Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 57
Filtrar
Mais filtros










Filtros aplicados
Base de dados
Intervalo de ano de publicação
1.
Rev. esp. enferm. dig ; 116(3): 165-166, 2024. ilus
Artigo em Inglês | IBECS | ID: ibc-231480

RESUMO

Indolent T-cell lymphoma is a rare disease. Here we presented a 53-year-old male patient initially diagnosed as ulcerative colitis in 2000 that finally developed into extensive indolent T-cell lymphoma in 2022. We also described the differences between indolent T-cell lymphoma and inflammatory bowel disease, and the possible disease progression into lymphoma after biological therapy. (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Linfoma de Células T/diagnóstico por imagem , Colite Ulcerativa/complicações , Transtornos Linfoproliferativos
2.
Rev. esp. enferm. dig ; 116(3): 175-176, 2024.
Artigo em Inglês | IBECS | ID: ibc-231490

RESUMO

A 48-year-old man with a diagnosis of ulcerative colitis 18 years ago, under immunosuppressive treatment with azathioprine in the last 6 years due to corticosteroid dependence, was admitted to the Emergency Department due to fever of one week’s evolution. Blood tests showed thrombocytopenia, CRP 96.9mg/L, ferritin 3021ng/mL and hypertriglyceridemia. Blood and urine cultures were negative. Viral serologies (hepatitis B and C, HIV, parvovirus, CMV, HSV), atypical bacteria (Borrelia, Chlamydia, Coxiella) and screening for latent tuberculosis were also negative. Thoracoabdominal CT scan only showed splenomegaly. The bone marrow aspirate revealed immature lymphoid cells and a hemophagocyte figure, fulfilling the criteria for hemophagocytic syndrome, starting corticosteroid therapy at a dose of 1mg/Kg. Subsequently, the existence of an intrasinusoidal CD3 + CD5- lymphoid infiltrate and a FISH study with isochromosome 7q was reported, a characteristic pattern of hepatosplenic T-cell lymphoma (HSTCL). The study was completed with liver biopsy appreciating a 70% infiltration of T lymphocytes (50% gamma-delta) therefore the diagnosis was confirmed. Chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide) was started with the aim of considering hematopoietic stem cell transplantation. Unfortunately, the patient died 6 months later. (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Linfoma de Células T/complicações , Linfoma de Células T/tratamento farmacológico , Doenças Inflamatórias Intestinais/diagnóstico , Hospedeiro Imunocomprometido
6.
Iberoam. j. med ; 4(4)nov. 2022. ilus
Artigo em Inglês | IBECS | ID: ibc-228565

RESUMO

Breast is an uncommon site of extra nodal lymphoma accounting for 2.2% of all extra nodal lymphomas. B cell lymphomas are more common than T cell types. The most common subtype is Diffuse Large B Cell Lymphoma. Breast lymphoma is very challenging to diagnose as it has nonspecific clinical and radiological features. We report a rare case of primary T cell lymphoma in a 20-year-old female. It was misdiagnosed as abscess on ultrasound and as suppurative mastitis on fine needle aspiration cytology (FNAC). However, excisional biopsy was suggestive of lymphoma and immunohistochemistry confirmed it as ALK positive, anaplastic large cell lymphoma. Even though FNAC is a part of the diagnostic triad for breast lesions, potential pitfalls cannot be overlooked and must be correlated with biopsy. (AU)


La mama es un sitio poco frecuente de linfoma extraganglionar que representa el 2,2 % de todos los linfomas extraganglionares. Los linfomas de células B son más comunes que los tipos de células T. El subtipo más común es el linfoma difuso de células B grandes. El linfoma de mama es muy difícil de diagnosticar, ya que tiene características clínicas y radiológicas inespecíficas. Presentamos un caso raro de linfoma primario de células T en una mujer de 20 años. Fue mal diagnosticado como absceso en ultrasonido y como mastitis supurativa en citología por aspiración con aguja fina (FNAC). Sin embargo, la biopsia por escisión sugirió linfoma y la inmunohistoquímica lo confirmó como linfoma anaplásico de células grandes ALK positivo. Aunque la FNAC es parte de la tríada diagnóstica de las lesiones mamarias, no se pueden pasar por alto los peligros potenciales y se deben correlacionar con la biopsia. (AU)


Assuntos
Humanos , Feminino , Adulto Jovem , Linfoma Anaplásico de Células Grandes/diagnóstico por imagem , Linfoma Anaplásico de Células Grandes/diagnóstico , Erros de Diagnóstico/efeitos adversos , Mastite/terapia , Biologia Celular , Linfoma não Hodgkin/diagnóstico , Linfoma de Células T/diagnóstico
9.
Clin. transl. oncol. (Print) ; 23(6): 1134-1141, jun. 2021. graf
Artigo em Inglês | IBECS | ID: ibc-221334

RESUMO

Purpose Our study aimed to explore the programmed death 1 (PD-1) expression on tumor-associated macrophage (TAM) in T cell non-Hodgkin lymphoma (T-NHL) and its relationship with lymphoma prognosis. The effect of PD-1 expression on the function of macrophages was also studied. Methods Multispectral image quantitative analysis was applied for detecting PD-1 expression on macrophages in T cell lymphoma tissues. The Kaplan–Meier analysis was performed to evaluate the value of PD-1 expression of TAM in predicting the overall survival of T-NHL. PD-1 overexpression THP-1-derived macrophage was constructed and was cocultured with Jurkat cells to explore the effect of PD-1 on macrophage function. Results In 17 T cell lymphoma cases, the 1-year overall survival rate was significantly lower in patients with higher PD-1 expression on TAMs (0.25 vs 0.86, p < 0.05). After co-cultured with Jurkat cells, classically activated (M1)-related markers on PD-1 overexpressed macrophages were significantly lower than those on controls, while the expressions of alternatively activated (M2) related markers were similar. The PD-1 overexpressed macrophages showed inhibited phagocytosis (4.42% vs 40.7%, p < 0.001) and increased IL-10 secretion (144.48 pg/ml vs 32.32 pg/ml, p < 0.001). Conclusion High PD-1 expression on TAMs in T-NHL may predict poor prognosis. The PD-1 overexpression of macrophages significantly inhibited polarization of M1 macrophages and phagocytosis, and more IL-10 was excreted. These changes may enhance the pro-tumor effects of tumor microenvironmen (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Linfoma de Células T/metabolismo , Receptor de Morte Celular Programada 1/biossíntese , Macrófagos/metabolismo , Macrófagos/patologia , Células Tumorais Cultivadas , Microambiente Tumoral , Prognóstico
10.
Galicia clin ; 82(1): 26-28, Enero-Febrero-Marzo 2021. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-221100

RESUMO

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an extremely rare form of skin lymphoma that primarily involves subcutaneous adipose tissue. SPTCL diagnosis is demanding because of its nonspecific systemic features, such as fever or weight loss, that usually mimic other more common conditions. Further complicating diagnosis, lesion biopsies are often inconclusive. For this matter, patients are frequently seen by different clinicians and may be submitted to various cutaneous biopsies before a definitive diagnosis is reached. We present the case of a 64-year-old man with a two-month history of fever and subcutaneous nodular lesions scattered by the lower limbs and torso, whose final diagnosis of SPTCL illustrates the main features of the disease as well as the challenge of its identification. (AU)


Assuntos
Humanos , Biópsia , Extremidade Inferior , Febre , Paniculite , Pele , Diagnóstico , Tronco , Linfoma de Células T , Redução de Peso , Gordura Subcutânea , Doença , Pacientes
15.
Rev. clín. med. fam ; 9(2): 110-113, jun. 2016. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-155705

RESUMO

Presentamos el caso de una mujer de 61 años con antecedentes de enfermedad celiaca desde los 21, que empieza desde hace doce meses con epigastralgias intermitentes postprandiales, alteraciones del hábito intestinal y pérdida de peso. Afirma el cumplimiento estricto de la dieta sin gluten y sin lactosa, comprobándose esto mediante la titulación de anticuerpos, que fueron negativos. Ante esta clínica se realiza una gastroscopia, donde se evidencia atrofia vellositaria y en la biopsia se objetiva una afectación de la mucosa grado Marsh III. Con estas pruebas se alcanza el diagnóstico de enfermedad celiaca refractaria (ECR). La ECR es una entidad rara que padece el 5-8 % de los enfermos celiacos diagnosticados en la edad adulta y que produce un aumento del riesgo de desarrollo de linfoma intestinal. Por tanto, es evidente la importancia de conocerlo y sospecharlo (AU)


We present the case of a 61-year-old woman with celiac disease since age 21, who starts 12 months ago with intermittent postprandial epigastralgia, altered bowel habit and weight loss. The patient affirms the strict observance of the gluten and lactose free diet, which is confirmed by negative antibody titration analysis. Due to these symptoms, a gastroscopy is performed in which an atrophy of the villous architecture is detected. A Marsh grade III mucosa damage is also found in the biopsy, being diagnosed of refractory celiac disease (RCD). RCD is a rare entity present in 5-8% of all celiac patients diagnosed in adulthood; it produces an increased risk of intestinal T-cell lymphoma, this is why it is important to know and suspect this disease (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Doença Celíaca/complicações , Doença Celíaca/dietoterapia , Doença Celíaca/diagnóstico , Dieta Livre de Glúten , Linfoma de Células T/complicações , Linfoma de Células T/diagnóstico , Anemia Macrocítica/complicações , Anemia Macrocítica/tratamento farmacológico , Doença Celíaca/fisiopatologia , Linfoma de Células T Associado a Enteropatia/complicações , Linfoma de Células T Associado a Enteropatia/epidemiologia , Budesonida/uso terapêutico , Sucralfato/uso terapêutico
17.
Clin. transl. oncol. (Print) ; 18(1): 73-81, ene. 2016. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-148054

RESUMO

Background. In India, Epithelial ovarian cancer has emerged as one of the most common malignancies affecting women. Tumor protein 53 (TP53) induces expression of the B cell lymphoma 2-associated X protein (BAX) gene by directly binding to the TP53-binding element in the BAX promoter. Therefore, we hypothesized that single-nucleotide polymorphism of BAX promoter −248G>A and TP53 72Arg>Pro gene may jointly contribute to ovarian cancer risk. Objectives. This study aimed at exploring the association of BAX promoter −248G>A and TP53 72Arg>Pro gene polymorphism with risk of developing EOC and its clinicopathological features and to evaluate gene-gene interaction of these two polymorphisms with risk of developing EOC. Materials. The study was conducted on 70 Epithelial ovarian cancer patients and 70 healthy controls. Genotyping of p53 codon 72 and BAX promoter gene was examined by ASO-PCR and PICA-PCR, respectively. Odds ratios and 95 % confidence intervals were calculated. Results. We found an increased cancer risk associated with the BAX AA (ORs = 4.1, 95 %, CI = 1.23-13.97) genotype. An increased risk was also associated with the TP53 Pro/Pro (OR = 4.4, 95 % CI = 1.40-13.99) and Arg/Pro genotype (OR = 2.3, 95 % CI = 1.13-4.86). The gene-gene interaction of these polymorphisms increased EOC risk in a more than additive manner (ORs for the presence of both BAX AA and TP53 Arg/Pro genotypes = 8.7, 95 % CI = 1.66-45.48). BAX GG genotype was associated with adverse staging of cancer (P = 0.01). Conclusions. The findings suggest that polymorphism of BAX and TP53 genes may be potential genetic modifiers for developing ovarian cancer (AU)


No disponible


Assuntos
Humanos , Feminino , Adulto , Neoplasias Ovarianas/metabolismo , Neoplasias Ovarianas/patologia , Linfoma de Células T/diagnóstico , Fumar/genética , Alcoolismo/metabolismo , Ginecologia , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/radioterapia , Linfoma de Células T/complicações , Manuais e Guias para a Gestão da Pesquisa , Fumar/prevenção & controle , Alcoolismo/complicações , Ginecologia/métodos , Literatura de Revisão como Assunto
20.
Acta otorrinolaringol. esp ; 64(3): 230-232, mayo-jun. 2013. ilus
Artigo em Espanhol | IBECS | ID: ibc-112689

RESUMO

El linfoma anaplásico de células grandes es una patología rara en la infancia. La localización más frecuente es en la piel y nódulos linfáticos, siendo infrecuente la afectación del pabellón auricular. Presentamos el caso de un niño de 6 años con tumoración en el lóbulo de la oreja. Se realizó tratamiento quirúrgico y el resultado de la anatomía patológica mostró linfoma anaplásico de células grandes. Los estudios radiológicos fueron negativos y no hubo afectación sistémica (AU)


Anaplastic large T-cell lymphoma is a very rare disease in childhood. The most common locations are lymph nodes and skin, while the external ear location is uncommon. We present the case of a 6-year-old child with an earlobe tumour. Surgical treatment was performed and the anatomopathological results showed anaplastic large cell lymphoma. Radiological tests were negative and there was no systemic involvement (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Linfoma de Células T/patologia , Linfoma Anaplásico de Células Grandes/patologia , Neoplasias da Orelha/patologia , Pavilhão Auricular/patologia , Neoplasias Cutâneas/patologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...