Homeopatia em trombocitopenia canina: relato de caso / Homeopathy in canine thrombocytopenia: case report

Hemoparasitoses constituem-se de enfermidades cosmopolitas que são causadas por parasitos intracelulares obrigatórios de células sanguínea. Os mais frequentemente encontrados nos cães são a babesiose, erliquiose e anaplasmose. O tratamento consiste no uso de antibiótico do grupo das tetraciclinas, sendo a doxiciclina o medicamento mais indicado. O objetivo deste relato de caso é descrever o tratamento homeopático em um cão da raça shih-tzu, senil (8 anos de idade), cardiopata com trombocitopenia discreta secundário a hemoparasitose ­ ehrlichiose. O medicamento homeopático repertorizado foi Phosphorus 30 cH 3 glóbulos 2x ao dia por 3 dias. Foi administrado também a Calcarea Carbonica 6 cH 3 glóbulos 2x ao dia por 7 dias. Tal sucesso terapêutico foi atingido em 3 dias de tratamento, com melhora laboratorial da trombocitopenia e do quadro de dispnéia. Este estudo contribui com pesquisas existentes a caráter de novos tratamentos para a ehrlichiose canina.

Hemoparasitoses are cosmopolitan diseases that are caused by obligate intracellular parasites of blood cells. The most frequently found in dogs are babesiosis, ehrlichiosis and anaplasmosis. Treatment consists of the use of antibiotics from the tetracycline group, with doxycycline being the most indicated medication. The objective of this case report is to describe the homeopathic treatment in a dog of the shih-tzu breed, senile (8 years old), heart disease with mild thrombocytopenia secondary to hemoparasitosis - ehrlichiosis. The repertorized homeopathic medicine was Phosphorus 30 cH 3 globules 2x a day for 3 days. Calcarea Carbonica 6 cH 3 globules was also administered twice a day for 7 days. Such therapeutic success was achieved in 3 days of treatment, with laboratory improvement of thrombocytopenia and dyspnea. This study contributes to existing research on new treatments for canine ehrlichiosis.

Dor em cães e gatos: avaliações, técnicas de diagnóstico e homeopatia / Pain in dogs and cats: assessments, diagnostic techniques and homeopathy

A dor é uma experiência multidimensional complexa e subjetiva, que engloba componentes sensoriais e/ou emocionais, manifestada por posturas anormais, mudanças de comportamento ou reações como medo e estresse. A dor pode ser dividida essencialmente em aguda ou crônica, porém há diversas outras classificações, como em relação à natureza (nociceptiva ou neuropática), à origem (inflamatória) e à causa (traumática, pós-operatória ou oncológica). Além disso, a dor sem causa definida é chamada de nociplástica. As técnicas para quantificação e reconhecimento em cães e gatos são escalas que mensuram a dor e foram adaptadas das que já existiam em medicina humana. A Medicina Veterinária Integrativa consiste em uma abordagem médica ampla que inclui e combina diversos aspectos para melhorar a qualidade de vida de um animal. Nesse âmbito, a homeopatia pode tratar de forma mais rápida e segura. Além disso, prolonga e beneficia a qualidade de vida do paciente. Portanto, o objetivo deste trabalho de conclusão de curso é realizar uma revisão de literatura acerca dos principais métodos de avaliação da dor e recomendar a homeopatia como tratamento integrativo da dor em cães e gatos.

Pain is a complex and subjective multidimensional experience that encompasses sensory and/or emotional components, manifested by abnormal postures, changes in behavior or reactions equivalent to fear and stress. Pain can be divided essentially into acute or chronic, but there are several other classifications, as related to nature (nociceptive or neuropathic), origin (inflammatory) and cause (traumatic, postoperative or cancer). In addition, nociplastic pain occurs in the absence of a causing factor. The techniques for quantification and assessment of pain in dogs and cats are scales that measure it and were adapted from those that already existed in human medicine. Integrative Veterinary Medicine consists of a broad medical approach that includes and combines several different aspects to improve an animal's quality of life. In this context, homeopathy can treat more quickly and safely. In addition, it prolongs and benefits the patient's quality of life. Therefore, the aim of this work is to do a literature's review about the main methods of pain assessment and recommend homeopathy as an integrative treatment for pain in dogs and cats.

Doença policística felina tratada com homeopatia: relato de caso / Feline polycystic disease treated withhomeopathy: case report

Foi avaliado o tratamento homeopático de um felino com doença renal policística, moléstia hereditária muito comum na espécie felina. Por ser progressiva, o prognóstico depende do estágio de evolução da doença renal crônica, da resposta do felino ao tratamento inicial e do desejo do tutor em dar continuidade ao tratamento. A observação teve duração de 9 (nove) meses e a avaliação dos resultados foi realizada com o emprego de exame clínico e de exames complementares como imagens ultrassonográficas e exames laboratoriais. A terapia foi composta por medicamento homeopático constitucional Phosphorus 30CH e episódico Kresolum 6CH associado à introdução de dieta renal (ração seca adjuvante). O medicamento homeopático não provocou eventos adversos no animal. Os resultados sugerem que um animal com doença policística felina pode ser tratado pela homeopatia.(AU)

The homeopathic treatment of a feline with polycystic kidney disease was evaluated, a common hereditary disease in the feline species. Because it is progressive, the prognosis depends on the stage of evolution of the chronic kidney disease, the feline response to the initial treatment and the guardian's desire to continue the treatment. The observation lasted 9 (nine) months and the evaluation of the results was performed through clinical examination and complementary tests such as ultrasound images and laboratory tests. The therapy was composed of constitutional Phosphorus 30CH and episodic Kresolum 6CH homeopathic medication associated with the introduction of diet kidney diet (adjunct dry feed). The homeopathic medicine did not cause adverse events in the animal. The results suggest that an animal with feline polycystic disease can be treated by homeopathy.(AU)

Lycopodium clavatum as a homeopathic treatment in Magellanic penguins (Sphenicus magellanicus)

Uric acid is the main form of excretion of nitrogenous components in birds. The assessment verification samples, control, check of uric acid concentrations is widely used to detect kidney disease. High concentrations (up to five times) of uric acid in plasma can lead to the precipitation of this acid in the form of crystals, which accumulate in the tissues, mainly in the synovial joints and the viscera surface. Aims: report the evolution of homeopathic treatment in increased uric acid in Magellanic penguins (Spheniscus magellanicus) from Santo André Municipal Zoo. Methodology: 12 animals showed an increase in uric acid (reference values 0,3-16,1mg/dL) and received homeopathic treatment with Lycopodium clavatum 6cH. The protocol established was the administration of two globules of Lycopodium clavatum 6cH, once a day, inside fishes offered in the animal's beak. Treatment started on 25/09/2019. On 30/10/2019 was collected a new blood sample, those who were not discharged were kept on treatment and new collections were made on 27/11/2019 and 17/12/2019. Results: 8 animals had an average uric acid of 20.45mg /dl and responded to the 35-days treatment, normalizing the biochemical values with an average of 12.24mg /dl. Two animals with 18.27 mg /dl were discharged in 62 days with 11.70 mg /dl and another two penguins with 19.85 mg /dl were discharged in 82 days later with 9.57 mg /dl of uric acid. Conclusion: Homeopathy proved to be successful in the treatment of increased uric acid in Magellanic penguins, easy to administer, affordable and without side effects.

High Dilution in Dyslipidemia treatment in Dogs and Rabbits

Excess weight causes disorders in locomotor, cardiorespiratory and reproductive systems and increases the incidence of endocrinopathies, as well it can often cause dyslipidemias, leading to atherosclerosis. Aims: Report the evolution of homeopathic treatment in 4 overweight patients, being 2 female dogs and 2 female rabbits with hypertriglyceridemia, analyzing the values in biochemical test. Methodology:Homeopathic treatment was chosen, based on the principle of similitude, using Cholesterinum due to its action to decrease cholesterol and triglyceride levels. Results:The same protocol was made for all of the four patients, included 2 globules of Cholesterinum 30CH direct in its mouth, every 12 hours for 30 days. The first dog attended on 01/09/2019, and presented 328 mg/dL of triglycerides, decreasing this level to 132 mg/dL after just one-monthtreatment. The second dog attended on 04/05/2019, presented higher hypertriglyceridemia with 617 mg/dL that decreased to 259 mg/dL. Likewise, on 02/06/2019, the first rabbit attended, presented 445mg/dL of triglycerides, which were reduced to 337 mg/dL, while the second rabbit, on 06/27/2019, presented 372 mg/dL of triglycerides, decreasing to 274 mg/dL after. Although the values of cholesterol in all patients were in agreement with the reference, the treatment still proved improvements. In the beginning of the treatment, the first dog showed 207 mg/dL of cholesterol and in the end, it reduced to 170 mg/dL, as well with the second dog with 218 mg/dL in the beginning and 200 mg/dL after. Regarding rabbits, the first one presented an initialvalue of 60 mg/dL, which decreased to 52 mg/dL, while the second started with 57 mg/dL and went to 41 mg/dL. Conventionally, Bezafibrate is indicated as a lipid-lowering agent, but it is contraindicated in patients with liver or kidney failure, vesicular diseases,and for pregnant or lactating. Conclusion:Dyslipidemia can be controlled with High dilution. (The exposed information is consented by the tutors)

Environmental parameters modulate lead chloride toxicity on Artemia salina

Different environmental conditions can influence the effects of toxic agents on living beings. Recently, a series of experiments performed in Artemia salina submitted to different kinds of intoxication have shown that both, isotherapic and succussed watercan change Artemia salina ́s bio resilience at different levels. Moreover, it seems to vary according to the circalunar cycle. Objective:To verify if circalunar phases and water agitation can modify the toxicity of lead chloride on Artemia salina in vitro. Methodology:Artemia salina cysts were exposed to seawater containing 0.04% of lead chloride (equal to EC10 or 10% effective concentration, previously determined in a pilot study) in 96-well culture plates. Thirty-six experimental repetitions were performed in four series to observe the possible effects of adding stirred water, the so-called succussed water, and the moon phases. The hatched cysts were recorded after 48 hours using a digital microscope (1000x magnification) to identify the hatching percentage and the viability and mobility of the born nauplii. Results:The exposition of cysts to PbCl2 led to an increase in the hatching rate, and it was more evident during the full moon (p = 0.00014) The addition of succussed water into the seawater medium reduced this effect to the baseline levels. An increase in mobility was seen in nauplii born from exposed cysts during the full moon (p = 0.00077), but this effect was not affected by the treatment with succussed water. Discussion:Although the effects of lead chloride EC10 on the increase of nauplii hatching were expected, two environmental variables changed the sensitivity of cysts to this harmful stimulus. The circalunar cycle varied the hatching rate according to the moon phase, even in laboratory conditions, and the addition of succussed water into the medium reduced the hatching rate, even with different intensities according to the moon phase. The organization of nano and microbubbles generated after the succussion of water could be related to this protective effect and can explain, at least partially the effects of high diluted preparations on this biological context. Conclusion:Environmental factors, such as the circalunar cycle and products of water agitation, can modulate the adaptative control of hatching in Artemia salina exposed to lead chloride at EC10.

Veterinary Biotypology: a review and new possibilities

The truths surrounding medical practices are seasonally challenged by innovative concepts that can aggregate changing procedures in many degrees. The Galtonian eugenics issues supported the pure-breed idea in dictatorial governments, and introduced mesological studies, turning possible to join genetic concepts to the physiology and psychology of the human organism. Following human medicine, more therapeutic models need to forthcoming in domestic animals. The companionship necessity and the highly responsive behavior have addressed the domestication of dogs and their relationship to owners, to an endpoint that both share the same pathologies. Thus, traditional human concepts of biotypology could be extended to companion animals. Grauvogl (1811-1877) proposeda simple biochemical correlation between physiological states and the miasmas of sick individuals (oxygenoid -syphilis, hydrogenoid -sycosis, carbo-nitrogenoid -psora). Antoine Nebel (1870-1954) correlated biochemical status with the musculoskeletal system and behavior as well. Leon Vannier (1880-1963) model, whose morphophysiological distortions and behavioral inconsistencies were explained by the carbon element and variations in its bonds with phosphorus or fluor radicals was another attempt to categorize and predefine physiology states. Following the advent of structural and functional identification of thyroid hormone in the 1940s, Henri Bernard described the neuro-morphofunctional plasticity of individuals guided by their predominant embryonic leaflet and consequent hormonal diseases. Methods:This work is a narrative review with the purpose of describing and discussingthe legacy ofbiotypology studies and their applicability in dog therapy, and proposinga new homeopathic approach in veterinary medicine based on the miasmas, also contributing to the scarcelyavailable literature. Results:Based on cellular exchanges and consequent metabolic rate, animals can be classified into psoric (no evidence of clinical signs, stable behavior, and adequate exonerative cellular processes); sycotic (cellular dysfunction with alterations in oxidative phosphorylation processes allowing accumulation of cellular toxins such as reactive oxygen and nitrogen species; clinically culminating in chronic inflammations in noble organs, and purulent discharges; unstable and polarized behavior) and syphilitic (whose cellular alterations have reached the molecular level, reducing protein expression and determining cellular toxicity and loss of function; indifferentbehavior). Generalities such as temperature influence, weight, thirst and feedingshall also be considered. Discussion and Conclusion: Thismodel could benefit stray animals, newly adopted or even from shelters, whose actual behavior is unknown, and the search for the Simillimum may be impaired.

Arsenicum albumas a treatment for pneumonia in snakes: three serial cases

two Python bivittatussnakes were received at Project Selva Viva, a zoo in Taubaté, Brazil, both presenting respiratory noises and oro-nasal discharge. A thoracic ultrasonographic examination was performed for evaluation on February 25th,2022, which diagnosed the presence of multiple vertical hyperechoic artifactsemerging from the pleural line, coalescing in some of the examined areas, and the presence a hypoechoic structure located in the subpleural region. Another serpent, from the Boa constrictor species, was apprehended and arrived at the same zoo without medical history, showing a low body score. During a thoracic ultrasonographic evaluation realized on April 1st,2022, B lines emerging from the pleural line were found. These vertical reverberating lines are a result of respiratory illness (SOLDATI et al., 2014).Methodology:The report was authorized by the owner of the zoo. All the patients received homeopathic therapy with 2 globules of Arsenicum album30 cH/ BID into the mouth, after being diagnosed with the respiratory condition by the ultrasonographic examination. The medication was chosen according to the similarity with the symptoms. The snakes had a runny nose and hissing breathing noise. Weekly ultrasound scans were performed on the Python bivittatus snakes to follow up on the respiratory condition. Results: On March 04th, it was observed that both snakes showed a reduction in respiratory noises and were more active. Ars 30 cH was maintained BID. On March 25th, both presented significant improvement in the ultrasound images, which showed only A lines, compatible with a healthy lung, and the treatment was suspended. Boa constrictor snake ́streatment started on April 1st. On April 8th, the ultrasonographic examination performed only presented A lines, which are characterized in ultrasound by parallel horizontal lines in the near field with the loss of image continuity in the far field, indicating improvement of the condition (LICHTENSTEIN et al., 2003). Conclusion:Given these results, the homeopathic treatment is an option to be considered for the treatment of respiratory symptoms in snakes, although the duration of the therapy varies based on the stage and chronicity of the disease.

Apocrine gland adenocarcinoma in a persian cat remission with homeopathic treatment: case report

Apocrine gland carcinomas are rare malignant neoplasms that occur in cats. Available treatment is surgical, would lead to total ablation of the external acoustic meatus and usually recurrent [1,2].Methodology:In December 2020, a homeopathic consultation of the feline, male, Persian, 13 years old, a history of the disease was reported, which started in 2015, adding up to six recurrences of tumor processes in the eyelids and recent formation in the left ear canal.The result of the histopathological examination confirmed apocrine adenocarcinoma.Prior to homeopathic treatment, tumors recurred despite surgical interventions and prophylactic treatment with trichloracetic acid.However, remaining formations were noted in the eyelids and ear canal. It has a rounded blackened shape in the upper right eyelid measuring 0.4 cm and the lower 0.2 cm, round. In the left ear canal, around 1.6 cm, in addition to 4 points scattered in the ear folds. Homeopathic treatment was started for two months with Arsenicum album30 cH, twice a day; Carcinosinum 200 cH, once a day, and complex containing Avena sativa4 cH, Echinacea angustifolia4 cH, Conium maculatum6 cH, Thuja officinalis6 cH and Silicea terra6 cH, four times a day. Every two months, the clinical picturewas reassessed, potenciesand frequencies readjusted.In a few months,there was complete remission of the tumor, recovery of welfare, and improvement in mood and appetite. The free and informed consent term was signed. There was no recurrence of tumors until May2022. Conclusion:This study proved to be effective, documented with photos and exams. Approaching a rare case may provide a new therapeutic possibility. The credibility of quality homeopathic case reports has been increasing due to methodological requirements using tools developed in recent studies.

Feline Injection-Site Sarcoma Complete Remission After Treatment with Isopathic medicine: a case repor

Feline injection-site sarcomas (FISS) were described for the first time in 1991. They are neoplasms of mesenchymal origin that appear in body regions routinely used for the application of vaccines or other injections [1]. Those are very aggressive tumours that relapse and have a high rate of mortality. The tumour can appear between 3 months and 3 years after the injection, but in some cases, it can happen after 15 years of the vaccineor otherinjections. Isopathy is one approach of homeopathy, in which the biological agent thatcausesa disease are prepared in high dilution to treat the same disease. This case report is about a 13-year-old mix breed spay cat. In September 2019 it received the vaccine Rabsin® (Boehringer Ingelheim) and 4 months later the owner noticed a lump at the injection area. One year later (September 2020) the lump start growing rapidly and on January 12th, 2021,started the appointments.The other veterinarians recommend euthanasia since the tumour was very bigand the catwasnot mild, was losing weightand appetite. The owner wanted to try another treatment before euthanasia since the cat was still active, interacting with the other cat and the people at the house.The lump was located on her back, in the end of the right ribcage, and it was around 7cm of diameter. It wasfirmandattachedto the muscles. AnIsopathy medicine with the same vaccinewas prepared, being the isotherapic 12CH administered 5 drops BID.Beside the isopathyvitaminsof Bcomplex and Omega 3were prescribed.The cat was seen every15 days andcontact telephonically was kept as well. The treatment started on January 19th, 2021. On January 21st, 2021,all the tumour was ulcerated and looser. On February 2nd,2021 the potencywas changedto 14CH, 5 drops, BID. On February 4ththe tumour felt away and was sent for histopathological study. On February 20th, 2021,the result described it as a Fibrosarcoma grade II. The ulcer that appeared after the tumour felt away became a big wound and the ownerstarted cleaning itwith propolis and lavender oleateeveryday anditwas controlledonce a week. OnMarch31st, 2021,the catwas eating well,strong, not mild,didnot allowedit to be cleaned. The woundseems to be more superficial,largerand it appears thata small lump was growing again.Isotherapic 15CH, 5 drops once a weekwas indicated.On April4th, 2021,the cat waseating well, good general conditionand the small lump that was growing wasshrinkingand the wound becoming more superficial. OnApril 9th,2021the cat seems painful, not eating well, constipated. Isopathy was suspended and started with Meloxican0,1mg/kg SID for 3 days.Was indicatedNatrum muriaticum30CH, 5 drops every hour, total 3 treatments and then once a day. On April 13th, 2021,the cat was better, defecate. But since April 9ththe cat could never be stable again. It has ups and downs and was treated withdifferent homeopathic remedies (Natrum muriaticum30Ch, Silicea200CHand Silicea1000CH, Staphisagria 200CH)until June 8th, 2021,when it was euthanised.No necropsy was done. The question was,what happenedwith the catsince itwas getting better?The following aphorisms could explain it:§156 "...The restoration, however, leads to the goal of the cure, if it is not preventedby strange medicinal influence, by errors in the lifestyle or by passions." And§10"With no vital powerthe material organism is not capable of any sensation, function or self-preservation..."[2].The informed consent formwas obtained from the owner of the cat.

Homeopathy treatment of Malassezia Pachydermatis in vitro

A common clinical occurrence in dogs is otitis externa caused by excessive growth of yeasts Malassezia pachydermatis, which can become chronic after wrong treatments, in which microbial resistance can occur. Homeopathic remedies can be considered a successful alternative, selecting the medicine through the similitude principle. Herein, 50 µL of a 1:1000 dilution of Malassezia pachydermatis suspension at 0.5 McFarland scale was used to seed the yeast into Sabouraud dextrose agar plates using a Drigalski spreader to proceed with colony unit counting. Before being seeded, the yeast suspensions were treated with 1% of different homeopathic treatments previously selected from a pilot study, which means Sulphur 6cH, Dolichos pruriens 6cH, and Kali carbonicum 6cH, being water, and succussed water used as controls. For comparison, a set of Sabouraud dextrose agar plates containing 1% Tween 80 was seeded in parallel. The treatments were made blind and evaluated in triplicate. Contaminated cultures were withdrawn. The number of colonies per plate was assessed, and smears were made from the cultures to classify yeast growth according to cytomorphology on ImageJ®software. The preliminary results show no significant effect of all tested medicines compared to the controls. High data variability was also observed, mainly in those cultures whose medium was prepared with Twin 80. In conclusion, at this point of the study, no evidence of the effects of the studied medicines on Malassezia pachydermatis growth in vitro could be identified. The analysis of cytomorphology is still in course.

Tarantula cubensis extract (Theranekron®) inhibits inflammation in carrageenan-induced acute paw edema in rats / [Extrato de tarântula cubensis (Theranekron®) inibe a inflamação no edema induzido por algas vermelhas na pata de ratos]

The aim of this study was to investigate the anti-inflammatory effect of alcoholic extract of Tarantula cubensis alcoholic extract (TCAE) in experimentally induced inflammation in rats. Fifty-four adult Sprague-Dawley male rats were randomly divided into nine groups. Paw edema was induced by 0.2mL subplantar (s.p.) injection of 1% carrageenan (CAR) into the right hind paw. Rats were treated with the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) (10mg/kg, p.o.) or TCAE at different doses (1, 10 or 100µg/kg) injected s.c. for systemic or s.p. for local anti-inflammatory effect. Saline was used as control. Changes in paw thickness, volume, and weight were calculated as percentages. Formalin-fixed paws were used for histopathological examination. We detected that TCAE applied s.c. at 10µg/kg and 100µg/kg doses resulted in thinner paw thickness, lower paw volume, and lower paw weights four hours after the induction of inflammation when compared with the INDO group (p<0.05). The paw edema inhibitory effect of TCAE applied at a dose of 10µg/kg, s.c. was 68% when compared with the INDO which had an inhibitory effect of 56%. These results were verified with similar histopathological findings. The anti-inflammatory feature of 10µg/kg of TCAE given systematically was similar to the effects of INDO. Our results suggest that TCAE has anti-inflammatory effects by reducing edema and decreasing inflammatory reaction. These results may be attributed to the inhibition of the production of proinflammatory mediators. Thus, TCAE may be considered as a potential anti-inflammatory agent for treating acute inflammatory conditions.

O objetivo deste estudo foi investigar o efeito anti-inflamatório do extrato alcoólico de Tarantula cubensis (TCAE) na inflamação induzida experimentalmente em ratos. Cinqüenta e quatro ratos Sprague-Dawley adultos machos foram divididos aleatoriamente em nove grupos. O edema da pata foi induzido pela injeção de 0,2mL de subplantar (s.p.) de 1% de carragena (CAR) na pata traseira direita. Ratos foram tratados com o medicamento antiinflamatório não esteróide (NSAID) indometacina (INDO) (10mg/kg, p.o.) ou TCAE em doses diferentes (1, 10 ou 100µg/kg) injetado s.c. para efeito sistêmico ou s.p. para efeito antiinflamatório local. A soro fisiológico foi usado como controle. As mudanças na espessura da pata, volume e peso foram calculadas como porcentagens. As patas fixadas com fórmalina foram usadas para exame histopatológico. Detectamos que o TCAE aplicado s.c. em doses de 10µg/kg e 100µg/kg resultou em menor espessura da pata, menor volume da pata e menor peso da pata quatro horas após a indução da inflamação quando comparado com o grupo INDO (p<0,05). O efeito inibidor do edema da pata de TCAE aplicado na dose de 10µg/kg, s.c. foi de 68% quando comparado com o INDO que teve um efeito inibidor de 56%. Estes resultados foram verificados com resultados histopatológicos semelhantes. A característica anti-inflamatória de 10µg/kg de TCAE dada sistematicamente foi semelhante aos efeitos do INDO. Nossos resultados sugerem que o TCAE tem efeitos anti-inflamatórios reduzindo o edema e diminuindo a reação inflamatória. Estes resultados podem ser atribuídos à inibição da produção de mediadores pró-inflamatórios. Assim, o TCAE pode ser considerado como um agente antiinflamatório potencial para o tratamento de condições inflamatórias agudas.

Uso de terapêutica homeopática em dermatites recorrentes na rotina clínica de animais de companhia: uma revisão / use of homeopathic therapeutics in recurrent dermatitis in the clinical routine of companion animals: a review

Na clínica veterinária as patologias chamadas afecções dermatológicas representam uma porcentagem significativa dos atendimentos, podendo ser de cunho multifatorial ou unifatorial como infecciosa, alérgena ou psicogênica e acometem felinos e caninos de todas as idades. Comumente os medicamentos homeopáticos são usados como último recurso após insucessos consecutivos com a utilização da terapia alopática. Desta forma, esse artigo visa trazer uma revisão bibliográfica de trabalhos científicos que confirmam a eficácia de terapêuticas que utilizam intervenções homeopáticas para o tratamento de dermatites em animais de companhia. Tem-se, portanto, o intuito de propiciar uma maior divulgação das possibilidades de ação/utilização da homeopatia pela comunidade médica veterinária, evitando-se com isso possíveis efeitos adversos devido à utilização de medicações alopáticas.

In the veterinary clinic, the pathologies called dermatological illnesses represent a significant percentage of the consultations, being of a multifactorial or unifactorial nature such as infectious, allergenic or psychogenic and affect felines and canines of all ages. Homeopathic medicines are commonly used as a last resort after consecutive failures with the use of alopathic therapy. Thus this article aims to bring a bibliographic review of scientific papers that confirm the efficacy of therapies that use homeopathic interventions for the treatment of dermatitis in company animals. Therefore it is intended to provide a greater dissemination of the possibilities of action/use of homeopathy by the veterinary medical community thereby avoiding possible adverse effects due to the use of alopathic medications.

Análise histopatológica dos efeitos do bioterápico 200dh em camundongos infectados por Trypanosoma Cruzi / Histopathological analysis of the effects of 200dh biotherapeutic in mice infected with Trypanosoma Cruzi

O Trypanosoma cruzi é um protozoário que instaura uma infecção grave em seu hospedeiro vertebrado, podendo causar danos irreversíveis, principalmente em suas células musculares, conhecida como a doença tripanossomíase ou Doença de Chagas. dicação disponível no mercado, que combate esse parasito, não é completamente eficiente e produz danos indesejáveis e irreversíveis, fazendo-se necessário a busca por outros campos da medicina, em termos de medicação, para combater essa doença. Nesse sentido, pesquisas com medicamentos homeopáticos têm se revelado promissoras no combate ao parasito, sobretudo as formas amastigotas, que são mais difíceis de serem exterminadas. Os bioterápicos são os homeopáticos que obtiveram maior sucesso em relação à infecção por T. cruzi, uma vez que esses medicamentos possuem seu princípio ativo retirado do próprio parasito, suas toxinas, parte de membros, realizando uma terapia conhecida como isoterapia ­ cura pelo igual. Resultados encontrados indicam que o bioterápico 200dH atua coagindo o sistema imune a combater o T. cruzi em cobaias contaminadas, fomentando uma resposta imune celular e humoral mais eficiente do que a fisiológica. Acredita-se que esse medicamento atue estimulando as células de defesa, que passarão a responder de forma antígeno- -específico, favorecendo o combate de amastigotas. Esse processo, provavelmente, é iniciado pela estimulação do macrófago, que por sua vez, de acordo com os resultados encontrados, inicia uma cascata inflamatória, com predominância da via Th1, fomentando a produção de IL4, IL-10 e interferon, auxiliando no combate as amastigotas.

The trypanosoma cruzi is a protozoan that causes a serious infeccion in the vertebrate host, being capable of causing irreversible damages mainly in the muscle cells, also known as trypanosomiasis disease or Chagas Disease. The commercially available drug medication which fights this parasite is not completely efficient and causes undesirable and irreversible damages making it necessary to search for other fields of medicine in terms of medication to combat this disease. Therefore research with homeopathic medicines has being promising in the fight against the parasite, especially the amastigote forms, which are more difficult to be exterminated. Biotherapics are the homeopathic ones that have been more successful in relation to T. cruzi infection, since these drugs have their active principle removed from the parasite itself, its toxins, part of its members, performing a therapy known as isotherapy - cure by the same. The results indicates that the 200dH biotherapic acts by coercing the immune system to fight T. cruzi in contaminated guinea pigs, promoting a cellular and humoral imune response more efficient than the physiological one. It is believed that this medicine works by stimulating the defense cells which will respond in an antigen-specific manner favoring the fight against amastigotes. This process is probably initiated by the stimulation of the macrophage which in turn, according to the remains found, initiates an inflammatory cascade with predominance of the Th1 pathway, promoting the production of IL-4e IL-5 and interferon helping to combat amastigotes

Is the addition of spray homeopathic in feed able to change dog behavior? / A adição de spray homeopático na ração é capaz de alterar o comportamento de cães?

This study aimed to determine if the homeopathic formulation based on Natrum muriaticum, Matricaria, Chamomilla, and Ignatia amara was effective for stress control in dogs in order to prevent and/or reduce the frequency of unwanted behaviors. Ten male beagle dogs were divided into two groups, with five animals per group. The control group was animals receiving 0.5 mL/day of placebo via spray in the feed for 30 consecutive days as a preventive. The treated group received 0.5 mL/day of tested drug spray in the feed for 30 consecutive days as a preventive. Behavioral tests were performed at two time points, before and after receiving the tested drug. We performed the following behavioral tests: a) persons known and unknown in the internal and external environment; b) interaction with toys; c) interaction with an unknown dog, d) test with a leash; and e) firecracker test. There was more engagement in digging and scaling the fence in the control group than in the treatment group (P < 0.05). The animals that received homeopathic medicine sat 2.54 times longer than the control (P = 0.0269). Dogs that received homeopathic showed 4.49 times more interest in general at D30 than at D1 (P = 0.0214). Animals in the treated group showed an 83% less chance of urinating than the control group in the tests involving displacements. We conclude that the preventive addition of homeopathic medicine containing Natrum muriaticum, Chamomilla, and Ignatia amara reduced undesirable behaviors related to anxiety and increased the incidence of interest behavior.(AU)

Este estudo visou determinar se a formulação homeopática baseada em Natrum muriaticum, Matricaria, Chamomilla, e Ignatia amara foi eficaz para o controle de stress em cães, a fim de prevenir e/ou reduzir a frequência de comportamentos indesejados. Dez cães beagle machos foram divididos em dois grupos, com cinco animais por grupo. O grupo controle recebeu 0,5 mL/dia de placebo via spray na ração durante 30 dias consecutivos, como preventivo. O grupo tratado recebeu 0,5 mL/dia de homeopático via spray na ração durante 30 dias consecutivos, como preventivo. Os testes comportamentais foram realiza-dos em dois momentos, antes e depois de receber o fármaco testado. Foram realizados os seguintes testes comportamentais: a) pessoas conhecidas e desconhecidas no ambiente interno e externo; b) interação com brinquedos; c) interação com um cão desconhecido, d) teste com a guia; e teste com fogos de artifício. Houve um aumento nos comportamentos cavar e escalar a grade no controle (P < 0,05). Os animais que receberam o homeopático sentaram-se 2,54 vezes mais do que o grupo con-trole (P = 0,0269). Os cães que receberam homeopático mostraram 4,49 vezes mais interesse em geral no D30 do que no D1 (P = 0,0214). Os animais do grupo tratado mostraram uma probabilidade 83% menor de urinar do que o grupo controle nos testes envolvendo deslocamento. Concluímos que a adição preventiva de medicamentos homeopáticos contendo Natrum muriaticum, Chamomilla, e Ignatia amara reduziu os comportamentos indesejáveis relacionados com a ansiedade e aumentou a incidência de comportamentos de interesse.(AU)

Homeopathic treatment of rectal prolapse in a kitten: a case report

Rectal prolapse be either partial or incomplete in nature and is defined as double layer evagination of the rectum through the anal canal. The common associated causations which can be seen in kittens are severe endoparasitism, enteritis, and associated tenesmus (Fossum, 2002). Rectal prolapse is the one of the most encountered surgical conditions involving the rectum in all domestic animal species (Tyagi and Singh, 1993). Surgical intervention is the most common treatment methodology adopted but however, in cases where surgery is not indicated, required, not opted by the owner, becomes a challenge to treat. Therefore, finding alternative therapies for clinical management is the need of hour. The objective of this study is to report successful management of rectal prolapse in a 5-month-old kitten having 4 episodes of prolapse in five days. The homeopathic medicines used in this case were Sepia 200C and Ruta g. 200C. The patient revealed a favourable response by 2nd day of the treatment and complete healing was observed on 7th day. This therapeutic protocol used was conclusive and it re-established the normal intake of food and energy level. Hence, homeopathic treatment can be considered as an alternative therapy for clinical management of rectal prolapse in a Felines and Canines.

Assessment of weight gain and control of parasitism by Rhipicephalus microplus in dairy cattle in the field using organosynthetic parasiticide, phytotherapics and homeopathy / Avaliação do ganho de peso e controle do parasitismo por Rhipicephalus microplus em bovinos leiteiros a campo usando parasiticida organosintético, fitoterápicos e homeopatia

The goal of this research was to compare the effect of the following products on dairy cattle, parasitized by Rhipicephalus microplus: organosynthetics - Clorfenvinfós and Ivermectina (OG); phytotherapics - Eucalyptus oil (EG) and Neem cake (NG); Homeopathy (HG); The control group (CG) received no treatment. Infestation was by R. microplus (MIC) and weight gain (GP) were evaluated. The study included 60 animals (5 groups) from ­ Dutch / Zebu, aged between 25-44 months and initial weight between 211-477kg. EG and NG showed MIC 84.9% and 14.0% greater than CG, respectively (P <0.05; P = 0). HG and OG had MIC less than CG 24.4% and 16.9%, respectively (P<0.05; P <0.05). EG, NG and OG obtained GP lower than CG in 7.9%, 8.9% and 8.06% (P <0.05) respectively. The HG GP was 4.9% higher (P <0.05) than CG. This was the first research to prove parasitism control by R. microplus in a field test, using homeopathy. The methodology for choosing Homeopathy for the control of enzooties, developed and tested for the first time in this study, proved to be adequate and efficient, opening the possibility for establishing a new methodology for strategic control of parasitism by R. microplus.(AU)

O objetivo desta pesquisa foi comparar o efeito dos seguintes produtos sobre bovinos leiteiros, parasitados por Rhipicephalus microplus: organossintéticos - clorfenvinfós e ivermectina (OG); fitoterápicos - óleo de eucalipto (EG) e torta de Neem (NG) e homeopatia (HG). O grupo controle (CG) não recebeu tratamento. Foram avaliados infestação por R. microplus (MIC) e ganho de peso/grupo (GP) em 60 animais (5 grupos), a partir de ­ holandês/zebu, com idade entre 25 e 44 meses e peso inicial entre 211 e 477kg. EG e NG apresentaram MIC 84,9% e 14,0% maior que CG, respectivamente (P<0,05; P=0). HG e OG apresentaram MIC menor que CG 24,4% e 16,9%, respectivamente (P<0,05; P<0,05). EG, NG e OG obtiveram GP menor que CG em 7,9%, 8,9% e 8,06% (P<0,05), respectivamente. O GP do HG foi 4,9% maior (P<0,05) que o CG. Esta foi a primeira pesquisa a comprovar controle do parasitismo por R. microplus em teste a campo, usando homeopatia. A metodologia para escolha de medicamentos homeopáticos para controle de enzootias, desenvolvida e testada pela primeira vez neste estudo, mostrou-se adequada e eficiente, abrindo a possibilidade para estabelecimento de nova metodologia para controle estratégico do parasitismo por R. microplus.(AU)

Anxiolytic activity of ultra-diluted Aconitum napellus on Wistar rats

BackgroundAnxiety disorders are highly prevalent that affect millions of people worldwide. Homeopathic system is gaining popularity due to its efficacy in chronic diseases. Ultra-diluted Aconitum napellusis a homeopathic medicine used by clinicians for treatment ofacute anxiety.AimObjective of this study is to test the efficacy of Aconiteon experimental anxiety models of Wistar rats. Methodology18 Female Wistar rats were dividedinto Control, Anxiety, andAnxiety + Aconite(ANX+ACO) groups. Acute stress was induced by restraining the rats for sixhours daily for fivedays in Anxiety and ANX + ACO groups. After fivedays of stress,a single dose of Aconite200cH was given to ANX + ACO group through oral gavage, whereas control and anxiety group rats were maintainedwith a normaldiet. Following this, behavioral assessment was done. Histological sections of the hippocampal area weretaken and stained with Hematoxylin and Eosin and also Cresyl violet stain. ResultsIt was observedthat the Aconitetreated group had morenumber of entries and also the percentage of time spent in the open arm was higher than the stressed anxiety group. Histological study of the brain tissue procured from all three groups was analyzed. ConclusionIt was inferred that ultra-diluted homeopathicAconitehas decreased anxiety in Wistar rats which were subjectedto acute restrainstress. However,the decrease was not statistically significant to deduce Aconiteas an anxiolytic.(AU)

Contribuição dos nosódios intestinais para o tratamento homeopático

Trabalho realizado a partir da revisão bibliográfica a respeito da importância da relação do equilíbrio do microbioma intestinal, com o eixo psico-neuro-endócrino ­imunológico e os nosódios intestinais de Edward Bach e John Paterson. Evidencia como a abordagem isoterápica, por meio dos nosódios intestinais, se mostra relevante para reduzir os sintomas de desequilíbrios físicos e comportamentais de um indivíduo. Por esse viés, elucida a contribuição dos nosódios intestinais para a descoberta do medicamento constitucional do paciente, bem como o reestebelecimento da qualidade de vida e retomada da sua funcionalidade e bem estar geral, de forma ágil. (AU)