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Resultados  1-12 de 8.494

In vitro and in vivo characterization of novel neuraminidase substitutions in influenza A(H1N1)pdm09 identified using Laninamivir-mediated selection.

Autor(es): Lloren, Khristine Kaith S; Kwon, Jin Jung; Choi, Won-Suk; Jeong, Ju Hwan; Jeong Ahn, Su; Ki Choi, Young; Baek, Yun Hee; Song, Min-Suk
Fonte: J Virol;2019 Jan 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30602610
Resumo: Neuraminidase inhibitors (NAIs) are widely used antiviral drugs for the treatment of humans with influenza virus infections. There have been widespread reports of NAI resistance among seasonal A(H1N1) viruses, and most have been identified in oseltamivir-exposed patients or those treated with other NAIs. Thus, monitoring and identifying NA markers conferring resistance to NAIs-particularly newly introduced treatments-is critical to manage viral infections. Therefore, we screened and identif (mais)

Respiratory Pathogens in Infants Diagnosed with Acute Lower Respiratory Tract Infection in a Tertiary Care Hospital of Western India Using Multiplex Real Time PCR.

Autor(es): Sonawane, Anuja A; Shastri, Jayanthi; Bavdekar, Sandeep B
Fonte: Indian J Pediatr;2019 Jan 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30637585
Resumo: OBJECTIVE: To determine the frequency of respiratory pathogens in infants diagnosed with acute lower respiratory tract infections. METHODS: A prospective cross-sectional observational study was conducted in infants hospitalized with a diagnosis of acute lower respiratory tract infection (ALRTI), in a tertiary care hospital in a metropolitan city of Western India. Nasopharyngeal swabs were analyzed by multiplex real time polymerase chain reaction, for 18 viruses and 3 bacteria (H. influenzae (mais)

Predictors of Fatality in Influenza A Virus Subtypes Infection among inpatients in 2015-2016 season.

Autor(es): Tekin, S; Keske, S; Alan, S; Batirel, A; Karakoc, C; Tasdelen-Fisgin, N; Simsek-Yavuz, S; Isler, B; Aydin, M; Kapmaz, M; Yilmaz-Karadag, F; Ergonul, O
Fonte: Int J Infect Dis;2019 Jan 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30641199
Resumo: BACKGROUND: Influenza A infection could cause to severe disease and mortality. The effect of different subtypes of Influenza on morbidity and mortality is not known yet in Turkey OBJECTIVES: We aimed to describe the predictors for fatality related to influenza A infection among hospitalized patients in Istanbul in 2015-2016 influenza season, and to detail the differences between H3N2 and H1N1. STUDY DESIGN: This is a multicenter study performed by Istanbul respiratory infections study group (mais)

Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral Hemagglutinin.

Autor(es): Superti, Fabiana; Agamennone, Mariangela; Pietrantoni, Agostina; Ammendolia, Maria Grazia
Fonte: Viruses;11(1)2019 Jan 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30641890
Resumo: Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial and immunomodulatory activities. Recently, we have shown that bLf, and in particular its C-lobe, interacts with influenza A virus hemagglutinin and prevents infection by different H1 and H3 viral subtypes. Influenza virus hemagglutinin (HA), and in particular its highly conserved fusion peptide involved in the low-pH-mediated fusion process, plays a sign (mais)

miR-193b represses influenza A virus infection by inhibiting Wnt/ß-catenin signaling.

Autor(es): Yang, Xiaoyun; Zhao, Chunling; Bamunuarachchi, Gayan; Wang, Yang; Liang, Yurong; Huang, Chaoqun; Zhu, Zhengyu; Xu, Dao; Lin, Kong; Senavirathna, Lakmini Kumari; Xu, Lan; Liu, Lin
Fonte: Cell Microbiol;: e13001, 2019 Jan 16.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30650225
Resumo: Due to an increasing emergence of new and drug-resistant strains of the influenza A virus (IAV), developing novel measures to combat influenza is necessary. We have previously shown that inhibiting Wnt/ß-catenin pathway reduces IAV infection. In this study, we aimed to identify antiviral human microRNAs (miRNAs) that target the Wnt/ß-catenin signaling pathway. Using a miRNA expression library, we identified 85 miRNAs that upregulated and 20 miRNAs that downregulated the Wnt/ß-catenin sig (mais)

Pediatric influenza and illness severity: what is known and what questions remain?

Autor(es): Doyle, Joshua D; Campbell, Angela P
Fonte: Curr Opin Pediatr;31(1): 119-126, 2019 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30531402
Resumo: PURPOSE OF REVIEW: Influenza causes a range of illnesses in children, from uncomplicated self-limited illness to severe disease and death. This review provides an update on the severity and burden of influenza in US children over recent seasons. RECENT FINDINGS: The 2017-2018 influenza season was widespread and severe across all ages, including children. Disease severity is influenced by influenza virologic characteristics and host factors, as well as public health interventions such as inf (mais)

Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.

Autor(es): Li, Haiwei; Li, Man; Xu, Renyang; Wang, Shouxin; Zhang, Yongmin; Zhang, Lihe; Zhou, Demin; Xiao, Sulong
Fonte: Eur J Med Chem;163: 560-568, 2019 Feb 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30554131
Resumo: It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of influenza virus infection. In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 ( (mais)

Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity.

Autor(es): Hong, Bei-Tao; Cheng, Yih-Shyun E; Cheng, Ting-Jen; Fang, Jim-Min
Fonte: Eur J Med Chem;163: 710-721, 2019 Feb 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30576902
Resumo: Tamiflu readily undergoes endogenous hydrolysis to give oseltamivir carboxylic acid (OC) as the active anti-influenza agent to inhibit the viral neuraminidase (NA). GOC is derived from OC by replacing the 5-amino group with a guanidino group. In this study, OC and GOC congeners with the carboxylic acid bioisosteres of boronic acid, trifluoroborate, sulfone, sulfinic acid, sulfonic acid and sulfonate ester were first synthesized, starting with conversion of OC to a Barton ester, followed by (mais)

A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9.

Autor(es): Li, Zhanping; Wan, Zhimin; Li, Tuofan; Xie, Quan; Sun, Haiwei; Chen, Hongjun; Liang, Guangchen; Shao, Hongxia; Qin, Aijian; Ye, Jianqiang
Fonte: Vet Microbiol;228: 39-44, 2019 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30593378
Resumo: In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus (IAV). These mAbs could react with HA of H7N9, H3N2, and H9N2 with neutralizing activity. A novel linear epitope recognized by these mAbs was identified by peptide-based ELISA, and this epitope was located in TAADYKSTQSAIDQITGKLN at the C terminus of the helix A of H7N9. 3 A11, which is one of (mais)

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza.

Autor(es): Uyeki, Timothy M; Bernstein, Henry H; Bradley, John S; Englund, Janet A; File, Thomas M; Fry, Alicia M; Gravenstein, Stefan; Hayden, Frederick G; Harper, Scott A; Hirshon, Jon Mark; Ison, Michael G; Johnston, B Lynn; Knight, Shandra L; McGeer, Allison; Riley, Laura E; Wolfe, Cameron R; Alexander, Paul E; Pavia, Andrew T
Fonte: Clin Infect Dis;2018 Dec 19.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30566567
Resumo: These clinical practice guidelines are an update of the guidelines published by the Infectious Diseases Society of America (IDSA) in 2009, prior to the 2009 H1N1 influenza pandemic. This document addresses new information regarding diagnostic testing, treatment and chemoprophylaxis with antiviral medications, and issues related to institutional outbreak management for seasonal influenza. It is intended for use by primary care clinicians, obstetricians, emergency medicine providers, hospital (mais)

Development of a novel oil-in-water emulsion and evaluation of its potential adjuvant function in a swine influenza vaccine in mice.

Autor(es): Zhang, Jinqiu; Miao, Jinfeng; Han, Xiangan; Lu, Yu; Deng, Bihua; Lv, Fang; Zhao, Yanhong; Ding, Chan; Hou, Jibo
Fonte: BMC Vet Res;14(1): 415, 2018 Dec 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30577861
Resumo: BACKGROUND: Vaccination is the principal strategy for prevention and control of diseases, and adjuvant use is an effective strategy to enhance vaccine efficacy. Traditional mineral oil-based adjuvants have been reported with post-immunization reactions. Developing new adjuvant formulations with improved potency and safety will be of great value. RESULTS: In the study reported herein, a novel oil-in-water (O/W) Emulsion Adjuvant containing Squalane (termed EAS) was developed, characterized a (mais)

Feeding melancholic microbes: MyNewGut recommendations on diet and mood.

Autor(es): Dinan, Timothy G; Stanton, Catherine; Long-Smith, Caitriona; Kennedy, Paul; Cryan, John F; Cowan, Caitlin S M; Cenit, María Carmen; van der Kamp, Jan-Willem; Sanz, Yolanda
Fonte: Clin Nutr;2018 Nov 17.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30497694
Resumo: Depression is a highly prevalent disorder which exerts a major economic impact in all European countries. The brain-gut-microbiota axis has been described as a new paradigm for advancing understanding and treatment of the disorder. There is now over-whelming evidence to support the fact that gut microbes have a major impact on central neurochemistry and behaviour, especially stress related disorders such as depression. Recent studies indicate that patients with depression have a gut dysbios (mais)
Resultados  1-12 de 8.494