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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 680
1.

Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient

Autor(es): Pontoriero, Andrea; Avaro, Martín; Benedetti, Estefania; Russo, Mara; Czech, Andrea; Periolo, Natalia; Campos, Ana; Zamora, Ana; Baumeister, Elsa
Fonte: Mem Inst Oswaldo Cruz;111(12): 745-749, Dec. 2016. graf
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 829259
Resumo: Although vaccines are the best means of protection against influenza, neuraminidase inhibitors are currently the main antiviral treatment available to control severe influenza cases. One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation. We describe the emergence of a mixed viral population with the E119E/V mutation in the NA protein sequence in a post-treatment influenza sample (mais)
2.

Establishment of memory CD8+ T cells with live attenuated influenza virus across different vaccination doses.

Autor(es): Wang, Zhongfang; Kedzierski, Lukasz; Nuessing, Simone; Chua, Brendon Yew Loong; Quiñones-Parra, Sergio M; Huber, Victor C; Jackson, David C; Thomas, Paul G; Kedzierska, Katherine
Fonte: J Gen Virol;97(12): 3205-3214, 2016 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27902386
Resumo: FluMist has been used in children and adults for more than 10 years. As pre-existing CD8+ T cell memory pools can provide heterologous immunity against distinct influenza viruses, it is important to understand influenza-specific CD8+ T cell responses elicited by different live attenuated influenza virus (LAIV) regimens. In this study, we immunized mice intranasally with two different doses of live-attenuated PR8 virus (PR8 ts, H1N1), low and high, and then assessed protective efficacy by ch (mais)
3.

Regulation of Matrix Metalloproteinases-2 and -9 Gene Expression in Cultured Human Fetal Membrane Cells by Influenza Virus Infection.

Autor(es): Uchide, Noboru; Obatake, Kyoko; Yamada, Rie; Sadanari, Hidetaka; Matsubara, Keiko; Murayama, Tsugiya; Ohyama, Kunio
Fonte: Biol Pharm Bull;39(12): 1912-1921, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27904034
Resumo: In order to understand a possible etiology of adverse pregnancy outcomes associated with intrauterine influenza virus infection, we examined the effect of influenza virus infection on gene expression of matrix metalloproteinases (MMPs) in cultured amnion epithelial, amnion mesenchymal and chorion trophoblast cells prepared from human fetal membrane tissues by gelatin zymography, Western blotting and reverse transcriptase-PCR. The cells were infected with influenza A (H1N1) virus. The levels (mais)
4.

Prevalence and correlates of vaccine hesitancy among general practitioners: a cross-sectional telephone survey in France, April to July 2014.

Autor(es): Verger, Pierre; Collange, Fanny; Fressard, Lisa; Bocquier, Aurélie; Gautier, Arnaud; Pulcini, Céline; Raude, Jocelyn; Peretti-Watel, Patrick
Fonte: Euro Surveill;21(47)2016 Nov 24.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27918262
Resumo: This article sought to estimate the prevalence of vaccine hesitancy (VH) among French general practitioners (GPs) and to study its demographic, professional and personal correlates. We conducted a cross-sectional telephone survey about GPs' vaccination-related attitudes and practices in 2014 in a national panel of 1,712 GPs in private practice, randomly selected from an exhaustive database of health professionals in France. A cluster analysis of various dimensions of VH (self-reported vacci (mais)
5.

A major impact of the influenza seasonal epidemic on intensive care units, Réunion, April to August 2016.

Autor(es): Filleul, Laurent; Ranoaritiana, Dany Bakoly; Balleydier, Elsa; Vandroux, David; Ferlay, Clémence; Jaffar-Bandjee, Marie-Christine; Jaubert, Julien; Roquebert, Bénédicte; Lina, Bruno; Valette, Martine; Hubert, Bruno; Larrieu, Sophie; Brottet, Elise
Fonte: Euro Surveill;21(47)2016 Nov 24.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27918264
Resumo: The 2016 seasonal influenza in Réunion in the southern hemisphere, was dominated by influenza A(H1N1)pdm09 (possibly genogroup 6B.1). An estimated 100,500 patients with acute respiratory infection (ARI) consulted a physician (cumulative attack rate 11.9%). Sixty-six laboratory-confirmed cases (65.7/100,000 ARI consultations) were hospitalised in an intensive care unit, the highest number since 2009. Impact on intensive care units was major. Correlation between severe cases was 0.83 between Réunion and France and good for 2009 to 2015.
6.

Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains.

Autor(es): Petrie, Joshua G; Parkhouse, Kaela; Ohmit, Suzanne E; Malosh, Ryan E; Monto, Arnold S; Hensley, Scott E
Fonte: J Infect Dis;214(12): 1947-1951, 2016 Dec 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27923954
Resumo: During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 st (mais)
7.

Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

Autor(es): Macchi, Eleonora; Rudd, Timothy R; Raman, Rahul; Sasisekharan, Ram; Yates, Edwin A; Naggi, Annamaria; Guerrini, Marco; Elli, Stefano
Fonte: Biochemistry;55(48): 6605-6616, 2016 Dec 06.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27933797
Resumo: Avian influenza A viruses, which can also propagate between humans, present serious pandemic threats, particularly in Asia. The specificity (selectivity) of interactions between the recognition protein hemagglutinin (HA) of the virus capsid and the glycoconjugates of host cells also contributes to the efficient spread of the virus by aerosol between humans. Some avian origin viruses, such as H1N1 (South Carolina 1918), have improved their selectivity for human receptors by mutation in the H (mais)
8.

Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016.

Autor(es): Fraaij, Pieter L A; Wildschut, Enno D; Houmes, Robert J; Swaan, Corien M; Hoebe, Christian J; de Jonge, H C C; Tolsma, Paulien; de Kleer, Isme; Pas, Suzan D; Oude Munnink, Bas B; Phan, My V T; Bestebroer, Theo M; Roosenhoff, R Shanty; van Kampen, Jeroen J A; Cotten, Matthew; Beerens, Nancy; Fouchier, Ron A M; van den Kerkhof, Johannes H; Timen, Aura; Koopmans, Marion P
Fonte: Euro Surveill;21(48)2016 Dec 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934581
Resumo: In October 2016, a severe infection with swine influenza A(H1N1) virus of the Eurasian avian lineage occurred in a child with a previous history of eczema in the Netherlands, following contact to pigs. The patient's condition deteriorated rapidly and required life support through extracorporeal membrane oxygenation. After start of oseltamivir treatment and removal of mucus plugs, the patient fully recovered. Monitoring of more than 80 close unprotected contacts revealed no secondary cases.
9.

Generation and characterisation of monoclonal antibodies specific to avian influenza H7N9 haemagglutinin protein.

Autor(es): Malik, A; Mallajosyula, Vva; Mishra, N N; Arukha, A P; Varadarajan, R; Gupta, S K
Fonte: Indian J Med Microbiol;34(4): 489-494, 2016 Oct-Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27934828
Resumo: INTRODUCTION: Emerging virulent strains of influenza virus pose a serious public health threat with potential pandemic consequences. A novel avian influenza virus, H7N9, breached the species barrier from infected domestic poultry to humans in 2013 in China. Since then, it has caused numerous infections in humans with a close contact to poultry. MATERIALS AND METHODS: In this study, we describe the preliminary characterisation of five murine monoclonal antibodies (MAbs) developed against rec (mais)
10.

Epidemiological and Virological Characteristics of Influenza in Chongqing, China, 2011-2015.

Autor(es): Qi, Li; Xiong, Yu; Xiao, Bangzhong; Tang, Wenge; Ling, Hua; Long, Jiang; Xiao, Dayong; Zhao, Han; Ye, Sheng; Chen, Shuang; Yu, Zhen; Li, Qin
Fonte: PLoS One;11(12): e0167866, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27936139
Resumo: BACKGROUND: Chongqing is the largest municipality and located in Southwestern of China, with over 30 million registered inhabitants. There are few reports regarding the epidemiology of influenza in Chongqing. The objective of the paper is to explore the epidemiology of influenza in Chongqing, in order to provide scientific basis for prevention and control of influenza. METHODOLOGY /PRINCIPAL FINDINGS: From 2011 to 2015, we collected information on influenza-like illness (ILI) patients fulfi (mais)
11.

Acute Respiratory Distress Syndrome Secondary to Influenza A(H1N1)pdm09: Clinical Characteristics and Mortality Predictors.

Autor(es): Hernández-Cárdenas, Carmen Margarita; Serna-Secundino, Héctor; García-Olazarán, José Guadalupe; Aguilar-Pérez, Cristina Leticia; Rocha-Machado, Jesús; Campos-Calderón, Luis Fernando; Lugo-Goytia, Gustavo
Fonte: Rev Invest Clin;68(5): 235-244, 2016 Sep-Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27941959
Resumo: BACKGROUND: Acute respiratory distress syndrome secondary to influenza A(H1N1)pdm09 virus is the leading cause of death among this patient population. Expanding the knowledge of its course and predictors of mortality is relevant to decision making. We aimed to describe the clinical characteristics and identify factors associated with mortality in patients with acute respiratory distress syndrome secondary to influenza A(H1N1)pdm09 during the 2013-2014 influenza season. METHODS: This is an o (mais)
12.

A highly pathogenic avian influenza virus H5N1 with 2009 pandemic H1N1 internal genes demonstrates increased replication and transmission in pigs.

Autor(es): Abente, Eugenio J; Kitikoon, Pravina; Lager, Kelly M; Gauger, Phillip C; Anderson, Tavis K; Vincent, Amy
Fonte: J Gen Virol;2016 Dec 09.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27959778
Resumo: This study investigated the pathogenicity and transmissibility of a reverse-genetics derived highly pathogenic avian influenza (HPAI) H5N1 lineage influenza A virus (IAV) that was isolated from a human, A/Iraq/755/06. We also examined surface gene reassortant viruses comprised of the HA and NA from A/Iraq/755/06 and the internal genes of a 2009 pandemic H1N1 virus, A/New York/18/2009 (2Iraq/06:6NY/09 H5N1), and HA and NA from A/New York/18/2009 with the internal genes of A/Iraq/755/06 (2NY/ (mais)
Resultados  1-12 de 680