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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 175

Establishment of memory CD8+ T cells with live attenuated influenza virus across different vaccination doses.

Autor(es): Wang, Zhongfang; Kedzierski, Lukasz; Nuessing, Simone; Chua, Brendon Yew Loong; Quiñones-Parra, Sergio M; Huber, Victor C; Jackson, David C; Thomas, Paul G; Kedzierska, Katherine
Fonte: J Gen Virol;97(12): 3205-3214, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27902386
Resumo: FluMist has been used in children and adults for more than 10 years. As pre-existing CD8+ T cell memory pools can provide heterologous immunity against distinct influenza viruses, it is important to understand influenza-specific CD8+ T cell responses elicited by different live attenuated influenza virus (LAIV) regimens. In this study, we immunized mice intranasally with two different doses of live-attenuated PR8 virus (PR8 ts, H1N1), low and high, and then assessed protective efficacy by ch (mais)

Regulation of Matrix Metalloproteinases-2 and -9 Gene Expression in Cultured Human Fetal Membrane Cells by Influenza Virus Infection.

Autor(es): Uchide, Noboru; Obatake, Kyoko; Yamada, Rie; Sadanari, Hidetaka; Matsubara, Keiko; Murayama, Tsugiya; Ohyama, Kunio
Fonte: Biol Pharm Bull;39(12): 1912-1921, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27904034
Resumo: In order to understand a possible etiology of adverse pregnancy outcomes associated with intrauterine influenza virus infection, we examined the effect of influenza virus infection on gene expression of matrix metalloproteinases (MMPs) in cultured amnion epithelial, amnion mesenchymal and chorion trophoblast cells prepared from human fetal membrane tissues by gelatin zymography, Western blotting and reverse transcriptase-PCR. The cells were infected with influenza A (H1N1) virus. The levels (mais)

An Epidemiological Analysis of Summer Influenza Epidemics in Okinawa.

Autor(es): Sunagawa, Satoko; Iha, Yoshikazu; Taira, Katsuya; Okano, Sho; Kinjo, Takeshi; Higa, Futoshi; Kuba, Kazufumi; Tateyama, Masao; Nakamura, Katsunori; Nakamura, Shota; Motooka, Daisuke; Horii, Toshihiro; Parrott, Gretchen L; Fujita, Jiro
Fonte: Intern Med;55(24): 3579-3584, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27980256
Resumo: Objective This study evaluates the difference between winter influenza and summer influenza in Okinawa. Methods From January 2007 to June 2014, weekly rapid antigen test (RAT) results performed in four acute care hospitals were collected for the surveillance of regional influenza prevalence in the Naha region of the Okinawa Islands. Results An antigenic data analysis revealed that multiple H1N1 and H3N2 viruses consistently co-circulate in Okinawa, creating synchronized seasonal patterns an (mais)

Genetic Characterization of Circulating 2015 A(H1N1)pdm09 Influenza Viruses from Eastern India.

Autor(es): Mukherjee, Anupam; Nayak, Mukti Kant; Dutta, Shanta; Panda, Samiran; Satpathi, Biswa Ranjan; Chawla-Sarkar, Mamta
Fonte: PLoS One;11(12): e0168464, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27997573
Resumo: In 2015, the swine derived A(H1N1)pdm09 pandemic strain outbreak became widespread throughout the different states of India. The reported cases and deaths in 2015 surpassed the previous years with more than 39000 laboratory confirmed cases and a death toll of more than 2500 people. There are relatively limited complete genetic sequences available for this virus from Asian countries. In this study, we describe the full genome analysis of influenza 2015 A(H1N1)pdm09 viruses isolated from West (mais)

Update: Influenza Activity - United States, October 2-December 17, 2016.

Autor(es): Shang, Mei; Blanton, Lenee; Kniss, Krista; Mustaquim, Desiree; Alabi, Noreen; Barnes, Stephen; Budd, Alicia; Davlin, Stacy L; Kramer, Natalie; Garg, Shikha; Cummings, Charisse N; Flannery, Brendan; Fry, Alicia M; Grohskopf, Lisa A; Olsen, Sonja J; Bresee, Joseph; Sessions, Wendy; Garten, Rebecca; Xu, Xiyan; Elal, Anwar Isa Abd; Gubareva, Larisa; Barnes, John; Wentworth, David E; Burns, Erin; Katz, Jacqueline; Jernigan, Daniel; Brammer, Lynnette
Fonte: MMWR Morb Mortal Wkly Rep;65(5051): 1439-1444, 2016 Dec 30.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 28033315
Resumo: This report summarizes U.S. influenza activity during October 2-December 17, 2016. Influenza activity in the United States remained low in October and has been slowly increasing since November. Influenza A viruses were identified most frequently, with influenza A (H3N2) viruses predominating. Most influenza viruses characterized during this period were genetically or antigenically similar to the reference viruses representing vaccine components recommended for production in the 2016-17 Northern Hemisphere influenza vaccines.

Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus.

Autor(es): Kerviel, Adeline; Dash, Shantoshini; Moncorgé, Olivier; Panthu, Baptiste; Prchal, Jan; Décimo, Didier; Ohlmann, Théophile; Lina, Bruno; Favard, Cyril; Decroly, Etienne; Ottmann, Michèle; Roingeard, Philippe; Muriaux, Delphine
Fonte: PLoS One;11(11): e0165421, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27814373
Resumo: The influenza A(H1N1)pdm09 virus caused the first influenza pandemic of the 21st century. In this study, we wanted to decipher the role of conserved basic residues of the viral M1 matrix protein in virus assembly and release. M1 plays many roles in the influenza virus replication cycle. Specifically, it participates in viral particle assembly, can associate with the viral ribonucleoprotein complexes and can bind to the cell plasma membrane and/or the cytoplasmic tail of viral transmembrane (mais)

Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China.

Autor(es): Veljkovic, Veljko; Veljkovic, Nevena; Paessler, Slobodan; Goeijenbier, Marco; Perovic, Vladimir; Glisic, Sanja; Muller, Claude P
Fonte: PLoS One;11(11): e0165451, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27828989
Resumo: Influenza A virus (IAV) subtypes against which little or no pre-existing immunity exists in humans represent a serious threat to global public health. Monitoring of IAV in animal hosts is essential for early and rapid detection of potential pandemic IAV strains to prevent their spread. Recently, the increased pandemic potential of the avian-like swine H1N1 IAV A/swine/Guangdong/104/2013 has been suggested. The virus is infectious in humans and the general population seems to lack neutralizi (mais)

Viral factors in influenza pandemic risk assessment.

Autor(es): Lipsitch, Marc; Barclay, Wendy; Raman, Rahul; Russell, Charles J; Belser, Jessica A; Cobey, Sarah; Kasson, Peter M; Lloyd-Smith, James O; Maurer-Stroh, Sebastian; Riley, Steven; Beauchemin, Catherine Aa; Bedford, Trevor; Friedrich, Thomas C; Handel, Andreas; Herfst, Sander; Murcia, Pablo R; Roche, Benjamin; Wilke, Claus O; Russell, Colin A
Fonte: Elife;52016 Nov 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27834632
Resumo: The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence (mais)

Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.

Autor(es): López-Labrador, F Xavier; Natividad-Sancho, Angels; Pisareva, Maria; Komissarov, Andrey; Salvatierra, Karina; Fadeev, Artem; Moya, Andrés; Grudinin, Mikhail; Díez-Domingo, Javier; Afanasieva, Olga; Konovalova, Nadezhda; Sominina, Anna; Puig-Barberà, Joan
Fonte: J Clin Virol;84: 32-38, 2016 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27690141
Resumo: BACKGROUND: Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control. OBJECTIVES: To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season. STUDY DESIGN: Comparative phylogenetic analysis of full-length hemagglutinin genes from 77 isolated influenza A viruses from the St. Petersburg, Ru (mais)

Cleavage of influenza RNA by using a human PUF-based artificial RNA-binding protein-staphylococcal nuclease hybrid.

Autor(es): Mori, Tomoaki; Nakamura, Kento; Masaoka, Keisuke; Fujita, Yusuke; Morisada, Ryosuke; Mori, Koichi; Tobimatsu, Takamasa; Sera, Takashi
Fonte: Biochem Biophys Res Commun;479(4): 736-740, 2016 Oct 28.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27693585
Resumo: Various viruses infect animals and humans and cause a variety of diseases, including cancer. However, effective methodologies to prevent virus infection have not yet been established. Therefore, development of technologies to inactivate viruses is highly desired. We have already demonstrated that cleavage of a DNA virus genome was effective to prevent its replication. Here, we expanded this methodology to RNA viruses. In the present study, we used staphylococcal nuclease (SNase) instead of (mais)

The microRNA-let-7b-mediated attenuated strain of influenza A (H1N1) virus in a mouse model.

Autor(es): Tan, Mingming; Sun, Wenkui; Feng, Chunlai; Xia, Di; Shen, Xiaoyue; Ding, Yuan; Liu, Zhicheng; Xing, Zheng; Su, Xin; Shi, Yi
Fonte: J Infect Dev Ctries;10(9): 973-981, 2016 Sep 30.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27694730
Resumo: INTRODUCTION: Evaluating the attenuation of influenza viruses in animal studies is important in developing safe and effective vaccines. This study aimed to demonstrate that the microRNA (miRNA)-let-7b-mediated attenuated influenza viruses (miRT-H1N1) are sufficiently attenuated and safe in mice. METHODOLOGY: The pathogenicity of the miRT-H1N1virus was investigated in a mouse model, evaluated with median lethal dose (LD50). The replicative dynamics of the miRT-H1N1, wild type (wt)-H1N1, and (mais)
Resultados  1-12 de 175