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Pesquisa | Influenza A (H1N1)

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Molekulární a antigenní analýza hemaglutininu viru chripky A H3N2 detekovaných v Ceské republice v epidemické sezone 2014/2015./ Molecular and antigenic characterization of the H3 hemagglutinin of H3N2 influenza A virus strains collected in the Czech Republic during the 2014/2015 epidemic season.

Autor(es): Nagy, A; Jirincová, H; Kyncl, J; Havlícková, M
Fonte: Epidemiol Mikrobiol Imunol;65(2): 92-101, Summer 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27467326
Resumo: The 2014/2015 influenza epidemic season was characterized by the predominance of the H3N2 subtype. The presented study investigated the genetic and antigenic heterogeneity of the H3N2 strains collected in the Czech Republic from November 2014 to March 2015. Phylogenetic analysis of the representative H3 hemagglutinin sequences was performed and the glycosylation status and crucial antigenic mutations were compared relative to the 2014 and 2015 vaccine strains (A/Texas/50/2012 and A/Switzerl (mais)

The mechanisms of sudden-onset type adverse reactions to oseltamivir.

Autor(es): Hama, R; Bennett, C L
Fonte: Acta Neurol Scand;135(2): 148-160, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27364959
Resumo: Oseltamivir is contraindicated for people aged 10-19 in principle in Japan, due to concern about abnormal behaviours. Sudden death is another concern. This review examines growing evidence of their association and discusses underlying mechanisms of these sudden-onset type reactions to oseltamivir. First, the importance of animal models and the concept of human equivalent dose (HED) is summarized. Second, the specific condition for oseltamivir use, influenza infection, is reviewed. Third, fi (mais)

Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.

Autor(es): Zheng, Weinan; Cao, Shuaishuai; Chen, Can; Li, Jing; Zhang, Shuang; Jiang, Jingwen; Niu, Yange; Fan, Wenhui; Li, Yun; Bi, Yuhai; Gao, George F; Sun, Lei; Liu, Wenjun
Fonte: Cell Microbiol;19(2)2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27376632
Resumo: Influenza A virus evades host antiviral defense through hijacking innate immunity by its non-structural protein 1 (NS1). By using mass spectrometry, threonine 80 (T80) was identified as a novel phosphorylated residue in the NS1 of the influenza virus A/WSN/1933(H1N1). By generating recombinant influenza viruses encoding NS1 T80 mutants, the roles of this phosphorylation site were characterized during viral replication. The T80E (phosphomimetic) mutant attenuated virus replication, whereas t (mais)

Antiviral activity of aspirin against RNA viruses of the respiratory tract-an in vitro study.

Autor(es): Glatthaar-Saalmüller, Bernadette; Mair, Kerstin H; Saalmüller, Armin
Fonte: Influenza Other Respir Viruses;11(1): 85-92, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27542891
Resumo: AIM: Aspirin (acetylsalicylic acid) has been used for more than 115 years in medicine. Research exists to show that aspirin has antiviral effects in vitro, for example, by blocking influenza virus propagation via NF-κB inhibition when used at high concentrations and short-term incubation steps. The aim of this study was to confirm the antiviral activity of aspirin against influenza virus and further elucidate the activity of aspirin against other respiratory viruses. METHODS: Tests to (mais)

The Superiority of IFN-λ as a Therapeutic Candidate to Control Acute Influenza Viral Lung Infection.

Autor(es): Kim, Sujin; Kim, Min-Ji; Kim, Chang-Hoon; Kang, Ju Wan; Shin, Ha Kyung; Kim, Dong-Young; Won, Tae-Bin; Han, Doo Hee; Rhee, Chae Seo; Yoon, Joo-Heon; Kim, Hyun Jik
Fonte: Am J Respir Cell Mol Biol;56(2): 202-212, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27632156
Resumo: Here, we studied the IFN-regulated innate immune response against influenza A virus (IAV) infection in the mouse lung and the therapeutic effect of IFN-λ2/3 in acute IAV lung infection. For viral infections, IAV (WS/33, H1N1, PR8 H1N1, H5N1) were inoculated into wild-type mice by intranasal delivery, and IAV mRNA level and viral titer were measured. To compare the antiviral effect of IFNs in vivo in the lung, neutralizing antibodies and recombinant IFNs were used. After intranasal inoc (mais)

Community- and hospital-acquired infections with oseltamivir- and peramivir-resistant influenza A(H1N1)pdm09 viruses during the 2015-2016 season in Japan.

Autor(es): Hibino, Akinobu; Kondo, Hiroki; Masaki, Hironori; Tanabe, Yoshinari; Sato, Isamu; Takemae, Nobuhiro; Saito, Takehiko; Zaraket, Hassan; Saito, Reiko
Fonte: Virus Genes;53(1): 89-94, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27714496
Resumo: We report five cases of community- and hospital-acquired infections with oseltamivir- and peramivir-resistant A(H1N1)pdm09 viruses possessing the neuraminidase (NA) H275Y mutation during January-February 2016 in Japan. One case was hospitalized and was receiving oseltamivir for prophylaxis. The remaining four cases were not taking antiviral drugs at the time of sampling. These cases were geographically distant and epidemiologically unrelated. The five viruses showed ~300-fold rise in IC va (mais)

Successful use of oseltamivir prophylaxis in managing a nosocomial outbreak of influenza A in a hematology and allogeneic stem cell transplant unit.

Autor(es): Yue, Mimi C; Collins, Joel T; Subramoniapillai, Elango; Kennedy, Glen A
Fonte: Asia Pac J Clin Oncol;13(1): 37-43, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27730741
Resumo: AIM: To describe a nosocomial outbreak of H1N1 influenza A in an inpatient hematology and allogeneic stem cell transplant unit and outcomes of universal oseltamivir prophylaxis. METHODS: Medical records of all patients admitted to the unit were reviewed to define the nosocomial outbreak, commencing 1 week prior to the index case until 4 weeks following institution of oseltamivir prophylaxis. Timelines for clinical symptoms, viral spread, management, patient outcomes and follow up testing we (mais)

Dose-dependent antiviral activity of released-active form of antibodies to interferon-gamma against influenza A/California/07/09(H1N1) in murine model.

Autor(es): Don, Еlena S; Emelyanova, Alexandra G; Yakovleva, Natalia N; Petrova, Nataliia V; Nikiforova, Marina V; Gorbunov, Evgeniy A; Tarasov, Sergey А; Morozov, Sergey G; Epstein, Оleg I
Fonte: J Med Virol;89(5): 759-766, 2017 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27769099
Resumo: The assessment of dose-response is an essential part of drug development in terms of the determination of a drug's effective dose, finding the safety endpoint, estimation of the pharmacokinetic profile, and even validation of drug activity, especially for therapeutic agents with a principally novel mechanism of action. Drugs based on released-active forms of antibodies are a good example of such a target. In this study, the efficacy of the antiviral drug Anaferon for children (released-acti (mais)

The pharmacological management of severe influenza infection - 'existing and emerging therapies'.

Autor(es): Mc Mahon, Aisling; Martin-Loeches, Ignacio
Fonte: Expert Rev Clin Pharmacol;10(1): 81-95, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27797595
Resumo: INTRODUCTION: Over the last century several influenza outbreaks have traversed the globe, most recently the influenza A(H1N1) 2009 pandemic. On each occasion, a highly contagious, virulent pathogen has emerged, leading to significant morbidity and mortality amongst those affected. Areas covered: Early antiviral therapy and supportive care is the mainstay of treatment. Treatment should be started as soon as possible and not delayed for the results of diagnostic testing. Whilst oseltamivir is (mais)

Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function.

Autor(es): Marvin, Shauna A; Russier, Marion; Huerta, C Theodore; Russell, Charles J; Schultz-Cherry, Stacey
Fonte: J Virol;91(2)2017 Jan 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27807237
Resumo: Whether influenza virus replication in macrophages is productive or abortive has been a topic of debate. Utilizing a panel of 28 distinct human, avian, and swine influenza viruses, we found that only a small subset can overcome cellular blocks to productively replicate in murine and primary human macrophages. Murine macrophages have two cellular blocks. The first block is during viral entry, where virions with relatively acid-stable hemagglutinin (HA) proteins are rendered incapable of pH-i (mais)

Antigenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from poultry in India, 2006-2015.

Autor(es): Bhat, Sudipta; Nagarajan, Shanmugasundaram; Kumar, Manoj; Murugkar, Harshad V; Kalaiyarasu, Semmannan; Venkatesh, Govindarajulu; Tosh, Chakradhar
Fonte: Arch Virol;162(2): 487-494, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27812833
Resumo: Highly pathogenic avian influenza (HPAI) is a major health concern worldwide. In this study, we focused on antigenic analysis of HPAI H5N1 viruses isolated from poultry in India between 2006 and 2015 comprising 25 isolates from four phylogenetic clades 2.2 (1 isolate), (1 isolate), (17 isolates) and (6 isolates). Seven H5N1 isolates from all four clades were selected for production of chicken antiserum, and antigenic analysis was carried out by hemagglutination inh (mais)

Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1.

Autor(es): Sokolova, Anastasiya S; Yarovaya, Оlga I; Baev, Dmitry S; Shernyukov, Аndrey V; Shtro, Anna A; Zarubaev, Vladimir V; Salakhutdinov, Nariman F
Fonte: Eur J Med Chem;127: 661-670, 2017 Feb 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27823881
Resumo: A series of camphor derived imines was synthesised and evaluated in vitro for antiviral activity. Theoretical evaluations of ADME properties were also carried out. Most of these compounds exhibited significant activity against the drug-resistant strains of influenza A virus. Especially, compounds 2 (SI = 632) and 3 (SI = 417) presented high inhibition against influenza subtypes A/Puerto Rico/8/34 and A/California/07/09 of H1N1pdm09. Analysis of the structure-activity relationship showe (mais)
Resultados  1-12 de 698