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Pesquisa | Influenza A (H1N1)

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Molekulární a antigenní analýza hemaglutininu viru chripky A H3N2 detekovaných v Ceské republice v epidemické sezone 2014/2015./ Molecular and antigenic characterization of the H3 hemagglutinin of H3N2 influenza A virus strains collected in the Czech Republic during the 2014/2015 epidemic season.

Autor(es): Nagy, A; Jirincová, H; Kyncl, J; Havlícková, M
Fonte: Epidemiol Mikrobiol Imunol;65(2): 92-101, Summer 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27467326
Resumo: The 2014/2015 influenza epidemic season was characterized by the predominance of the H3N2 subtype. The presented study investigated the genetic and antigenic heterogeneity of the H3N2 strains collected in the Czech Republic from November 2014 to March 2015. Phylogenetic analysis of the representative H3 hemagglutinin sequences was performed and the glycosylation status and crucial antigenic mutations were compared relative to the 2014 and 2015 vaccine strains (A/Texas/50/2012 and A/Switzerl (mais)

Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study.

Autor(es): Kidszun, André; Klein, Lena; Winter, Julia; Schmeh, Isabella; Gröndahl, Britta; Gehring, Stephan; Knuf, Markus; Weise, Kerstin; Mildenberger, Eva
Fonte: Am J Perinatol;34(1): 1-7, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27182999
Resumo: The aim of our study was to evaluate the occurrence of viral infections in infants with suspected late-onset bacterial sepsis in a neonatal intensive care unit. In a prospective study, infants with suspected late-onset bacterial sepsis underwent viral testing alongside routine blood culture sampling. Using a multiplex reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay, nasopharyngeal aspirates were analyzed for adenovirus, respiratory syncytial virus (RSV), i (mais)

Drug-Resistant and Genetic Evolutionary Analysis of Influenza Virus from Patients During the 2013 and 2014 Influenza Season in Beijing.

Autor(es): Li, Xiaodong; Liao, Hao; Liu, Yan; Liu, Liming; Wang, Fusheng; Song, Hongbin; Cheng, Jun; Liu, Xinguang; Xu, Dongping
Fonte: Microb Drug Resist;23(2): 253-260, 2017 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27203354
Resumo: The study aimed to analyze drug resistance and mutations and genetic evolution of influenza A and influenza B viruses during the 2013 and 2014 influenza season in Beijing, China. RNA was extracted from pharyngeal or nasal swabs of 28 patients, and determination of influenza genotypes was performed by using real-time reverse-transcription polymerase chain reaction. Influenza A virus samples were sequenced with the neuraminidase (NA) gene and M2 matrix protein gene to determine the NA inhibit (mais)

Maternal influenza and birth outcomes: systematic review of comparative studies.

Autor(es): Fell, D B; Savitz, D A; Kramer, M S; Gessner, B D; Katz, M A; Knight, M; Luteijn, J M; Marshall, H; Bhat, N; Gravett, M G; Skidmore, B; Ortiz, J R
Fonte: BJOG;124(1): 48-59, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27264387
Resumo: BACKGROUND: Although pregnant women are considered at high risk for severe influenza disease, comparative studies of maternal influenza and birth outcomes have not been comprehensively summarised. OBJECTIVE: To review comparative studies evaluating maternal influenza disease and birth outcomes. SEARCH STRATEGY: We searched bibliographic databases from inception to December 2014. SELECTION CRITERIA: Studies of preterm birth, small-for-gestational-age (SGA) birth or fetal death, comparing wom (mais)

A Low-Cost and Fast Real-Time PCR System Based on Capillary Convection.

Autor(es): Qiu, Xianbo; Ge, Shengxiang; Gao, Pengfei; Li, Ke; Yang, Yongliang; Zhang, Shiyin; Ye, Xiangzhong; Xia, Ningshao; Qian, Shizhi
Fonte: SLAS Technol;22(1): 13-17, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27272156
Resumo: A low-cost and fast real-time PCR system in a pseudo-isothermal manner with disposable capillary tubes based on thermal convection for point-of-care diagnostics is developed and tested. Once stable temperature gradient along the capillary tube has been established, a continuous circulatory flow or thermal convection inside the capillary tube will repeatedly transport PCR reagents through temperature zones associated with the DNA denaturing, annealing, and extension stages of the reaction. T (mais)

The mechanisms of sudden-onset type adverse reactions to oseltamivir.

Autor(es): Hama, R; Bennett, C L
Fonte: Acta Neurol Scand;135(2): 148-160, 2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27364959
Resumo: Oseltamivir is contraindicated for people aged 10-19 in principle in Japan, due to concern about abnormal behaviours. Sudden death is another concern. This review examines growing evidence of their association and discusses underlying mechanisms of these sudden-onset type reactions to oseltamivir. First, the importance of animal models and the concept of human equivalent dose (HED) is summarized. Second, the specific condition for oseltamivir use, influenza infection, is reviewed. Third, fi (mais)

Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.

Autor(es): Zheng, Weinan; Cao, Shuaishuai; Chen, Can; Li, Jing; Zhang, Shuang; Jiang, Jingwen; Niu, Yange; Fan, Wenhui; Li, Yun; Bi, Yuhai; Gao, George F; Sun, Lei; Liu, Wenjun
Fonte: Cell Microbiol;19(2)2017 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27376632
Resumo: Influenza A virus evades host antiviral defense through hijacking innate immunity by its non-structural protein 1 (NS1). By using mass spectrometry, threonine 80 (T80) was identified as a novel phosphorylated residue in the NS1 of the influenza virus A/WSN/1933(H1N1). By generating recombinant influenza viruses encoding NS1 T80 mutants, the roles of this phosphorylation site were characterized during viral replication. The T80E (phosphomimetic) mutant attenuated virus replication, whereas t (mais)

Heterologous Immune Responses to Influenza Vaccine in Kidney Transplant Recipients.

Autor(es): Kumar, D; Ferreira, V H; Campbell, P; Hoschler, K; Humar, A
Fonte: Am J Transplant;17(1): 281-286, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27402204
Resumo: Influenza vaccine is known to have suboptimal immunogenicity in transplant recipients. Despite this, influenza vaccine may have the added benefit of inducing a cross-reactive immune response to viral strains not found in the vaccine. This is termed "heterologous immunity" and has not been assessed previously in transplant patients. Pre- and postvaccination sera from kidney transplant recipients (n = 60) immunized with the 2012-2013 adjuvanted or nonadjuvanted influenza vaccine underwent tes (mais)

Investigating obesity as a risk factor for influenza-like illness during the 2009 H1N1 influenza pandemic using the Health Survey for England.

Autor(es): Murphy, Rachel; Fragaszy, Ellen B; Hayward, Andrew C; Warren-Gash, Charlotte
Fonte: Influenza Other Respir Viruses;11(1): 66-73, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27480326
Resumo: BACKGROUND: Following the 2009 H1N1 influenza pandemic, obesity was shown to be associated with severe influenza outcomes. It remains unclear whether obesity was a risk factor for milder influenza-like illness (ILI). OBJECTIVES: To determine whether obesity was associated with an increased risk of self-reported ILI during the 2009 H1N1 influenza pandemic using Health Survey for England (HSE) 2010 cross-sectional data. METHODS: This study used HSE data collected from English households betwe (mais)

Antiviral activity of aspirin against RNA viruses of the respiratory tract-an in vitro study.

Autor(es): Glatthaar-Saalmüller, Bernadette; Mair, Kerstin H; Saalmüller, Armin
Fonte: Influenza Other Respir Viruses;11(1): 85-92, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27542891
Resumo: AIM: Aspirin (acetylsalicylic acid) has been used for more than 115 years in medicine. Research exists to show that aspirin has antiviral effects in vitro, for example, by blocking influenza virus propagation via NF-κB inhibition when used at high concentrations and short-term incubation steps. The aim of this study was to confirm the antiviral activity of aspirin against influenza virus and further elucidate the activity of aspirin against other respiratory viruses. METHODS: Tests to (mais)

Physician's knowledge, attitudes, and practices regarding seasonal influenza, pandemic influenza, and highly pathogenic avian influenza A (H5N1) virus infections of humans in Indonesia.

Autor(es): Mangiri, Amalya; Iuliano, A Danielle; Wahyuningrum, Yunita; Praptiningsih, Catharina Y; Lafond, Kathryn E; Storms, Aaron D; Samaan, Gina; Ariawan, Iwan; Soeharno, Nugroho; Kreslake, Jennifer M; Storey, J Douglas; Uyeki, Timothy M
Fonte: Influenza Other Respir Viruses;11(1): 93-99, 2017 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27554302
Resumo: Indonesia has reported highest number of fatal human cases of highly pathogenic avian influenza (HPAI) A (H5N1) virus infection worldwide since 2005. There are limited data available on seasonal and pandemic influenza in Indonesia. During 2012, we conducted a survey of clinicians in two districts in western Java, Indonesia, to assess knowledge, attitudes, and practices (KAP) of clinical diagnosis, testing, and treatment of patients with seasonal influenza, pandemic influenza, or HPAI H5N1 v (mais)

Managing boundaries between professional and lay nursing following the influenza pandemic, 1918-1919: insights for professional resilience today?

Autor(es): Wood, Pamela J
Fonte: J Clin Nurs;26(5-6): 805-812, 2017 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27571312
Resumo: AIMS AND OBJECTIVES: To examine lay-professional nursing boundaries, using challenges to the New Zealand nursing profession following the 1918-1919 influenza pandemic as the example. BACKGROUND: The influenza pandemic of 1918-1919 had an overwhelming international impact on communities and the nursing profession. After the pandemic, the expectation for communities to be able to nurse the sick reflects today's increasing reliance on families to care for people at home. It similarly raised qu (mais)
Resultados  1-12 de 3.547