Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas

Purpose The purpose of the study was to evaluate the prognostic value of low T3 syndrome in peripheral T-cell lymphomas (PTCLs). Methods One hundred and seventy-four patients of newly diagnosed PTCLs were enrolled in the study. We performed statistical analysis based on the clinical data collected. Results Thirty-Six (20.69%) patients had low T3 syndrome at first admission. Results suggested that the patients with higher score of ECOG PS, International Prognostic Index (IPI) and Prognostic Index for T-cell lymphoma (PIT), bone marrow involvement and lower level of albumin tended to develop low T3 syndrome. The median progression-free survival (PFS) and overall survival (OS) were 10 months and 36 months, respectively, for all patients. Pre-existing low T3 syndrome was in correlation with worse PFS and OS. Patients with low T3 syndrome showed worse PFS (4 months vs 13 months, P = 0.0001) and OS (7 months vs 83 months, P < 0.0001) than patients without low T3 syndrome. IPI and PIT, respectively, combined with low T3 syndrome improved the ability to predict OS and PFS of PTCLs. Conclusions The study indicated that low T3 syndrome may be a good candidate for predicting prognosis of peripheral T-cell lymphomas (AU)

Long-time follow-up of patients with untreated peripheral T cell lymphoma following chidamide combined with cyclophosphamide, epirubicin, vindesine, prednisone, and etoposide therapy: a single-center propensity score-matching study

Purpose This is a retrospective, single-center PSM study evaluating the efficacy and safety of chidamide combined with the CHOEP (C-CHOEP) regimen versus the single CHOEP regimen in patients with untreated peripheral T cell lymphomas (PTCL). Patients Patients newly diagnosed with PTCL between January 2015 and June 2021 were recruited, and were 1:1 divided into C-CHOEP and CHOEP groups according to their first-line chemotherapy regimens. The PSM method was used to match the baseline variables to balance the confounding factors. Results A cohort of 33 patients each in the C-CHOEP and CHOEP groups was generated after propensity score-matching (PSM). The complete remission (CR) rates of the C-CHOEP regimen were higher than that of the CHOEP regimen (56.3 vs. 25.8%, p = 0.014), whereas the duration of response of the C-CHOEP group was shorter (median DOR 30 vs. 57 months), resulting in roughly similar progression-free survival (PFS) and (overall survival) OS between the two groups. The responding patients who received chidamide maintenance therapy showed a trend of superior PFS and OS compared with patients who did not receive maintenance therapy. Conclusions The C-CHOEP regimen was well tolerated but failed to show advantages over the CHOEP regimen in patients with untreated PTCL; however, the chidamide maintenance may contribute to a more durable response and stable long-term survival (AU)

Mujer de 82 años con dolor abdominal, fiebre y lesiones cutáneas de larga evolución / Eighty-two year old female with long term abdominal pain, fever and skin lesions

Presentamos el caso de una mujer mayor, que consulta por cuadro de fiebre, dolor abdominal y síndrome constitucional de un año de evolución. El diagnóstico diferencial se realiza entre patología infecciosa, tumoral, o inflamatoria, que pudieran localizarse a nivel abdominal, realizándose exploraciones complementarias que descartaron proceso abdominal. La existencia de dolor en las piernas y la exploración a nivel de muslo izquierdo de una masa de consistencia dura, nos hace plantear otro diagnóstico. Finalmente se demuestran en la ecografía de partes blandas cambios inflamatorios en relación con paniculitis. A partir de este hallazgo se revisan las etiologías de la paniculitis. Se realiza la biopsia cutánea que nos demuestra el diagnóstico final (AU)

We report the case of an old woman, consulting for fever, abdominal pain and constitutional symptoms one year of evolution. The differential diagnosis is between infectious, tumoral, or inflammatory disease, which may be located at the abdominal level, performing additional tests to rule out abdominal process. The existence of pain in the legs and level scan left thigh of a mass of hard consistency, makes us raise another diagnosis. Finally show on ultrasound soft tissue inflammatory changes regarding panniculitis. From this finding aetiologies of panniculitis are reviewed. Skin biopsy that shows the final diagnosis is made (AU)

Linfoma T angioinmunoblástico: caso clínico y revisión de la literatura / Angioimmunoblastic T-cell lymphoma: a case report and review of the literature

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Infección diseminada por citomegalovirus en una paciente diagnosticada de linfoma T periférico (variante Lennert) / Disseminated cytomegalovirus infection in a patient with peripheral T cell unspecified (variant-Lennert) non-Hodgking lymphoma

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Hemorragia laríngea: una manifestación del linfoma T primario de laringe / Laryngeal blooding: a laryngeal T-cell primary lymphoma manifestation

Los linfomas primarios a nivel laríngeo son una manifestación poco frecuente de linfoma. La mayoría corresponden a la estirpe celular B y sólo un 11 por ciento aproximadamente se diagnostican como linfomas T. El origen más común de estas neoplasias a nivel de cabeza y cuello es el anillo linfático de Waldeyer. Presentamos un caso clínico de linfoma T primario de laringe cuyo síntoma clínico principal fue una hemorragia súbita que precisó taponamiento laríngeo. Se discuten aspectos relacionados con el diagnóstico y tratamiento (AU)

Bultoma en hipocondrio y vacío izquierdos tras traumatismo casual en parrilla costal izquierda / Left hypochondrium mass after left rib cage accidental injury

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Hepatitis fulminante como forma de presentación de un linfoma T periférico / Fulminant hepatic failure as form of presentation o a peripheral T cell lymphoma

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Hipertrofia cardíaca en paciente con trasplante renal en tratamiento con tacrolimus / Cardiac hypertrophy in kidney transplanted female patient treated with tacrolimus

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Mujer de 87 años con mal estado general, fiebre, hepatomegalia y hemofagocitosis / Eighty-seven-year-old woman with malaise, fever, hepatomegaly and hemophagocyctosis

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