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Resultados  1-10 de 339.308
1.

Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease.

Autor(es): Pinazo MJ; Guerrero L; Posada E; Rodríguez E; Soy D; Gascon J
Fonte: Antimicrob Agents Chemother;57(1): 390-5, 2013 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: For treating Chagas disease (CD), a current worldwide health problem, only benznidazole and nifurtimox have been approved to be used. In both cases, unwanted drug-related adverse events (ADRs) are frequent when these drugs are used in adults in the chronic stage. The main objective of this study was to establish benznidazole ADRs and their relationship to serum concentrations in patients with chronic Trypanosoma cruzi infection in order to perform more accurate dosages to minimize ADRs. A t (mais)
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2.

4(1H)-Quinolones with liver stage activity against Plasmodium berghei.

Autor(es): Lacrue AN; Sáenz FE; Cross RM; Udenze KO; Monastyrskyi A; Stein S; Mutka TS; Manetsch R; Kyle DE
Fonte: Antimicrob Agents Chemother;57(1): 417-24, 2013 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: With the exception of primaquine, tafenoquine, and atovaquone, there are very few antimalarials that target liver stage parasites. In this study, a transgenic Plasmodium berghei parasite (1052Cl1; PbGFP-Luc(con)) that expresses luciferase was used to assess the anti-liver stage parasite activity of ICI 56,780, a 7-(2-phenoxyethoxy)-4(1H)-quinolone (PEQ), as well as two 3-phenyl-4(1H)-quinolones (P4Q), P4Q-146 and P4Q-158, by using bioluminescent imaging (BLI). Results showed that all of the (mais)
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3.

Mechanism-based model of parasite growth and dihydroartemisinin pharmacodynamics in murine malaria.

Autor(es): Patel K; Batty KT; Moore BR; Gibbons PL; Bulitta JB; Kirkpatrick CM
Fonte: Antimicrob Agents Chemother;57(1): 508-16, 2013 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: Murine models are used to study erythrocytic stages of malaria infection, because parasite morphology and development are comparable to those in human malaria infections. Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models for antimalarials are scarce, despite their potential to optimize antimalarial combination therapy. The aim of this study was to develop a mechanism-based growth model (MBGM) for Plasmodium berghei and then characterize the parasiticidal effect of dihydroartemi (mais)
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4.

Pharmacokinetic-pharmacodynamic modeling of Unboosted Atazanavir in a cohort of stable HIV-infected patients.

Autor(es): Goutelle S; Baudry T; Gagnieu MC; Boibieux A; Livrozet JM; Peyramond D; Chidiac C; Tod M; Ferry T
Fonte: Antimicrob Agents Chemother;57(1): 517-23, 2013 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: Limited data on the pharmacokinetics and pharmacodynamics (PK/PD) of unboosted atazanavir (uATV) in treatment-experienced patients are available. The aim of this work was to study the PK/PD of unboosted atazanavir in a cohort of HIV-infected patients. Data were available for 58 HIV-infected patients (69 uATV-based regimens). Atazanavir concentrations were analyzed by using a population approach, and the relationship between atazanavir PK and clinical outcome was examined using logistic regr (mais)
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5.

Multiple NF-κB sites in HIV-1 subtype C long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominance.

Autor(es): Bachu M; Yalla S; Asokan M; Verma A; Neogi U; Sharma S; Murali RV; Mukthey AB; Bhatt R; Chatterjee S; Rajan RE; Cheedarla N; Yadavalli VS; Mahadevan A; Shankar SK; Rajagopalan N; Shet A; Saravanan S; Balakrishnan P; Solomon S; Vajpayee M; Satish KS; Kundu TK; Jeang KT; Ranga U
Fonte: J Biol Chem;287(53): 44714-35, 2012 Dec 28.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: We demonstrate that at least three different promoter variant strains of HIV-1 subtype C have been gradually expanding and replacing the standard subtype C viruses in India, and possibly in South Africa and other global regions, over the past decade. The new viral strains contain an additional NF-κB, NF-κB-like, or RBEIII site in the viral promoter. Although the acquisition of an additional RBEIII site is a property shared by all the HIV-1 subtypes, acquiring an additional NF-κB si (mais)
Assunto(s): Infecções por HIV/metabolismo Infecções por HIV/virologia Repetição Terminal Longa de HIV HIV-1/genética NF-kappa B/metabolismo Transcrição Genética Adulto Estudos de Coortes Feminino Regulação Viral da Expressão Gênica Infecções por HIV/genética HIV-1/química HIV-1/classificação HIV-1/fisiologia Humanos Masculino Dados de Sequência Molecular NF-kappa B/genética Ligação Proteica Replicação Viral Adulto Jovem
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6.

Crystal structure of reduced MsAcg, a putative nitroreductase from Mycobacterium smegmatis and a close homologue of Mycobacterium tuberculosis Acg.

Autor(es): Chauviac FX; Bommer M; Yan J; Parkin G; Daviter T; Lowden P; Raven EL; Thalassinos K; Keep NH
Fonte: J Biol Chem;287(53): 44372-83, 2012 Dec 28.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: This paper presents the structure of MsAcg (MSMEG_5246), a Mycobacterium smegmatis homologue of Mycobacterium tuberculosis Acg (Rv2032) in its reduced form at 1.6 Å resolution using x-ray crystallography. Rv2032 is one of the most induced genes under the hypoxic model of tuberculosis dormancy. The Acg family turns out to be unusual flavin mononucleotide (FMN)-binding proteins that have probably arisen by gene duplication and fusion from a classical homodimeric nitroreductase such that (mais)
Assunto(s): Mycobacterium smegmatis/enzimologia Mycobacterium tuberculosis/enzimologia Nitrorredutases/química Sítios de Ligação Cristalografia por Raios X Mononucleotídeo de Flavina/metabolismo Modelos Moleculares Mycobacterium smegmatis/química Mycobacterium smegmatis/genética Mycobacterium tuberculosis/química Mycobacterium tuberculosis/genética NAD/metabolismo NADP/metabolismo Nitrorredutases/genética Nitrorredutases/metabolismo
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7.

Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1).

Autor(es): Valdés R; Shinde U; Landfear SM
Fonte: J Biol Chem;287(53): 44036-45, 2012 Dec 28.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: Equilibrative nucleoside transporters are a unique family of proteins that enable uptake of nucleosides/nucleobases into a wide range of eukaryotes and internalize a myriad of drugs used in the treatment of cancer, heart disease, AIDs, and parasitic infections. In previous work we generated a structural model for such a transporter, the LdNT1.1 nucleoside permease from the parasitic protozoan Leishmania donovani, using ab initio computation. The model suggested that aromatic residues presen (mais)
Assunto(s): Cisteína/química Leishmania donovani/metabolismo Nucleosídeos/metabolismo Proteínas de Protozoários/química Proteínas de Protozoários/metabolismo Motivos de Aminoácidos Cisteína/genética Cisteína/metabolismo Leishmania donovani/química Leishmania donovani/genética Modelos Moleculares Estrutura Secundária de Proteína Estrutura Terciária de Proteína Proteínas de Protozoários/genética
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8.

Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis.

Autor(es): De Leon J; Jiang G; Ma Y; Rubin E; Fortune S; Sun J
Fonte: J Biol Chem;287(53): 44184-91, 2012 Dec 28.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: Mycobacterium tuberculosis ESAT-6 (MtbESAT-6) reportedly shows membrane/cell-lysis activity, and recently its biological roles in pathogenesis have been implicated in rupture of the phagosomes for bacterial cytosolic translocation. However, molecular mechanism of MtbESAT-6-mediated membrane interaction, particularly in relation with its biological functions in pathogenesis, is poorly understood. In this study, we investigated the pH-dependent membrane interaction of MtbESAT-6, MtbCFP-10, an (mais)
Assunto(s): Antígenos de Bactérias/metabolismo Proteínas de Bactérias/metabolismo Membrana Celular/microbiologia Infecções por Mycobacterium/microbiologia Mycobacterium smegmatis/metabolismo Mycobacterium tuberculosis/metabolismo Sequência de Aminoácidos Antígenos de Bactérias/genética Proteínas de Bactérias/genética Membrana Celular/metabolismo Dimerização Dados de Sequência Molecular Infecções por Mycobacterium/metabolismo Mycobacterium smegmatis/genética Mycobacterium tuberculosis/genética Ligação Proteica Alinhamento de Sequência
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9.

Peptide derived from HIV-1 TAT protein destabilizes a monolayer of endothelial cells in an in vitro model of the blood-brain barrier and allows permeation of high molecular weight proteins.

Autor(es): Cooper I; Sasson K; Teichberg VI; Schnaider-Beeri M; Fridkin M; Shechter Y
Fonte: J Biol Chem;287(53): 44676-83, 2012 Dec 28.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: Most chemotherapeutic agents are blood-brain barrier (BBB) impermeants. HIV-1-derived TAT protein variants contain a transmembrane domain, which may enable them to cross the BBB and reach the brain. Here we synthesized CAYGRKKRRQRRR, a peptide containing a cysteine moiety attached to the N terminus of the transmembrane domain (C-TAT peptide), and studied its effects in an in vitro BBB model, which we found to reflect penetration by a receptor-independent pathway. Incubation of the brain cap (mais)
Assunto(s): Células Endoteliais/metabolismo Infecções por HIV/metabolismo HIV-1/metabolismo Peptídeos/metabolismo Proteínas/metabolismo Produtos do Gene tat do Vírus da Imunodeficiência Humana/metabolismo Animais Barreira Hematoencefálica Encéfalo/metabolismo Infecções por HIV/virologia HIV-1/genética Humanos Modelos Biológicos Peso Molecular Peptídeos/genética Permeabilidade Transporte Proteico Proteínas/química Suínos Produtos do Gene tat do Vírus da Imunodeficiência Humana/química Produtos do Gene tat do Vírus da Imunodeficiência Humana/genética
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10.

The size and conservation of a coiled-coil structure in the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release.

Autor(es): Andrew AJ; Berndsen CE; Kao S; Strebel K
Fonte: J Biol Chem;287(53): 44278-88, 2012 Dec 28.
MEDLINE - Literatura Internacional em Ciências da Saúde
Idioma(s): Inglês
Resumo: BST-2/CD317/tetherin is a host factor that inhibits HIV-1 release and is counteracted by HIV-1 Vpu. Structural studies indicate that the BST-2 ectodomain assumes a coiled-coil conformation. Here we studied the role of the BST-2 ectodomain for tethering function. First, we addressed the importance of the length and structure of the ectodomain by adding or substituting heterologous coiled-coil or non-coiled-coil sequences. We found that extending or replacing the BST-2 ectodomain using non-co (mais)
Assunto(s): Antígenos CD/química Antígenos CD/metabolismo Regulação para Baixo Infecções por HIV/metabolismo HIV-1/fisiologia Virion/fisiologia Liberação de Vírus Sequência de Aminoácidos Antígenos CD/genética Dimerização Proteínas Ligadas por GPI/química Proteínas Ligadas por GPI/genética Proteínas Ligadas por GPI/metabolismo Infecções por HIV/genética Infecções por HIV/virologia HIV-1/genética Células HeLa Humanos Dados de Sequência Molecular Ligação Proteica Estrutura Terciária de Proteína Alinhamento de Sequência Virion/genética
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Resultados  1-10 de 339.308
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