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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 649
1.

Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient

Autor(es): Pontoriero, Andrea; Avaro, Martín; Benedetti, Estefania; Russo, Mara; Czech, Andrea; Periolo, Natalia; Campos, Ana; Zamora, Ana; Baumeister, Elsa
Fonte: Mem Inst Oswaldo Cruz;111(12): 745-749, Dec. 2016. graf
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 829259
Resumo: Although vaccines are the best means of protection against influenza, neuraminidase inhibitors are currently the main antiviral treatment available to control severe influenza cases. One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation. We describe the emergence of a mixed viral population with the E119E/V mutation in the NA protein sequence in a post-treatment influenza sample (mais)
2.

Establishment of memory CD8+ T cells with live attenuated influenza virus across different vaccination doses.

Autor(es): Wang, Zhongfang; Kedzierski, Lukasz; Nuessing, Simone; Chua, Brendon Yew Loong; Quiñones-Parra, Sergio M; Huber, Victor C; Jackson, David C; Thomas, Paul G; Kedzierska, Katherine
Fonte: J Gen Virol;97(12): 3205-3214, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27902386
Resumo: FluMist has been used in children and adults for more than 10 years. As pre-existing CD8+ T cell memory pools can provide heterologous immunity against distinct influenza viruses, it is important to understand influenza-specific CD8+ T cell responses elicited by different live attenuated influenza virus (LAIV) regimens. In this study, we immunized mice intranasally with two different doses of live-attenuated PR8 virus (PR8 ts, H1N1), low and high, and then assessed protective efficacy by ch (mais)
3.

Presenting Influenza A M2e Antigen on Recombinant Spores of Bacillus subtilis.

Autor(es): Lega, Tomasz; Weiher, Paulina; Obuchowski, Michal; Nidzworski, Dawid
Fonte: PLoS One;11(11): e0167225, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27902762
Resumo: Effective vaccination against influenza virus infection is a serious problem mainly due to antigenic variability of the virus. Among many of investigated antigens, the extracellular domain of the M2 protein (M2e) features high homology in all strains of influenza A viruses and antibodies against M2e and is protective in animal models; this makes it a potential candidate for generation of a universal influenza vaccine. However, due to the low immunogenicity of the M2e, formulation of a vacci (mais)
5.

A major impact of the influenza seasonal epidemic on intensive care units, Réunion, April to August 2016.

Autor(es): Filleul, Laurent; Ranoaritiana, Dany Bakoly; Balleydier, Elsa; Vandroux, David; Ferlay, Clémence; Jaffar-Bandjee, Marie-Christine; Jaubert, Julien; Roquebert, Bénédicte; Lina, Bruno; Valette, Martine; Hubert, Bruno; Larrieu, Sophie; Brottet, Elise
Fonte: Euro Surveill;21(47)2016 Nov 24.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27918264
Resumo: The 2016 seasonal influenza in Réunion in the southern hemisphere, was dominated by influenza A(H1N1)pdm09 (possibly genogroup 6B.1). An estimated 100,500 patients with acute respiratory infection (ARI) consulted a physician (cumulative attack rate 11.9%). Sixty-six laboratory-confirmed cases (65.7/100,000 ARI consultations) were hospitalised in an intensive care unit, the highest number since 2009. Impact on intensive care units was major. Correlation between severe cases was 0.83 between Réunion and France and good for 2009 to 2015.
6.

Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains.

Autor(es): Petrie, Joshua G; Parkhouse, Kaela; Ohmit, Suzanne E; Malosh, Ryan E; Monto, Arnold S; Hensley, Scott E
Fonte: J Infect Dis;214(12): 1947-1951, 2016 Dec 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27923954
Resumo: During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 st (mais)
7.

Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

Autor(es): Macchi, Eleonora; Rudd, Timothy R; Raman, Rahul; Sasisekharan, Ram; Yates, Edwin A; Naggi, Annamaria; Guerrini, Marco; Elli, Stefano
Fonte: Biochemistry;55(48): 6605-6616, 2016 Dec 06.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27933797
Resumo: Avian influenza A viruses, which can also propagate between humans, present serious pandemic threats, particularly in Asia. The specificity (selectivity) of interactions between the recognition protein hemagglutinin (HA) of the virus capsid and the glycoconjugates of host cells also contributes to the efficient spread of the virus by aerosol between humans. Some avian origin viruses, such as H1N1 (South Carolina 1918), have improved their selectivity for human receptors by mutation in the H (mais)
8.

Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016.

Autor(es): Fraaij, Pieter L A; Wildschut, Enno D; Houmes, Robert J; Swaan, Corien M; Hoebe, Christian J; de Jonge, H C C; Tolsma, Paulien; de Kleer, Isme; Pas, Suzan D; Oude Munnink, Bas B; Phan, My V T; Bestebroer, Theo M; Roosenhoff, R Shanty; van Kampen, Jeroen J A; Cotten, Matthew; Beerens, Nancy; Fouchier, Ron A M; van den Kerkhof, Johannes H; Timen, Aura; Koopmans, Marion P
Fonte: Euro Surveill;21(48)2016 Dec 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934581
Resumo: In October 2016, a severe infection with swine influenza A(H1N1) virus of the Eurasian avian lineage occurred in a child with a previous history of eczema in the Netherlands, following contact to pigs. The patient's condition deteriorated rapidly and required life support through extracorporeal membrane oxygenation. After start of oseltamivir treatment and removal of mucus plugs, the patient fully recovered. Monitoring of more than 80 close unprotected contacts revealed no secondary cases.
9.

Generation and characterisation of monoclonal antibodies specific to avian influenza H7N9 haemagglutinin protein.

Autor(es): Malik, A; Mallajosyula, Vva; Mishra, N N; Arukha, A P; Varadarajan, R; Gupta, S K
Fonte: Indian J Med Microbiol;34(4): 489-494, 2016 Oct-Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934828
Resumo: INTRODUCTION: Emerging virulent strains of influenza virus pose a serious public health threat with potential pandemic consequences. A novel avian influenza virus, H7N9, breached the species barrier from infected domestic poultry to humans in 2013 in China. Since then, it has caused numerous infections in humans with a close contact to poultry. MATERIALS AND METHODS: In this study, we describe the preliminary characterisation of five murine monoclonal antibodies (MAbs) developed against rec (mais)
10.

Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.

Autor(es): Wang, Biao; Russell, Margaret L; Moss, Lorraine; Fonseca, Kevin; Earn, David J D; Aoki, Fred; Horsman, Gregory; Caeseele, Paul Van; Chokani, Khami; Vooght, Mark; Babiuk, Lorne; Webby, Richard; Walter, Stephen D; Loeb, Mark
Fonte: PLoS One;11(12): e0167281, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27977707
Resumo: BACKGROUND: An earlier cluster randomized controlled trial (RCT) of Hutterite colonies had shown that if more than 80% of children and adolescents were immunized with influenza vaccine there was a statistically significant reduction in laboratory-confirmed influenza among all unimmunized community members. We assessed the impact of this intervention for two additional influenza seasonal periods. METHODS: Follow-up data for two influenza seasonal periods of a cluster randomized trial involvi (mais)
11.

Genetic Characterization of Circulating 2015 A(H1N1)pdm09 Influenza Viruses from Eastern India.

Autor(es): Mukherjee, Anupam; Nayak, Mukti Kant; Dutta, Shanta; Panda, Samiran; Satpathi, Biswa Ranjan; Chawla-Sarkar, Mamta
Fonte: PLoS One;11(12): e0168464, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27997573
Resumo: In 2015, the swine derived A(H1N1)pdm09 pandemic strain outbreak became widespread throughout the different states of India. The reported cases and deaths in 2015 surpassed the previous years with more than 39000 laboratory confirmed cases and a death toll of more than 2500 people. There are relatively limited complete genetic sequences available for this virus from Asian countries. In this study, we describe the full genome analysis of influenza 2015 A(H1N1)pdm09 viruses isolated from West (mais)
12.

The 2009 influenza A virus subtype H1N1 pandemic, a glance from Greece.

Autor(es): Tsoucalas, Gregory; Sgantzos, Markos
Fonte: Infez Med;24(4): 259-264, 2016 12 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 28011959
Resumo: The 2009 influenza A - subtype H1N1 pandemic tested the public health care systems all around the globe, infecting millions and leading to thousands of deaths. Greece became the epidemic centre of the 2009 flu pandemic due to the low compliance of the general population towards the vaccination programme, the resistance acquired against antiviral drugs and the economic scenario at the time. Our study, after a thorough research in the "Medline/PubMed, Scopus, Google Scholars" medical database (mais)
Resultados  1-12 de 649