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Resultados  1-12 de 74

Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains.

Autor(es): Petrie, Joshua G; Parkhouse, Kaela; Ohmit, Suzanne E; Malosh, Ryan E; Monto, Arnold S; Hensley, Scott E
Fonte: J Infect Dis;214(12): 1947-1951, 2016 Dec 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27923954
Resumo: During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 st (mais)

Generation and characterisation of monoclonal antibodies specific to avian influenza H7N9 haemagglutinin protein.

Autor(es): Malik, A; Mallajosyula, Vva; Mishra, N N; Arukha, A P; Varadarajan, R; Gupta, S K
Fonte: Indian J Med Microbiol;34(4): 489-494, 2016 Oct-Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934828
Resumo: INTRODUCTION: Emerging virulent strains of influenza virus pose a serious public health threat with potential pandemic consequences. A novel avian influenza virus, H7N9, breached the species barrier from infected domestic poultry to humans in 2013 in China. Since then, it has caused numerous infections in humans with a close contact to poultry. MATERIALS AND METHODS: In this study, we describe the preliminary characterisation of five murine monoclonal antibodies (MAbs) developed against rec (mais)

Detection of porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) in oral fluid of pigs.

Autor(es): Biernacka, Kinga; Karbowiak, Pawel; Wróbel, Pawel; Chareza, Tomasz; Czopowicz, Michal; Balka, Gyula; Goodell, Christa; Rauh, Rolf; Stadejek, Tomasz
Fonte: Res Vet Sci;109: 74-80, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27892877
Resumo: Recently oral fluid has become a novel sample type for pathogen nucleic acid and antibody detection, as it is easy to obtain with non-invasive procedures. The objective of the study was to analyze porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) circulation in growing pigs from three Polish production farms, using Real Time PCR and ELISA testing of oral fluid and serum. Oral fluids were collected every 2weeks, in the same 3-4 pens of pigs aged between (mais)

Establishment of memory CD8+ T cells with live attenuated influenza virus across different vaccination doses.

Autor(es): Wang, Zhongfang; Kedzierski, Lukasz; Nuessing, Simone; Chua, Brendon Yew Loong; Quiñones-Parra, Sergio M; Huber, Victor C; Jackson, David C; Thomas, Paul G; Kedzierska, Katherine
Fonte: J Gen Virol;97(12): 3205-3214, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27902386
Resumo: FluMist has been used in children and adults for more than 10 years. As pre-existing CD8+ T cell memory pools can provide heterologous immunity against distinct influenza viruses, it is important to understand influenza-specific CD8+ T cell responses elicited by different live attenuated influenza virus (LAIV) regimens. In this study, we immunized mice intranasally with two different doses of live-attenuated PR8 virus (PR8 ts, H1N1), low and high, and then assessed protective efficacy by ch (mais)

HA1-2-fljB Vaccine Induces Immune Responses against Pandemic Swine-Origin H1N1 Influenza Virus in Mice.

Autor(es): Kang, Xilong; Yang, Yun; Jiao, Yang; Song, Hongqin; Song, Li; Xiong, Dan; Wu, Lili; Pan, Zhiming; Jiao, Xinan
Fonte: J Mol Microbiol Biotechnol;26(6): 422-432, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27721310
Resumo: In 2009, a novel pandemic swine-origin influenza A (H1N1) virus caused a public emergency of international concern. Vaccination is the primary strategy for the control of influenza epidemics. However, the poor immunopotency of many vaccine antigens is a major barrier to the development of effective vaccines against influenza. Flagellin, a Toll-like receptor 5 (TLR5) ligand, has been used as an adjuvant to enhance the immunopotency of vaccines in preclinical studies. Here, we developed a rec (mais)

Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.

Autor(es): Liu, William J; Tan, Shuguang; Zhao, Min; Quan, Chuansong; Bi, Yuhai; Wu, Ying; Zhang, Shuijun; Zhang, Haifeng; Xiao, Haixia; Qi, Jianxun; Yan, Jinghua; Liu, Wenjun; Yu, Hongjie; Shu, Yuelong; Wu, Guizhen; Gao, George F
Fonte: J Infect Dis;214(12): 1937-1946, 2016 Dec 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27738054
Resumo: BACKGROUND: The emergence of infections by the novel avian influenza A(H7N9) virus has posed a threat to human health. Cross-immunity between A(H7N9) and other heterosubtypic influenza viruses affected by antigenicity-dependent substitutions needs to be investigated. METHODS: We investigated the cellular and humoral immune responses against A(H7N9) and 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09), by serological and T-cell-specific assays, in a healthy population. The molecular ba (mais)

Human Monoclonal Antibody 81.39a Effectively Neutralizes Emerging Influenza A Viruses of Group 1 and 2 Hemagglutinins.

Autor(es): Marjuki, Henju; Mishin, Vasiliy P; Chai, Ning; Tan, Man-Wah; Newton, Elizabeth M; Tegeris, John; Erlandson, Karl; Willis, Melissa; Jones, Joyce; Davis, Todd; Stevens, James; Gubareva, Larisa V
Fonte: J Virol;90(23): 10446-10458, 2016 Dec 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27630240
Resumo: The pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza virus infections. Here, we investigated the ability of the hMAb 81.39a to inhibit in vitro replication of human and zoonotic viruses, representing 16 HA subtypes. The majority of viruses were effectively neutralized (mais)

Influenza virus A(H1N1)2009 antibody-dependent cellular cytotoxicity in young children prior to the H1N1 pandemic.

Autor(es): Mesman, Annelies W; Westerhuis, Brenda M; Ten Hulscher, Hinke I; Jacobi, Ronald H; de Bruin, Erwin; van Beek, Josine; Buisman, Annemarie M; Koopmans, Marion P; van Binnendijk, Robert S
Fonte: J Gen Virol;97(9): 2157-65, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27412007
Resumo: Pre-existing immunity played a significant role in protection during the latest influenza A virus H1N1 pandemic, especially in older age groups. Structural similarities were found between A(H1N1)2009 and older H1N1 virus strains to which humans had already been exposed. Broadly cross-reactive antibodies capable of neutralizing the A(H1N1)2009 virus have been implicated in this immune protection in adults. We investigated the serological profile of a group of young children aged 9 years (n=5 (mais)

Influenza-associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S-deficient boy.

Autor(es): Tsujii, Nobuyuki; Nogami, Keiji; Yoshizawa, Hiroyuki; Hayakawa, Masaki; Isonishi, Ayami; Matsumoto, Masanori; Shima, Midori
Fonte: Pediatr Int;58(9): 926-9, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27435311
Resumo: Influenza infections often cause pneumonia, but there is limited information on thrombotic microangiopathy (TMA) in these circumstances. We report the case of an 11-year-old boy who developed TMA during the acute phase of H1N1 influenza. Plasma von Willebrand factor (VWF) was elevated, whereas a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity was mildly reduced in the absence of ADAMTS13-neutralizing autoantibody, resulting in low ratio of (mais)

Vitamins as influenza vaccine adjuvant components.

Autor(es): Quintilio, Wagner; de Freitas, Fábio Alessandro; Rodriguez, Dunia; Kubrusly, Flavia Saldanha; Yourtov, Dimitri; Miyaki, Cosue; de Cerqueira Leite, Luciana Cezar; Raw, Isaias
Fonte: Arch Virol;161(10): 2787-95, 2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27449155
Resumo: A number of adjuvant formulations were assayed in mice immunized with 3.75 µg of A/California/7/2009 (H1N1) pdm09 influenza vaccine with vitamins A, D and/or E in emulsions or B2 and/or B9 combined with Bordetella pertussis MPLA and/or alum as adjuvants. Squalene was used as positive control, as well as MPLA with alum. The immune response was evaluated by a panel of tests, including a hemagglutination inhibition (HAI) test, ELISA for IgG, IgG1, and IgG2a and IFN-γ, IL-2, IL-6 and IL-10 (mais)

Neutralization and Binding Profile of Monoclonal Antibodies Generated Against Influenza A H1N1 Viruses.

Autor(es): Shembekar, Nachiket; Mallajosyula, Vamsee V Aditya; Malik, Ankita; Saini, Ashok; Varadarajan, Raghavan; Gupta, Satish Kumar
Fonte: Monoclon Antib Immunodiagn Immunother;35(4): 191-8, 2016 Aug.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27463230
Resumo: Monoclonal antibodies (MAbs) provide scope for the development of better therapeutics and diagnostic tools. Herein, we describe the binding and neutralization profile(s) for a panel of murine MAbs generated against influenza A H1N1 viruses elicited by immunization with pandemic H1 recombinant hemagglutinin (rHA)/whole virus or seasonal H1 rHA. Neutralizing MAbs, MA-2070 and MA-M, were obtained after pandemic A/California/07/2009 (H1N1) virus/rHA immunization(s). Both MAbs reacted specifical (mais)

Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir.

Autor(es): Puryear, Wendy Blay; Keogh, Mandy; Hill, Nichola; Moxley, Jerry; Josephson, Elizabeth; Davis, Kimberly Ryan; Bandoro, Chistopher; Lidgard, Damian; Bogomolni, Andrea; Levin, Milton; Lang, Shelley; Hammill, Michael; Bowen, Don; Johnston, David W; Romano, Tracy; Waring, Gordon; Runstadler, Jonathan
Fonte: Emerg Microbes Infect;5(8): e81, 2016 Aug 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27485496
Resumo: Influenza A virus (IAV) has been associated with multiple unusual mortality events (UMEs) in North Atlantic pinnipeds, frequently attributed to spillover of virus from wild-bird reservoirs. To determine if endemic infection persists outside of UMEs, we undertook a multiyear investigation of IAV in healthy, live-captured Northwest Atlantic gray seals (Halichoerus grypus). From 2013 to 2015, we sampled 345 pups and 57 adults from Cape Cod, MA, USA and Nova Scotia, Canada consistently detectin (mais)
Resultados  1-12 de 74