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Resultados  1-12 de 226

Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses.

Autor(es): Nikolaidis NM; White MR; Allen K; Tripathi S; Qi L; McDonald B; Taubenberger J; Seaton BA; McCormack FX; Crouch EC; Hartshorn KL
Fuente: Am J Physiol Lung Cell Mol Physiol;306(11): L1036-44, 2014 Jun 1.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24705721
Resumen: We recently reported that a trimeric neck and carbohydrate recognition domain (NCRD) fragment of human surfactant protein D (SP-D), a host defense lectin, with combinatorial substitutions at the 325 and 343 positions (D325A+R343V) exhibits markedly increased antiviral activity for seasonal strains of influenza A virus (IAV). The NCRD binds to glycan-rich viral envelope proteins including hemagglutinin (HA). We now show that replacement of D325 with serine to create D325S+R343V provided equa (mas)

Antiviral activity of Ladania067, an extract from wild black currant leaves against influenza A virus in vitro and in vivo.

Autor(es): Haasbach E; Hartmayer C; Hettler A; Sarnecka A; Wulle U; Ehrhardt C; Ludwig S; Planz O
Fuente: Front Microbiol;5: 171, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24795704
Resumen: Influenza, a respiratory disease caused by influenza viruses, still represents a major threat to humans and several animal species. Besides vaccination, only two classes of drugs are available for antiviral treatment against this pathogen. Thus, there is a strong need for new effective antivirals against influenza viruses. Here, we tested Ladania067, an extract from the leaves of the wild black currant (Ribes nigrum folium) for potential antiviral activity against influenza A virus in vitro (mas)

Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.

Autor(es): Strengert M; Jennings R; Davanture S; Hayes P; Gabriel G; Knaus UG
Fuente: Antioxid Redox Signal;20(17): 2695-709, 2014 Jun 10.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24128054
Resumen: AIMS: Influenza A virus (IAV), a major airborne pathogen, is closely associated with significant morbidity and mortality. The primary target for influenza virus replication is the respiratory epithelium, which reacts to infection by mounting a multifaceted antiviral response. A part of this mucosal host defense is the generation of reactive oxygen species (ROS) by NADPH oxidases. Duox1 and Duox2 are the main ROS-producing enzymes in the airway epithelium, but their contribution to mammalian (mas)

A Review of the Antiviral Susceptibility of Human and Avian Influenza Viruses over the Last Decade.

Autor(es): Oh DY; Hurt AC
Fuente: Scientifica (Cairo);2014: 430629, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24800107
Resumen: Antivirals play an important role in the prevention and treatment of influenza infections, particularly in high-risk or severely ill patients. Two classes of influenza antivirals have been available in many countries over the last decade (2004-2013), the adamantanes and the neuraminidase inhibitors (NAIs). During this period, widespread adamantane resistance has developed in circulating influenza viruses rendering these drugs useless, resulting in the reliance on the most widely available N (mas)

Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus.

Autor(es): Hossain MK; Choi HY; Hwang JS; Dayem AA; Kim JH; Kim YB; Poo H; Cho SG
Fuente: J Microbiol;52(6): 521-6, 2014 Jun.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24871979
Resumen: Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2᾿dihydroxyflavone (3,2᾿DHF) and 3,4ᾠ(mas)

Rapid influenza diagnostic test use and antiviral prescriptions in outpatient settings pre- and post-2009 H1N1 pandemic.

Autor(es): Williams LO; Kupka NJ; Schmaltz SP; Barrett S; Uyeki TM; Jernigan DB
Fuente: J Clin Virol;60(1): 27-33, 2014 May.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24630481
Resumen: BACKGROUND: Rapid influenza diagnostic tests (RIDTs) can be used at the point-of-care and are often the only influenza tests readily available in outpatient facilities. OBJECTIVES: To determine the use of RIDTs and antiviral prescription practices in outpatient facilities. STUDY DESIGN: Surveys were mailed to U.S. physician's offices, emergency departments, and community health centers in 2008 (pre-2009 H1N1 pandemic) and 2010 (post-2009 H1N1 pandemic). The 2010 survey included questions to (mas)

Drug susceptibility surveillance of influenza viruses circulating in the United States in 2011-2012: application of the WHO antiviral working group criteria.

Autor(es): Okomo-Adhiambo M; Nguyen HT; Abd Elal A; Sleeman K; Fry AM; Gubareva LV
Fuente: Influenza Other Respir Viruses;8(2): 258-65, 2014 Mar.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24299049
Resumen: BACKGROUND: Assessing susceptibility of influenza viruses to neuraminidase (NA) inhibitors (NAIs) is primarily done in NA inhibition (NI) assays, supplemented by NA sequence analysis. However, two factors present challenges for NI assay data interpretation: lack of established IC50 values indicative of clinically relevant resistance and insufficient harmonization of NI testing methodologies among surveillance laboratories. In 2012, the WHO working group on influenza antiviral susceptibility (mas)

1,2,3-Triazole-containing derivatives of rupestonic acid: click-chemical synthesis and antiviral activities against influenza viruses.

Autor(es): He YW; Dong CZ; Zhao JY; Ma LL; Li YH; Aisa HA
Fuente: Eur J Med Chem;76: 245-55, 2014 Apr 9.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24583605
Resumen: Two series of rupestonic acid derivatives, (1-substituted-1H-1,2,3-triazol-4-yl)methyl 2-((5R,8S,8aS)-3,8-dimethyl-2-oxo-1,2,4,5,6,7,8,8a-octahydroazulen-5-yl)acrylate and N-(1-substituted-1H-1,2,3-triazol-4-yl)methyl 2-((5R,8S,8aS)-3,8-dimethyl-2-oxo-1,2,4,5,6,7,8,8a-octahydroazulen-5-yl)acrylamide were easily and efficiently synthesized via click chemistry. These compounds were tested for their in vitro activities against various strains of influenza A virus (H1N1, oseltamivir resistant H (mas)

Outpatient influenza antiviral prescription trends with influenza-like illness in the USA, 2008-2010.

Autor(es): Suda KJ; Regen SM; Lee TA; Easterling JL; Hunkler RJ; Danziger LH
Fuente: Int J Antimicrob Agents;43(3): 279-83, 2014 Mar.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24373618
Resumen: The 2009 novel H1N1 influenza A virus (H1N1) became a global pandemic. Data on antiviral prescriptions by location from 2008 to 2010 have not been reported. The purpose of this study was to assess antiviral geographic trends and correlation with influenza-like illness (ILI) over 3 years. Percent of outpatient ILI visits and antiviral prescriptions from 1 January 2008 to 31 December 2010 were included. Linear regression was used to assess correlation. In total, 14 million antivirals were dis (mas)

Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus.

Autor(es): Ha SY; Youn H; Song CS; Kang SC; Bae JJ; Kim HT; Lee KM; Eom TH; Kim IS; Kwak JH
Fuente: J Microbiol;52(4): 340-4, 2014 Apr.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24682996
Resumen: The ethanol extract of Zanthoxylum piperitum (L.) DC. showed in vitro antiviral activity against influenza A virus. Three flavonol glycosides were isolated from the EtOAc fraction of Z. piperitum leaf by means of activity-guided chromatographic separation. Structures of isolated compounds were identified as quercetin 3-O-ß-D-galactopyranoside (1), quercetin 3-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-rhamnopyranoside (3) by comparing their spectral data with literature values. T (mas)

Antiviral susceptibility of variant influenza A(H3N2)v viruses isolated in the United States from 2011 to 2013.

Autor(es): Sleeman K; Mishin VP; Guo Z; Garten RJ; Balish A; Fry AM; Villanueva J; Stevens J; Gubareva LV
Fuente: Antimicrob Agents Chemother;58(4): 2045-51, 2014 Apr.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24449767
Resumen: Since 2011, outbreaks caused by influenza A(H3N2) variant [A(H3N2)v] viruses have become a public health concern in the United States. The A(H3N2)v viruses share the A(H1N1)pdm09 M gene containing the marker of M2 blocker resistance, S31N, but do not contain any known molecular markers associated with resistance to neuraminidase (NA) inhibitors (NAIs). Using a fluorescent NA inhibition (NI) assay, the susceptibilities of recovered A(H3N2)v viruses (n=168) to FDA-approved (oseltamivir and za (mas)

Trends in antiviral therapy of adults hospitalized with influenza in Canada since the end of the 2009 pandemic.

Autor(es): Taylor G; Mitchell R; Fernandes R; McGeer A; Frenette C; Suh KN; Wong A; Katz K; Wilkinson K; Amihod B; Gravel D
Fuente: Antimicrob Resist Infect Control;3(1): 2, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24405855
Resumen: BACKGROUND: Multiple observational studies have associated antiviral treatment of patients hospitalized with influenza with improved outcome, including reduced mortality. During the 2009-2010 H1N1 pandemic increased use of antiviral treatment of hospital patients was reported. We have carried out prospective surveillance for influenza in patients in a large network of Canadian hospitals since 2006. We wished to assess trends in antiviral use in the two seasons (2010-2011 and 2011-2012) sinc (mas)
Resultados  1-12 de 226