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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 2.426
1.

Molecular epidemiology of the hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran.

Autor(es): Mohebbi, Atefeh; Fotouhi, Fatemeh; Jamali, Abbas; Yaghobi, Ramin; Farahmand, Behrokh; Mohebbi, Reza
Fonte: Virus Res;259: 38-45, 2019 01 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30336188
Resumo: In 2015, the influenza virus A/H1N1/pdm09 strain outbreak became prevalent throughout the different provinces of Iran. There are relatively limited complete genetic sequences available for this virus from Asian countries. Diagnosis and virological surveillance of influenza is essential for detecting novel genetic variants causing epidemic potential. This study describes the genetic properties of HA genome of influenza A/H1N1 pdm09 viruses circulating in Iran during the 2015/2016 season. In (mais)
2.

Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus.

Autor(es): Wang, Zhao; Yu, Jieshi; Thomas, Milton; Sreenivasan, Chithra C; Hause, Ben M; Wang, Dan; Francis, David H; Kaushik, Radhey S; Li, Feng
Fonte: Vet Microbiol;228: 26-31, 2019 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30593376
Resumo: There is an urgent need to develop a broad-spectrum vaccine that can effectively prevent or eliminate the spread of co-circulating swine influenza virus strains in multiple lineages or subtypes. We describe here that pre-exposure with a live virus generated via a A/WSN/1933(H1N1) reverse genetics system resulted in a significant reduction of viral shedding from pigs exposed to either a swine H1N1 virus or a swine H3N2 virus. At 3-day post challenge (DPC), approximately 1 log and 1.5 logs re (mais)
3.

A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population.

Autor(es): Gao, Xiaobo; Yang, Liping; Luo, Haiyan; Tan, Fengwei; Ma, Xu; Lu, Cailing
Fonte: DNA Cell Biol;37(2): 109-116, 2018 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 29298094
Resumo: miR-138 modulates cardiac morphogenesis in zebrafish. We explored whether a genetic polymorphism in miR-138 might contribute to the occurrence of sporadic congenital heart disease (CHD) and the potential mechanism. We performed a case-control study consisting of 857 CHD cases and 938 non-CHD controls by genotyping miR-138 in a Chinese population. Two SNPs, including rare rs139365823 located in the pre-miR-138 sequence and rs76987351 located in the pri-miR-138 sequence, were identified by se (mais)
4.

Update on the pathogenesis and treatment of juvenile idiopathic arthritis.

Autor(es): Giancane, Gabriella; Alongi, Alessandra; Ravelli, Angelo
Fonte: Curr Opin Rheumatol;29(5): 523-529, 2017 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 28538013
Resumo: PURPOSE OF REVIEW: To provide an overview of recently published studies on pathogenesis and management of juvenile idiopathic arthritis (JIA). RECENT FINDINGS: In the past year, the potential role of network analysis in the understanding of the molecular phenotype of individual JIA subgroups has been highlighted. In addition, potential new targets for pharmacologic interventions have been identified through the elucidation of mechanisms that modulate the function of cells involved in the in (mais)
5.

Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture.

Autor(es): Baker, Lauren A; Kirkpatrick, Brian; Rosa, Guilherme J M; Gianola, Daniel; Valente, Bruno; Sumner, Julia P; Baltzer, Wendy; Hao, Zhengling; Binversie, Emily E; Volstad, Nicola; Piazza, Alexander; Sample, Susannah J; Muir, Peter
Fonte: PLoS One;12(4): e0173810, 2017.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 28379989
Resumo: Anterior cruciate ligament (ACL) rupture is a common condition that can be devastating and life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL ruptures through rupture of the contralateral ACL or rupture of a graft repair is also common. Risk of rupture is increased in females. ACL rupture is also common in dogs. Disease prevalence exceeds 5% in several dog breeds, ~100 fold higher than human beings. We provide insight into the genetic etiology of ACL (mais)
6.

TP53 and CDKN1A mutation analysis in families with Li-Fraumeni and Li-Fraumeni like syndromes.

Autor(es): Andrade, Raissa Coelho; Dos Santos, Anna Claudia Evangelista; de Aguirre Neto, Joaquim Caetano; Nevado, Julián; Lapunzina, Pablo; Vargas, Fernando Regla
Fonte: Fam Cancer;16(2): 243-248, 2017 04.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27714481
Resumo: Li-Fraumeni and Li-Fraumeni like syndromes (LFS/LFL) represent rare cancer-prone conditions associated mostly with sarcomas, breast cancer, brain tumors, and adrenocortical carcinomas. TP53 germline mutations are present in up to 80 % of families with classic Li-Fraumeni syndrome, and in 20-60 % of families with Li-Fraumeni like phenotypes. The frequency of LFS/LFL families with no TP53 mutations detected suggests the involvement of other genes in the syndrome. In this study, we searched (mais)
7.

Lessons from the canine Oxtr gene: populations, variants and functional aspects.

Autor(es): Bence, M; Marx, P; Szantai, E; Kubinyi, E; Ronai, Z; Banlaki, Z
Fonte: Genes Brain Behav;16(4): 427-438, 2017 04.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27860243
Resumo: Oxytocin receptor (OXTR) acts as a key behavioral modulator of the central nervous system, affecting social behavior, stress, affiliation and cognitive functions. Variants of the Oxtr gene are known to influence behavior both in animals and humans; however, canine Oxtr polymorphisms are less characterized in terms of possible relevance to function, selection criteria in breeding and domestication. In this report, we provide a detailed characterization of common variants of the canine Oxtr g (mais)
8.

Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice.

Autor(es): Kuah, Li-Fang; Tang, Lay-Hoon; Sutton, Troy; Lim, Jie-Hui; Sin, Wan-Ling; Lamirande, Elaine; Subbarao, Kanta; Lau, Yuk-Fai
Fonte: J Gen Virol;98(2): 155-165, 2017 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27983474
Resumo: Human infections with A/Jiangxi-Donghu/346/2013 (H10N8) virus have raised concerns about its pandemic potential. In order to develop a vaccine against this virus, the immunogenicity of its haemagglutinin protein was evaluated in mice. Using both whole-virion and recombinant subunit protein vaccines, we showed that two doses of either vaccine elicited neutralizing antibody responses. The protective efficacy of the vaccine-induced responses was assessed using a reverse-genetics-derived H10 re (mais)
10.

Domestic dog exposure at birth reduces the incidence of atopic dermatitis.

Autor(es): Thorsteinsdottir, S; Thyssen, J P; Stokholm, J; Vissing, N H; Waage, J; Bisgaard, H
Fonte: Allergy;71(12): 1736-1744, 2016 12.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27385647
Resumo: BACKGROUND: While the etiopathogenesis of atopic dermatitis is complex and poorly understood, neonatal exposures are important for disease occurrence. However, the effect of dog exposure on the risk of atopic dermatitis is unresolved. OBJECTIVE: We investigated whether domestic dog exposure affected the risk of atopic dermatitis in children during the first 3 years of life. METHODS: Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) are ongoing prospective clinical birth cohort (mais)
11.

LDLR, ApoB and ApoE genes polymorphisms and classical risk factors in premature coronary artery disease.

Autor(es): Abd El-Aziz, Tarek A; Mohamed, Randa H
Fonte: Gene;590(2): 263-9, 2016 Sep 30.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27236033
Resumo: Lipoproteins play a central role in the development of atherosclerotic disease. So, with their ability to affect lipid levels, the LDLR, ApoB and ApoE polymorphisms could be one of the factors influencing development of atherosclerosis. This hypothesis has been tested in different populations with conflicting results. The purpose of the present study was to investigate the association between the LDLR, ApoB and ApoE genes polymorphisms with premature CAD (PCAD) in Egyptians. One hundred thi (mais)
12.

A CpG-SNP Located within the ARPC3 Gene Promoter Is Associated with Hypertriglyceridemia in Severely Obese Patients.

Autor(es): de Toro-Martín, Juan; Guénard, Frédéric; Tchernof, André; Deshaies, Yves; Pérusse, Louis; Biron, Simon; Lescelleur, Odette; Biertho, Laurent; Marceau, Simon; Vohl, Marie-Claude
Fonte: Ann Nutr Metab;68(3): 203-12, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27055012
Resumo: AIMS: To test the potential association of cytosine-phosphate-guanine dinucleotides (CpG)-single-nucleotide polymorphisms (SNPs) located within actin-related protein 2/3 complex subunit 3 (ARPC3), a gene recently linked to adipogenesis and lipid accumulation, with metabolic syndrome (MetS) features in severely obese patients. METHODS: Prioritized SNPs within the ARPC3 locus were genotyped and tested for associations with MetS features in a cohort of 1,749 obese patients with and without Met (mais)
Resultados  1-12 de 2.426