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Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
Long, Feng; Fong, Rachel H; Austin, Stephen K; Chen, Zhenguo; Klose, Thomas; Fokine, Andrei; Liu, Yue; Porta, Jason; Sapparapu, Gopal; Akahata, Wataru; Doranz, Benjamin J; Crowe, James E; Diamond, Michael S; Rossmann, Michael G.
Afiliação
  • Long F; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;
  • Fong RH; Integral Molecular, Inc., Philadelphia, PA 19104;
  • Austin SK; Departments of Medicine, Molecular Microbiology, Pathology, and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
  • Chen Z; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;
  • Klose T; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;
  • Fokine A; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;
  • Liu Y; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;
  • Porta J; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;
  • Sapparapu G; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232;
  • Akahata W; VLP Therapeutics, LLC, Gaithersburg, MD 20878;
  • Doranz BJ; Integral Molecular, Inc., Philadelphia, PA 19104;
  • Crowe JE; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232; Departments of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232.
  • Diamond MS; Departments of Medicine, Molecular Microbiology, Pathology, and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
  • Rossmann MG; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907; mr@purdue.edu.
Proc Natl Acad Sci U S A ; 112(45): 13898-903, 2015 Nov 10.
Article em En | MEDLINE | ID: mdl-26504196
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Microscopia Crioeletrônica / Anticorpos Neutralizantes / Febre de Chikungunya / Anticorpos Monoclonais Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Microscopia Crioeletrônica / Anticorpos Neutralizantes / Febre de Chikungunya / Anticorpos Monoclonais Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article