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Resultados  1-12 de 227
1.

Actividad antiviral de un extracto acuoso del alga roja Laurencia obtusa frente a virus influenza A y B/ Antiviral activity of an aqueous extract from the red alga Laurencia obtusa against influenza A and B viruses

Autor(es): Pérez-Riverol, Amilcar; Piñón Ramos, Alexander; Morier Díaz, Luis Francisco; Torres López, Yuneysi; Mendoza Llanes, Dianeya; del Barrio Alonso, Gloria
Fuente: Rev Cubana Med Trop;66(2): 273-285, Mayo.-ago. 2014. .
LILACS - Literatura Latinoamericana y del Caribe en Ciencias de la Salud ID: 731979  LILACS Express
Resumen: Introducción: la terapia antiviral frente a las infecciones provocadas por virus influenza se basa en empleo de inhibidores de las proteínas M2 y neuraminidasa (NA). Sin embargo, la emergencia de cepas estacionales resistentes a ambos grupos de fármacos motiva la búsqueda de nuevos fármacos anti-influenza. Los extractos de algas pueden ser utilizados como fuente para la obtención de estos compuestos, teniendo en cuenta la diversidad de metabolitos descrita en estos organismos. Objetiv (mas)
2.

Effect of rapid influenza diagnostic testing on antiviral treatment decisions for patients with influenza-like illness: southwestern U.S., May-December 2009.

Autor(es): Suryaprasad A; Redd JT; Ricks PM; Podewils LJ; Brett M; Oski J; Minenna W; Armao F; Vize BJ; Cheek JE
Fuente: Public Health Rep;129(4): 322-7, 2014 Jul-Aug.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24982534
Resumen: Rapid influenza diagnostic tests (RIDTs) had low test sensitivity for detecting 2009 pandemic influenza A (H1N1pdm09) infection, causing public health authorities to recommend that treatment decisions be based primarily upon risk for influenza complications. We used multivariate Poisson regression analysis to estimate the contribution of RIDT results and risk for H1N1pdm09 complications to receipt of early antiviral (AV) treatment among 290 people with influenza-like illness (ILI) who recei (mas)
3.

[The antiviral activity of the adamantane derivatives against the influenza virus A (H1N1) pdm2009 model in vivo].

Autor(es): Shchelkanov MIu; Shibnev VA; Finogenova IT; Fediakina TM; Garaev TM; Markova NV; Kirillov IM
Fuente: Vopr Virusol;59(2): 37-40, 2014 Mar-Apr.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 25069284
Resumen: For the first time in vivo, the model of the viral pneumonia in mice was used to study the antiviral activity against influenza A virus (H1N1) pdm09 synthetic derivatives of adamantane series including the amino acid residues and lipoid acid. It was found that the adamantane derivatives with histidine, serine, and lipoid acid could inhibit the rimantadine-resistant strain of the influenza A (H1N1) pdm09. As a result, the lifespan of the mice infected with the virus has increased by 1.6 time (mas)
4.

Actividad antiviral in vitro de un extracto acuoso del alga roja Tricleocarpa fragilis frente a virus influenza A/ In vitro antiviral activity of aqueous extract from red seaweed Tricleocarpa fragilis to Influenza A virus

Autor(es): Pérez-Rivero, Amilcar; Piñon Ramos, Alexander; Morier Díaz, Luis Francisco; Acosta Herrera, Belsy; Valdés Iglesias, Olga; del Barrio Alonso, Gloria
Fuente: Rev Cubana Farm;48(2): 316-328, abr.-jun. 2014. .
LILACS - Literatura Latinoamericana y del Caribe en Ciencias de la Salud ID: 731965  LILACS Express
Resumen: Introducción: los virus influenza constituyen importantes patógenos de humanos que anualmente causan alrededor de 500 000 muertes a nivel mundial. La emergencia de variantes virales resistentes a los fármacos antiinfluenza disponibles, motiva la búsqueda de nuevos antivirales. Los extractos obtenidos a partir de algas pueden ser empleados con esta finalidad, teniendo en cuenta la diversidad de metabolitos secundarios descritos en estos organismos. Objetivo: evaluar la actividad antivira (mas)
5.

Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses.

Autor(es): Nikolaidis NM; White MR; Allen K; Tripathi S; Qi L; McDonald B; Taubenberger J; Seaton BA; McCormack FX; Crouch EC; Hartshorn KL
Fuente: Am J Physiol Lung Cell Mol Physiol;306(11): L1036-44, 2014 Jun 1.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24705721
Resumen: We recently reported that a trimeric neck and carbohydrate recognition domain (NCRD) fragment of human surfactant protein D (SP-D), a host defense lectin, with combinatorial substitutions at the 325 and 343 positions (D325A+R343V) exhibits markedly increased antiviral activity for seasonal strains of influenza A virus (IAV). The NCRD binds to glycan-rich viral envelope proteins including hemagglutinin (HA). We now show that replacement of D325 with serine to create D325S+R343V provided equa (mas)
6.

Antiviral activity of Ladania067, an extract from wild black currant leaves against influenza A virus in vitro and in vivo.

Autor(es): Haasbach E; Hartmayer C; Hettler A; Sarnecka A; Wulle U; Ehrhardt C; Ludwig S; Planz O
Fuente: Front Microbiol;5: 171, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24795704
Resumen: Influenza, a respiratory disease caused by influenza viruses, still represents a major threat to humans and several animal species. Besides vaccination, only two classes of drugs are available for antiviral treatment against this pathogen. Thus, there is a strong need for new effective antivirals against influenza viruses. Here, we tested Ladania067, an extract from the leaves of the wild black currant (Ribes nigrum folium) for potential antiviral activity against influenza A virus in vitro (mas)
7.

A Review of the Antiviral Susceptibility of Human and Avian Influenza Viruses over the Last Decade.

Autor(es): Oh DY; Hurt AC
Fuente: Scientifica (Cairo);2014: 430629, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24800107
Resumen: Antivirals play an important role in the prevention and treatment of influenza infections, particularly in high-risk or severely ill patients. Two classes of influenza antivirals have been available in many countries over the last decade (2004-2013), the adamantanes and the neuraminidase inhibitors (NAIs). During this period, widespread adamantane resistance has developed in circulating influenza viruses rendering these drugs useless, resulting in the reliance on the most widely available N (mas)
8.

Drug susceptibility surveillance of influenza viruses circulating in the United States in 2011-2012: application of the WHO antiviral working group criteria.

Autor(es): Okomo-Adhiambo M; Nguyen HT; Abd Elal A; Sleeman K; Fry AM; Gubareva LV
Fuente: Influenza Other Respir Viruses;8(2): 258-65, 2014 Mar.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24299049
Resumen: BACKGROUND: Assessing susceptibility of influenza viruses to neuraminidase (NA) inhibitors (NAIs) is primarily done in NA inhibition (NI) assays, supplemented by NA sequence analysis. However, two factors present challenges for NI assay data interpretation: lack of established IC50 values indicative of clinically relevant resistance and insufficient harmonization of NI testing methodologies among surveillance laboratories. In 2012, the WHO working group on influenza antiviral susceptibility (mas)
9.

Antiviral susceptibility of variant influenza A(H3N2)v viruses isolated in the United States from 2011 to 2013.

Autor(es): Sleeman K; Mishin VP; Guo Z; Garten RJ; Balish A; Fry AM; Villanueva J; Stevens J; Gubareva LV
Fuente: Antimicrob Agents Chemother;58(4): 2045-51, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24449767
Resumen: Since 2011, outbreaks caused by influenza A(H3N2) variant [A(H3N2)v] viruses have become a public health concern in the United States. The A(H3N2)v viruses share the A(H1N1)pdm09 M gene containing the marker of M2 blocker resistance, S31N, but do not contain any known molecular markers associated with resistance to neuraminidase (NA) inhibitors (NAIs). Using a fluorescent NA inhibition (NI) assay, the susceptibilities of recovered A(H3N2)v viruses (n=168) to FDA-approved (oseltamivir and za (mas)
10.

Outpatient influenza antiviral prescription trends with influenza-like illness in the USA, 2008-2010.

Autor(es): Suda KJ; Regen SM; Lee TA; Easterling JL; Hunkler RJ; Danziger LH
Fuente: Int J Antimicrob Agents;43(3): 279-83, 2014 Mar.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24373618
Resumen: The 2009 novel H1N1 influenza A virus (H1N1) became a global pandemic. Data on antiviral prescriptions by location from 2008 to 2010 have not been reported. The purpose of this study was to assess antiviral geographic trends and correlation with influenza-like illness (ILI) over 3 years. Percent of outpatient ILI visits and antiviral prescriptions from 1 January 2008 to 31 December 2010 were included. Linear regression was used to assess correlation. In total, 14 million antivirals were dis (mas)
11.

Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus.

Autor(es): Ha SY; Youn H; Song CS; Kang SC; Bae JJ; Kim HT; Lee KM; Eom TH; Kim IS; Kwak JH
Fuente: J Microbiol;52(4): 340-4, 2014 Apr.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24682996
Resumen: The ethanol extract of Zanthoxylum piperitum (L.) DC. showed in vitro antiviral activity against influenza A virus. Three flavonol glycosides were isolated from the EtOAc fraction of Z. piperitum leaf by means of activity-guided chromatographic separation. Structures of isolated compounds were identified as quercetin 3-O-ß-D-galactopyranoside (1), quercetin 3-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-rhamnopyranoside (3) by comparing their spectral data with literature values. T (mas)
12.

Evolution of influenza neuraminidase and the detection of antiviral resistant strains using mass trees.

Autor(es): Swaminathan K; Downard KM
Fuente: Anal Chem;86(1): 629-37, 2014 Jan 7.
MEDLINE - Literatura Internacional en Ciencias de la Salud PMID: 24224726
Resumen: A new approach employing mass trees is described and implemented which enables the evolution of influenza neuraminidase across all subtypes (N1-N9) in human and animal hosts to be monitored and charted without gene or protein sequencing. These mass trees are shown to be congruent with sequence based trees. Such trees can be built solely from the masses of the proteolytic peptide ions of viral proteins recorded by a mass spectrometer. They are shown to be able to correctly chart the evolutio (mas)
Resultados  1-12 de 227