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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 10.219
1.

In vitro and in vivo characterization of novel neuraminidase substitutions in influenza A(H1N1)pdm09 identified using Laninamivir-mediated selection.

Autor(es): Lloren, Khristine Kaith S; Kwon, Jin Jung; Choi, Won-Suk; Jeong, Ju Hwan; Jeong Ahn, Su; Ki Choi, Young; Baek, Yun Hee; Song, Min-Suk
Fonte: J Virol;2019 Jan 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30602610
Resumo: Neuraminidase inhibitors (NAIs) are widely used antiviral drugs for the treatment of humans with influenza virus infections. There have been widespread reports of NAI resistance among seasonal A(H1N1) viruses, and most have been identified in oseltamivir-exposed patients or those treated with other NAIs. Thus, monitoring and identifying NA markers conferring resistance to NAIs-particularly newly introduced treatments-is critical to manage viral infections. Therefore, we screened and identif (mais)
2.

Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype.

Autor(es): Martínez, Ana; Soldevila, Núria; Romero-Tamarit, Arantxa; Torner, Núria; Godoy, Pere; Rius, Cristina; Jané, Mireia; Domínguez, Àngela
Fonte: PLoS One;14(1): e0210353, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30633778
Resumo: Seasonal influenza is a cause of hospitalization, especially in people with underlying disease or extreme age, and its severity may differ depending on the types and subtypes of circulating viruses. We investigated the factors associated with ICU admission or death in hospitalized patients with severe laboratory-confirmed influenza according to the viral type and subtype. An observational epidemiological study was carried out in patients aged ≥18 years from 12 Catalan hospitals betwee (mais)
3.

Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study.

Autor(es): Hershberger, Ellie; Sloan, Susan; Narayan, Kristin; Hay, Catherine A; Smith, Patrick; Engler, Frank; Jeeninga, Rienk; Smits, Saskia; Trevejo, Jose; Shriver, Zach; Oldach, David
Fonte: EBioMedicine;2019 Jan 09.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30638863
Resumo: BACKGROUND: VIS410, a broadly neutralizing monoclonal antibody that binds the hemagglutinin stem of influenza A viruses, was safe and efficacious in a human H1N1 virus challenge study. This study evaluated the safety and tolerability of VIS410 in non-hospitalized adult patients with uncomplicated influenza A. METHODS: Patients 18 to 65 years of age with symptom onset within 72 h were randomized 1:1:1 to receive a single intravenous infusion of VIS410 4000 mg, 2000 mg, or (mais)
4.

Pediatric influenza and illness severity: what is known and what questions remain?

Autor(es): Doyle, Joshua D; Campbell, Angela P
Fonte: Curr Opin Pediatr;31(1): 119-126, 2019 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30531402
Resumo: PURPOSE OF REVIEW: Influenza causes a range of illnesses in children, from uncomplicated self-limited illness to severe disease and death. This review provides an update on the severity and burden of influenza in US children over recent seasons. RECENT FINDINGS: The 2017-2018 influenza season was widespread and severe across all ages, including children. Disease severity is influenced by influenza virologic characteristics and host factors, as well as public health interventions such as inf (mais)
5.

Molecular epidemiology of the hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran.

Autor(es): Mohebbi, Atefeh; Fotouhi, Fatemeh; Jamali, Abbas; Yaghobi, Ramin; Farahmand, Behrokh; Mohebbi, Reza
Fonte: Virus Res;259: 38-45, 2019 01 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30336188
Resumo: In 2015, the influenza virus A/H1N1/pdm09 strain outbreak became prevalent throughout the different provinces of Iran. There are relatively limited complete genetic sequences available for this virus from Asian countries. Diagnosis and virological surveillance of influenza is essential for detecting novel genetic variants causing epidemic potential. This study describes the genetic properties of HA genome of influenza A/H1N1 pdm09 viruses circulating in Iran during the 2015/2016 season. In (mais)
6.

Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication.

Autor(es): Zhang, Jingting; Ruan, Tao; Sheng, Tianyu; Wang, Jiongjiong; Sun, Jing; Wang, Jin; Prinz, Richard A; Peng, Daxin; Liu, Xiufan; Xu, Xiulong
Fonte: Virology;526: 1-12, 2019 01 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30316042
Resumo: The non-structural protein 1 (NS1) of different influenza A virus (IAV) strains can differentially regulate the activity of c-Jun terminal kinase (JNK) and PI-3 kinase (PI3K). Whether varying JNK and PI3K activation impacts autophagy and IAV replication differently remains uncertain. Here we report that H5N1 (A/mallard/Huadong/S/2005) influenza A virus induced functional autophagy, as evidenced by increased LC3 lipidation and decreased p62 levels, and the presence of autolysosomes in chicke (mais)
7.

Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus.

Autor(es): Wang, Zhao; Yu, Jieshi; Thomas, Milton; Sreenivasan, Chithra C; Hause, Ben M; Wang, Dan; Francis, David H; Kaushik, Radhey S; Li, Feng
Fonte: Vet Microbiol;228: 26-31, 2019 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30593376
Resumo: There is an urgent need to develop a broad-spectrum vaccine that can effectively prevent or eliminate the spread of co-circulating swine influenza virus strains in multiple lineages or subtypes. We describe here that pre-exposure with a live virus generated via a A/WSN/1933(H1N1) reverse genetics system resulted in a significant reduction of viral shedding from pigs exposed to either a swine H1N1 virus or a swine H3N2 virus. At 3-day post challenge (DPC), approximately 1 log and 1.5 logs re (mais)
8.

A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9.

Autor(es): Li, Zhanping; Wan, Zhimin; Li, Tuofan; Xie, Quan; Sun, Haiwei; Chen, Hongjun; Liang, Guangchen; Shao, Hongxia; Qin, Aijian; Ye, Jianqiang
Fonte: Vet Microbiol;228: 39-44, 2019 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30593378
Resumo: In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus (IAV). These mAbs could react with HA of H7N9, H3N2, and H9N2 with neutralizing activity. A novel linear epitope recognized by these mAbs was identified by peptide-based ELISA, and this epitope was located in TAADYKSTQSAIDQITGKLN at the C terminus of the helix A of H7N9. 3 A11, which is one of (mais)
9.

Etiology of acute viral respiratory infections common in Pakistan: A review.

Autor(es): Naz, Riffat; Gul, Asma; Javed, Urooj; Urooj, Alina; Amin, Sidra; Fatima, Zareen
Fonte: Rev Med Virol;: e2024, 2018 Dec 12.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30548740
Resumo: Respiratory infections, especially those of the lower respiratory tract, remain a foremost cause of mortality and morbidity of children greater than 5 years in developing countries including Pakistan. Ignoring these acute-level infections may lead to complications. Particularly in Pakistan, respiratory infections account for 20% to 30% of all deaths of children. Even though these infections are common, insufficiency of accessible data hinders development of a comprehensive summary of the pr (mais)
10.

Influenza Activity - United States, September 30-December 1, 2018.

Autor(es): Budd, Alicia P; Abd Elal, Anwar Isa; Alabi, Noreen; Barnes, John; Blanton, Lenee; Brammer, Lynnette; Burns, Erin; Cummings, Charisse N; Dugan, Vivien G; Garg, Shikha; Garten, Rebecca; Grohskopf, Lisa A; Gubareva, Larisa; Kniss, Krista; Kramer, Natalie; O'Halloran, Alissa; Sessions, Wendy; Taylor, Calli; Wentworth, David E; Xu, Xiyan; Fry, Alicia M; Katz, Jacqueline; Jernigan, Daniel
Fonte: MMWR Morb Mortal Wkly Rep;67(49): 1369-1371, 2018 Dec 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30543604
Resumo: Influenza activity in the United States was low during October 2018, and, although it increased slowly during November, activity remains low across most of the country.* During the week ending December 1, 2018, the percentage of outpatient visits for influenza-like illness (ILI) was equal to the national baseline (Figure) and was at or slightly above the region-specific baseline in four of the 10 U.S. Department of Health and Human Services regions (Regions 4 and 7-9). The majority of juris (mais)
11.

Single-Step Detection of the Influenza Virus Hemagglutinin Using Bacterially-Produced Quenchbodies.

Autor(es): Jeong, Hee-Jin; Dong, Jinhua; Ueda, Hiroshi
Fonte: Sensors (Basel);19(1)2018 Dec 23.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30583603
Resumo: We have successfully generated a Quenchbody that enables the detection of the influenza virus hemagglutinin (HA), in a simple and convenient manner. By two-site labeling of the bacterially-produced anti-HA Fab with ATTO520, its fluorescence intensity was increased to 4.4-fold, in the presence of a nanomolar concentration of H1N1 HA. Our results indicate the potential use of this Quenchbody, as a sensor for the simple in situ detection of influenza A virus.
12.

A practical approach to adjusting for population stratification in genome-wide association studies: principal components and propensity scores (PCAPS).

Autor(es): Zhao, Huaqing; Mitra, Nandita; Kanetsky, Peter A; Nathanson, Katherine L; Rebbeck, Timothy R
Fonte: Stat Appl Genet Mol Biol;2018 Dec 04.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30507552
Resumo: Genome-wide association studies (GWAS) are susceptible to bias due to population stratification (PS). The most widely used method to correct bias due to PS is principal components (PCs) analysis (PCA), but there is no objective method to guide which PCs to include as covariates. Often, the ten PCs with the highest eigenvalues are included to adjust for PS. This selection is arbitrary, and patterns of local linkage disequilibrium may affect PCA corrections. To address these limitations, we e (mais)
Resultados  1-12 de 10.219