Evaluation of antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic rats

IntroductionDiabetes Mellitusis an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathic system of medicine uses ultra-molecular doses for treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes,nosodes and animal parts. Insulinum 6 CH, Pancreatinum 6CH and Uranium nitricum 6 CHareused in homeopathy for treatment of Diabetes Mellitus. However,no preclinical studies have been investigated for the anti-diabetic effect and its safety.MethodsHomeopathic medicines Insulinum 6CH, Pancreatinum 6CHandUranium nitricum6CH(1012)dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 daysoftreatment,bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathologyof (Liver, Kidney, Pancreas) weremeasured.ResultsAfter Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p<0.01) as compared to normal control animals. Treatment with homeopathic medicine Insulinum 6CH, Pancreatinum 6CHandUranium nitricum6CHpotency showed significant decrease in levels of Glucose (p<0.05), OGTT, Total protein (P<0.001), ALP (P<0.05), Cholesterol (P<0.001), SGPT (P<0.001), SGOT (p<0.01), Urea, HbA1C as compared to diabetic animal.ConclusionsIn the present study homeopathic medicine Insulinum 6CH, Pancreatinum 6CH andUranium nitricum6CHpotency exhibitantihyperglycemic effects in streptozotocin induced diabetic rats.(AU)

Modificaciones de la glucemia en conejos, con Cecropia sp / Blood glucose changes in rabbits with Cecropia sp

Existen una serie de vegetales en la Republica Mexicana que son enpleados empiricamente con fines farmacologicos por la poblacion rural. Es un compromiso de quienes se dirigen a la medicina experimental demostrar las funciones que estas plantas tienen en el organismo humano, ya que de comprobarse su utilidad su uso abaratara considerablemente los costos de la industria farmaceutica, en bien de la poblacion mas pobre del pais. En este caso el Guarumbo (Cecropia peltata, Cecropia mexicana o Cecropia obtusifolia) es mencionado continuadamente como util en algunos sintomas de la diabetes, cuya cualidad fue comunicada de manera verbal constantemente a medicos que realizaron su servicio social en regiones donde se encuentra dicho vegetal. El interes por el estudio de esta planta, se desarrollo en nosotros con objeto de esclarecer las relaciones farmacologicas existentes en pacientes con problemas de diabetes a los que se les administra la planta en forma de infusion, encontrandose que se conseguia la disminucion de la astenia y adinamia, asi como la normalizacion de la diuresis. Tomando en cuenta que dentro de la bibliografia conocida de Cecropia no existen informes de su probable actividad en esta estidad nosologica, resulta de gran importancia constatar a nivel de laboratorio si efectivamente contribuye a la regulacion homeostatica, escogiendo para analizar parametros de alteracion en la quimica sanguinea

Pancreatic beta-cell regeneration

Cephalendra indica (41//v/v alcoholic extract of the wild variety of Cephalendra indica Naud.), on regular administration in doses ranging from 25uml to 75uml/100g of body weight (gbw) by the oral or intraperitoneal (ip) route produced a significant fall in blood sugar level in alloxan-induced diabetic rats. Biochemical studies showed stabilization of blood sugar level in 70//of cases at fourteen to twenty days after withdrawal of the drug. Histopathological studies revealed regeneration of pancreatic B cells. The hypothesis is that the drug acts through the hypothalamo-hypophysial-pancreatic axis, producing selective regeneration of B cells. The drug may indirectly release inhibitory factors from hypothalamic neurons, inhibiting the secretion of growth hormone and triggering insulin secretions from B cells. The therapeutic action of the drug on pancreatic B cells and lack of acute and subacute toxicity may open up new prospects in the treatment of diabetes mellitus