Fever is a clinical symptom generally associated to infection, generating a large number of emergency cases and medical appointments, and an indiscriminate use of antipyretics. The fever is triggered by the action of endogenous and exogenous pyrogenic cytokines, performing protective functions in the organism and aiding in the recovery. Regarding the importance of the fever in the immune mechanism, and with the intent to relieve the discomfort of the patient, the homeopathic medicine aims to restore the vital force, accelerating the healing process. Among all homeopathic medicines, simillimum is found through totality of symptoms manifested by the patient.(AU)