Dermatitis granulomatosa intersticial y tocilizumab: ¿es este un tratamiento de utilidad para esta dermatosis? / Interstitial Granulomatous Dermatitis and Tocilizumab: Is This Treatment Useful for This Skin Condition?

No disponible

Soft tissue cell adhesion to titanium abutments after different cleaning procedures: Preliminary results of a randomized clinical trial

OBJECTIVES: A randomized controlled trial was performed to assess soft tissue cell adhesion to implant titanium abutments subjected to different cleaning procedures and test if plasma cleaning can enhance cell adhesion at an early healing time. Study DESIGN: Eighteen patients with osseointegrated and submerged implants were included. Before re-opening, 18 abutments were divided in 3 groups corresponding to different clinical conditions with different cleaning processes: no treatment (G1), laboratory customization and cleaning by steam (G2), cleaning by plasma of Argon (G3). Abutments were removed after 1 week and scanning electron microscopy was used to analyze cell adhesion to the abutment surface quantitatively (percentage of area occupied by cells) and qualitatively (aspect of adhered cells and presence of contaminants). RESULTS: Mean percentages of area occupied by cells were 17.6 ± 22.7%, 16.5 ± 12.9% and 46.3 ± 27.9% for G1, G2 and G3 respectively. Differences were statistically significant between G1 and G3 (p = 0.030), close to significance between G2 and G3 (p = 0.056), and non-significant between G1 and G2 (p = 0.530). The proportion of samples presenting adhered cells was homogeneous among the 3 groups (p-valor = 1.000). In all cases cells presented a flattened aspect; in 2 cases cells were less efficiently adhered and in 1 case cells presented filipodia. Three cases showed contamination with cocobacteria. CONCLUSIONS: Within the limits of the present study, plasma of Argon may enhance cell adhesion to titanium abutments, even at the early stage of soft tissue healing. Further studies with greater samples are necessary to confirm these findings

El factor de crecimiento de tejido conectivo (CTGF): factor clave en el inicio y la progresión del daño renal / No disponible

El factor de crecimiento de tejido conectivo (CTGF) aparece aumentado en diferentes patologías asociadas a fibrosis, incluidas múltiples enfermedades renales. CTGF participa en procesos biológicos, como la regulación del ciclo celular, migración, adhesión y angiogénesis. Su expresión está regulada por diversos factores implicados en el daño renal, entre los que destacan el factor la angiotensina II, el factor de crecimiento transformante-beta, altas concentraciones de glucosa y situaciones de estres celular. CTGF participa en el inicio y progresión del daño renal al ser capaz de inducir una respuesta inflamatoria y promover la fibrosis, señalándole como una posible diana terapéutica en el tratamiento de patologías renales. En este trabajo revisamos las principales acciones de CTGF en la patología renal, los mecanismos intracelulares de actuación y las estrategias terapéuticas para su bloqueo (AU)

Connective tissue growth factor (CTGF) is increased in several pathologies associated with fibrosis, including multiple renal diseases. CTGF is involved in biological processes such as cell cycle regulation, migration, adhesion and angiogenesis. Its expression is regulated by various factors involved in renal damage, such as Angiotensin II, transforming growth factor-beta, high concentrations of glucose and cellular stress. CTGF is involved in the initiation and progression of renal damage to be able to induce an inflammatory response and promote fibrosis, identified as a potential therapeutic target in the treatment of kidney diseases. In this paper we review the main actions of CTGF in renal disease, the intracellular action mechanisms and therapeutic strategies for its blocking (AU)

Las células intersticiales de Cajal: otra contribución a la medicina moderna / Interstitial cells of Cajal: another contribution to modern medicine

Las aportaciones de Santiago Ramón y Cajal a lamedicina moderna son innumerables. Este grancientífico y humanista, un hombre adelantado a sutiempo, habló por primera vez de conceptos comola angiogénesis, que representa uno de los camposmás novedosos hoy en día para la oncología,además de realizar investigaciones experimentalessobre la degeneración y regeneración del sistemanervioso mediante las cuales sentó las basesmorfofuncionales de la neurociencia actual. En estecaso, hemos querido recordar la relevancia deldescubrimiento de las llamadas «célulasintersticiales» de Cajal, que han sido involucradasen múltiples procesos y enfermedades digestivasque aquí recogemos, y, sobre todo, su recienterelación con los tumores del estromagastrointestinal con las implicaciones terapéuticasque esto podría traer consigo

The contributions of Santiago Ramon y Cajal toModern medicine are innumerable. This largescientist and humanist, a man ahead of his time,spoke for the first time such concepts asangiogenesis, which represents one of the mostinnovative fields for oncology today, in addition toconducting experimental research on thedegeneration and regeneration of the nervoussystem by which laid the foundationmorphofunctional of neuroscience today. In thiscase, we wanted to remember the significance ofthe discovery of so-called «interstitial cells ofCajal», which have been involved in multipleprocesses and digestive diseases we collect, andespecially his recent relationship withgastrointestinal stromal tumors with thetherapeutic implications this could bring

Hamartoma mesenquimal rabdomiomatoso / Rhabdomyomatous mesenchymal hamartoma

El hamartoma mesenquimal rabdomiomatoso es una lesión congénita extremadamente rara, con características macro y microscópicas que ayudan a su fácil diagnóstico; a pesar de lo anterior, se han descrito muy pocos casos. Presentamos el caso de una paciente de 18 años de edad, con una masa en la región medial de cuello, pediculada, la cual se extirpó quirúrgicamente obteniendo el diagnóstico de hamartoma mesenquimal rabdomiomatoso. Se analizan las características clínicas, macroscópicas, histológicas e inmunohistoquímicas, que permiten diagnosticar esta entidad. La asociación con anomalías congénitas, aunque poco frecuente, debe ser valorada por el clínico (AU)

Rhabdomyomatous mesenchymal hamartoma is an extremely rare congenital lesion, and very few cases have been reported even though its macroscopic and microscopic features make diagnosis easy. An 18-year-old woman consulted with a pedunculated mass in the medial region of her neck. The mass was surgically removed, and rhabdomyomatous mesenchymal hamartoma was diagnosed. The clinical, macroscopic, histologic, and immunochemical characteristics that allow diagnosis of this entity are discussed. Although association with congenital abnormalities is uncommon, this possibility should be assessed by the clinician (AU)

Espacio biológico. Parte I: La inserción diente-encía / Biology Space. Part I: The insertion dentogingival

Se denomina espacio biológico a la unión dentogingival, que está constituida por el epitelio de unión y el tejido conectivo de inserción de la encía. Cuando se habla de espacio biológico no sólo se debe pensar en la longitud de la inserción gingival, sino que se debe relacionar con el grosor de la encía, el biotipo periodontal y la profundidad del surco gingival, puesto que todos estos parámetros se integran, y deben ser tenidos en cuenta para comprender de manera exacta la morfología del tejido gingival supracrestal. La variabilidad de dimensiones de los componentes epitelial y conectivo que existe entre individuos, e incluso dentro del mismo individuo, es otro factor que debe ser considerado. Una vez que se ha invadido la unión dentogingival, el tipo de manifestación clínica que se produce va a ser distinta según los casos, ya que no hay que olvidar que la respuesta está relacionada con la susceptibilidad del paciente frente a la enfermedad periodontal, además de otros factores que se enumerarán. Y cuando se ha invadido el espacio biológica con sintomatología, ¿qué se puede hacer? La parte final esbozará las opciones terapéuticas disponibles frente a estas situaciones (AU)

Biological width is known as the dentogingival unit formed by the junction of the epithelium and the connective tissue attachement. Biological width does not only refer to the length of the gingival insertion, but also to the gingival thickness, the type of periodontal tissues and the depth of the gingival sulcus, because all these components are part of a unit and should be considered as such. Another factor to be considered is the dimensional range of the epithelial and connective tissue components between individuals and in a given individual. Once the dentogingival unit is invaded, different clinical processes can take place regarding the host response to periodontal disease among other different factors that we will expose. In the event that the biological width has been invaded, and symptoms have appeared, what can be done? At the end and in a nutshell, the reader will find a brief introduction to the different treatment options available for these patients (AU)