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1.
Clin. transl. oncol. (Print) ; 26(2): 414-423, feb. 2024.
Artigo em Inglês | IBECS | ID: ibc-230186

RESUMO

Background Cholangiocarcinoma (CCA) is a heterogeneous malignancy. The aim of the study was to investigate the regulatory role of long noncoding RNA LINC00844 in CCA progression, explore the underlying molecular mechanisms, and to analyze the potential prognostic value of LINC00844 in CCA patients. Methods Expression of LINC00844 in CCA cell lines and tissues was examined by reverse transcription-quantitative PCR. Cell counting kit-8 assay was used to assess CCA cell proliferation, and the Transwell assay was used to evaluate tumor cell migration and invasion. miRNAs sponged by LINC00844 were predicted and confirmed using a luciferase reporter assay. Kaplan–Meier survival analysis was performed to evaluate the survival prognosis of CCA patients. Results The expression levels of LINC00844 were decreased in CCA tissues and cells. Overexpression of LINC00844 inhibited cell proliferation, migration and invasion in CCA cells. miR-19a-5p is directly targeted by LINC00844, mediating the inhibitory effects of LINC00844 on the proliferation, migration and invasion of CCA cells. LINC00844 and miR-19a-5p expression were associated with differentiation and tumor node metastasis stage in CCA patients. CCA patients with low LINC00844 expression or overexpression of miR-19a-5p had worse overall survival. Conclusion The expression levels of LINC00844 were decreased in both CCA tissues and cells, and high LINC00844 inhibited CCA cell proliferation, migration and invasion through sponging miR-19a-5p. Low LINC00844 and high miR-19a-5p expression were associated with worse overall survival in CCA patients. All the data suggested that the LINC00844/miR-19a-5p axis may provide novel therapeutic targets and prognostic biomarkers for CCA patients (AU)


Assuntos
Humanos , Neoplasias dos Ductos Biliares/patologia , Colangiocarcinoma/patologia , MicroRNAs/genética , MicroRNAs/metabolismo , RNA Longo não Codificante/genética , RNA Longo não Codificante/metabolismo , Ductos Biliares Intra-Hepáticos/metabolismo , Ductos Biliares Intra-Hepáticos/patologia , Linhagem Celular Tumoral , Movimento Celular/genética , Proliferação de Células/genética
3.
Rev. esp. enferm. dig ; 115(12): 729-731, Dic. 2023. ilus, graf
Artigo em Inglês | IBECS | ID: ibc-228720

RESUMO

A 74-year-old female was admitted for painless jaundice. Laboratory tests showed hyperbilirubinemia, cholestasis, normal coagulation, and Ca19-9:163U/L. The CT-scan reported dilation of the intrahepatic and extrahepatic bile ducts secondary to a 24mm tumor in the intrapancreatic common bile duct. The magnetic cholangioresonance showed multiple endoluminal polypoid lesions, suggestive of intraductal papillary neoplasm of the bile duct (IPNB). The endoscopic bile duct brushing was non-conclusive.(AU)


Assuntos
Humanos , Feminino , Idoso , Ducto Colédoco/cirurgia , Síndromes Paraneoplásicas , Colangiocarcinoma/cirurgia , Hemofilia A , Neoplasias dos Ductos Biliares/diagnóstico por imagem , Tumor de Klatskin , Pacientes Internados , Exame Físico , Doenças do Sistema Digestório , Gastroenteropatias , Neoplasias dos Ductos Biliares/complicações , Neoplasias dos Ductos Biliares/patologia
4.
Clin. transl. oncol. (Print) ; 25(3): 731-738, mar. 2023.
Artigo em Inglês | IBECS | ID: ibc-216431

RESUMO

Purpose As a non-invasive treatment, stereotactic body radiation therapy (SBRT) has been an emerging and effective option for patients with unresectable intrahepatic cholangiocarcinoma (ICC). The Cyber Knife has an SBRT system, which can realize real-time tracking of tumors during treatment. It can protect the surrounding normal liver tissue while the tumor gets the therapeutic dose. The purpose of this study was to evaluate the factors affecting the local control rate for patients after SBRT treatment, and to predict the factors affecting survival rates, then to report the 3-year actual survival rates after treatment and identify the influencing factors of 3-year survival rate. Materials and Methods We conducted a long-term follow-up of 43 patients with unresectable intrahepatic cholangiocarcinoma who underwent Cyber Knife in our hospital from January 2016 to December 2018. Regular medical check-ups were performed every 2–3 months after SBRT to evaluated the effect of treatment. Results The median follow-up time was 15 months (4-78 months), and the median progression-free survival (PFS) was 6 months (95% CI, 2.788–9.212) and the median overall survival (OS) was 12 months (95% CI, 3.434–20.566), respectively. Based on modified Response Evaluation and Criteria in Solid Tumor (mRECIST), response rate (RR) and disease control rate (DCR) of SBRT in unresectable ICC were 55.2% and 86%. The 1-, 2- and 3-years OS rate were 51.2%, 32.6% and 23.3%. Multivariate analysis based on competing risk survival analysis identified that patients with multiple nodules, large diameter, high level of CA199 and CEA, poor ECOG performance status had worse overall survival (p < 0.05). Patients who survived ≥3 years had significantly lower levels of CEA, CA199, smaller tumor diameters and lower number of lesions (p < 0.05) (AU)


Assuntos
Humanos , Radiocirurgia/métodos , Colangiocarcinoma/radioterapia , Colangiocarcinoma/cirurgia , Neoplasias dos Ductos Biliares/radioterapia , Neoplasias dos Ductos Biliares/cirurgia , Ductos Biliares Intra-Hepáticos , Resultado do Tratamento , Estudos Retrospectivos
8.
Clin. transl. oncol. (Print) ; 24(11): 2107-2119, noviembre 2022. ilus
Artigo em Inglês | IBECS | ID: ibc-210139

RESUMO

Pancreatic cancer and biliary tract cancer have a poor prognosis. In recent years, the development of new diagnostic techniques has enabled the identification of the main genetic alterations involved in the development of these tumours. Multiple studies have assessed the ability of certain biomarkers, such as BRCA in pancreatic cancer, IDH1 or FGFR2 in biliary tract cancer and microsatellite instability or NTRK fusions in an agnostic tumour fashion, to predict response to treatment.In this consensus, a group of experts selected by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviewed the role played by these mutations in the process of carcinogenesis and their clinical implications. As a result, this article proposes a series of recommendations to optimize the determination of these biomarkers to help standardize the diagnosis and treatment of these tumours. (AU)


Assuntos
Humanos , Neoplasias dos Ductos Biliares/diagnóstico , Neoplasias dos Ductos Biliares/genética , Biomarcadores Tumorais , Oncologia , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/genética , Consenso
11.
Rev. esp. enferm. dig ; 114(4): 219-225, abril 2022. tab, graf
Artigo em Inglês | IBECS | ID: ibc-205600

RESUMO

Introduction: despite advances in imaging diagnosticmodalities, hepatocellular carcinoma is sometimes incidentally diagnosed on histological examination of the liver explant. The objectives of the study were: a) to compare the characteristics between incidental and known hepatocellular carcinoma; and b) to estimate survival and tumor recurrence after liver transplantation.Material and methods: a retrospective, single-center study was performed. The inclusion criteria were: a) cirrhotic patients, age ≥ 18 years; b) liver transplantation between 1998 and 2018; and c) hepatocellular carcinoma diagnosed via histopathologic examination of the explanted liver. Cholangiocarcinoma and patients with early retransplantation were excluded. Multivariate analysis was performed using binomial logistic regression to assess the factors associated with incidental hepatocellular carcinoma. Kaplan-Meier curves were plotted to explore the impact on overall survival and recurrence free survival.Results: two hundred and sixty-nine patients were enrolled. The prevalence of incidental hepatocellular carcinoma was 4.18 % (95 % CI: 2.89-6.01 %) of all liver transplants performed in cirrhotic patients. The median diameter of the main nodule was smaller in incidental hepatocellular carcinoma (20 vs 27 mm, p = 0.004), although they were more likely to be beyond the Up-to-Seven criteria on explant examination (22.2 % vs 7.5 %, p = 0.001), with no differences in any other histological features. No differences were found in overall survival rates (incidental 70.2 % vs 70.4 %, p = 0.87) or recurrence-free survival (incidental 100 % vs 83.8 %, p = 0.07) at five years. Conclusion: incidental hepatocellular carcinoma are smaller in size and are more frequently found to be beyond the Up-to-Seven criteria. However, no differences were found in overall survival rates or recurrence-free survival, although there was no tumor recurrence in the incidental hepatocellular carcinoma group. (AU)


Assuntos
Humanos , Neoplasias dos Ductos Biliares/patologia , Ductos Biliares Intra-Hepáticos/patologia , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/epidemiologia , Carcinoma Hepatocelular/cirurgia , Cirrose Hepática/patologia , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/cirurgia , Resultado do Tratamento , Estimativa de Kaplan-Meier , Transplante de Fígado , Estudos Retrospectivos
13.
Clin. transl. oncol. (Print) ; 23(5): 988-1000, mayo 2021. ilus
Artigo em Inglês | IBECS | ID: ibc-221239

RESUMO

Pancreatic cancer (PC) and biliary tract cancer (BTC) are both aggressive and highly fatal malignancies. Nowadays we have a profound knowledge about the molecular landscape of these neoplasms and this has allowed new therapeutic options. Surgery is the only potentially curative therapy in both cancers, but disease recurrence is frequent. In PC, adjuvant treatment with mFOLFIRINOX has improved overall survival (OS) and in BTC adjuvant treatment with capecitabine seems to improve OS and relapse-free survival. Concomitant radio-chemotherapy could also be considered following R1 surgery in both neoplasms. Neoadjuvant treatment represents the best option for achieving an R0 resection in borderline PC. Upfront systemic chemotherapy is the treatment of choice in unresectable locally advanced PC and BTC; then locoregional therapy could be considered after an initial period of at least 3–4 months of systemic chemotherapy. In metastatic PC, FOLFIRINOX or Gemcitabine plus nab-paclitaxel have improved OS compared with gemcitabine alone. In metastatic BTC, cisplatin plus gemcitabine constitute the standard treatment. Progress in the knowledge of molecular biology has enabled the identification of new targets for therapy with encouraging results that could in the future improve the survival and quality of life of patients with PC and BTC (AU)


Assuntos
Humanos , Neoplasias dos Ductos Biliares/diagnóstico , Neoplasias dos Ductos Biliares/terapia , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/terapia , Estadiamento de Neoplasias , Sociedades Médicas , Espanha
15.
Rev. esp. enferm. dig ; 113(1): 45-47, ene. 2021. ilus
Artigo em Espanhol | IBECS | ID: ibc-199888

RESUMO

Presentamos el caso de un varón de 76 años con antecedente de colecistitis aguda intervenido mediante colecistectomía laparoscópica. Intraoperatoriamente, se evidenció una colecistitis crónica con conducto cístico engrosado. La anatomía patológica informó de displasia de alto grado que afectaba al borde distal del cístico. Ante los hallazgos, se practicó colangiopancreatografía retrógrada endoscópica (CPRE) con SpyGlass(R) con la cual se observó, adyacente a la unión del cístico-colédoco, lesión excrecente sugestiva de malignidad. Se decidió nueva intervención quirúrgica y se realizó una resección de vía biliar extrahepática con linfadenectomía del hilio hepático y hepaticoyeyunostomía. El informe anatomopatológico definitivo informó de neoplasia mucinosa papilar intraductal pancreatobiliar con displasia de alto grado con márgenes libres


No disponible


Assuntos
Humanos , Masculino , Idoso , Neoplasias dos Ductos Biliares/cirurgia , Carcinoma Ductal/cirurgia , Neoplasias Císticas, Mucinosas e Serosas/cirurgia , Colangiopancreatografia Retrógrada Endoscópica/instrumentação , Endoscopia do Sistema Digestório/instrumentação , Valor Preditivo dos Testes , Neoplasias dos Ductos Biliares/patologia , Pancreatopatias/patologia , Ducto Colédoco/patologia
16.
Rev. esp. investig. quir ; 24(1): 19-20, 2021. ilus
Artigo em Espanhol | IBECS | ID: ibc-219087

RESUMO

La microhamartomatosis biliar múltiple o enfermedad deVon Meyenburg es una malformación benigna que puede simular enfermedad metastásica hepática, fundamentalmente en pacientes oncológicos. Se presenta el caso clínico de un paciente con neoplasia colónica y hallazgos intraoperatorios de lesiones hepáticas compatibles macroscópicamente con metástasis que demostraron corresponder a esta entidad en el informe patológico. (AU)


Multiple bile-duct microhamartomas (Von Meyenburg disease) is a benign malformation that simulates metastatic liver disease,mainly in case of oncologic patients. We present a case of a patient with colon neoplasia and liver intraoperative findings compatiblewith metastases that finally corresponded to this entity in the pathological report. (AU)


Assuntos
Humanos , Síndrome do Hamartoma Múltiplo , Metástase Neoplásica , Doenças dos Ductos Biliares , Neoplasias dos Ductos Biliares
17.
Rev. esp. enferm. dig ; 112(12): 921-924, dic. 2020. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-200580

RESUMO

INTRODUCCIÓN: se ha observado que la ablación endoscópica por radiofrecuencia en tumores irresecables de vía biliar prolonga la sobrevida. OBJETIVO: evaluar sobrevida, permeabilidad de prótesis y efectos adversos de la ablación contra un grupo control. METODOLOGÍA: estudio observacional en pacientes con estenosis biliar maligna irresecable. RESULTADOS: cuarenta pacientes, 12 radiofrecuencia, no hubo diferencias entre variables basales de ambos grupos. Hubo mayor sobrevida en el grupo de radiofrecuencia sin diferencia estadísticamente significativa (217 vs. 129 días, log-rank 0,31). No hubo diferencia en permeabilidad de prótesis o efectos adversos. CONCLUSIÓN: se encontró ganancia de tres meses en sobrevida a favor de la radiofrecuencia sin alcanzar diferencia estadísticamente significativa


No disponible


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Ablação por Radiofrequência/métodos , Resultado do Tratamento , Ablação por Cateter/métodos , Doenças dos Ductos Biliares/cirurgia , Colangiopancreatografia Retrógrada Endoscópica , Intervalo Livre de Progressão , Ablação por Cateter/instrumentação , Neoplasias dos Ductos Biliares/cirurgia , Ablação por Radiofrequência/efeitos adversos , Estudos Prospectivos
18.
Rev. patol. respir ; 23(3): 117-119, jul.-sept. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-198475

RESUMO

El hemotórax es una entidad causada habitualmente por traumatismos. Sin embargo, puede aparecer en el contexto de otras etiologías como las neoplasias, las coagulopatías o las enfermedades autoinmunes. Mujer de 77 años que acudió al Servicio de Urgencias por tos y disnea. La radiografía de tórax mostró derrame pleural izquierdo. Se colocó un drenaje pleural obteniendo contenido hemático. Se realizó una TAC que descartó patología torácica, pero mostró una neoplasia pancreática. La pleuroscopia confirmó la existencia de carcinomatosis pleural. El estudio anatomopatológico de las biopsias pleurales junto con los hallazgos clínicorradiológicos fueron altamente sugestivos de la etiología maligna pancreática como etiología del hemotórax. La etiología del hemotórax no traumático supone en ocasiones un reto diagnóstico. En pacientes con hemotórax y sin antecedentes traumáticos debe descartarse la etiología neoplásica del mismo


Haemothorax is more often caused by trauma. However, non-traumatic haemothorax has been associated to other aetiologies such as neoplasms, coagulopathy or autoimmune diseases. A 77-year-old woman was admitted to Hospital because of cough and dyspnoea. Chest-X-ray showed left pleural effusion. A chest tube revealed the presence of an haemothorax. A CT-scan dismissed thoracic aetiology of haemothorax but showed a pancreatobiliary neoplasm. Pleuroscopy confirmed pleural carcinomatosis. The anatomopathological features of pleural biopsies altogether with clinical and radiological findings suggested pancreatobiliary malignancy as the aetiology of the haemothorax. The aetiology of non-traumatic haemothorax is sometimes a diagnostic challenge. In patients with non-traumatic haemothorax, neoplastic aetiology should be always dismissed


Assuntos
Humanos , Feminino , Idoso , Hemotórax/diagnóstico por imagem , Neoplasias dos Ductos Biliares/diagnóstico por imagem , Neoplasias Pancreáticas/diagnóstico por imagem , Derrame Pleural Maligno/diagnóstico por imagem , Carcinoma/diagnóstico por imagem , Derrame Pleural Maligno/etiologia , Hemotórax/etiologia , Neoplasias dos Ductos Biliares/complicações , Neoplasias Pancreáticas/complicações , Carcinoma/complicações , Radiografia Torácica , Tomografia Computadorizada por Raios X , Toracoscopia , Biópsia
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