Cicatrization can be divided into three phases
inflammation , fibroblastic, maturation and
remodeling [1]. The
extracellular matrix may be replaced by a stronger and more elastic
connective tissue . In a
scar collagen is the major component of the mature
connective tissue [2]. In homeopathic area, the greater is the investigated segment ultra dilutions [6]. However, little
research has been done to explore the effect of dynamized
drugs in
in vitro cell culture [4]. Using the
Zincum metallicum 6CH and
Calendula officinalis 6CH applied independently in different concentrations in
fibroblast cultures sought to determine the increase in proliferative activity using
techniques such as
IC50 , MTT,
flow cytometry and quantification of
collagen . As expected from the
literature , ie both homeopathic according to the
literature are used for
treatments that Require
skin healing, both showed increased proliferative activity, having
Calendula most cellular response, presenting as
cell cycle stimulating checked via
flow cytometry .(AU)