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1.
Clin. transl. oncol. (Print) ; 26(2): 515-523, feb. 2024.
Artigo em Inglês | IBECS | ID: ibc-230195

RESUMO

Background Geriatric nutritional risk index (GNRI) on the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) remains unclear. The purpose of this meta-analysis was to discuss the value of the GNRI in evaluating long-term outcomes in DLBCL. Methods We systematically and roundly retrieved PubMed, Cochrane Library, Embase, Scopus and Web of Science electronic databases from inception of the databases to March 20, 2023. At the same time, we calculated the pool hazard ratios (HRs) with their 95% confidence interval (CI) for overall survival and progression-free survival to assess the effect of GNRI on the prognosis of DLBCL patients. Results In our primary meta-analysis, 7 trials with a total of 2448 patients were enrolled. Results showed that lower level of GNRI was related to poorer overall survival (HR = 1.78, 95% CI 1.27, 2.50, p < 0.01) and worse progression-free survival (HR = 2.31, 95% CI 1.71, 3.13, p < 0.01) in DLBCL patients. Conclusion The results of our meta-analysis indicate that a lower GNRI significantly associated with poorer prognosis for DLBCL. It is believed that GNRI was a promisingly predictive indicator of survival outcomes in DLBCL patients. However, large multicenter prospective studies are necessary to verify the results (AU)


Assuntos
Humanos , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Linfoma Difuso de Grandes Células B/imunologia , Estudos Prospectivos , Estudos Multicêntricos como Assunto , Estado Nutricional , Prognóstico
2.
Clín. investig. ginecol. obstet. (Ed. impr.) ; 50(4): [100886], Oct-Dic, 2023. ilus
Artigo em Espanhol | IBECS | ID: ibc-226529

RESUMO

Introducción: La afectación primaria del tracto genital femenino por linfoma no Hodgkin es muy poco frecuente, por lo que no existe un consenso sobre el tratamiento, y por ello presentamos este caso clínico y el tratamiento realizado, así como el pronóstico de nuestra paciente. Hallazgos clínicos: La paciente presentada es una mujer de 72años que consulta por hemorragia vaginal. Diagnóstico Se diagnostica de linfoma no Hodgkin extranodal primario de cérvix de inmunofenotipoB de alto grado citológico y elevado índice proliferativo. Intervenciones terapéuticas y resultados: El tratamiento de elección fue únicamente quimioterápico. Esta paciente ha presentado una supervivencia libre de enfermedad de 5años. Actualmente se encuentra en seguimiento mediante la realización de controles analíticos anuales. Conclusión: Los síntomas de este tipo de tumor son altamente inespecíficos y la citología es frecuentemente negativa, por lo que es necesario recurrir a la biopsia. La inmunohistoquímica resulta fundamental tanto para el diagnóstico como para el pronóstico. Existen múltiples técnicas de imagen empleadas tanto para estudio de extensión como para seguimiento, destacando el papel del FDG-PET. Actualmente parece que el tratamiento más recomendable es la pauta quimioterápica R-CHOP seguida de radioterapia. El pronóstico en general es bueno, con hasta un 80% de supervivencia a los 5años.(AU)


Introduction: Primary involvement of the female genital tract by non-Hodgkin lymphoma is very rare, so there is no consensus on treatment, and for this reason we present this clinical case and the treatment performed, as well as the prognosis of our patient. Clinical findings: The patient presented is a 72-year-old woman who consulted for vaginal bleeding. Diagnosis: Primary extranodal non-Hodgkin lymphoma of the cervix with immunophenotypeB of high cytological grade and high proliferative index was diagnosed. Therapeutic interventions and results: The treatment of choice was chemotherapy only. This patient has presented a disease-free survival of 5years. It is currently being monitored by carrying out annual analytical controls. Conclusion: The symptoms of this type of tumor are highly non-specific, as well as cytology is frequently negative, which is why it is necessary to resort to biopsy. Immunohistochemistry is essential for both diagnosis and prognosis. There are multiple imaging techniques used for both extension study and follow-up, highlighting the role of FDG-PET. It currently seems that the most recommendable treatment is the R-CHOP chemotherapy regimen followed by radiotherapy.The prognosis is generally good, with up to 80% survival at 5years.(AU)


Assuntos
Humanos , Feminino , Idoso , Linfoma Difuso de Grandes Células B , Genitália Feminina , Linfoma não Hodgkin/tratamento farmacológico , Neoplasias do Colo do Útero , Doenças dos Genitais Femininos , Ginecologia , Pacientes Internados , Exame Físico , Avaliação de Sintomas , Linfoma
3.
Clin. transl. oncol. (Print) ; 25(10): 2884-2891, oct. 2023. ilus
Artigo em Inglês | IBECS | ID: ibc-225069

RESUMO

Objectives Plasmablastic lymphoma (PBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) often associated with Epstein–Barr virus (EBV) infection. Despite recent advances in treatment, PBL still has a poor prognosis. EBV is listed as one of the human tumor viruses that may cause cancer, and is closely related to the occurrence of some nasopharyngeal carcinoma (NPC), lymphoma and 10% of gastric cancer (GC). It is very important to explore the differentially expressed genes (DEGs) between EBV-positive and EBV-negative PBL. Through bioinformatics analysis of DEGs between EBV-positive PBL and EBV-negative PBL, we gain a deeper understanding of the pathogenesis of EBV-positive PBL. Methods We selected the GSE102203 data set, and screened the DEGs between EBV-positive PBL and EBV-negative PBL. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were applied. The protein–protein interaction (PPI) network was constructed, and screened for the hub genes. Finally, Gene Set Enrichment Analysis (GSEA) was performed. Results In EBV-positive PBL, the immune-related pathway is upregulated and Cluster of differentiation 27 (CD27) and programmed cell death-ligand 1 (PD-L1) are hub genes. Conclusions In EBV-positive PBL, EBV may affect tumorigenesis through activation of immune-related pathways and upregulation of CD27, PD-L1. Immune checkpoint blockers of CD70/CD27 and programmed cell death 1 (PD-1)/PD-L1 pathways may be one of the effective strategies for the treatment of EBV-positive PBL (AU)


Assuntos
Humanos , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/genética , Linfoma Difuso de Grandes Células B/genética , Linfoma Plasmablástico/virologia , Linfoma Plasmablástico/genética , Antígeno B7-H1/metabolismo , Herpesvirus Humano 4/genética
4.
Clín. investig. ginecol. obstet. (Ed. impr.) ; 50(3): [100857], Jul-Sep. 2023. ilus
Artigo em Espanhol | IBECS | ID: ibc-223310

RESUMO

Introducción: El linfoma maligno primario de cuello uterino es una enfermedad muy rara, que representa solo el 0,008% de todos los tumores de cérvix y el 2% de todos los linfomas extraganglionares femeninos.Principales síntomas o hallazgos clínicos: Se presenta el caso de una mujer de 66 años, de los Andes peruanos, con tiempo de enfermedad de 4 meses caracterizado por ginecorragia, con evidencia de cérvix tumoral de 5cm. Se realizó inmunohistoquímica a la biopsia de cérvix para diferencia linfoma del carcinoma epidermoide.Diagnóstico principal: Linfoma difuso de células B grandes primario de cuello uterino con estadificación Ann Arbor IE IPI de bajo riesgo.Intervenciones terapéuticas y resultados: Fue manejada con inmunoquimioterapia (rituximab, ciclofosfamida, adriamicina, vincristina y prednisona), seguida de radioterapia externa consolidativa a dosis de 3.000 cGy en 15 sesiones con técnica especial IMRT. El control de la enfermedad resultó satisfactorio y no presentó complicaciones por la irradiación.Conclusión: El linfoma difuso de células B grandes primario de cuello uterino es muy raro, por lo que, en un caso de lesión primaria del estroma del cérvix, debe tenerse en cuenta la sospecha de linfoma.(AU)


Introduction: Primary malignant cervical lymphoma is a very rare disease, which represents only 0.008% of all cervical tumors and 2% of all female extranodal lymphomas. Main symptoms and/or clinical findings: The case of a 66-year-old woman from the Peruvian Andes is presented, with a disease period of 4 months characterized by gynaecorrhagia, with evidence of a 5cm tumor cervix. Immunohistochemistry was performed on the biopsy of cervix to differentiate lymphoma from squamous cell carcinoma. Primary diagnosis: Primary diffuse large B-cell lymphoma of the cervix with Ann Arbor IE IPI low-risk staging. Therapeutic interventions and results: She being managed with immunochemotherapy (rituximab, cyclophosphamide, adriamycin, vincristine and prednisone), followed by consolidative external radiotherapy at a dose of 3,000cGy in 15 sessions with a special IMRT technique. Resulting in satisfactory disease control and no complications from irradiation.Conclusion: Primary diffuse large B-cell lymphoma of the cervix is very rare, therefore, in a case of primary stromal lesion of the cervix, suspicion of lymphoma should be taken into account.(AU)


Assuntos
Humanos , Feminino , Idoso , Colo do Útero , Linfoma Difuso de Grandes Células B , Radioterapia , Imunoterapia , Ginecologia , Resultado do Tratamento , Pacientes Internados , Exame Físico , Avaliação de Sintomas , Peru , Doenças Uterinas , Neoplasias do Colo do Útero
5.
Clin. transl. oncol. (Print) ; 25(9): 2749-2758, sept. 2023. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-224138

RESUMO

Diffuse large B-cell lymphoma is the most frequent histological subtype of NHL and the paradigm for the management of aggressive lymphoma. An excisional or incisional lymph node biopsy evaluated by an experienced hemopathologist is recommended to establish the diagnosis. Twenty years following its introduction, R-CHOP remains the standard first-line treatment. No modification of this scheme (increased chemotherapy dose intensity, new monoclonal antibodies, or the addition of immunomodulators or anti-target agents) has significatively improved the clinical outcomes, whereas therapy for recurrence or progression is evolving rapidly. The irruption of CART cells, polatuzumab vedotin, tafasitamab, and CD20/CD3 bispecific antibodies are changing the natural history of relapsed patients and will challenge R-CHOP as the benchmark for newly diagnosed patients (AU)


Assuntos
Humanos , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma Difuso de Grandes Células B/terapia , Sociedades Médicas , Espanha
7.
Clin. transl. oncol. (Print) ; 25(8): 2438-2450, aug. 2023. ilus
Artigo em Inglês | IBECS | ID: ibc-222421

RESUMO

Background The tumor microenvironment plays a crucial role in the oncogenesis and treatment of diffuse large B-cell lymphoma (DLBCL). The H3K9me3-specific histone methyltransferase Suppressor of variegation 3-9 homolog 1 (SUV39H1) is a significant gene that promotes the progression of various malignancies. However, the specific expression of SUV39H1 in DLBCL remains unclear. Methods By retrieving data from GEPIA, UCSC XENA and TCGA public databases, we observed the high expression of SUV39H1 in DLBCL. Combined with an immunohistochemical validation assay, we analyzed our hospital’s clinical characteristics and prognosis of 67 DLBCL patients. The results showed that high SUV39H1 expression was closely associated with age over 50 years (P = 0.014) and low albumin levels (P = 0.023) of patients. Furthermore, the experiments in vitro were deployed to evaluate the regulation of SUV39H1 on the DLBCL immune microenvironment. Results The results showed that high SUV39H1 expression was closely associated with age over 50 years (P = 0.014) and low albumin levels (P = 0.023) of patients. The prognostic analysis showed that the high SUV39H1 expression group had a lower disease-free survival (DFS) rate than the low SUV39H1 expression group (P < 0.05). We further discovered that SUV39H1 upregulated the expression of CD86+ and CD163+ tumor-associated macrophages by DLBCL patients’ tissues and cell experiments in vitro (P < 0.05). And SUV39H1-associated T lymphocyte subsets and cytokines IL-6/CCL-2 were downregulated in DLBCL (P < 0.05). Conclusions In summary, SUV39H1 might be not only a potential target for treating DLBCL but also a clinical indicator for doctors to evaluate the trend of disease development (AU)


Assuntos
Humanos , Pessoa de Meia-Idade , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Linfoma Difuso de Grandes Células B/imunologia , Biomarcadores Tumorais , Microambiente Tumoral , Albuminas/uso terapêutico , Citocinas/metabolismo , Metiltransferases/metabolismo , Proteínas Repressoras/metabolismo , Linfócitos T/metabolismo , Linfócitos T/patologia , Prognóstico
8.
Psicooncología (Pozuelo de Alarcón) ; 20(1): 175-183, 11 abr. 2023. tab
Artigo em Espanhol | IBECS | ID: ibc-219025

RESUMO

Objetivo: Caso de un menor no acompañado que tras su llegada a España, le es diagnosticado un linfoma y como es necesaria una intervención a nivel psicosocial, para garantizar primero la cobertura de necesidades básicas para después abordar toda la sintomatología psicológica propia de su situación. Método: Una intervención por parte del área de Trabajo Social y Psicooncología para el manejo de toda la problemática asociada a la situación de migrante y adaptación al proceso oncológico. Resultado: Se inicia la cobertura de necesidades básicas (alojamiento y alimentación) y garantizar el acceso a los servicios sociosanitarios, para luego proceder a intervenir a nivel psicológico. Se consigue la reducción de la sintomatología ansiosa, gestionando la ideación suicida y la reducción de pensamientos negativos y depresivos, mejorando la gestión emocional y potenciando el autocontrol, así como una mejor adaptación a la situación de enfermedad. Conclusión: El abordaje psicosocial se convierte en una herramienta indispensable para la intervención en personas que se encuentras en una situación de extrema vulnerabilidad social, que son diagnosticadas de enfermedad oncológica (AU)


Objective: Case of an unaccompanied minor who, after his arrival in Spain, is diagnosed with lymphoma and how an intervention at a psychosocial level is necessary, to first ensure the coverage of basic needs and then address all the psychological symptoms of his situation. Method: An intervention by the area of Social Work and Psycho-Oncology for the management of all the problems associated with the migrant situation and adaptation to the oncological process. Results: At the begginning basic needs (accommodation and food) were coveres and it was ensured access to social and health services, and then psychological intervention started. There is a reduction of anxious symptomatology, managing suicidal ideation and the reduction of negative and depressive thoughts, improving emotional management and enhancing self-control, as well as a better adaptation to the disease situation. Conclusion: The psychosocial approach becomes an indispensable tool for the intervention in people who are in a situation of extreme social vulnerability, who are diagnosed with oncological disease (AU)


Assuntos
Humanos , Masculino , Adulto Jovem , Sistemas de Apoio Psicossocial , Linfoma Difuso de Grandes Células B/psicologia , Linfoma Difuso de Grandes Células B/terapia , Psico-Oncologia
13.
Neurocirugía (Soc. Luso-Esp. Neurocir.) ; 33(4): 204-208, jul. - ago. 2022. ilus
Artigo em Espanhol | IBECS | ID: ibc-204456

RESUMO

Introducción: Los quistes epidermoides (QE) son lesiones de lento crecimiento y naturaleza benigna. Se presenta un caso de un desarrollo de un linfoma cerebral (LC) con relación a un tumor epidermoide, segundo caso descrito en la literatura. Presentación del caso: Mujer de 40 años con QE intracraneal de larga evolución que desarrolla una lesión intraaxial rápidamente progresiva de acuerdo con dicho tumor. Tras la resección el diagnóstico es de linfoma primario difuso de células B. Discusión: La transformación de QE a carcinomas de células escamosas ha sido reportado en contadas ocasiones, siendo el desarrollo de otras lesiones malignas conforme este proceso, absolutamente excepcional. Se han invocado mecanismos inflamatorios como la causa de dicha transformación. En la génesis de los linfomas están involucrados estos mecanismos y en el caso que nos ocupa, podría haber jugado un papel en el desarrollo del tumor. Conclusiones: Aún siendo lesiones benignas, los QE tienen cierto potencial de malignización secundario a mecanismos de inflamación crónica (AU)


Introduction: Epidermoid cysts (EC) are benign and slow growing lesions. A primary brain lymphoma development related to a EC is presented, second case described in literature. Case presentation: A woman 40 years old, harbouring a EC for more than 20 years, develops a fast growing brain lesion next to the EC. Surgery was performed and diagnosis was primary diffuse B cells lymphoma. Discussion: Malignant transformation of EC has been described, usually to squamous cells carcinoma, and much less frequently, to another tumours. Inflammatory mechanisms have been advocated to explain this evolution. Chronic inflammation and lymphoma genesis are related, and this could be the mechanism behind this rare evolution of an EC. Conclusions: Even being benign lesions, EC can develop malignant tumours due to the chronic inflammation secondary to them (AU)


Assuntos
Humanos , Feminino , Adulto , Linfoma Difuso de Grandes Células B/patologia , Linfoma Difuso de Grandes Células B/cirurgia , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/cirurgia , Cisto Epidérmico/patologia , Imageamento por Ressonância Magnética , Cisto Epidérmico/diagnóstico por imagem , Craniotomia
14.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 41(4): 215-222, jul. - ago. 2022. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-205183

RESUMO

Introducción y objetivos: El volumen metabólico tumoral (VMT) y la glicólisis total de la lesión (TLG) son predictores pronósticos en los pacientes con linfoma B difuso de células grandes (LBDCG). El objetivo del presente estudio es evaluar el impacto pronóstico de los parámetros volumétricos basales calculados con la tomografía por emisión de positrones/tomografía computarizada con 18F-fluorodesoxiglucosa (18F-FDG PET/TC) y su valor agregado a las características moleculares en pacientes con LBDCG tipo no especificado (NOS). Metodología: Se trata de un estudio retrospectivo observacional, en el que se incluyeron 35 pacientes sometidos a un 18F-FDG PET/TC basal previo al tratamiento. Se realizó un análisis univariable de los parámetros volumétricos (VMT y TLG), estudio inmunohistoquímico y traslocaciones cromosómicas. El método para el cálculo de los parámetros volumétricos fue el umbral SUV 2,5. La comparación entre los modelos predictivos se seleccionó en función del valor de criterio de información de Akaike (AIC), bayesiano (BIC) y C de Harrell, después de realizar un modelo de regresión de riesgos proporcionales de Cox. Además, se realizó un análisis univariable de los parámetros volumétricos, según los datos del estudio inmunohistoquímico utilizando la prueba de Wilcoxon-Mann-Whitney. Resultados: Al realizar un análisis univariable se evidenció que el VMT y la TLG son predictores de la supervivencia libre de progresión (SLP) y de la supervivencia global (SG), con una alta capacidad de discriminación. El añadir el VMT y la TLG al estudio inmunohistoquímico y a la traslocación cromosómica proporcionó un mejor valor pronóstico a la SLP y SG en los pacientes diagnosticados con LBDCG tipo NOS. Así mismo, se evidenció que los valores de los parámetros volumétricos eran menores en los pacientes que presentaron un fenotipo células B centro germinal (GCB) frente a los pacientes con fenotipo células B activadas (ABC) que presentaron valores mayores (AU)


Introduction and objectives: Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are prognostic predictors in patients with diffuse large B-cell lymphoma (DLBCL). The objective of this study is to evaluate the prognostic impact of the baseline volumetric parameters calculated with positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) and its added value to the molecular characteristics in patients with DLBCL not otherwise specified (NOS). Methodology: This is a retrospective observational study, which included 35 patients who underwent a baseline 18F-FDG PET/CT prior to treatment. A univariate analysis of the volumetric parameters (MTV and TLG), immunohistochemical study and chromosomal translocations were performed. The method for calculating the volumetric parameters was the SUV 2.5 threshold. The comparison between the predictive models was selected based on the information criterion value of Akaike (AIC), bayesian (BIC) and Harrell's C, after performing a Cox proportional hazards regression model. In addition, a univariate analysis of the volumetric parameters was performed according to the data of the immunohistochemical study using the Wilcoxon-Mann-Whitney test. Results: A univariate analysis revealed that VMT and TLG are predictors of progression-free survival (PFS) and overall survival (OS), with a high discrimination capacity. Adding VMT and TLG to the immunohistochemical study and chromosomal translocation provided a better prognostic value for PFS and OS in patients diagnosed with DLBCL-NOS. Likewise, it was evidenced that the values of the volumetric parameters were lower in patients who presented a germinal center B cell phenotype (GCB) compared to patients with an activated B cell phenotype (ABC) who presented higher values. Conclusion: MTV and TLG added to the immunohistochemical study and chromosomal translocation provided a better prognostic value for PFS and OS (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Fluordesoxiglucose F18 , Compostos Radiofarmacêuticos , Linfoma Difuso de Grandes Células B/diagnóstico por imagem , Estudos Retrospectivos , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Teorema de Bayes , Prognóstico , Translocação Genética , Imuno-Histoquímica
17.
Med. oral patol. oral cir. bucal (Internet) ; 27(2): e99-e105, mar. 2022. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-204475

RESUMO

Background: HIV-related non-Hodgkin lymphomas of the oral cavity are rare lesions with aggressive clinical behaviour. The aim of this study is to describe the clinicopathological features of a series of HIV-related oral non-Hodgkin lymphomas. Material and Methods: Eleven cases of oral lymphomas affecting HIV-positive patients were retrieved from 2012 to 2019. Clinicopathological features regarding age, sex, tumour location, clinical presentation, laboratory findings, disease stage and follow-up were obtained. Histologic, immunohistochemical and in situ hybridization for EBV detection were done for diagnosis confirmation. Overall survival was estimated by Kaplan–Meier curve. Results: Males predominated, with a mean age of 40.3 years-old. Maxilla and mandible were the mostly affected. Plasmablastic lymphoma and diffuse large B-cell lymphoma not otherwise specified (NOS) were the main histological types. Lesions presented as reddish ulcerated swellings, representing the first sign of AIDS in six cases. Stage IV were common (7 cases) and the mean HIV viral load was 10,557 copies/mL, with a mean of 266 CD4+ cells/mm3, 1,278 CD8+ cells/mm3 and a CD4+/CD8+ ratio of 0.26. Eight patients died of the disease (72.7%). Overall survival revealed that 78.2% of the patients died after 21 months of follow-up. Conclusions: HIV-related oral lymphomas present a poor prognosis usually diagnosed in advanced stages and in our series plasmablastic lymphoma was the most common subtype.(AU)


Assuntos
Humanos , Masculino , Adulto , Infecções por HIV/complicações , Hibridização In Situ , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma Difuso de Grandes Células B/patologia , Linfoma não Hodgkin/diagnóstico , Linfoma não Hodgkin/patologia , Adulto , HIV , Boca/patologia
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