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1.
Braz. j. oral sci ; 15(3)July-Sept. 2016. tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-875027

RESUMO

Purpose: The objective of this study was to evaluate the prevalence of Porphyromonas gingivalis (Pg) and its filmA II genotype in a sample of Brazilian patients with generalized aggressive periodontitis (GAgP) and to correlate the presence of each pathogen/genotype eith clinical parameters. Methods: We used polymerase chain reaction (PCR) to evaluate the presence of Pg and filmA II genotype in subgingival plaque samples collected from the deepest site of 45 Brazilian patients aged 15-40 years with GAgP and correlated findings with age and clinical parameters (plaque index, gingival bleeding index, probing depth and clinical attachment loss). Results: Pg was identified in 64.4% patients. FilmA II genotype was present in 82.6% of Pg-positive patients. The presence of Pg and filmA II genotype was significantly associated with greater clinical attachment loss at the sampled periodontal site. Pg-positive patients were slightly older than Pg-negative patients. Conclusions: Pg and filmA II genotype were highly prevalente in Brazilian patients with GAgP. Pg was more commonly observed in slightly older individuals and in sites with more clinical attachment loss. (AU)


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Periodontite Agressiva , Fímbrias Bacterianas , Porphyromonas gingivalis , Reação em Cadeia da Polimerase
2.
Periodontia ; 22(3): 12-18, 2012. tab
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-728148

RESUMO

Porphyromonas gingivalis é um dos principais patógenos envolvidos com o início e progressão da doença periodontal. Este microorganismo exibe uma diversidade genotípica e fenotípica que pode resultar em diferenças na capacidade dos clones induzirem destruição periodontal. Variações no potencial patogênico dos distintos genótipos do gene fimA de P. gingivalis foram relacionadas a diferentes doenças periodontais em diversos estudos. Esta revisão teve o objetivo de analisar criticamente os estudos que relacionaram as condições periodontais e os diferentes genótipos fimA de P. gingivalis. Foram incluídas publicações na língua inglesa de estudos clínicos em humanos, que avaliaram a relação entre as condições periodontais e os diferentes genótipos fimA de P. gingivalis. Doze estudos foram considerados válidos para a realização desta revisão. Pôde-se concluir que os genótipos fimA II e IV de P. gingivalis encontram-se frequentemente associados à periodontite crônica


Porphyromonas gingivalis is a major pathogen involved in the initiation and progression of periodontal disease. This microorganism exhibits a genotypic and phenotypic diversity which may result in differences in the ability to induce periodontal destruction of the clones. Variations in the pathogenic potential of different genotypes of fimA gene of P. gingivalis were related to different periodontal diseases in several studies. This systematic review aimed to critically analyze the studies that have linked periodontal conditions and the different fimA genotypes of P. gingivalis. We included English language publications of human clinical studies that evaluated the relationship between periodontal conditions and the different fimA genotypes of P. gingivalis. Twelve studies were considered valid for the completion of this review. It was concluded that fimA genotypes II and IV of P. gingivalis are often associated with chronic periodontitis.


Assuntos
Fatores de Virulência , Fímbrias Bacterianas , Periodontite , Porphyromonas gingivalis
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