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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 30.180

In vitro and in vivo characterization of novel neuraminidase substitutions in influenza A(H1N1)pdm09 identified using Laninamivir-mediated selection.

Autor(es): Lloren, Khristine Kaith S; Kwon, Jin Jung; Choi, Won-Suk; Jeong, Ju Hwan; Jeong Ahn, Su; Ki Choi, Young; Baek, Yun Hee; Song, Min-Suk
Fonte: J Virol;2019 Jan 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30602610
Resumo: Neuraminidase inhibitors (NAIs) are widely used antiviral drugs for the treatment of humans with influenza virus infections. There have been widespread reports of NAI resistance among seasonal A(H1N1) viruses, and most have been identified in oseltamivir-exposed patients or those treated with other NAIs. Thus, monitoring and identifying NA markers conferring resistance to NAIs-particularly newly introduced treatments-is critical to manage viral infections. Therefore, we screened and identif (mais)

Corn-derived alpha-D-glucan nanoparticles as adjuvant for intramuscular and intranasal immunization in pigs.

Autor(es): Dhakal, Santosh; Lu, Fangjia; Ghimire, Shristi; Renu, Sankar; Laxmanappa, Yashavanth Shaan; Hogshead, Bradley T; Ragland, Darryl; HogenEsch, Harm; Renukaradhya, Gourapura J
Fonte: Nanomedicine;2019 Jan 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30611772
Resumo: Adjuvant potential of positively charged corn-derived nanoparticles (Nano-11) was earlier revealed in mice. We evaluated its adjuvant role to electrostatically adsorbed inactivated/killed swine influenza virus antigen (KAg) (Nano-11+KAg) in pigs. Nano-11 facilitated the uptake of KAg by antigen presenting cells and induced secretion of proinflammatory cytokines. In pigs vaccinated by an intranasal mist containing Nano-11+KAg, expression of T-helper 1 and T-helper 2 transcription factors and (mais)

Immune responses of mice inoculated with recombinant Lactobacillus plantarum NC8 expressing the fusion gene HA2 and 3M2e of the influenza virus and protection against different subtypes of influenza virus.

Autor(es): Bo, Feng; Yang, Wen-Tao; Shonyela, Seria Masole; Jin, Yu-Bei; Huang, Ke-Yan; Shao, Li-Na; Wang, Cong; Zhou, You; Li, Qiong-Yan; Jiang, Yan-Long; Huang, Hai-Bin; Shi, Chun-Wei; Wang, Jian-Zhong; Kang, Yuan-Huan; Yang, Gui-Lian; Wang, Chun-Feng
Fonte: Virus Res;2019 Jan 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30611823
Resumo: To evaluate the efficiency of preventing pathogenic avian influenza by vaccination with recombinant Lactobacillus plantarum (L. plantarum) that expresses conserved antigens, the mucosal and systemic immune responses in animals vaccinated with recombinant L. plantarum NC8-409-1 (NC8-pSIP409-pgsA'-HA2) and NC8-409-2 (NC8-pSIP409-pgsA'-3M2e-HA2) were evaluated. Our results showed that recombinant L. plantarum NC8-409-1 and NC8-409-2 could substantially stimulate the specific IgA titer in the i (mais)

The association between socioeconomic status and pandemic influenza: protocol for a systematic review and meta-analysis.

Autor(es): Mamelund, Svenn-Erik; Shelley-Egan, Clare; Rogeberg, Ole
Fonte: Syst Rev;8(1): 5, 2019 Jan 04.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30609940
Resumo: BACKGROUND: Pandemic mortality rates in 1918 and in 2009 were highest among those with the lowest socioeconomic status (SES). Despite this, low SES groups are not included in the list of groups prioritized for pandemic vaccination, and the ambition to reduce social inequality in health does not feature in international and national pandemic preparedness plans. We describe plans for a systematic review and meta-analysis of the association between SES and pandemic outcomes during the last fiv (mais)

Outcomes of infants born to women with influenza A(H1N1)pdm09.

Autor(es): Newsome, Kim; Alverson, C J; Williams, Jennifer; McIntyre, Anne F; Fine, Anne D; Wasserman, Cathy; Lofy, Kathryn H; Acosta, Meileen; Louie, Janice K; Jones-Vessey, Kathleen; Stanfield, Valoree; Yeung, Alice; Rasmussen, Sonja A
Fonte: Birth Defects Res;2019 Jan 09.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30623611
Resumo: BACKGROUND: Pregnant women with influenza are more likely to have complications, but information on infant outcomes is limited. METHODS: Five state/local health departments collected data on outcomes of infants born to pregnant women with 2009 H1N1 influenza reported to the Centers for Disease Control and Prevention from April to December 2009. Collaborating sites linked information on pregnant women with confirmed 2009 H1N1 influenza, many who were severely ill, to their infants' birth cer (mais)

Development and characterization of swine primary respiratory epithelial cells and their susceptibility to infection by four influenza virus types.

Autor(es): Sreenivasan, Chithra C; Thomas, Milton; Antony, Linto; Wormstadt, Tristen; Hildreth, Michael B; Wang, Dan; Hause, Ben; Francis, David H; Li, Feng; Kaushik, Radhey S
Fonte: Virology;528: 152-163, 2019 Jan 05.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30616205
Resumo: Influenza viruses are a group of respiratory pathogens that have evolved into four different types: A, B, C, and D. A common feature is that all four types are capable of replicating and transmitting among pigs. Here, we describe the development of isogenous cell culture system from the swine respiratory tract to study influenza viruses. Phenotypic characterization of swine primary nasal turbinate, trachea and lung cells revealed high expression of cytokeratin and demonstrated tissue site d (mais)

A plant-derived VLP influenza vaccine elicits a balanced immune response even in very old mice with co-morbidities.

Autor(es): Hodgins, Breanna; Pillet, Stephane; Landry, Nathalie; Ward, Brian James
Fonte: PLoS One;14(1): e0210009, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30629622
Resumo: BACKGROUND: The elderly are at high risk from influenza, in part because immunity wanes with age and through the accumulation of comorbidities. A novel plant-derived virus-like-particle (VLP) vaccine bearing influenza hemagglutinin can induce a balanced humoral and cellular response in old mice (16-18 months) while split virion vaccines elicit mostly antibodies. Because mice also collect comorbidities and lose immune competence as they age, we wished to determine how the plant-derived VLP v (mais)

Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010-2015.

Autor(es): Htwe, Khin Thu Zar; Dapat, Clyde; Shobugawa, Yugo; Odagiri, Takashi; Hibino, Akinobu; Kondo, Hiroki; Yagami, Ren; Saito, Takehiko; Takemae, Nobuhiro; Tamura, Tsutomu; Watanabe, Hisami; Kyaw, Yadanar; Lin, Nay; Myint, Yi Yi; Tin, Htay Htay; Thein, Win; Kyaw, Latt Latt; Soe, Pan Ei; Naito, Makoto; Zaraket, Hassan; Suzuki, Hiroshi; Abe, Takashi; Saito, Reiko
Fonte: PLoS One;14(1): e0210550, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30629691
Resumo: We investigated the circulation patterns of human influenza A and B viruses in Myanmar between 2010 and 2015 by analyzing full HA genes. Upper respiratory tract specimens were collected from patients with symptoms of influenza-like illness. A total of 2,860 respiratory samples were screened by influenza rapid diagnostic test, of which 1,577 (55.1%) and 810 (28.3%) were positive for influenza A and B, respectively. Of the 1,010 specimens that were positive for virus isolation, 370 (36.6%) we (mais)

Riesgo de absentismo laboral en el personal sanitario ante una hipotética pandemia por gripe./ [Risk of absenteeism in health personnel during a hypothetical flu pandemic].

Autor(es): Santana-López, B; Santana-Padilla, Y G; Martín Santana, J D; Santana-Cabrera, L
Fonte: J Healthc Qual Res;2019 Jan 07.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30630687

Influenza virus inoculum volume is critical to elucidate age-dependent mortality in mice.

Autor(es): Smith, Candice A; Kulkarni, Upasana; Chen, Judy; Goldstein, Daniel R
Fonte: Aging Cell;: e12893, 2019 Jan 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30632262
Resumo: The elderly exhibit increased mortality to influenza viral infection for unclear reasons. Mice are frequently used to model how aging impacts disease. Several studies have shown that aged mice exhibit an increased mortality to influenza virus, but two recent studies demonstrated the opposite. These two studies administered the virus intranasally in 20 µL, whereas the other studies used a viral inoculum in at least 30 µL. To determine whether the volume of the inoculum could explain the (mais)

Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype.

Autor(es): Martínez, Ana; Soldevila, Núria; Romero-Tamarit, Arantxa; Torner, Núria; Godoy, Pere; Rius, Cristina; Jané, Mireia; Domínguez, Àngela
Fonte: PLoS One;14(1): e0210353, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30633778
Resumo: Seasonal influenza is a cause of hospitalization, especially in people with underlying disease or extreme age, and its severity may differ depending on the types and subtypes of circulating viruses. We investigated the factors associated with ICU admission or death in hospitalized patients with severe laboratory-confirmed influenza according to the viral type and subtype. An observational epidemiological study was carried out in patients aged ≥18 years from 12 Catalan hospitals betwee (mais)

The PA Subunit of the Influenza Virus Polymerase Complex Affects Replication and Airborne Transmission of the H9N2 Subtype Avian Influenza Virus.

Autor(es): Hao, Mengchan; Han, Shaojie; Meng, Dan; Li, Rong; Lin, Jing; Wang, Meng; Zhou, Tong; Chai, Tongjie
Fonte: Viruses;11(1)2019 Jan 09.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30634394
Resumo: The polymerase acidic (PA) protein is the third subunit of the influenza A virus polymerase. In recent years, studies have shown that PA plays an important role in overcoming the host species barrier and host adaptation of the avian influenza virus (AIV). The objective of this study was to elucidate the role of the PA subunit on the replication and airborne transmission of the H9N2 subtype AIV. By reverse genetics, a reassortant rSD01-PA was derived from the H9N2 subtype AIV A/Chicken/Shand (mais)
Resultados  1-12 de 30.180