RESUMO
Neoplastic diseases are now among the most commonly seen conditions. Orthodox, non-surgical approaches, including chemotherapy and radiotherapy, have variable results, but many adverse affects that limit their use. These are sometimes the direct cause of death. More patients are choosing alternative treatments, mainly the homeopathic and herbal-nutrition approach. Homeopathy does not have highly effective remedies for cancerin its literature, and has been limited to palliating the adverse effects of... (AU)
Assuntos
Relatos de Casos , Humanos , Masculino , Feminino , Pré-Escolar , Pessoa de Meia-Idade , Neoplasias/terapia , Carcinógenos/uso terapêutico , ApoptoseAssuntos
Humanos , Animais , Cobaias , Técnicas In Vitro , Doses Mínimas , Pesquisa Homeopática Básica , Mecanismo de Ação do Medicamento Homeopático , Calorimetria , Técnicas de Cultura , Intoxicação por Cádmio , Cisplatino/envenenamento , Anuros , Tiroxina/farmacologia , /farmacologia , Fator de Crescimento Epidérmico/farmacologia , Fibroblastos , Cólera/terapia , Medicina Herbária , Galphimia/uso terapêutico , Rinite Alérgica Sazonal/terapia , Ensaios Clínicos como Assunto , Triticum , Argentum Nitricum/farmacologia , Conformação Molecular , Adjuvantes Imunológicos , Carcinógenos , Neoplasias/terapiaRESUMO
The protective effect of extracts of mistletoe Viscum album (Iscador) with reference to carcinogenesis was tested on in vitro cultured porcine gastric chief cells. Putative protection against in vitro methylation of lambda DNA by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was studied with restriction endonucleases. Preparations of Iscador from mistletoe grown on oak as host tree had a high cytotoxic effect on gastric chief cells, with an LC50 after 24hrs that ranged between 0.01 and 0.03 mg/ml. At 0.01 mg/ml, Iscador was also found to protect lambda DNA from methylation or destruction by MNNG. During the course of this study a high variability was found both in cytotoxicity and protection rate against methylation which we attribute to batch to batch differences. Thus the LC50 for Iscador MH86L12 was 0.005 mg/ml, while for MH87 D24 it was 0.05 mg/ml after 24hrs. The Iscador batch W frf 50 mg/ml, which was made from a fresh plant extract at the Hiscia Institute, showed less variability. Results are therefore given for this batch of Iscador only
