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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 5.401

A plant-derived VLP influenza vaccine elicits a balanced immune response even in very old mice with co-morbidities.

Autor(es): Hodgins, Breanna; Pillet, Stephane; Landry, Nathalie; Ward, Brian James
Fonte: PLoS One;14(1): e0210009, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30629622
Resumo: BACKGROUND: The elderly are at high risk from influenza, in part because immunity wanes with age and through the accumulation of comorbidities. A novel plant-derived virus-like-particle (VLP) vaccine bearing influenza hemagglutinin can induce a balanced humoral and cellular response in old mice (16-18 months) while split virion vaccines elicit mostly antibodies. Because mice also collect comorbidities and lose immune competence as they age, we wished to determine how the plant-derived VLP v (mais)

The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis.

Autor(es): Ramsay, Lauren C; Buchan, Sarah A; Stirling, Robert G; Cowling, Benjamin J; Feng, Shuo; Kwong, Jeffrey C; Warshawsky, Bryna F
Fonte: BMC Med;17(1): 9, 2019 Jan 10.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30626399
Resumo: BACKGROUND: Conflicting results regarding the impact of repeated vaccination on influenza vaccine effectiveness (VE) may cause confusion regarding the benefits of receiving the current season's vaccine. METHODS: We systematically searched MEDLINE, Embase, PubMed, and Cumulative Index to Nursing and Allied Health Literature from database inception to August 17, 2016, for observational studies published in English that reported VE against laboratory-confirmed influenza for the following four (mais)

H2 influenza viruses: designing vaccines against future H2 pandemics.

Autor(es): Reneer, Z Beau; Ross, Ted M
Fonte: Biochem Soc Trans;2019 Jan 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30647144
Resumo: Influenza-related pathologies affect millions of people each year and the impact of influenza on the global economy and in our everyday lives has been well documented. Influenza viruses not only infect humans but also are zoonotic pathogens that infect various avian and mammalian species, which serve as viral reservoirs. While there are several strains of influenza currently circulating in animal species, H2 influenza viruses have a unique history and are of particular concern. The 1957 'As (mais)

Safety and immunogenicity of influenza A(H5N1) vaccine stored up to twelve years in the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS).

Autor(es): Oshansky, Christine M; Zhou, James; Gao, Yonghong; Schweinle, Jo Ellen; Biscardi, Karen; DeBeauchamp, Jennifer; Pavetto, Corrina; Wollish, Amy; Webby, Richard J; Cioce, Vittoria; Donis, Ruben O; Bright, Rick A
Fonte: Vaccine;37(3): 435-443, 2019 Jan 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30553570
Resumo: BACKGROUND: As part of the U.S. Department of Health and Human Services (HHS) Pandemic Influenza Plan preparedness and response strategy, the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS) program was established by the Biomedical Advanced Research and Development Authority (BARDA) in 2005 with the goal of building and maintaining a stockpile of vaccines for influenza viruses with pandemic potential to vaccinate 20 million people in the critical workforce in the event of a pandem (mais)

A comparison of viral microneutralization and haemagglutination inhibition assays as measures of seasonal inactivated influenza vaccine immunogenicity in the first year after reduced intensity conditioning, lymphocyte depleted allogeneic haematopoietic stem cell transplant.

Autor(es): Miller, Paul D E; de Silva, Thushan I; Leonard, Hayley; Anthias, Chloe; Hoschler, Katja; Goddard, Kathryn; Peggs, Karl; Madrigal, Alejandro; Snowden, John A
Fonte: Vaccine;37(3): 452-457, 2019 Jan 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30554797
Resumo: Traditionally, immune response to influenza vaccines has been measured using the haemagglutination inhibition (HAI) assay. A broader repertoire of techniques including the sensitive viral microneutralization (VMN) assay is now recommended by the European Medicines Agency (EMA). Comparing HAI and VMN, we determined immune response to a trivalent 2015-2016 seasonal inactivated influenza vaccine (SIIV) administered to 28 recipients of allogeneic haematopoietic stem cell transplant (HSCT). Vacc (mais)

Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus.

Autor(es): Lim, Jong-Woo; Na, Woonsung; Kim, Hyun-Ouk; Yeom, Minjoo; Park, Geunseon; Kang, Aram; Chun, Haejin; Park, Chaewon; Oh, Seungseok; Le, Van Phan; Jeong, Hyoung Hwa; Song, Daesub; Haam, Seungjoo
Fonte: Adv Healthc Mater;: e1800953, 2018 Dec 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30549426
Resumo: Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly (mais)

Efficacy, immunogenicity, and safety of a quadrivalent inactivated influenza vaccine in children aged 6-35 months: A multi-season randomised placebo-controlled trial in the Northern and Southern Hemispheres.

Autor(es): Pepin, Stephanie; Dupuy, Martin; Borja-Tabora, Charissa Fay Corazon; Montellano, May; Bravo, Lulu; Santos, Jaime; de Castro, Jo-Anne; Rivera-Medina, Doris Maribel; Cutland, Clare; Ariza, Miguel; Diez-Domingo, Javier; Gonzalez, Celia Diaz; Martinón-Torres, Federico; Papadopoulou-Alataki, Efimia; Theodoriadou, Maria; Kazek-Duret, Marie Pierre; Gurunathan, Sanjay; De Bruijn, Iris
Fonte: Vaccine;2018 Dec 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30558818
Resumo: BACKGROUND: A quadrivalent split-virion inactivated influenza vaccine (VaxigripTetra™, Sanofi Pasteur; IIV4) containing two A strains (H1N1 and H3N2) and B strains from both lineages (Victoria and Yamagata) was approved in Europe in 2016 for individuals aged ≥ 3 years. This study examined the efficacy and safety of IIV4 in children aged 6-35 months. METHODS: This was a phase III randomised controlled trial conducted in Latin America, Asia, Africa, and Europe (mais)

Prevention of influenza hospitalization among adults in the US, 2015-16: Results from the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).

Autor(es): Ferdinands, J M; Gaglani, M; Martin, E T; Middleton, D; Monto, A S; Murthy, K; Silveira, F P; Talbot, H K; Zimmerman, R; Alyanak, E; Strickland, C; Spencer, S; Fry, A M
Fonte: J Infect Dis;2018 Dec 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30561689
Resumo: Background: Evidence establishing effectiveness of influenza vaccination for prevention of severe illness is limited. The US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) is a multi-year test-negative case-control study initiated in 2015-16 to estimate effectiveness of vaccine in preventing influenza hospitalization among adults. Methods: Adults aged ≥18 years admitted to eight US hospitals with acute respiratory illness and testing positive for influenza by PCR (mais)

Correction: Split inactivated COBRA vaccine elicits protective antibodies against H1N1 and H3N2 influenza viruses.

Autor(es): Allen, James D; Ray, Satyajit; Ross, Ted M
Fonte: PLoS One;13(12): e0210043, 2018.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30589902
Resumo: [This corrects the article DOI: 10.1371/journal.pone.0204284.].

Development of a novel oil-in-water emulsion and evaluation of its potential adjuvant function in a swine influenza vaccine in mice.

Autor(es): Zhang, Jinqiu; Miao, Jinfeng; Han, Xiangan; Lu, Yu; Deng, Bihua; Lv, Fang; Zhao, Yanhong; Ding, Chan; Hou, Jibo
Fonte: BMC Vet Res;14(1): 415, 2018 Dec 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30577861
Resumo: BACKGROUND: Vaccination is the principal strategy for prevention and control of diseases, and adjuvant use is an effective strategy to enhance vaccine efficacy. Traditional mineral oil-based adjuvants have been reported with post-immunization reactions. Developing new adjuvant formulations with improved potency and safety will be of great value. RESULTS: In the study reported herein, a novel oil-in-water (O/W) Emulsion Adjuvant containing Squalane (termed EAS) was developed, characterized a (mais)
Resultados  1-12 de 5.401