RESUMO
Failure to find any cases of vinyl chloride-induced cancer aoutside the heavily exposed reactor cleaner group calls into question the human relevance of predictive methods for carcinogenic potency. Potency estimates by six conventional routes are reviewed with special attention to the implication of each route for vinyl choride. New metabolic and mechanistic data are used to suggest a basis for the failure of "classical" risk assessment methods to provide accurate predictions for humans in this instance.(AU)
Assuntos
Carcinógenos , Neoplasias , Efeitos de Desastres na Saúde , Cloreto de Vinil , Saúde PúblicaRESUMO
Risk assessment is well accepted for those carcinogens for which there is human epidemiology. When there is only an animal biossay, or only toxicity data, the calculated risk is very uncertain. Many people reject the idea of calculating risks and suggest that anly a priority order is possible. But a risk still exists, however uncertain its calculation. A priority order based on uncertainty of information is different from one based on risk; yet it is the latter that is needed to improve public health.(AU)
