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Structure of New Delhi metallo-ß-lactamase 1 (NDM-1).

Green, Victoria L; Verma, Anil; Owens, Raymond J; Phillips, Simon E V; Carr, Stephen B.
Acta Crystallogr Sect F Struct Biol Cryst Commun; 67(Pt 10): 1160-4, 2011 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-22102018


Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-ß-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.