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Resultados  1-12 de 60

Community- and hospital-acquired infections with oseltamivir- and peramivir-resistant influenza A(H1N1)pdm09 viruses during the 2015-2016 season in Japan.

Autor(es): Hibino, Akinobu; Kondo, Hiroki; Masaki, Hironori; Tanabe, Yoshinari; Sato, Isamu; Takemae, Nobuhiro; Saito, Takehiko; Zaraket, Hassan; Saito, Reiko
Fonte: Virus Genes;53(1): 89-94, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27714496
Resumo: We report five cases of community- and hospital-acquired infections with oseltamivir- and peramivir-resistant A(H1N1)pdm09 viruses possessing the neuraminidase (NA) H275Y mutation during January-February 2016 in Japan. One case was hospitalized and was receiving oseltamivir for prophylaxis. The remaining four cases were not taking antiviral drugs at the time of sampling. These cases were geographically distant and epidemiologically unrelated. The five viruses showed ~300-fold rise in IC va (mais)

The pharmacological management of severe influenza infection - 'existing and emerging therapies'.

Autor(es): Mc Mahon, Aisling; Martin-Loeches, Ignacio
Fonte: Expert Rev Clin Pharmacol;10(1): 81-95, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27797595
Resumo: INTRODUCTION: Over the last century several influenza outbreaks have traversed the globe, most recently the influenza A(H1N1) 2009 pandemic. On each occasion, a highly contagious, virulent pathogen has emerged, leading to significant morbidity and mortality amongst those affected. Areas covered: Early antiviral therapy and supportive care is the mainstay of treatment. Treatment should be started as soon as possible and not delayed for the results of diagnostic testing. Whilst oseltamivir is (mais)

Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.

Autor(es): Kossyvakis, A; Mentis, A-F A; Tryfinopoulou, K; Pogka, V; Kalliaropoulos, A; Antalis, E; Lytras, T; Meijer, A; Tsiodras, S; Karakitsos, P; Mentis, A F
Fonte: Eur J Clin Microbiol Infect Dis;36(2): 361-371, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27848039
Resumo: There was an increase in severe and fatal influenza cases in Greece during the 2011-2015 post-pandemic period. To investigate causality, we determined neuraminidase (NA) inhibitor susceptibility and resistance-conferring NA and hemagglutinin (HA) mutations in circulating influenza type A viruses during the pandemic (2009-2010) and post-pandemic periods in Greece. One hundred thirty-four influenza A(H1N1)pdm09 and 95 influenza A(H3N2) viruses submitted to the National Influenza Reference Lab (mais)

Investigational hemagglutinin-targeted influenza virus inhibitors.

Autor(es): Zeng, Li-Yan; Yang, Jie; Liu, Shuwen
Fonte: Expert Opin Investig Drugs;26(1): 63-73, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27918208
Resumo: INTRODUCTION: Seasonal influenza and pandemic outbreaks typically result in high mortality and morbidity associated with severe economic burdens. Vaccines and anti-influenza drugs have made great contributions to control the infection. However, antigenic drifts and shifts allow influenza viruses to easily escape immune neutralization and antiviral drug activity. Hemagglutinin (HA)is an important envelope protein for the entry of influenza viruses into host cells, thus, HA-targeted agents ma (mais)

Strengthening public health systems: assessing the attributes of the NSW influenza surveillance system.

Autor(es): Dawson, Greer; Gilmour, Robin; Tobin, Sean; Travaglia, Joanne
Fonte: Public Health Res Pract;26(2)2016 Apr 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27734064
Resumo: OBJECTIVE: In New South Wales (NSW), influenza surveillance is informed by a number of discrete data sources, including laboratories, emergency departments, death registrations and community surveillance programs. The purpose of this study was to evaluate the NSW influenza surveillance system using the US Centers for Disease Control and Prevention guidelines for evaluating public health surveillance systems. Importance of study: Having a strong influenza surveillance system is important for (mais)

In vitro neuraminidase inhibitory concentration (IC50) of four neuraminidase inhibitors against clinical isolates of the influenza viruses circulating in the 2010-2011 to 2014-2015 Japanese influenza seasons.

Autor(es): Ikematsu, Hideyuki; Kawai, Naoki; Iwaki, Norio; Kashiwagi, Seizaburo
Fonte: J Infect Chemother;22(9): 599-604, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27346379
Resumo: To assess the extent of viral resistance to the four neuraminidase inhibitors (NAIs), we measured their 50% inhibitory concentration (IC50) for influenza virus isolates from the 2014-2015 influenza season for comparison with those circulating in the 2010-2011 to 2013-2014 influenza seasons. Viral isolation was done with specimens obtained prior to treatment, and the type and subtype of influenza was determined by RT-PCR using type- and subtype-specific primers. The IC50 was determined by a (mais)

The matrix gene of influenza A H5N1 in Egypt, 2006-2016: molecular insights and distribution of amantadine-resistant variants.

Autor(es): Naguib, Mahmoud M; Hagag, Naglaa; El-Sanousi, Ahmed A; Hussein, Hussein Ali; Arafa, Abdel-Satar
Fonte: Virus Genes;52(6): 872-876, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27448682
Resumo: Large-scale sequence analysis of Matrix (M) gene and its coding proteins M1 and M2 was performed for 274 highly pathogenic avian influenza viruses H5N1 circulated in Egypt from 2006 to 2016. The aim is to study the amantadine-resistant markers distribution and to estimate the evolutionary rate. 246 viruses were obtained from the Global Initiative on Sharing All Influenza Data base, and 28 additional viruses were sequenced. Maximum clade credibility (MCC) phylogenetic tree revealed that the (mais)

Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.

Autor(es): Kawakami, Toru; Hirabayashi, Yukio; Kawakami, Fumihiro; Isobe, Rei; Kaneko, Naoto; Mimura, Yuto; Ito, Toshiro; Furuta, Kiyoshi; Shimazaki, Mami; Nakazawa, Hideyuki; Kitano, Kiyoshi
Fonte: Intern Med;55(13): 1807-10, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27374689
Resumo: We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a (mais)

Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers.

Autor(es): Ma, Chunlong; Zhang, Jiantao; Wang, Jun
Fonte: Mol Pharmacol;90(3): 188-98, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27385729
Resumo: Adamantanes (amantadine and rimantadine) are one of the two classes of Food and Drug Administration-approved antiviral drugs used for the prevention and treatment of influenza A virus infections. They inhibit viral replication by blocking the wild-type (WT) M2 proton channel, thus preventing viral uncoating. However, their use was discontinued due to widespread drug resistance. Among a handful of drug-resistant mutants, M2-S31N is the predominant mutation and persists in more than 95% of cu (mais)

A Computational Model for Docking of Noncompetitive Neuraminidase Inhibitors and Probing their Binding Interactions with Neuraminidase of Influenza Virus H5N1.

Autor(es): Chintakrindi, Anand S; Martis, Elvis A F; Gohil, Devanshi J; Kothari, Sweta T; Chowdhary, Abhay S; Coutinho, Evans C; Kanyalkar, Meena A
Fonte: Curr Comput Aided Drug Des;12(4): 272-281, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27412704
Resumo: BACKGROUND: With cases of emergence of drug resistance to the current competitive inhibitors of neuraminidase (NA) such as oseltamivir and zanamavir, there is a present need for an alternative approach in the treatment of avian influenza. With this in view, some flavones and chalcones were designed based on quercetin, the most active naturally occurring noncompetitive inhibitor. OBJECTIVE: We attempt to understand the binding of quercetin to H5N1-NA, and synthetic analogs of quercetin namel (mais)

The significance of naturally occurring neuraminidase quasispecies of H5N1 avian influenza virus on resistance to oseltamivir: a point of concern.

Autor(es): Schaduangrat, Nalini; Phanich, Jiraphorn; Rungrotmongkol, Thanyada; Lerdsamran, Hatairat; Puthavathana, Pilaipan; Ubol, Sukathida
Fonte: J Gen Virol;97(6): 1311-23, 2016 Jun.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26935590
Resumo: Viral adaptability and survival arise due to the presence of quasispecies populations that are able to escape the immune response or produce drug-resistant variants. However, the presence of H5N1 virus with natural mutations acquired without any drug selection pressure poses a great threat. Cloacal samples collected from the 2004-2005 epidemics in Thailand from Asian open-billed storks revealed one major and several minor quasispecies populations with mutations on the oseltamivir (OTV)-bind (mais)
Resultados  1-12 de 60