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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 51

Detection of porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) in oral fluid of pigs.

Autor(es): Biernacka, Kinga; Karbowiak, Pawel; Wróbel, Pawel; Chareza, Tomasz; Czopowicz, Michal; Balka, Gyula; Goodell, Christa; Rauh, Rolf; Stadejek, Tomasz
Fonte: Res Vet Sci;109: 74-80, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27892877
Resumo: Recently oral fluid has become a novel sample type for pathogen nucleic acid and antibody detection, as it is easy to obtain with non-invasive procedures. The objective of the study was to analyze porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) circulation in growing pigs from three Polish production farms, using Real Time PCR and ELISA testing of oral fluid and serum. Oral fluids were collected every 2weeks, in the same 3-4 pens of pigs aged between (mais)

Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14.

Autor(es): Broberg, Eeva; Hungnes, Olav; Schweiger, Brunhilde; Prosenc, Katarina; Daniels, Rod; Guiomar, Raquel; Ikonen, Niina; Kossyvakis, Athanasios; Pozo, Francisco; Puzelli, Simona; Thomas, Isabelle; Waters, Allison; Wiman, Åsa; Meijer, Adam
Fonte: Euro Surveill;21(41)2016 Oct 13.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27762211
Resumo: Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We (mais)

Molecular epidemiology and phylogenetic analysis of HA gene of influenza A(H1N1)pdm09 strain during 2010-2014 in Dalian, North China.

Autor(es): Han, Yan; Sun, Nan; Lv, Qiu-Yue; Liu, Dan-Hong; Liu, Da-Peng
Fonte: Virus Genes;52(5): 606-12, 2016 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27251702
Resumo: The objective of the present study was to evaluate the epidemiology of influenza A(H1N1)pdm09 and its hemagglutinin (HA) molecular and phylogenetic analysis during 2010-2014 in Dalian, North China. A total of 3717 influenza-like illness (ILI) cases were tested by real-time PCR and 493 were found to be positive. Out of these 493 cases, 121 were subtype influenza A(H1N1)pdm09, of which 14 cases were reported in 2010-2011, 29 in 2012-2013, and 78 in 2013-2014. HA coding regions of 45 isolates (mais)

IFITM3 and severe influenza virus infection. No evidence of genetic association.

Autor(es): López-Rodríguez, M; Herrera-Ramos, E; Solé-Violán, J; Ruíz-Hernández, J J; Borderías, L; Horcajada, J P; Lerma-Chippirraz, E; Rajas, O; Briones, M; Pérez-González, M C; García-Bello, M A; López-Granados, E; Rodriguez de Castro, F; Rodríguez-Gallego, C
Fonte: Eur J Clin Microbiol Infect Dis;35(11): 1811-1817, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27492307
Resumo: Influenza virus infection (IVI) is typically subclinical or causes a self-limiting upper respiratory disease. However, in a small subset of patients IVI rapidly progresses to primary viral pneumonia (PVP) with respiratory failure; a minority of patients require intensive care unit admission. Inherited and acquired variability in host immune responses may influence susceptibility and outcome of IVI. However, the molecular basis of such human factors remains largely elusive. It has been propo (mais)

Statistical inference of a convergent antibody repertoire response to influenza vaccine.

Autor(es): Strauli, Nicolas B; Hernandez, Ryan D
Fonte: Genome Med;8(1): 60, 2016 06 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27255379
Resumo: BACKGROUND: Vaccines dramatically affect an individual's adaptive immune system and thus provide an excellent means to study human immunity. Upon vaccination, the B cells that express antibodies (Abs) that happen to bind the vaccine are stimulated to proliferate and undergo mutagenesis at their Ab locus. This process may alter the composition of B cell lineages within an individual, which are known collectively as the antibody repertoire (AbR). Antibodies are also highly expressed in whole (mais)

Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells.

Autor(es): Wörmann, Xenia; Lesch, Markus; Welke, Robert-William; Okonechnikov, Konstantin; Abdurishid, Mirshat; Sieben, Christian; Geissner, Andreas; Brinkmann, Volker; Kastner, Markus; Karner, Andreas; Zhu, Rong; Hinterdorfer, Peter; Anish, Chakkumkal; Seeberger, Peter H; Herrmann, Andreas; Meyer, Thomas F; Karlas, Alexander
Fonte: Virology;492: 118-29, 2016 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26914510
Resumo: The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isolate A/Hamburg/04/2009 in A549 human lung epithelial cells. After passage 6, we observed a 100-fold increased replication rate. High-throughput sequencing of viral gene segments identified five dominant mutations, whose contribution to the e (mais)

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses.

Autor(es): Neher, Richard A; Bedford, Trevor; Daniels, Rodney S; Russell, Colin A; Shraiman, Boris I
Fonte: Proc Natl Acad Sci U S A;113(12): E1701-9, 2016 Mar 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26951657
Resumo: Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and reinfect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA), and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies. Here, we show that antigenic differences measured through serological assay data are well described by a sum of antigenic changes along the path connecting v (mais)

Automatic detection of rate change in large data sets with an unsupervised approach: the case of influenza viruses.

Autor(es): Labonté, Kasandra; Aris-Brosou, Stéphane
Fonte: Genome;59(4): 253-62, 2016 Apr.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26966881
Resumo: Influenza viruses evolve at such a high rate that vaccine recommendations need to be changed, but not quite on a regular basis. This observation suggests that the rate of evolution of these viruses is not constant through time, which begs the question as to when such rate changes occur, if they do so independently of the host in which they circulate and (or) independently of their subtype. To address these outstanding questions, we introduce a novel heuristics, Mclust*, that is based on a t (mais)

Genome Hotspots for Nucleotide Substitutions and the Evolution of Influenza A (H1N1) Human Strains.

Autor(es): Civetta, Alberto; Ostapchuk, David Cecil Murphy; Nwali, Basil
Fonte: Genome Biol Evol;8(4): 986-93, 2016 Apr 08.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26988249
Resumo: In recent years a number of studies have brought attention to the role of positive selection during the evolution of antigenic escape by influenza strains. Particularly, the identification of positively selected sites within antigenic domains of viral surface proteins has been used to suggest that the evolution of viral-host receptor binding specificity is driven by selection. Here we show that, following the 1918 outbreak, the antigenic sites of the hemagglutinin (HA) viral surface protein (mais)

Core-6 fucose and the oligomerization of the 1918 pandemic influenza viral neuraminidase.

Autor(es): Wu, Zhengliang L; Zhou, Hui; Ethen, Cheryl M; N Reinhold, Vernon
Fonte: Biochem Biophys Res Commun;473(2): 524-9, 2016 Apr 29.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27012207
Resumo: The 1918 H1N1 influenza virus was responsible for one of the most deadly pandemics in human history. Yet to date, the structure component responsible for its virulence is still a mystery. In order to search for such a component, the neuraminidase (NA) antigen of the virus was expressed, which led to the discovery of an active form (tetramer) and an inactive form (dimer and monomer) of the protein due to different glycosylation. In this report, the N-glycans from both forms were released and (mais)

Predominance of influenza A(H1N1)pdm09 virus genetic subclade 6B.1 and influenza B/Victoria lineage viruses at the start of the 2015/16 influenza season in Europe.

Autor(es): Broberg, Eeva; Melidou, Angeliki; Prosenc, Katarina; Bragstad, Karoline; Hungnes, Olav
Fonte: Euro Surveill;21(13)2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27074657
Resumo: Influenza A(H1N1)pdm09 viruses predominated in the European influenza 2015/16 season. Most analysed viruses clustered in a new genetic subclade 6B.1, antigenically similar to the northern hemisphere vaccine component A/California/7/2009. The predominant influenza B lineage was Victoria compared with Yamagata in the previous season. It remains to be evaluated at the end of the season if these changes affected the effectiveness of the vaccine for the 2015/16 season.
Resultados  1-12 de 51