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Resultados  1-12 de 63

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.

Autor(es): Lee, Jiwon; Boutz, Daniel R; Chromikova, Veronika; Joyce, M Gordon; Vollmers, Christopher; Leung, Kwanyee; Horton, Andrew P; DeKosky, Brandon J; Lee, Chang-Han; Lavinder, Jason J; Murrin, Ellen M; Chrysostomou, Constantine; Hoi, Kam Hon; Tsybovsky, Yaroslav; Thomas, Paul V; Druz, Aliaksandr; Zhang, Baoshan; Zhang, Yi; Wang, Lingshu; Kong, Wing-Pui; Park, Daechan; Popova, Lyubov I; Dekker, Cornelia L; Davis, Mark M; Carter, Chalise E; Ross, Ted M; Ellington, Andrew D; Wilson, Patrick C; Marcotte, Edward M; Mascola, John R; Ippolito, Gregory C; Krammer, Florian; Quake, Stephen R; Kwong, Peter D; Georgiou, George
Fonte: Nat Med;22(12): 1456-1464, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27820605
Resumo: Molecular understanding of serological immunity to influenza has been confounded by the complexity of the polyclonal antibody response in humans. Here we used high-resolution proteomics analysis of immunoglobulin (referred to as Ig-seq) coupled with high-throughput sequencing of transcripts encoding B cell receptors (BCR-seq) to quantitatively determine the antibody repertoire at the individual clonotype level in the sera of young adults before and after vaccination with trivalent seasonal (mais)

Detection of porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) in oral fluid of pigs.

Autor(es): Biernacka, Kinga; Karbowiak, Pawel; Wróbel, Pawel; Chareza, Tomasz; Czopowicz, Michal; Balka, Gyula; Goodell, Christa; Rauh, Rolf; Stadejek, Tomasz
Fonte: Res Vet Sci;109: 74-80, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27892877
Resumo: Recently oral fluid has become a novel sample type for pathogen nucleic acid and antibody detection, as it is easy to obtain with non-invasive procedures. The objective of the study was to analyze porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) circulation in growing pigs from three Polish production farms, using Real Time PCR and ELISA testing of oral fluid and serum. Oral fluids were collected every 2weeks, in the same 3-4 pens of pigs aged between (mais)

Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.

Autor(es): López-Labrador, F Xavier; Natividad-Sancho, Angels; Pisareva, Maria; Komissarov, Andrey; Salvatierra, Karina; Fadeev, Artem; Moya, Andrés; Grudinin, Mikhail; Díez-Domingo, Javier; Afanasieva, Olga; Konovalova, Nadezhda; Sominina, Anna; Puig-Barberà, Joan
Fonte: J Clin Virol;84: 32-38, 2016 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27690141
Resumo: BACKGROUND: Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control. OBJECTIVES: To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season. STUDY DESIGN: Comparative phylogenetic analysis of full-length hemagglutinin genes from 77 isolated influenza A viruses from the St. Petersburg, Ru (mais)

Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning.

Autor(es): Gaiotto, Tiziano; Hufton, Simon E
Fonte: PLoS One;11(10): e0164296, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27741319
Resumo: Cross-neutralising monoclonal antibodies against influenza hemagglutinin (HA) are of considerable interest as both therapeutics and diagnostic tools. We have recently described five different single domain antibodies (nanobodies) which share this cross-neutralising activity and suggest their small size, high stability, and cleft binding properties may present distinct advantages over equivalent conventional antibodies. We have used yeast display in combination with deep mutational scanning (mais)

Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14.

Autor(es): Broberg, Eeva; Hungnes, Olav; Schweiger, Brunhilde; Prosenc, Katarina; Daniels, Rod; Guiomar, Raquel; Ikonen, Niina; Kossyvakis, Athanasios; Pozo, Francisco; Puzelli, Simona; Thomas, Isabelle; Waters, Allison; Wiman, Åsa; Meijer, Adam
Fonte: Euro Surveill;21(41)2016 Oct 13.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27762211
Resumo: Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We (mais)

Evaluating the potential of a loop-extended scorpion toxin-like peptide as a protein scaffold.

Autor(es): Zhang, Shangfei; Zhu, Limei; Yu, Jie; Xu, Jun; Gao, Bin; Zhou, Changlin; Zhu, Shunyi
Fonte: Protein Eng Des Sel;29(12): 607-616, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27672050
Resumo: Grafting of exogenous bioactive sites or functional motifs onto structurally stable scaffolds to gain new functions represents an important research direction in protein engineering. Some engineered proteins have been developed into therapeutic drugs. MeuNaTxα-3 (abbreviated as MT-3) is a newly characterized scorpion sodium channel toxin-like peptide isolated from the venom of the scorpion Mesobuthus eupeus, which contains a rigid scaffold highly similar to classical scorpion sodium ch (mais)

Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis.

Autor(es): Vanderlinden, Evelien; Vrancken, Bram; Van Houdt, Jeroen; Rajwanshi, Vivek K; Gillemot, Sarah; Andrei, Graciela; Lemey, Philippe; Naesens, Lieve
Fonte: Antimicrob Agents Chemother;60(11): 6679-6691, 2016 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27572398
Resumo: T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy. It is supposed to act as an alternative substrate for the viral polymerase, causing inhibition of viral RNA synthesis or virus mutagenesis. These mechanisms were also proposed for ribavirin, an established and broad antiviral drug that shares structural similarity with T-705. We here performed a comparative analysis of the effects of T-705 and ribavirin on influenza virus and host cell funct (mais)

Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014.

Autor(es): Matsuzaki, Yoko; Sugawara, Kanetsu; Furuse, Yuki; Shimotai, Yoshitaka; Hongo, Seiji; Oshitani, Hitoshi; Mizuta, Katsumi; Nishimura, Hidekazu
Fonte: J Virol;90(18): 8251-65, 2016 Sep 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27384661
Resumo: Since influenza C virus was first isolated in 1947, the virus has been only occasionally isolated by cell culture; there are only four strains for which complete genome sequences are registered. Here, we analyzed a total of 106 complete genomes, ranging from the first isolate from 1947 to recent isolates from 2014, to determine the genetic lineages of influenza C virus, the reassortment events, and the rates of nucleotide substitution. The results showed that there are six lineages, named C (mais)

Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers.

Autor(es): Ma, Chunlong; Zhang, Jiantao; Wang, Jun
Fonte: Mol Pharmacol;90(3): 188-98, 2016 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27385729
Resumo: Adamantanes (amantadine and rimantadine) are one of the two classes of Food and Drug Administration-approved antiviral drugs used for the prevention and treatment of influenza A virus infections. They inhibit viral replication by blocking the wild-type (WT) M2 proton channel, thus preventing viral uncoating. However, their use was discontinued due to widespread drug resistance. Among a handful of drug-resistant mutants, M2-S31N is the predominant mutation and persists in more than 95% of cu (mais)

Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study.

Autor(es): Voltersvik, Pål; Aqrawi, Lara A; Dudman, Susanne; Hungnes, Olav; Bostad, Leif; Brokstad, Karl A; Cox, Rebecca J
Fonte: Influenza Other Respir Viruses;10(6): 525-531, 2016 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27413002
Resumo: BACKGROUND: During the pandemic outbreak of the 2009 swine influenza (A(H1N1)pdm09), 32 fatal cases occurred in Norway and 19 of these were included in this study. OBJECTIVES: We characterised pulmonary changes in these fatal Norwegian cases. PATIENTS AND METHODS: Upon hospitalisation, detailed clinical information and specimens from the upper and lower respiratory pathways were collected. At post-mortem, lung tissue was collected, formalin-fixed and paraffin-embedded. Immunohistochemical a (mais)
Resultados  1-12 de 63