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Resultados  1-12 de 57
1.

Generation and characterisation of monoclonal antibodies specific to avian influenza H7N9 haemagglutinin protein.

Autor(es): Malik, A; Mallajosyula, Vva; Mishra, N N; Arukha, A P; Varadarajan, R; Gupta, S K
Fonte: Indian J Med Microbiol;34(4): 489-494, 2016 Oct-Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934828
Resumo: INTRODUCTION: Emerging virulent strains of influenza virus pose a serious public health threat with potential pandemic consequences. A novel avian influenza virus, H7N9, breached the species barrier from infected domestic poultry to humans in 2013 in China. Since then, it has caused numerous infections in humans with a close contact to poultry. MATERIALS AND METHODS: In this study, we describe the preliminary characterisation of five murine monoclonal antibodies (MAbs) developed against rec (mais)
2.

Detection of porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) in oral fluid of pigs.

Autor(es): Biernacka, Kinga; Karbowiak, Pawel; Wróbel, Pawel; Chareza, Tomasz; Czopowicz, Michal; Balka, Gyula; Goodell, Christa; Rauh, Rolf; Stadejek, Tomasz
Fonte: Res Vet Sci;109: 74-80, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27892877
Resumo: Recently oral fluid has become a novel sample type for pathogen nucleic acid and antibody detection, as it is easy to obtain with non-invasive procedures. The objective of the study was to analyze porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) circulation in growing pigs from three Polish production farms, using Real Time PCR and ELISA testing of oral fluid and serum. Oral fluids were collected every 2weeks, in the same 3-4 pens of pigs aged between (mais)
3.

Vitamins as influenza vaccine adjuvant components.

Autor(es): Quintilio, Wagner; de Freitas, Fábio Alessandro; Rodriguez, Dunia; Kubrusly, Flavia Saldanha; Yourtov, Dimitri; Miyaki, Cosue; de Cerqueira Leite, Luciana Cezar; Raw, Isaias
Fonte: Arch Virol;161(10): 2787-95, 2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27449155
Resumo: A number of adjuvant formulations were assayed in mice immunized with 3.75 µg of A/California/7/2009 (H1N1) pdm09 influenza vaccine with vitamins A, D and/or E in emulsions or B2 and/or B9 combined with Bordetella pertussis MPLA and/or alum as adjuvants. Squalene was used as positive control, as well as MPLA with alum. The immune response was evaluated by a panel of tests, including a hemagglutination inhibition (HAI) test, ELISA for IgG, IgG1, and IgG2a and IFN-γ, IL-2, IL-6 and IL-10 (mais)
4.

Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir.

Autor(es): Puryear, Wendy Blay; Keogh, Mandy; Hill, Nichola; Moxley, Jerry; Josephson, Elizabeth; Davis, Kimberly Ryan; Bandoro, Chistopher; Lidgard, Damian; Bogomolni, Andrea; Levin, Milton; Lang, Shelley; Hammill, Michael; Bowen, Don; Johnston, David W; Romano, Tracy; Waring, Gordon; Runstadler, Jonathan
Fonte: Emerg Microbes Infect;5(8): e81, 2016 Aug 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27485496
Resumo: Influenza A virus (IAV) has been associated with multiple unusual mortality events (UMEs) in North Atlantic pinnipeds, frequently attributed to spillover of virus from wild-bird reservoirs. To determine if endemic infection persists outside of UMEs, we undertook a multiyear investigation of IAV in healthy, live-captured Northwest Atlantic gray seals (Halichoerus grypus). From 2013 to 2015, we sampled 345 pups and 57 adults from Cape Cod, MA, USA and Nova Scotia, Canada consistently detectin (mais)
5.

Particle and subunit-based hemagglutinin vaccines provide protective efficacy against H1N1 influenza in pigs.

Autor(es): Hernandez, Luis A; Miller, Cathy L; Vaughn, Eric M
Fonte: Vet Microbiol;191: 35-43, 2016 Aug 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27374905
Resumo: The increasing diversity of influenza strains circulating in swine herds escalates the potential for the emergence of novel pandemic viruses and highlights the need for swift development of new vaccines. Baculovirus has proven to be a flexible platform for the generation of recombinant forms of hemagglutinin (HA) including subunit, VLP-displayed, and baculovirus-displayed antigens. These presentations have been shown to be efficacious in mouse, chicken, and ferret models but little is known (mais)
6.

[Preparation and Identification of High Immunogenic A/PR/8/34 Maternal Strain HA Protein for Influenza Virus Classical Reassortment].

Autor(es): Tang, Jing; Xin, Li; Guo, Junfeng; Zhu, Wenfei; Zhang, Heyuan; Lang, Shaohui; Wang, Dayan; Shu, Yuelong
Fonte: Bing Du Xue Bao;32(2): 141-4, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27396155
Resumo: Preparation of maternal strain A/PR/8/34 HA antiserum for influenza virus classical reassortment. A/PR/8/34 virus was digested by bromelain after inactivation and purification. 5%-20% sucrose continuous density gradient centrifugation method was used to purify HA protein. SIRD method was used to select the target protein. SDS-PAGE method was used to identified HA protein. High Immunogenic A/PR/8/34 HA protein was successfully prepared and HI titer reached 10240. High purity HA antiserum was (mais)
7.

What Lies Beneath: Antibody Dependent Natural Killer Cell Activation by Antibodies to Internal Influenza Virus Proteins.

Autor(es): Vanderven, Hillary A; Ana-Sosa-Batiz, Fernanda; Jegaskanda, Sinthujan; Rockman, Steven; Laurie, Karen; Barr, Ian; Chen, Weisan; Wines, Bruce; Hogarth, P Mark; Lambe, Teresa; Gilbert, Sarah C; Parsons, Matthew S; Kent, Stephen J
Fonte: EBioMedicine;8: 277-90, 2016 Jun.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27428437
Resumo: The conserved internal influenza proteins nucleoprotein (NP) and matrix 1 (M1) are well characterised for T cell immunity, but whether they also elicit functional antibodies capable of activating natural killer (NK) cells has not been explored. We studied NP and M1-specific ADCC activity using biochemical, NK cell activation and killing assays with plasma from healthy and influenza-infected subjects. Healthy adults had antibodies to M1 and NP capable of binding dimeric FcγRIIIa and activ (mais)
8.

Statistical inference of a convergent antibody repertoire response to influenza vaccine.

Autor(es): Strauli, Nicolas B; Hernandez, Ryan D
Fonte: Genome Med;8(1): 60, 2016 06 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27255379
Resumo: BACKGROUND: Vaccines dramatically affect an individual's adaptive immune system and thus provide an excellent means to study human immunity. Upon vaccination, the B cells that express antibodies (Abs) that happen to bind the vaccine are stimulated to proliferate and undergo mutagenesis at their Ab locus. This process may alter the composition of B cell lineages within an individual, which are known collectively as the antibody repertoire (AbR). Antibodies are also highly expressed in whole (mais)
9.

[DEVELOPMENT OF THE QUADRIVALENT LIVE ATTENUATED INFLUENZA VACCINE INCLUDING TWO INFLUENZA B LINEAGES--VICTORIA AND YAMAGATA].

Autor(es): Desheva, Yu A; Smolonogina, T A; Doroshenko, E M; Rudenko, L G
Fonte: Vopr Virusol;61(1): 16-20, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27145595
Resumo: This work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. The intranasal immunization of the CBA mice with both Victoria and Yamagata strains induced 100% lung protection against the subsequent infection with the wild-type influenza B viruses of any antigen lineage. The quadrivalent LAIV (qLAIV) comprising both reassortant influenza B viruses Victoria and Yamagata were s (mais)
10.

Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?

Autor(es): Tamura, Shin-Ichi; Ainai, Akira; Suzuki, Tadaki; Kurata, Takeshi; Hasegawa, Hideki
Fonte: Jpn J Infect Dis;69(3): 165-79, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27212584
Resumo: Influenza is a contagious, acute respiratory disease caused by the influenza virus. The mucosal lining in the host respiratory tract is not only the site of virus infection, but also the site of defense; it is at this site that the host immune response targets the virus and protects against reinfection. One of the most effective methods to prevent influenza is to induce specific antibody (Ab) responses in the respiratory tract by vaccination. Two types of influenza vaccines, intranasal live (mais)
11.

Evaluation of the immunogenicity and protective effects of a trivalent chimeric norovirus P particle immunogen displaying influenza HA2 from subtypes H1, H3 and B.

Autor(es): Gong, Xin; Yin, He; Shi, Yuhua; He, Xiaoqiu; Yu, Yongjiao; Guan, Shanshan; Kuai, Ziyu; Haji, Nasteha M; Haji, Nafisa M; Kong, Wei; Shan, Yaming
Fonte: Emerg Microbes Infect;5: e51, 2016 May 25.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27222326
Resumo: The ectodomain of the influenza A virus (IAV) hemagglutinin (HA) stem is highly conserved across strains and has shown promise as a universal influenza vaccine in a mouse model. In this study, potential B-cell epitopes were found through sequence alignment and epitope prediction in a stem fragment, HA2:90-105, which is highly conserved among virus subtypes H1, H3 and B. A norovirus (NoV) P particle platform was used to express the HA2:90-105 sequences from subtypes H1, H3 and B in loops 1, (mais)
12.

Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses.

Autor(es): Carter, Donald M; Darby, Christopher A; Lefoley, Bradford C; Crevar, Corey J; Alefantis, Timothy; Oomen, Raymond; Anderson, Stephen F; Strugnell, Tod; Cortés-Garcia, Guadalupe; Vogel, Thorsten U; Parrington, Mark; Kleanthous, Harold; Ross, Ted M
Fonte: J Virol;90(9): 4720-34, 2016 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26912624
Resumo: UNLABELLED: One of the challenges of developing influenza A vaccines is the diversity of antigenically distinct isolates. Previously, a novel hemagglutinin (HA) for H5N1 influenza was derived from a methodology termed computationally optimized broadly reactive antigen (COBRA). This COBRA HA elicited a broad antibody response against H5N1 isolates from different clades. We now report the development and characterization of a COBRA-based vaccine for both seasonal and pandemic H1N1 influenza v (mais)
Resultados  1-12 de 57