Biological dosimetry of absorbed radiation based on the frequencies of chromosomal aberrations in human lymphocytes

In the investigation of radiation accidents, it is important to estimate the dose absorbed by exposes persons in order to plan their therapy. For this task information such as magnitude of dose received, as external or internal radiation exposure, or partial or whole body irradiation are necessary. For example following exposure to high doses (>5 Gy) of low LET radiation the victim may need bone marrow transplantation and in case of partial body exposure to high doses the victim may be isolated and kept under very hygienic conditions in order to allow repopulation from surviving stem cells in the bone marrow. The document explains methods to estimate radiation doses, chromosomal aberrations and types of them; dose-response curves and dose estimates. It summarizes the Goiania accident and a retrospective dosimetry based on translocation frequencies

Joint report of the Jilin 192Ir radiation accident : A clinical study on a case of moderate degree bone marrow form of acute radiation sickness with extremely severe local radiation injury

After the medical handling of a patient exposed to extremely uneven total body irradiation from an 192ir source (the activity was 2.765 TBq) on January 5, 1996 in Jilin City in order to afford new experience and information for similar case in the future. The authors emphasize the early amputation as the key to success, the importance of rhG-CSF effect and the significance of rational nutrition for the support of the patient, who had total body irradiation, massive local radiation injury and extensive surgical intervention to sustain. The document describe the accident, early clinical manifestation and posterior clinical manifestations (peripheral blood changes and bone marrow examination), evolution of local radiation injury; the assay of myocardial and musculature enzymes; assay of hemopoietic activity in the patient's sera and the treatment