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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 923

A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9.

Autor(es): Li, Zhanping; Wan, Zhimin; Li, Tuofan; Xie, Quan; Sun, Haiwei; Chen, Hongjun; Liang, Guangchen; Shao, Hongxia; Qin, Aijian; Ye, Jianqiang
Fonte: Vet Microbiol;228: 39-44, 2019 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30593378
Resumo: In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus (IAV). These mAbs could react with HA of H7N9, H3N2, and H9N2 with neutralizing activity. A novel linear epitope recognized by these mAbs was identified by peptide-based ELISA, and this epitope was located in TAADYKSTQSAIDQITGKLN at the C terminus of the helix A of H7N9. 3 A11, which is one of (mais)

Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice.

Autor(es): Kuah, Li-Fang; Tang, Lay-Hoon; Sutton, Troy; Lim, Jie-Hui; Sin, Wan-Ling; Lamirande, Elaine; Subbarao, Kanta; Lau, Yuk-Fai
Fonte: J Gen Virol;98(2): 155-165, 2017 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27983474
Resumo: Human infections with A/Jiangxi-Donghu/346/2013 (H10N8) virus have raised concerns about its pandemic potential. In order to develop a vaccine against this virus, the immunogenicity of its haemagglutinin protein was evaluated in mice. Using both whole-virion and recombinant subunit protein vaccines, we showed that two doses of either vaccine elicited neutralizing antibody responses. The protective efficacy of the vaccine-induced responses was assessed using a reverse-genetics-derived H10 re (mais)

A Molecular-Level Account of the Antigenic Hantaviral Surface.

Autor(es): Li, Sai; Rissanen, Ilona; Zeltina, Antra; Hepojoki, Jussi; Raghwani, Jayna; Harlos, Karl; Pybus, Oliver G; Huiskonen, Juha T; Bowden, Thomas A
Fonte: Cell Rep;15(5): 959-967, 2016 05 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27117403
Resumo: Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula han (mais)

Mapping Antigenic Epitopes on the Human Bocavirus Capsid.

Autor(es): Kailasan, Shweta; Garrison, Jamie; Ilyas, Maria; Chipman, Paul; McKenna, Robert; Kantola, Kalle; Söderlund-Venermo, Maria; Kucinskaite-Kodze, Indre; Zvirbliene, Aurelija; Agbandje-McKenna, Mavis
Fonte: J Virol;90(9): 4670-4680, 2016 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26912619
Resumo: UNLABELLED: Human bocaviruses (HBoV1 to -4) are emerging pathogens associated with pneumonia and/or diarrhea in young children. Currently, there is no treatment or vaccination, so there is a need to study these pathogens to understand their disease mechanisms on a molecular and structural level for the development of control strategies. Here, we report the structures of six HBoV monoclonal antibody (MAb) fragment complexes, HBoV1-15C6, HBoV2-15C6, HBoV4-15C6, HBoV1-4C2, HBoV1-9G12, and HBoV (mais)

Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination.

Autor(es): Luo, Zhenwu; Ma, Lei; Zhang, Lumin; Martin, Lisa; Wan, Zhuang; Warth, Stephanie; Kilby, Andrew; Gao, Yong; Bhargava, Pallavi; Li, Zhen; Wu, Hao; Meissner, Eric G; Li, Zihai; Kilby, J Michael; Liao, Guoyang; Jiang, Wei
Fonte: Vaccine;34(16): 1945-55, 2016 Apr 07.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26721328
Resumo: BACKGROUND: There is increasing recognition of the role of B cell dysfunction in HIV pathogenesis, but little is known about how these perturbations may influence responses to vaccinations. METHODS: Healthy controls (n=16) and antiretroviral therapy (ART)-treated aviremic HIV-infected subjects (n=26) receiving standard-of-care annual influenza vaccinations were enrolled in the present study. Total bacterial 16S rDNA levels were assessed by quantitative polymerase chain reactions in plasma. (mais)

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Autor(es): Sobolev, Olga; Binda, Elisa; O'Farrell, Sean; Lorenc, Anna; Pradines, Joel; Huang, Yongqing; Duffner, Jay; Schulz, Reiner; Cason, John; Zambon, Maria; Malim, Michael H; Peakman, Mark; Cope, Andrew; Capila, Ishan; Kaundinya, Ganesh V; Hayday, Adrian C
Fonte: Nat Immunol;17(2): 204-13, 2016 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26726811
Resumo: Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was subtly but significantly different in people older than ∼35 years. Wide-ran (mais)

Concurrent epidemics of influenza A/H3N2 and A/H1N1pdm in Southern China: A serial cross-sectional study.

Autor(es): Wu, Chunli; Wang, Maggie Haitian; Lu, Xing; Chong, Ka Chun; He, Jason; Yau, Chun-Yip; Hui, Mark; Cheng, Xiaowen; Yang, Li; Zee, Benny Chung-Ying; Zhang, Renli; He, Ming-Liang
Fonte: J Infect;72(3): 369-76, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26747013
Resumo: OBJECTIVES: This study aimed to elucidate the antibody response pattern of multiple influenza subtypes through a 4-year serological study of a general population in Shenzhen, Southern China. METHODS: A serial cross-sectional serological survey was conducted at eight time points between 2009 and 2012. A total number of 5876 subjects were recruited from all age groups. The influenza subtypes tested were A/H1N1, A/H3N2, B/Yamagata, B/Victoria, and A/H1N1pdm. Genetic sequencing and phylogenetic (mais)

Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

Autor(es): Wang, Wei; Alvarado-Facundo, Esmeralda; Chen, Qiong; Anderson, Christine M; Scott, Dorothy; Vassell, Russell; Weiss, Carol D
Fonte: J Infect Dis;213(3): 403-6, 2016 Feb 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26243315
Resumo: We examined serum samples from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (≥160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/H (mais)

Immunogenicity and sustainability of the immune response in Brazilian HIV-1-infected individuals vaccinated with inactivated triple influenza vaccine.

Autor(es): Souza, Thiago Moreno L; Santini-Oliveira, Marilia; Martorelli, Andressa; Luz, Paula M; Vasconcellos, Mauricio T L; Giacoia-Gripp, Carmem B W; Morgado, Mariza; Nunes, Estevão P; Lemos, Alberto S; Ferreira, Ana C G; Moreira, Ronaldo I; Veloso, Valdiléa G; Siqueira, Marilda; Grinsztejn, Beatriz; Camacho, Luiz A B
Fonte: J Med Virol;88(3): 426-36, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26267817
Resumo: HIV-infected individuals have a higher risk of serious illnesses following infection by infection with influenza. Although anti-influenza vaccination is recommended, immunosuppression may limit their response to active immunization. We followed-up a cohort of HIV-infected individuals vaccinated against influenza to assess the immunogenicity and sustainability of the immune response to vaccination. Individuals were vaccinated 2011 with inactivated triple influenza vaccine (TIV), and they had (mais)

Randomized Controlled Trial of Adjuvanted Versus Nonadjuvanted Influenza Vaccine in Kidney Transplant Recipients.

Autor(es): Kumar, Deepali; Campbell, Patricia; Hoschler, Katja; Hidalgo, Luis; Al-Dabbagh, Mona; Wilson, Leticia; Humar, Atul
Fonte: Transplantation;100(3): 662-9, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26335915
Resumo: BACKGROUND: Influenza vaccine containing an oil-in-water emulsion adjuvant (MF-59) may lead to greater immunogenicity in organ transplant recipients. However, alloimmunization may be a concern with adjuvanted vaccines. METHODS: We conducted a randomized trial comparing the safety and immunogenicity of adjuvanted versus nonadjuvanted influenza vaccine in adult kidney transplant patients. Patients were randomized 1:1 to receive 2012 to 2013 influenza vaccine with or without MF59 adjuvant. Pre (mais)

Comparative Efficacy of Monoclonal Antibodies That Bind to Different Epitopes of the 2009 Pandemic H1N1 Influenza Virus Neuraminidase.

Autor(es): Jiang, Lianlian; Fantoni, Giovanna; Couzens, Laura; Gao, Jin; Plant, Ewan; Ye, Zhiping; Eichelberger, Maryna C; Wan, Hongquan
Fonte: J Virol;90(1): 117-28, 2016 01 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26468531
Resumo: UNLABELLED: Antibodies against the neuraminidase (NA) of influenza virus correlate with resistance against disease, but the effectiveness of antibodies against different NA epitopes has not been compared. In the present study, we evaluated the in vitro and in vivo efficacies of four monoclonal antibodies (MAbs): HF5 and CD6, which are specific to two different epitopes in the NA of 2009 pandemic H1N1 (pH1N1) virus, and 4E9 and 1H5, which are specific to a conserved epitope in the NA of both (mais)

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin.

Autor(es): Brazzoli, Michela; Magini, Diletta; Bonci, Alessandra; Buccato, Scilla; Giovani, Cinzia; Kratzer, Roland; Zurli, Vanessa; Mangiavacchi, Simona; Casini, Daniele; Brito, Luis M; De Gregorio, Ennio; Mason, Peter W; Ulmer, Jeffrey B; Geall, Andrew J; Bertholet, Sylvie
Fonte: J Virol;90(1): 332-44, 2016 01 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26468547
Resumo: UNLABELLED: Seasonal influenza is a vaccine-preventable disease that remains a major health problem worldwide, especially in immunocompromised populations. The impact of influenza disease is even greater when strains drift, and influenza pandemics can result when animal-derived influenza virus strains combine with seasonal strains. In this study, we used the SAM technology and characterized the immunogenicity and efficacy of a self-amplifying mRNA expressing influenza virus hemagglutinin (H (mais)
Resultados  1-12 de 923