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Resultados  1-12 de 650

Dose-dependent antiviral activity of released-active form of antibodies to interferon-gamma against influenza A/California/07/09(H1N1) in murine model.

Autor(es): Don, Elena S; Emelyanova, Alexandra G; Yakovleva, Natalia N; Petrova, Nataliia V; Nikiforova, Marina V; Gorbunov, Evgeniy A; Tarasov, Sergey A; Morozov, Sergey G; Epstein, Oleg I
Fuente: J Med Virol;2016 Oct 21.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27769099
Resumen: The assessment of dose-response is an essential part of drug development in terms of the determination of a drug's effective dose, finding the safety endpoint, estimation of the pharmacokinetic profile and even validation of drug activity, especially for therapeutic agents with a principally novel mechanism of action. Drugs based on released-active forms of antibodies are a good example of such a target. In this study, the efficacy of the antiviral drug Anaferon for children (released-activ (mas)

Synthesis of Pyrazine-1,3-thiazine Hybrid Analogues as Antiviral Agent Against HIV-1, Influenza A (H1N1), Enterovirus 71 (EV71), and Coxsackievirus B3 (CVB3).

Autor(es): Wu, Hong-Min; Zhou, Kuo; Wu, Tao; Cao, Yin-Guang
Fuente: Chem Biol Drug Des;88(3): 411-21, 2016 Sep.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27062664
Resumen: A novel series of pyrazine-1,3-thiazine hybrid conjugates were synthesized in excellent yield. These derivatives were subsequently tested against human immunodeficiency virus (HIV-1); hemagglutinin type 1 and neuraminidase type 1-'influenza' A (H1N1) virus; enterovirus 71 (EV71); and coxsackievirus B3. The effect of these conjugates on the key enzymes responsible for the progression of these viral infections was also illustrated via enzyme-based assay, such as HIV-1 reverse transcriptase (R (mas)

Antiviral susceptibility of influenza viruses isolated from patients pre- and post-administration of favipiravir.

Autor(es): Takashita, Emi; Ejima, Miho; Ogawa, Rie; Fujisaki, Seiichiro; Neumann, Gabriele; Furuta, Yousuke; Kawaoka, Yoshihiro; Tashiro, Masato; Odagiri, Takato
Fuente: Antiviral Res;132: 170-7, 2016 Aug.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27321665
Resumen: Favipiravir, a viral RNA-dependent RNA polymerase inhibitor, has recently been approved in Japan for influenza pandemic preparedness. Here, we conducted a cell-based screening system to evaluate the susceptibility of influenza viruses to favipiravir. In this assay, the antiviral activity of favipiravir is determined by inhibition of virus-induced cytopathic effect, which can be measured by using a colorimetric cell proliferation assay. To demonstrate the robustness of the assay, we compared (mas)

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans.

Autor(es): To, Kelvin K W; Mok, Ka-Yi; Chan, Andy S F; Cheung, Nam N; Wang, Pui; Lui, Yin-Ming; Chan, Jasper F W; Chen, Honglin; Chan, Kwok-Hung; Kao, Richard Y T; Yuen, Kwok-Yung
Fuente: J Gen Virol;97(8): 1807-17, 2016 Aug.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27259985
Resumen: Immunomodulators have been shown to improve the outcome of severe pneumonia. We have previously shown that mycophenolic acid (MPA), an immunomodulator, has antiviral activity against influenza A/WSN/1933(H1N1) using a high-throughput chemical screening assay. This study further investigated the antiviral activity and mechanism of action of MPA against contemporary clinical isolates of influenza A and B viruses. The 50 % cellular cytotoxicity (CC50) of MPA in Madin Darby canine kidney cell l (mas)

A Defective Interfering Influenza RNA Inhibits Infectious Influenza Virus Replication in Human Respiratory Tract Cells: A Potential New Human Antiviral.

Autor(es): Smith, Claire M; Scott, Paul D; O'Callaghan, Christopher; Easton, Andrew J; Dimmock, Nigel J
Fuente: Viruses;8(8)2016.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27556481
Resumen: Defective interfering (DI) viruses arise during the replication of influenza A virus and contain a non-infective version of the genome that is able to interfere with the production of infectious virus. In this study we hypothesise that a cloned DI influenza A virus RNA may prevent infection of human respiratory epithelial cells with infection by influenza A. The DI RNA (244/PR8) was derived by a natural deletion process from segment 1 of influenza A/PR/8/34 (H1N1); it comprises 395 nucleoti (mas)

Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection.

Autor(es): Stevens, Natalie E; Hatjopolous, Antoinette; Fraser, Cara K; Alsharifi, Mohammed; Diener, Kerrilyn R; Hayball, John D
Fuente: Sci Rep;6: 29154, 2016.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27380890
Resumen: Passive immunotherapy may have particular benefits for the treatment of severe influenza infection in at-risk populations, however little is known of the impact of passive immunotherapy on the formation of memory responses to the virus. Ideally, passive immunotherapy should attenuate the severity of infection while still allowing the formation of adaptive responses to confer protection from future exposure. In this study, we sought to determine if administration of influenza-specific ovine (mas)

Antiviral activity of hydroalcoholic extract from Eupatorium perfoliatum L. against the attachment of influenza A virus.

Autor(es): Derksen, Andrea; Kühn, Joachim; Hafezi, Wali; Sendker, Jandirk; Ehrhardt, Christina; Ludwig, Stephan; Hensel, Andreas
Fuente: J Ethnopharmacol;188: 144-52, 2016 Jul 21.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27178637
Resumen: ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Eupatorium perfoliatum have been traditionally used by American natives as a treatment for fever and infections. Also modern phytotherapy in Europe documents the use of hydroalcoholic extracts of this herbal material for the treatment of infections of the upper respiratory tract. AIM OF THE STUDY: The aim of the present study was to characterize the anti-influenza A virus (IAV) potential of extracts derived from the aerial parts of E. perfolia (mas)

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

Autor(es): Geisman, Alexander N; Valuev-Elliston, Vladimir T; Ozerov, Alexander A; Khandazhinskaya, Anastasia L; Chizhov, Alexander O; Kochetkov, Sergey N; Pannecouque, Christophe; Naesens, Lieve; Seley-Radtke, Katherine L; Novikov, Mikhail S
Fuente: Bioorg Med Chem;24(11): 2476-85, 2016 Jun 1.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 27112451
Resumen: A series of 1,6-bis[(benzyloxy)methyl]uracil derivatives combining structural features of both diphenyl ether and pyridone types of NNRTIs were synthesized. Target compounds were found to inhibit HIV-1 reverse transcriptase at micro- and submicromolar levels of concentrations and exhibited anti-HIV-1 activity in MT-4 cell culture, demonstrating resistance profile similar to first generation NNRTIs. The synthesized compounds also showed profound activity against influenza virus (H1N1) in MDC (mas)

In vitro and in vivo mechanism of immunomodulatory and antiviral activity of Edible Bird's Nest (EBN) against influenza A virus (IAV) infection.

Autor(es): Haghani, Amin; Mehrbod, Parvaneh; Safi, Nikoo; Aminuddin, Nur Ain; Bahadoran, Azadeh; Omar, Abdul Rahman; Ideris, Aini
Fuente: J Ethnopharmacol;185: 327-40, 2016 Jun 5.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26976767
Resumen: ETHNOPHARMACOLOGICAL RELEVANCE: For centuries, Edible Bird Nest (EBN) has been used in treatment of variety of respiratory diseases such as flu and cough as a Chinese natural medicine. AIM OF THE STUDY: This natural remedy showed the potential to inhibit influenza A virus (IAV). However, little is known about the mechanism of this process and also the evaluation of this product in an animal model. Hence, the current study was designed to elucidate the antiviral and immunomodulatory effects (mas)

Outcomes and Prognostic Features of Patients With Influenza Requiring Hospitalization and Receiving Early Antiviral Therapy: A Prospective Multicenter Cohort Study.

Autor(es): Maruyama, Takaya; Fujisawa, Takao; Suga, Shigeru; Nakamura, Haruna; Nagao, Mizuho; Taniguchi, Kiyosu; Tsutsui, Kiyoyuki; Ihara, Toshiaki; Niederman, Michael S
Fuente: Chest;149(2): 526-34, 2016 Feb.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26203671
Resumen: BACKGROUND: In Japan, the routine use of early antiviral therapy for patients with influenza is standard. METHODS: This multicenter prospective cohort evaluation of hospitalized patients with laboratory-confirmed influenza identified prognostic factors among the patients receiving antiviral therapy. RESULTS: Of 1,345 patients with influenza (766 pediatric, 579 adult), excluding those aged < 1 year (who are not approved for antiviral therapy), 97.7% (1,224 of 1,253) received antiviral therap (mas)

[Reasonable use of antiviral drugs in influenza is important].

Autor(es): Lin, Jiangtao; Qiu, Ruofan
Fuente: Zhonghua Nei Ke Za Zhi;55(3): 175-6, 2016 Mar.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26926366

Antiviral activity of SA-2 against influenza A virus in vitro/vivo and its inhibition of RNA polymerase.

Autor(es): Yu, Jie; Wang, Dechuan; Jin, Jing; Xu, Jun; Li, Mengwei; Wang, Hui; Dou, Jie; Zhou, Changlin
Fuente: Antiviral Res;127: 68-78, 2016 Mar.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 26802558
Resumen: A target-free and cell-based approach was applied to evaluate the anti-influenza properties of six newly synthesized benzoic acid derivatives. SA-2, the ethyl 4-(2-hydroxymethyl-5-oxopyrrolidin-1-yl)-3-[3-(3-methylbenzoyl)-thioureido] benzoate (compound 2) was screened as a potential drug candidate. In a cytopathic effect assay, SA-2 dose dependently inhibited H1N1, H3N2 and the oseltamivir-resistant mutant H1N1-H275Y influenza viruses in both virus-infected MDCK and A549 cells, with 50% ef (mas)
Resultados  1-12 de 650