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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 641
1.

Molekulární a antigenní analýza hemaglutininu viru chripky A H3N2 detekovaných v Ceské republice v epidemické sezone 2014/2015./ Molecular and antigenic characterization of the H3 hemagglutinin of H3N2 influenza A virus strains collected in the Czech Republic during the 2014/2015 epidemic season.

Autor(es): Nagy, A; Jirincová, H; Kyncl, J; Havlícková, M
Fonte: Epidemiol Mikrobiol Imunol;65(2): 92-101, Summer 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27467326
Resumo: The 2014/2015 influenza epidemic season was characterized by the predominance of the H3N2 subtype. The presented study investigated the genetic and antigenic heterogeneity of the H3N2 strains collected in the Czech Republic from November 2014 to March 2015. Phylogenetic analysis of the representative H3 hemagglutinin sequences was performed and the glycosylation status and crucial antigenic mutations were compared relative to the 2014 and 2015 vaccine strains (A/Texas/50/2012 and A/Switzerl (mais)
2.

G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice.

Autor(es): Kaewborisuth, Challika; Kaplan, Bryan; Zanin, Mark; Finkelstein, David; Webby, Richard J; Lekcharoensuk, Porntippa
Fonte: Arch Virol;162(1): 45-55, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27664027
Resumo: Nonstructural protein 1 (NS1) is a multifunctional protein that is a viral replication enhancer and virulence factor. In this study, we investigated the effect of the amino acid substitution G45R on the NS1 of A/Puerto Rico/8/1934 (H1N1) (G45R/NS1) on viral virulence and host gene expression in a mouse model and the human lung cell line A549. The G45R/NS1 virus had increased virulence by inducing an earlier and robust proinflammatory cytokine response in mice. Mice infected with the G45R/NS (mais)
3.

IL-1ß is a key cytokine that induces trypsin upregulation in the influenza virus-cytokine-trypsin cycle.

Autor(es): Indalao, I L; Sawabuchi, T; Takahashi, E; Kido, H
Fonte: Arch Virol;162(1): 201-211, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27714503
Resumo: Severe influenza is characterized by a cytokine storm, and the influenza virus-cytokine-trypsin cycle is one of the important mechanisms of viral multiplication and multiple organ failure. The aim of this study was to define the key cytokine(s) responsible for trypsin upregulation. Mice were infected with influenza virus strain A/Puerto Rico/8/34 (H1N1) or treated individually or with a combination of interleukin-1ß, interleukin-6, and tumor necrosis factor α. The levels of these cyto (mais)
4.

Dose-dependent antiviral activity of released-active form of antibodies to interferon-gamma against influenza A/California/07/09(H1N1) in murine model.

Autor(es): Don, Еlena S; Emelyanova, Alexandra G; Yakovleva, Natalia N; Petrova, Nataliia V; Nikiforova, Marina V; Gorbunov, Evgeniy A; Tarasov, Sergey А; Morozov, Sergey G; Epstein, Оleg I
Fonte: J Med Virol;89(5): 759-766, 2017 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27769099
Resumo: The assessment of dose-response is an essential part of drug development in terms of the determination of a drug's effective dose, finding the safety endpoint, estimation of the pharmacokinetic profile, and even validation of drug activity, especially for therapeutic agents with a principally novel mechanism of action. Drugs based on released-active forms of antibodies are a good example of such a target. In this study, the efficacy of the antiviral drug Anaferon for children (released-acti (mais)
5.

Influenza A Viruses of Swine (IAV-S) in Vietnam from 2010 to 2015: Multiple Introductions of A(H1N1)pdm09 Viruses into the Pig Population and Diversifying Genetic Constellations of Enzootic IAV-S.

Autor(es): Takemae, Nobuhiro; Harada, Michiyo; Nguyen, Phuong Thanh; Nguyen, Tung; Nguyen, Tien Ngoc; To, Thanh Long; Nguyen, Tho Dang; Pham, Vu Phong; Le, Vu Tri; Do, Hoa Thi; Vo, Hung Van; Le, Quang Vinh Tin; Tran, Tan Minh; Nguyen, Thanh Duy; Thai, Phuong Duy; Nguyen, Dang Hoang; Le, Anh Quynh Thi; Nguyen, Diep Thi; Uchida, Yuko; Saito, Takehiko
Fonte: J Virol;91(1)2017 Jan 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27795418
Resumo: Active surveillance of influenza A viruses of swine (IAV-S) involving 262 farms and 10 slaughterhouses in seven provinces in northern and southern Vietnam from 2010 to 2015 yielded 388 isolates from 32 farms; these viruses were classified into H1N1, H1N2, and H3N2 subtypes. Whole-genome sequencing followed by phylogenetic analysis revealed that the isolates represented 15 genotypes, according to the genetic constellation of the eight segments. All of the H1N1 viruses were entirely A(H1N1)pd (mais)
6.

The pharmacological management of severe influenza infection - 'existing and emerging therapies'.

Autor(es): Mc Mahon, Aisling; Martin-Loeches, Ignacio
Fonte: Expert Rev Clin Pharmacol;10(1): 81-95, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27797595
Resumo: INTRODUCTION: Over the last century several influenza outbreaks have traversed the globe, most recently the influenza A(H1N1) 2009 pandemic. On each occasion, a highly contagious, virulent pathogen has emerged, leading to significant morbidity and mortality amongst those affected. Areas covered: Early antiviral therapy and supportive care is the mainstay of treatment. Treatment should be started as soon as possible and not delayed for the results of diagnostic testing. Whilst oseltamivir is (mais)
7.

Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function.

Autor(es): Marvin, Shauna A; Russier, Marion; Huerta, C Theodore; Russell, Charles J; Schultz-Cherry, Stacey
Fonte: J Virol;91(2)2017 Jan 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27807237
Resumo: Whether influenza virus replication in macrophages is productive or abortive has been a topic of debate. Utilizing a panel of 28 distinct human, avian, and swine influenza viruses, we found that only a small subset can overcome cellular blocks to productively replicate in murine and primary human macrophages. Murine macrophages have two cellular blocks. The first block is during viral entry, where virions with relatively acid-stable hemagglutinin (HA) proteins are rendered incapable of pH-i (mais)
8.

Versatility of a localized surface plasmon resonance-based gold nanoparticle-alloyed quantum dot nanobiosensor for immunofluorescence detection of viruses.

Autor(es): Takemura, Kenshin; Adegoke, Oluwasesan; Takahashi, Naoto; Kato, Tatsuya; Li, Tian-Cheng; Kitamoto, Noritoshi; Tanaka, Tomoyuki; Suzuki, Tetsuro; Park, Enoch Y
Fonte: Biosens Bioelectron;89(Pt 2): 998-1005, 2017 Mar 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27825520
Resumo: Flu infection, caused by the influenza virus, constitutes a serious threat to human lives worldwide. A rapid, sensitive and specific diagnosis is urgently needed for point-of-care treatment and to control the rapid spread of this disease. In this study, an ultrasensitive, rapid and specific localized surface plasmon resonance (LSPR)-induced immunofluorescence nanobiosensor has been developed for the influenza virus based on a gold nanoparticle (AuNP)-induced quantum dot (QD) fluorescence si (mais)
9.

Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO).

Autor(es): Hermann, B; Lehners, N; Brodhun, M; Boden, K; Hochhaus, A; Kochanek, M; Meckel, K; Mayer, K; Rachow, T; Rieger, C; Schalk, E; Weber, T; Schmeier-Jürchott, A; Schlattmann, P; Teschner, D; von Lilienfeld-Toal, M
Fonte: Eur J Clin Microbiol Infect Dis;36(3): 565-573, 2017 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27838792
Resumo: Influenza virus infections (IVI) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. In this study, we collected data on patients with active cancer or with a history of cancer, presenting with documented IVI in eight centres in Germany. Two hundred and three patients were identified, suffering from haematological malignancies or solid tumours; 109 (54 %) patients had ac (mais)
10.

An Amino Acid in the Stalk Domain of N1 Neuraminidase Is Critical for Enzymatic Activity.

Autor(es): Zanin, Mark; Duan, Susu; Wong, Sook-San; Kumar, Gyanendra; Baviskar, Pradyumna; Collin, Emily; Russell, Charles; Barman, Subrata; Hause, Benjamin; Webby, Richard
Fonte: J Virol;91(2)2017 Jan 15.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27847354
Resumo: Neuraminidase (NA) is a sialidase expressed on the surface of influenza A viruses that releases progeny viruses from the surface of infected cells and prevents viruses becoming trapped in mucus. It is a homotetramer, with each monomer consisting of a transmembrane region, a stalk, and a globular head with sialidase activity. We recently characterized two swine viruses of the pandemic H1N1 lineage, A/swine/Virginia/1814-1/2012 (pH1N1 -1) and A/swine/Virginia/1814-2/2012 (pH1N1 -2), with almo (mais)
11.

Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.

Autor(es): Kossyvakis, A; Mentis, A-F A; Tryfinopoulou, K; Pogka, V; Kalliaropoulos, A; Antalis, E; Lytras, T; Meijer, A; Tsiodras, S; Karakitsos, P; Mentis, A F
Fonte: Eur J Clin Microbiol Infect Dis;36(2): 361-371, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27848039
Resumo: There was an increase in severe and fatal influenza cases in Greece during the 2011-2015 post-pandemic period. To investigate causality, we determined neuraminidase (NA) inhibitor susceptibility and resistance-conferring NA and hemagglutinin (HA) mutations in circulating influenza type A viruses during the pandemic (2009-2010) and post-pandemic periods in Greece. One hundred thirty-four influenza A(H1N1)pdm09 and 95 influenza A(H3N2) viruses submitted to the National Influenza Reference Lab (mais)
12.

Origin, distribution, and potential risk factors associated with influenza A virus in swine in two production systems in Guatemala.

Autor(es): Gonzalez-Reiche, Ana S; Ramírez, Ana L; Müller, María L; Orellana, David; Sosa, Silvia M; Ola, Pablo; Paniagua, Jorge; Ortíz, Lucía; Hernandez, Jorge; Cordón-Rosales, Celia; Perez, Daniel R
Fonte: Influenza Other Respir Viruses;11(2): 182-192, 2017 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27860313
Resumo: BACKGROUND: Guatemala is the country with the largest swine production in Central America; however, evidence of influenza A virus (IAV) in pigs has not been clearly delineated. OBJECTIVES: In this study, we analyzed the presence and spatial distribution of IAV in commercial and backyard swine populations. METHODS: Samples from two nationwide surveys conducted in 2010 and 2011 were tested using virological (rRT-PCR and virus isolation) and serological (ELISA and hemagglutination inhibition) (mais)
Resultados  1-12 de 641