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Resultados  1-12 de 150

Influenza A Viruses of Swine (IAV-S) in Vietnam from 2010 to 2015: Multiple Introductions of A(H1N1)pdm09 Viruses into the Pig Population and Diversifying Genetic Constellations of Enzootic IAV-S.

Autor(es): Takemae, Nobuhiro; Harada, Michiyo; Nguyen, Phuong Thanh; Nguyen, Tung; Nguyen, Tien Ngoc; To, Thanh Long; Nguyen, Tho Dang; Pham, Vu Phong; Le, Vu Tri; Do, Hoa Thi; Vo, Hung Van; Le, Quang Vinh Tin; Tran, Tan Minh; Nguyen, Thanh Duy; Thai, Phuong Duy; Nguyen, Dang Hoang; Le, Anh Quynh Thi; Nguyen, Diep Thi; Uchida, Yuko; Saito, Takehiko
Fonte: J Virol;91(1)2017 Jan 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27795418
Resumo: Active surveillance of influenza A viruses of swine (IAV-S) involving 262 farms and 10 slaughterhouses in seven provinces in northern and southern Vietnam from 2010 to 2015 yielded 388 isolates from 32 farms; these viruses were classified into H1N1, H1N2, and H3N2 subtypes. Whole-genome sequencing followed by phylogenetic analysis revealed that the isolates represented 15 genotypes, according to the genetic constellation of the eight segments. All of the H1N1 viruses were entirely A(H1N1)pd (mais)

Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.

Autor(es): Kossyvakis, A; Mentis, A-F A; Tryfinopoulou, K; Pogka, V; Kalliaropoulos, A; Antalis, E; Lytras, T; Meijer, A; Tsiodras, S; Karakitsos, P; Mentis, A F
Fonte: Eur J Clin Microbiol Infect Dis;36(2): 361-371, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27848039
Resumo: There was an increase in severe and fatal influenza cases in Greece during the 2011-2015 post-pandemic period. To investigate causality, we determined neuraminidase (NA) inhibitor susceptibility and resistance-conferring NA and hemagglutinin (HA) mutations in circulating influenza type A viruses during the pandemic (2009-2010) and post-pandemic periods in Greece. One hundred thirty-four influenza A(H1N1)pdm09 and 95 influenza A(H3N2) viruses submitted to the National Influenza Reference Lab (mais)

Reassortment between Swine H3N2 and 2009 Pandemic H1N1 in the United States Resulted in Influenza A Viruses with Diverse Genetic Constellations with Variable Virulence in Pigs.

Autor(es): Rajão, Daniela S; Walia, Rasna R; Campbell, Brian; Gauger, Phillip C; Janas-Martindale, Alicia; Killian, Mary Lea; Vincent, Amy L
Fonte: J Virol;91(4)2017 Feb 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27928015
Resumo: Repeated spillovers of the H1N1 pandemic virus (H1N1pdm09) from humans to pigs resulted in substantial evolution of influenza A viruses infecting swine, contributing to the genetic and antigenic diversity of influenza A viruses (IAV) currently circulating in swine. The reassortment with endemic swine viruses and maintenance of some of the H1N1pdm09 internal genes resulted in the circulation of different genomic constellations in pigs. Here, we performed a whole-genome phylogenetic analysis (mais)

The influenza A virus matrix protein 2 undergoes retrograde transport from the endoplasmic reticulum into the cytoplasm and bypasses cytoplasmic proteasomal degradation.

Autor(es): Bhowmick, Sanchari; Chakravarty, Chandrani; Sellathamby, Shanmugaapriya; Lal, Sunil K
Fonte: Arch Virol;162(4): 919-929, 2017 Apr.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27942972
Resumo: The matrix protein 2 (M2) is a spliced product of segment 7 genome of influenza A virus. Previous studies indicate its role in uncoating of the viral ribonucleoprotein complex during viral entry and in membrane scission while budding. Despite its crucial role in the viral life cycle, little is known about its subcellular distribution and dynamics. In this study, we have shown that the M2 protein is translocated from the membrane to the cytoplasm by a retrograde route via endosomes and the G (mais)

Regulation of Matrix Metalloproteinases-2 and -9 Gene Expression in Cultured Human Fetal Membrane Cells by Influenza Virus Infection.

Autor(es): Uchide, Noboru; Obatake, Kyoko; Yamada, Rie; Sadanari, Hidetaka; Matsubara, Keiko; Murayama, Tsugiya; Ohyama, Kunio
Fonte: Biol Pharm Bull;39(12): 1912-1921, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27904034
Resumo: In order to understand a possible etiology of adverse pregnancy outcomes associated with intrauterine influenza virus infection, we examined the effect of influenza virus infection on gene expression of matrix metalloproteinases (MMPs) in cultured amnion epithelial, amnion mesenchymal and chorion trophoblast cells prepared from human fetal membrane tissues by gelatin zymography, Western blotting and reverse transcriptase-PCR. The cells were infected with influenza A (H1N1) virus. The levels (mais)

The microRNA-let-7b-mediated attenuated strain of influenza A (H1N1) virus in a mouse model.

Autor(es): Tan, Mingming; Sun, Wenkui; Feng, Chunlai; Xia, Di; Shen, Xiaoyue; Ding, Yuan; Liu, Zhicheng; Xing, Zheng; Su, Xin; Shi, Yi
Fonte: J Infect Dev Ctries;10(9): 973-981, 2016 Sep 30.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27694730
Resumo: INTRODUCTION: Evaluating the attenuation of influenza viruses in animal studies is important in developing safe and effective vaccines. This study aimed to demonstrate that the microRNA (miRNA)-let-7b-mediated attenuated influenza viruses (miRT-H1N1) are sufficiently attenuated and safe in mice. METHODOLOGY: The pathogenicity of the miRT-H1N1virus was investigated in a mouse model, evaluated with median lethal dose (LD50). The replicative dynamics of the miRT-H1N1, wild type (wt)-H1N1, and (mais)

Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14.

Autor(es): Broberg, Eeva; Hungnes, Olav; Schweiger, Brunhilde; Prosenc, Katarina; Daniels, Rod; Guiomar, Raquel; Ikonen, Niina; Kossyvakis, Athanasios; Pozo, Francisco; Puzelli, Simona; Thomas, Isabelle; Waters, Allison; Wiman, Åsa; Meijer, Adam
Fonte: Euro Surveill;21(41)2016 Oct 13.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27762211
Resumo: Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We (mais)

Genetic diversity of the haemagglutinin (HA) of human influenza a (H1N1) virus in montenegro: Focus on its origin and evolution.

Autor(es): Mugosa, Boban; Vujosevic, Danijela; Ciccozzi, Massimo; Valli, Maria Beatrice; Capobianchi, Maria Rosaria; Lo Presti, Alessandra; Cella, Eleonora; Giovanetti, Marta; Lai, Alessia; Angeletti, Silvia; Scarpa, Fabio; Terzic, Dragica; Vratnica, Zoran
Fonte: J Med Virol;88(11): 1905-13, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27088433
Resumo: In 2009 an influenza A epidemic caused by a swine origin H1N1strain, unusual in human hosts, has been described. The present research is aimed to perform the first phylogenetic investigation on the influenza virus A (H1N1) strains circulating in Montenegro, from December 1, 2009, when the first case of death due to H1N1 was confirmed, and the epidemic began causing a total of four fatalities. The phylogenetic analysis of the strains circulating showed the absence of a pure Montenegrin clust (mais)

Long-term detection of seasonal influenza RNA in faeces and intestine.

Autor(es): Hirose, R; Daidoji, T; Naito, Y; Watanabe, Y; Arai, Y; Oda, T; Konishi, H; Yamawaki, M; Itoh, Y; Nakaya, T
Fonte: Clin Microbiol Infect;22(9): 813.e1-813.e7, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27424942
Resumo: Some cases of seasonal influenza virus (human influenza A virus (IAV)/human influenza B virus (IBV)) are associated with abdominal symptoms. Although virus RNA has been detected in faeces, intestinal infection has not been clearly demonstrated. We aimed to provide evidence that IAV/IBV infects the human intestine. This prospective observational study measured virus RNA in faecal and sputum samples from 22 patients infected with IAV/IBV (19 IAV positive and three IBV positive). Nineteen pati (mais)

Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.

Autor(es): López-Labrador, F Xavier; Natividad-Sancho, Angels; Pisareva, Maria; Komissarov, Andrey; Salvatierra, Karina; Fadeev, Artem; Moya, Andrés; Grudinin, Mikhail; Díez-Domingo, Javier; Afanasieva, Olga; Konovalova, Nadezhda; Sominina, Anna; Puig-Barberà, Joan
Fonte: J Clin Virol;84: 32-38, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27690141
Resumo: BACKGROUND: Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control. OBJECTIVES: To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season. STUDY DESIGN: Comparative phylogenetic analysis of full-length hemagglutinin genes from 77 isolated influenza A viruses from the St. Petersburg, Ru (mais)

Genetic and antigenic characterization of hemagglutinin of influenza A/H3N2 virus from the 2015 season in Thailand.

Autor(es): Tewawong, Nipaporn; Suntronwong, Nungruthai; Vichiwattana, Preeyaporn; Vongpunsawad, Sompong; Theamboonlers, Apiradee; Poovorawan, Yong
Fonte: Virus Genes;52(5): 711-5, 2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27146171
Resumo: Antigenic changes in the HA1 domain of the influenza A/H3N2 hemagglutinin (HA) present a challenge in the design of the annual influenza vaccine. We examined the genetic variability in the nucleotide and amino acid of encoding HA1 sequences of the influenza A/H3N2 virus during the 2015 influenza season in Thailand. Toward this, the HA genes of 45 influenza A/H3N2 strains were amplified and sequenced. Although a clade 3C.3a strain (A/Switzerland/9715293/2013) was chosen for the 2015 vaccine, (mais)

Reverse genetics vaccine seeds for influenza: Proof of concept in the source of PB1 as a determinant factor in virus growth and antigen yield.

Autor(es): Gíria, Marta; Santos, Luís; Louro, João; Rebelo de Andrade, Helena
Fonte: Virology;496: 21-7, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27240145
Resumo: Growth deficits of reverse genetics vaccine seeds have compromised effective immunization. The impairment has been attributed to sub-optimal protein interactions. Some level of dependence may exist between PB1 and antigenic glycoproteins, however, further research is necessary to clarify the extent to which it can be used in favor of seed production. Our objective was to establish proof of concept on the phenotypic outcome of PB1 source in the PR8: A(H1N1)pdm09 reassortants. Reassortants we (mais)
Resultados  1-12 de 150