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Resultados  1-12 de 6.020

Methods for Mapping Neuronal Activity to Synaptic Connectivity: Lessons From Larval Zebrafish.

Autor(es): Wanner, Adrian A; Vishwanathan, Ashwin
Fonte: Front Neural Circuits;12: 89, 2018.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30410437
Resumo: For a mechanistic understanding of neuronal circuits in the brain, a detailed description of information flow is necessary. Thereby it is crucial to link neuron function to the underlying circuit structure. Multiphoton calcium imaging is the standard technique to record the activity of hundreds of neurons simultaneously. Similarly, recent advances in high-throughput electron microscopy techniques allow for the reconstruction of synaptic resolution wiring diagrams. These two methods can be c (mais)

Applicability of the lung-molGPA index in non-small cell lung cancer patients with different gene alterations and brain metastases.

Autor(es): Chen, Kaiyan; Yu, Xiaoqing; Zhang, Fanrong; Xu, Yanjun; Zhang, Peng; Huang, Zhiyu; Fan, Yun
Fonte: Lung Cancer;125: 8-13, 2018 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30429042
Resumo: OBJECTIVES: The Lung-molGPA index is based on the original diagnosis-specific graded prognostic assessment (DS-GPA) and incorporates recently reported gene alteration data, predicting the outcomes of non-small cell lung cancer (NSCLC) patients with brain metastases (BM). However, the prognostic values of both DS-GPA and Lung-molGPA remain undetermined, especially for patients with different molecular types. MATERIALS AND METHODS: A total of 1184 NSCLC patients with BM were analyzed for clin (mais)

Out of school female adolescent employment status and sexually transmitted infections (STIs) risk in Uganda: is it a plausible relationship?

Autor(es): Misinde, Cyprian; Nansubuga, Elizabeth; Nankinga, Olivia
Fonte: BMC Public Health;18(1): 1173, 2018 Oct 12.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30314473
Resumo: BACKGROUND: High prevalence of Sexually Transmitted Infections (STIs) among adolescents is a serious public health concern. Although many factors are attributed to adolescents' risk of STI infections, the association between out of school adolescents' employment status and STIs has not been thoroughly explored in Uganda, yet many adolescents are known to be employed. Consequently, the extent to which adolescents' employment status may be a risk factor for unprotected sex and STIs among fema (mais)

Tumor Microenvironment-Responsive Ultrasmall Nanodrug Generators with Enhanced Tumor Delivery and Penetration.

Autor(es): Zhang, Pengfei; Wang, Junqing; Chen, Hu; Zhao, Lei; Chen, Binbin; Chu, Chengchao; Liu, Heng; Qin, Zainen; Liu, Jingyi; Tan, Yuanzhi; Chen, Xiaoyuan; Liu, Gang
Fonte: J Am Chem Soc;140(44): 14980-14989, 2018 Nov 07.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30359020
Resumo: Tumor microenvironment-induced ultrasmall nanodrug generation (TMIUSNG) is an unprecedented approach to overcome the drug penetration barriers across complex biological systems, poor circulation stability and limited drug loading efficiency (DLE). Herein, a novel strategy was designed to synthesize metal-organic nanodrug complexes (MONCs) through supramolecular coassembly of photosensitizer sinoporphyrin sodium, chemotherapeutic drug doxorubicin and ferric ions. Compared with the free photo (mais)

Synthesis of Furan-Annelated BINOL Derivatives: Acid-Catalyzed Cyclization Induces Partial Racemization.

Autor(es): Octa-Smolin, Frescilia; van der Vight, Felix; Yadav, Rohan; Bhangu, Jasmine; Soloviova, Kateryna; Wölper, Christoph; Daniliuc, Constantin G; Strassert, Cristian A; Somnitz, Holger; Jansen, Georg; Niemeyer, Jochen
Fonte: J Org Chem;2018 Nov 08.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30359025
Resumo: In this account, we describe the synthesis of a series of BINOL-based bis- and trisphosphoric acids 11d/e/f, which commonly feature an unusual phosphoric acid monoester motif. This motif is generated by an acid-catalyzed 5- endo- dig cyclization of the 3-alkynyl-substituted BINOL precursors to give the corresponding Furan-annelated derivatives, followed by phosphorylation of the remaining phenolic alcohols. In the cyclization reaction, we observed an unexpected partial racemization in the b (mais)

The temporal dynamics of perceptual and conceptual fluency on recognition memory.

Autor(es): Wang, Wei; Li, Bingbing; Gao, Chuanji; Guo, Chunyan
Fonte: Brain Cogn;127: 1-12, 2018 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30176534
Resumo: Recognition memory can be driven by both perceptual and conceptual fluency, but when and to what extent they contribute to recognition memory remains an open question. The present study used event-related potentials (ERPs) to investigate the neural correlates of perceptual and conceptual fluency, when they gave rise to recognition. We manipulated the perceptual and conceptual fluency of retrieval cues in the recognition test independently to obtain the effects of different types of fluency. (mais)

ACL Function in Bicruciate-Retaining Total Knee Arthroplasty.

Autor(es): Okada, Yohei; Teramoto, Atsushi; Takagi, Tetsuya; Yamakawa, Satoshi; Sakakibara, Yuzuru; Shoji, Hiroaki; Watanabe, Kota; Fujimiya, Mineko; Fujie, Hiromichi; Yamashita, Toshihiko
Fonte: J Bone Joint Surg Am;100(17): e114, 2018 Sep 05.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30180063
Resumo: BACKGROUND: Bicruciate-retaining total knee arthroplasty (BCR-TKA) is attracting attention because of the functional and satisfaction outcomes associated with keeping the anterior cruciate ligament (ACL) intact. However, knowledge of the functional importance of the ACL after BCR-TKA is limited. We performed a biomechanical investigation of ACL function following BCR-TKA compared with that in the intact knee. METHODS: We investigated 8 fresh-frozen human cadaveric knees using a 6-degrees-of (mais)

Quantitative Evaluation of Hip Impingement Utilizing Computed Tomography Measurements.

Autor(es): Kalia, Vivek; Fader, Ryan F; Mintz, Douglas N; Bogner, Eric A; Buly, Robert L; Carrino, John A; Kelly, Bryan T
Fonte: J Bone Joint Surg Am;100(17): 1526-1535, 2018 Sep 05.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30180064

Effects of weak static magnetic fields on the gene expression of seedlings of Arabidopsis thaliana.

Autor(es): Dhiman, Sunil K; Galland, Paul
Fonte: J Plant Physiol;231: 9-18, 2018 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30199755
Resumo: Magnetic-field reception of animals and plants is currently discussed in the framework of a cryptochrome-based radical-pair mechanism. Efforts to unravel magnetoreception in plants suffered historically from several shortcomings, most prominently, the conspicuous absence of detailed stimulus-response relationships. To determine the sensitivity of seedlings of Arabidopsis thaliana to weak static magnetic fields we generated stimulus-response curves between near zero and 188 µT for the trans (mais)
Resultados  1-12 de 6.020