08da descexport-xml.xslid:mdl-2195539020standardxslt12BACKGROUND: Guillain-Barre syndrome (GBS) is a rare autoimmune disease characterized by acute, progressive peripheral neuropathy and is commonly associated with the presence of antiganglioside antibodies. Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside antibodies are subsequently induced remains unresolved. METHODS: Sera from human subjects vaccinated with seasonal influenza vaccines from the 2007-2008, 2008-2009, or 1976-1977 influenza seasons were screened for the induction of immunity to influenza and the presence of antiganglioside antibodies pre- and post-vaccination. Likewise, sera from mice vaccinated with seasonal influenza vaccines (1988-1989, 2007-2008) or "swine flu" pandemic vaccines (1976, 2009) were assessed in the same manner. Viruses were also screened for cross-reacting ganglioside epitopes. RESULTS: Antiganglioside antibodies were found to recognize influenza viruses; this reactivity correlated with virus glycosylation. Antibodies to influenza viruses were detected in human and mouse sera, but the prevalence of antiganglioside antibodies was extremely low. CONCLUSIONS: Although the correlation between antiganglioside antibody cross-reactivity and glycosylation of viruses suggests the role of shared carbohydrate epitopes, no correlation was observed between hemagglutinin-inhibition titers and the induction of antiganglioside antibodies after influenza vaccination.Wang DJBoltz DAMcElhaney JMcCullers JAWebby RJWebster RGh1n1England201204MEDLINEInfluenza Other Respi Viruses;6(3): 159-66, 2012 May. mdl-219553903enAnticorpos/imunologiaGangliosídeos/imunologiaSíndrome de Guillain-Barré/etiologiaVacinas contra Influenza/administração & dosagemAdultoIdosoIdoso de 80 Anos ou maisAnimaisReações CruzadasFemininoSíndrome de Guillain-Barré/imunologiaHumanosVacinas contra Influenza/efeitos adversosInfluenza Humana/imunologiaInfluenza Humana/prevenção & controleMasculinoCamundongosCamundongos Endogâmicos C57BLMeia-IdadeVacinação/efeitos adversosAdulto Jovem159-66Artigo de RevistaResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tInfluenza Other Respi VirusesNo evidence of a link between influenza vaccines and Guillain-Barre syndrome-associated antiganglioside antibodies.articlehttp://dx.doi.org/10.1111/j.1750-2659.2011.00294.x611111111111