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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 82

Establishment of memory CD8+ T cells with live attenuated influenza virus across different vaccination doses.

Autor(es): Wang, Zhongfang; Kedzierski, Lukasz; Nuessing, Simone; Chua, Brendon Yew Loong; Quiñones-Parra, Sergio M; Huber, Victor C; Jackson, David C; Thomas, Paul G; Kedzierska, Katherine
Fonte: J Gen Virol;97(12): 3205-3214, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27902386
Resumo: FluMist has been used in children and adults for more than 10 years. As pre-existing CD8+ T cell memory pools can provide heterologous immunity against distinct influenza viruses, it is important to understand influenza-specific CD8+ T cell responses elicited by different live attenuated influenza virus (LAIV) regimens. In this study, we immunized mice intranasally with two different doses of live-attenuated PR8 virus (PR8 ts, H1N1), low and high, and then assessed protective efficacy by ch (mais)

Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains.

Autor(es): Petrie, Joshua G; Parkhouse, Kaela; Ohmit, Suzanne E; Malosh, Ryan E; Monto, Arnold S; Hensley, Scott E
Fonte: J Infect Dis;214(12): 1947-1951, 2016 Dec 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27923954
Resumo: During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 st (mais)

Generation and characterisation of monoclonal antibodies specific to avian influenza H7N9 haemagglutinin protein.

Autor(es): Malik, A; Mallajosyula, Vva; Mishra, N N; Arukha, A P; Varadarajan, R; Gupta, S K
Fonte: Indian J Med Microbiol;34(4): 489-494, 2016 Oct-Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934828
Resumo: INTRODUCTION: Emerging virulent strains of influenza virus pose a serious public health threat with potential pandemic consequences. A novel avian influenza virus, H7N9, breached the species barrier from infected domestic poultry to humans in 2013 in China. Since then, it has caused numerous infections in humans with a close contact to poultry. MATERIALS AND METHODS: In this study, we describe the preliminary characterisation of five murine monoclonal antibodies (MAbs) developed against rec (mais)

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.

Autor(es): Lee, Jiwon; Boutz, Daniel R; Chromikova, Veronika; Joyce, M Gordon; Vollmers, Christopher; Leung, Kwanyee; Horton, Andrew P; DeKosky, Brandon J; Lee, Chang-Han; Lavinder, Jason J; Murrin, Ellen M; Chrysostomou, Constantine; Hoi, Kam Hon; Tsybovsky, Yaroslav; Thomas, Paul V; Druz, Aliaksandr; Zhang, Baoshan; Zhang, Yi; Wang, Lingshu; Kong, Wing-Pui; Park, Daechan; Popova, Lyubov I; Dekker, Cornelia L; Davis, Mark M; Carter, Chalise E; Ross, Ted M; Ellington, Andrew D; Wilson, Patrick C; Marcotte, Edward M; Mascola, John R; Ippolito, Gregory C; Krammer, Florian; Quake, Stephen R; Kwong, Peter D; Georgiou, George
Fonte: Nat Med;22(12): 1456-1464, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27820605
Resumo: Molecular understanding of serological immunity to influenza has been confounded by the complexity of the polyclonal antibody response in humans. Here we used high-resolution proteomics analysis of immunoglobulin (referred to as Ig-seq) coupled with high-throughput sequencing of transcripts encoding B cell receptors (BCR-seq) to quantitatively determine the antibody repertoire at the individual clonotype level in the sera of young adults before and after vaccination with trivalent seasonal (mais)

Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China.

Autor(es): Veljkovic, Veljko; Veljkovic, Nevena; Paessler, Slobodan; Goeijenbier, Marco; Perovic, Vladimir; Glisic, Sanja; Muller, Claude P
Fonte: PLoS One;11(11): e0165451, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27828989
Resumo: Influenza A virus (IAV) subtypes against which little or no pre-existing immunity exists in humans represent a serious threat to global public health. Monitoring of IAV in animal hosts is essential for early and rapid detection of potential pandemic IAV strains to prevent their spread. Recently, the increased pandemic potential of the avian-like swine H1N1 IAV A/swine/Guangdong/104/2013 has been suggested. The virus is infectious in humans and the general population seems to lack neutralizi (mais)

Detection of porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) in oral fluid of pigs.

Autor(es): Biernacka, Kinga; Karbowiak, Pawel; Wróbel, Pawel; Chareza, Tomasz; Czopowicz, Michal; Balka, Gyula; Goodell, Christa; Rauh, Rolf; Stadejek, Tomasz
Fonte: Res Vet Sci;109: 74-80, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27892877
Resumo: Recently oral fluid has become a novel sample type for pathogen nucleic acid and antibody detection, as it is easy to obtain with non-invasive procedures. The objective of the study was to analyze porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) circulation in growing pigs from three Polish production farms, using Real Time PCR and ELISA testing of oral fluid and serum. Oral fluids were collected every 2weeks, in the same 3-4 pens of pigs aged between (mais)

HA1-2-fljB Vaccine Induces Immune Responses against Pandemic Swine-Origin H1N1 Influenza Virus in Mice.

Autor(es): Kang, Xilong; Yang, Yun; Jiao, Yang; Song, Hongqin; Song, Li; Xiong, Dan; Wu, Lili; Pan, Zhiming; Jiao, Xinan
Fonte: J Mol Microbiol Biotechnol;26(6): 422-432, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27721310
Resumo: In 2009, a novel pandemic swine-origin influenza A (H1N1) virus caused a public emergency of international concern. Vaccination is the primary strategy for the control of influenza epidemics. However, the poor immunopotency of many vaccine antigens is a major barrier to the development of effective vaccines against influenza. Flagellin, a Toll-like receptor 5 (TLR5) ligand, has been used as an adjuvant to enhance the immunopotency of vaccines in preclinical studies. Here, we developed a rec (mais)

Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.

Autor(es): Liu, William J; Tan, Shuguang; Zhao, Min; Quan, Chuansong; Bi, Yuhai; Wu, Ying; Zhang, Shuijun; Zhang, Haifeng; Xiao, Haixia; Qi, Jianxun; Yan, Jinghua; Liu, Wenjun; Yu, Hongjie; Shu, Yuelong; Wu, Guizhen; Gao, George F
Fonte: J Infect Dis;214(12): 1937-1946, 2016 Dec 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27738054
Resumo: BACKGROUND: The emergence of infections by the novel avian influenza A(H7N9) virus has posed a threat to human health. Cross-immunity between A(H7N9) and other heterosubtypic influenza viruses affected by antigenicity-dependent substitutions needs to be investigated. METHODS: We investigated the cellular and humoral immune responses against A(H7N9) and 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09), by serological and T-cell-specific assays, in a healthy population. The molecular ba (mais)

Titration of individual strains in trivalent live-attenuated influenza vaccine without neutralization.

Autor(es): Sirinonthanawech, Naraporn; Surichan, Somchaiya; Namsai, Aphinya; Puthavathana, Pilaipan; Auewarakul, Prasert; Kongchanagul, Alita
Fonte: J Virol Methods;237: 154-158, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27596269
Resumo: Formulation and quality control of trivalent live-attenuated influenza vaccine requires titration of infectivity of individual strains in the trivalent mix. This is usually performed by selective neutralization of two of the three strains and titration of the un-neutralized strain in cell culture or embryonated eggs. This procedure requires standard sera with high neutralizing titer against each of the three strains. Obtaining standard sera, which can specifically neutralize only the corres (mais)

Human Monoclonal Antibody 81.39a Effectively Neutralizes Emerging Influenza A Viruses of Group 1 and 2 Hemagglutinins.

Autor(es): Marjuki, Henju; Mishin, Vasiliy P; Chai, Ning; Tan, Man-Wah; Newton, Elizabeth M; Tegeris, John; Erlandson, Karl; Willis, Melissa; Jones, Joyce; Davis, Todd; Stevens, James; Gubareva, Larisa V
Fonte: J Virol;90(23): 10446-10458, 2016 Dec 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27630240
Resumo: The pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza virus infections. Here, we investigated the ability of the hMAb 81.39a to inhibit in vitro replication of human and zoonotic viruses, representing 16 HA subtypes. The majority of viruses were effectively neutralized (mais)

Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir.

Autor(es): Puryear, Wendy Blay; Keogh, Mandy; Hill, Nichola; Moxley, Jerry; Josephson, Elizabeth; Davis, Kimberly Ryan; Bandoro, Chistopher; Lidgard, Damian; Bogomolni, Andrea; Levin, Milton; Lang, Shelley; Hammill, Michael; Bowen, Don; Johnston, David W; Romano, Tracy; Waring, Gordon; Runstadler, Jonathan
Fonte: Emerg Microbes Infect;5(8): e81, 2016 Aug 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27485496
Resumo: Influenza A virus (IAV) has been associated with multiple unusual mortality events (UMEs) in North Atlantic pinnipeds, frequently attributed to spillover of virus from wild-bird reservoirs. To determine if endemic infection persists outside of UMEs, we undertook a multiyear investigation of IAV in healthy, live-captured Northwest Atlantic gray seals (Halichoerus grypus). From 2013 to 2015, we sampled 345 pups and 57 adults from Cape Cod, MA, USA and Nova Scotia, Canada consistently detectin (mais)

Maternally-derived antibodies do not prevent transmission of swine influenza A virus between pigs.

Autor(es): Cador, Charlie; Hervé, Séverine; Andraud, Mathieu; Gorin, Stéphane; Paboeuf, Frédéric; Barbier, Nicolas; Quéguiner, Stéphane; Deblanc, Céline; Simon, Gaëlle; Rose, Nicolas
Fonte: Vet Res;47(1): 86, 2016 Aug 17.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27530456
Resumo: A transmission experiment involving 5-week-old specific-pathogen-free (SPF) piglets, with (MDA(+)) or without maternally-derived antibodies (MDA(-)), was carried out to evaluate the impact of passive immunity on the transmission of a swine influenza A virus (swIAV). In each group (MDA(+)/MDA(-)), 2 seeders were placed with 4 piglets in direct contact and 5 in indirect contact (3 replicates per group). Serological kinetics (ELISA) and individual viral shedding (RT-PCR) were monitored for 28 (mais)
Resultados  1-12 de 82