Assessment of homeopathic medicine Aconitum napellus in the treatment of anxiety in an animal model / Avaliação do medicamento homeopático Aconitum napellus no tratamento da ansiedade em modelo animal / Evaluación del medicamento homeopático aconitum napellus en el tratamiento de la ansiedad en un modelo animal
48 adult (two to three months old) maleWistar rats (Rattusrattus) were randomly divided in six groups (n= 8/treatment) and given the following treatments by gastric tube along 10 days 1) control (diazepam 1 mg/kg/day); 2) negative control (0.15 mL saline solution/day); 3) ACH6 (0.15 mL Acon (6cH/day); 4) ACH12 (0.15 mL Acon 12cH/day); 5) ACH30 (0.15 mL Acon 30cH/day); and 6) ALC30 (0.15 mL 30% cereal alcohol/day). Behavioral effects were blindly and randomly assessed in elevated plus maze (EPM) and open test.
Results:
Acon in dilutions 12cH and 30cH exhibited possible anxiolytic effects on the central nervous system (CNS) since they increased the number of entries in the EPM open arms (12cH and 30cH) and the permanence time in the EPM open arms (30cH only). In the open test the homeopathic preparations did not show effects on the locomotor system of rats.
As potências 12cH e 30cH apresentaram um possível efeito ansiolítico sobre o sistema nervoso central (SNC), visto que foram capazes de aumentar a frequência de entrada nos braços abertos do LCE (12cH e 30cH) e o tempo nos braços abertos do LCE (apenas CH30). No teste do Campo Aberto observou-se que as potências homeopáticas não foram capazes de afetar o sistema locomotor.