycin (NN-DNJ), on human influenza A viruses was examined. METHODS: The viruses examined were a recently cir (mas)
11.

Synthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments.

Autor(es): Matusevich OV; Egorov VV; Gluzdikov IA; Titov MI; Zarubaev VV; Shtro AA; Slita AV; Dukov MI; Shurygina AP; Smirnova TD; Kudryavtsev IV; Vasin AV; Kiselev OI
Fuente: Antiviral Res;113: 4-10, 2015 Jan.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25446335
Resumen: This study is devoted to the antiviral activity of peptide fragments from the PB1 protein - a component of the influenza A RNA polymerase. The antiviral activity of the peptides synthesized was studied in MDCK cell cultures against the pandemic influenza strain A/California/07/2009 (H1N1) pdm09. We found that peptide fragments 6-13, 6-14, 26-30, 395-400, and 531-540 of the PB1 protein were capable of suppressing viral replication in cell culture. Terminal modifications i.e. N-acetylation an (mas)
12.

[The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza ].

Autor(es): Kolobukhina LV; Burtseva EI; Shelkanov MIu; Al'khovskii SV; Prilipov AG; Merkulova LN; Kisteneva LB; Vartanian RV; Kruzhkova IS; Trushakova SV; Krasnoslobodtsev KG; Avdeev SM; Sutochnikova OA; Bazarova MV; Kelly EI; Ambrosi OE; Malyshev nA; L'vov DK; Chuchalin AG
Fuente: Ter Arkh;86(10): 52-9, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25509893
Resumen: AIM: To characterize the 2013-2014 epidemic season from the results of detection of influenza infection in patients; to provide the molecular genetic characteristics of the strains isolated from deceased patients. SUBJECTS AND METHODS: The investigators examined 1203 patients (387 children, 509 people older than 16 years of age, 307 pregnant women) admitted to Moscow Clinical Infectious Diseases Hospital One with the clinical signs of acute respiratory viral diseases. Nasal lavage and autop (mas)
Resultados  1-12 de 266